Giulio Genovese

Summary

Publications

  1. pmc Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes
    Giulio Genovese
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Am J Hum Genet 93:411-21. 2013
  2. pmc Improved IBD detection using incomplete haplotype information
    Giulio Genovese
    Department of Mathematics, Dartmouth College, Hanover NH 03755, USA
    BMC Genet 11:58. 2010
  3. pmc Using population admixture to help complete maps of the human genome
    Giulio Genovese
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Genet 45:406-14, 414e1-2. 2013
  4. doi APOL1 variants and kidney disease in people of recent African ancestry
    Giulio Genovese
    Stanley Center, Broad Institute, Cambridge, MA 02142, USA
    Nat Rev Nephrol 9:240-4. 2013
  5. pmc Large multiallelic copy number variations in humans
    Robert E Handsaker
    1 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 47:296-303. 2015
  6. pmc No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia
    Douglas M Ruderfer
    1 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 2 Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 3 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Eur J Hum Genet 23:555-7. 2015
  7. pmc Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection
    Gaurav Bhatia
    Harvard Massachusetts Institute of Technology MIT Division of Health, Science and Technology, Cambridge, USA
    Am J Hum Genet 89:368-81. 2011
  8. pmc Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion
    Hakan R Toka
    Division of Nephrology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e71885. 2013

Collaborators

Detail Information

Publications8

  1. pmc Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes
    Giulio Genovese
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Am J Hum Genet 93:411-21. 2013
    ..Genome assembly efforts and future builds of the human genome reference will be strongly informed by this localization of genes and other euchromatic sequences that are embedded within highly repetitive pericentromeric regions. ..
  2. pmc Improved IBD detection using incomplete haplotype information
    Giulio Genovese
    Department of Mathematics, Dartmouth College, Hanover NH 03755, USA
    BMC Genet 11:58. 2010
    ..The use of these platforms has enabled population-based genome-wide association studies. However, in inheritance-based studies, current methods do not take full advantage of the information present in such genotyping analyses...
  3. pmc Using population admixture to help complete maps of the human genome
    Giulio Genovese
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Genet 45:406-14, 414e1-2. 2013
    ..We describe how knowledge of the locations of these sequences can inform disease association and genome biology studies...
  4. doi APOL1 variants and kidney disease in people of recent African ancestry
    Giulio Genovese
    Stanley Center, Broad Institute, Cambridge, MA 02142, USA
    Nat Rev Nephrol 9:240-4. 2013
    ..Although no biological evidence currently exists for the causality of APOL1 variants with kidney disease, our statistical reasoning provides a strong case for causality, and a region to target in future functional studies...
  5. pmc Large multiallelic copy number variations in humans
    Robert E Handsaker
    1 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 47:296-303. 2015
    ..We also describe partially successful initial strategies for analyzing mCNVs via imputation and provide an initial data resource to support such analyses. ..
  6. pmc No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia
    Douglas M Ruderfer
    1 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 2 Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 3 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Eur J Hum Genet 23:555-7. 2015
    ..We do not find evidence for association with SCZ, either genome wide or at specific loci. However, we note the possible impact of sample size and population genetic factors on the power to detect and quantify any burden that may exist. ..
  7. pmc Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection
    Gaurav Bhatia
    Harvard Massachusetts Institute of Technology MIT Division of Health, Science and Technology, Cambridge, USA
    Am J Hum Genet 89:368-81. 2011
    ..The most significantly differentiated marker in our analysis, rs2920283, is highly differentiated in both Africa and East Asia and has prior genome-wide significant associations to bladder and gastric cancers...
  8. pmc Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion
    Hakan R Toka
    Division of Nephrology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e71885. 2013
    ..In the tested set of candidate genes, rare allelic variants do not appear to contribute significantly to differences in urinary calcium excretion between individuals...