Christof Geldmacher

Summary

Publications

  1. ncbi CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
    Christof Geldmacher
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 81:2440-8. 2007
  2. ncbi In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype
    Christof Geldmacher
    Mbeya Medical Research Program, Referral Hospital, Mbeya, Tanzania
    AIDS 21:135-43. 2007
  3. ncbi A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection
    Christof Geldmacher
    Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
    J Virol 81:13809-15. 2007
  4. ncbi Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
    Melody G Duvall
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Virol 81:13486-98. 2007
  5. ncbi Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo
    Alexandra Schuetz
    NIMR Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
    PLoS ONE 6:e27284. 2011
  6. ncbi Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
  7. ncbi Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
  8. ncbi Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
  9. ncbi Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
  10. ncbi SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007

Detail Information

Publications10

  1. ncbi CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
    Christof Geldmacher
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 81:2440-8. 2007
    ..36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection...
  2. ncbi In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype
    Christof Geldmacher
    Mbeya Medical Research Program, Referral Hospital, Mbeya, Tanzania
    AIDS 21:135-43. 2007
    ..This study was designed to assess whether the Gag- and Nef-specific T-cell response is biased towards recognizing the infecting subtype...
  3. ncbi A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection
    Christof Geldmacher
    Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
    J Virol 81:13809-15. 2007
    ..0001) and subdominant in the hierarchy of Gag-specific responses. The present study indicates that chronic exposure of the human immune system to high levels of HIV viremia is a determinant of virus-specific CD8 T-cell loss...
  4. ncbi Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
    Melody G Duvall
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Virol 81:13486-98. 2007
    ....
  5. ncbi Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo
    Alexandra Schuetz
    NIMR Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
    PLoS ONE 6:e27284. 2011
    ..The analysis of T cell maturation and activation markers might thus be a useful tool to monitor TB disease progression...
  6. ncbi Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:2869-81. 2010
    ....
  7. ncbi Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
    ..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection...
  8. ncbi Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Blood 114:1553-62. 2009
    ..Thus, minor viral and host genetic polymorphisms can dramatically alter the immunologic and virologic outcome of an epitope-specific CD8 T-cell response...
  9. ncbi Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection
    Christof Geldmacher
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 198:1590-8. 2008
    ..This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection...
  10. ncbi SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, 40 Convent Drive, Bethesda, MD 20892, USA
    Blood 110:928-36. 2007
    ..Manipulation of the interaction of PD-1 with its ligands could thus potentially restore the CD8+ T-cell responses in SIV infection...