The role of genetics in the etiology of schizophreniaPablo V Gejman
Department of Psychiatry and Behavioral Sciences and Research Institute, Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
Psychiatr Clin North Am 33:35-66. 2010
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Genome-wide approaches to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL 60201, USA
Brain Res Bull 83:93-102. 2010
..Deep resequencing for rare variants and system biology approaches (e.g., integrating DNA sequence and functional data) are expected to further improve our understanding of the genetic architecture of SZ and its underlying biology...
No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008
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DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the geneJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, Ill, USA
Hum Hered 64:97-106. 2007
..We have performed an association study with two well-characterized family samples not previously investigated at the DTNBP1 locus...
Neuregulin 1 (NRG1 ) and schizophrenia: analysis of a US family sample and the evidence in the balanceJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare Research Institute, and Northwestern University, 1001 University Place, Evanston, IL 60201, USA
Psychol Med 35:1599-610. 2005
..A gene from this region, neuregulin 1 (NRG1 ), known to be involved with glutamatergic function, has been found to be associated in some studied samples...
The Internet-based MGS2 control sample: self report of mental illnessAlan R Sanders
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, Ill 60201 3137, USA
Am J Psychiatry 167:854-65. 2010
..The Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N=3,364) and African American (N=1,301) subjects...
Genetics of schizophrenia: new findings and challengesPablo V Gejman
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
Annu Rev Genomics Hum Genet 12:121-44. 2011
..A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia...
Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell linesJubao Duan
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute Evanston, Illinois 60201, USA
Sci Rep 3:1318. 2013
..These results suggest widespread interindividual differences in RNA stability related to DNA sequence and composition variation...
Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
Am J Hum Genet 75:624-38. 2004
..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples...
[The etiology of schizophrenia]Pablo V Gejman
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois, USA
Medicina (B Aires) 72:227-34. 2012
..The current and upcoming resequencing programs - both exomes (all exons) and full genomes - and genome-wide transcriptional analyses will allow a more thorough dissection of the molecular genetics of the disorder...