Elisabetta Gazzerro

Summary

Publications

  1. ncbi request reprint Skeletal overexpression of gremlin impairs bone formation and causes osteopenia
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105 1299, USA
    Endocrinology 146:655-65. 2005
  2. ncbi request reprint Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105 1299, USA
    Bone 39:1252-60. 2006
  3. ncbi request reprint Bone morphogenetic proteins and their antagonists
    Elisabetta Gazzerro
    Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, Genoa, Italy
    Rev Endocr Metab Disord 7:51-65. 2006
  4. doi request reprint The spectrum of GNE mutations: allelic heterogeneity for a common phenotype
    Marina Grandis
    Section of Neurology and Neurological Rehabilitation, Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132, Genoa, Italy
    Neurol Sci 31:377-80. 2010
  5. doi request reprint Neuromuscular disorders of glycogen metabolism
    Elisabetta Gazzerro
    Center of Myology, Pediatric Neurology Unit, Department of Neuroscience and Rehabilitation, G Gaslini Institute, Largo G Gaslini, 5, 16147, Genoa, Italy
    Curr Neurol Neurosci Rep 13:333. 2013
  6. ncbi request reprint Potential drug targets within bone morphogenetic protein signaling pathways
    Elisabetta Gazzerro
    Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, L go G Gaslini 5, 16148 Genoa, Italy
    Curr Opin Pharmacol 7:325-33. 2007
  7. ncbi request reprint Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies
    Stefania Assereto
    Muscular and Neurodegenerative Disease Unit, Department of Pediatrics of University of Genova, Department of Neuroscience and Rehabilitation, G Gaslini Institute, Genoa, Italy
    Cell Cycle 7:2199-207. 2008
  8. ncbi request reprint Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
  9. ncbi request reprint Conditional deletion of gremlin causes a transient increase in bone formation and bone mass
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105 1299, USA
    J Biol Chem 282:31549-57. 2007
  10. ncbi request reprint Phenotypic characterization of hypomyelination and congenital cataract
    Roberta Biancheri
    Muscular and Neurodegenerative Disease Unit, G Gaslini Institute and University of Genova, Genova, Italy
    Ann Neurol 62:121-7. 2007

Collaborators

  • ERNESTO M CANALIS
  • Claudio Bruno
  • Carlo Minetti
  • Vincenzo Nigro
  • M P Lisanti
  • Marina Grandis
  • A Frigeri
  • Stefania Assereto
  • Roberta Biancheri
  • Federico Zara
  • Silvia Stringara
  • Angelo Schenone
  • Marina Pedemonte
  • Andrea Rossi
  • Laura Bordo
  • Paolo Tortori-Donati
  • Graziella Uziel
  • Marjo S van der Knaap
  • Federica Sotgia
  • Valerie Deregowski
  • Filomena Cetani
  • Paolo Broda
  • Maria Svelto
  • Mauro Mastrototaro
  • Grazia Paola Nicchia
  • Annemieke J M Rozemuller
  • Valeria Costa
  • Sara Scapolan
  • Marianna Bugiani
  • Massimo Bado
  • Laura Doria Lamba
  • Leah Priest
  • Sheila Rydziel
  • Xiao Bo Wang
  • Stefania Gianotti
  • Simona Borsari
  • Elena Pardi
  • Piero Berti
  • Giacomo Colussi
  • Claudio Marcocci
  • Elena Ambrogini
  • Luisella Cianferotti
  • Paolo Miccoli
  • Aldo Pinchera
  • Paolo Viacava
  • Giada Dipollina

Detail Information

Publications14

  1. ncbi request reprint Skeletal overexpression of gremlin impairs bone formation and causes osteopenia
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105 1299, USA
    Endocrinology 146:655-65. 2005
    ..In conclusion, transgenic mice overexpressing gremlin in the bone microenvironment have decreased osteoblast number and function leading to osteopenia and spontaneous fractures...
  2. ncbi request reprint Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105 1299, USA
    Bone 39:1252-60. 2006
    ..In conclusion, endogenous Tsg is required for normal BMP activity in osteoblastic cells in vitro, but it plays a minor role in the regulation of adult bone homeostasis in vivo...
  3. ncbi request reprint Bone morphogenetic proteins and their antagonists
    Elisabetta Gazzerro
    Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, Genoa, Italy
    Rev Endocr Metab Disord 7:51-65. 2006
    ..Both intracellular and extracellular antagonists are regulated by BMPs, indicating the existence of local feedback mechanisms to modulate BMP cellular activities...
  4. doi request reprint The spectrum of GNE mutations: allelic heterogeneity for a common phenotype
    Marina Grandis
    Section of Neurology and Neurological Rehabilitation, Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132, Genoa, Italy
    Neurol Sci 31:377-80. 2010
    ..The second patient showed a slowly progressive deterioration, different from other patients carrying mutations in the epimerase domain, who had a severe and rapid progression...
  5. doi request reprint Neuromuscular disorders of glycogen metabolism
    Elisabetta Gazzerro
    Center of Myology, Pediatric Neurology Unit, Department of Neuroscience and Rehabilitation, G Gaslini Institute, Largo G Gaslini, 5, 16147, Genoa, Italy
    Curr Neurol Neurosci Rep 13:333. 2013
    ..These experimental models are greatly improving the understanding of the pathogenetic mechanisms underlying the muscle degenerative process associated to these diseases and provide in vivo platforms to test new therapeutic strategies...
  6. ncbi request reprint Potential drug targets within bone morphogenetic protein signaling pathways
    Elisabetta Gazzerro
    Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, L go G Gaslini 5, 16148 Genoa, Italy
    Curr Opin Pharmacol 7:325-33. 2007
    ..Both extracellular and intracellular antagonists are regulated by BMPs, indicating the existence and need for local feedback mechanisms to modulate BMP biological responses...
  7. ncbi request reprint Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies
    Stefania Assereto
    Muscular and Neurodegenerative Disease Unit, Department of Pediatrics of University of Genova, Department of Neuroscience and Rehabilitation, G Gaslini Institute, Genoa, Italy
    Cell Cycle 7:2199-207. 2008
    ..In conclusion, AQP4 expression and membrane localization are markedly reduced in LGMD 2B-2F. The role of AQP4 in the degenerative mechanism occurring in these diseases will be the object of our future research...
  8. ncbi request reprint Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
    ..The finding that two of the seven patients with sporadic parathyroid cancer carried an HRPT2 germline mutation suggests that they might have occult HPT-JT. Our results also confirm the need for testing HRPT2 gene in FIHP families...
  9. ncbi request reprint Conditional deletion of gremlin causes a transient increase in bone formation and bone mass
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105 1299, USA
    J Biol Chem 282:31549-57. 2007
    ..In conclusion, deletion of grem1 in the bone microenvironment results in sensitization of BMP signaling and activity and enhanced bone formation in vivo...
  10. ncbi request reprint Phenotypic characterization of hypomyelination and congenital cataract
    Roberta Biancheri
    Muscular and Neurodegenerative Disease Unit, G Gaslini Institute and University of Genova, Genova, Italy
    Ann Neurol 62:121-7. 2007
    ..3-p15.3...
  11. ncbi request reprint Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro
    Elisabetta Gazzerro
    Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105 1299, USA
    Endocrinology 146:3875-82. 2005
    ..In conclusion, Tsg overexpression inhibits BMP action in stromal and preosteoblastic cells and, accordingly, arrests their differentiation toward the osteoblastic pathway...
  12. ncbi request reprint Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract
    Federico Zara
    Muscular and Neurodegenerative Disease Unit, G Gaslini Institute and University of Genova, Italy
    Nat Genet 38:1111-3. 2006
    ..We identified mutations in five affected families, resulting in a deficiency of hyccin, a newly identified 521-amino acid membrane protein. Our study highlights the essential role of hyccin in central and peripheral myelination...
  13. ncbi request reprint Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling
    Valerie Deregowski
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105 1299, USA
    J Biol Chem 281:6203-10. 2006
    ..In conclusion, NICD overexpression prevents BMP-2 and Wnt biological effects by suppressing Wnt but not BMP signaling. HES-1 appears to mediate effects of Notch on osteoblastogenesis...
  14. ncbi request reprint Bone morphogenetic proteins, their antagonists, and the skeleton
    Ernesto Canalis
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    Endocr Rev 24:218-35. 2003
    ..The antagonists tend to be specific for BMPs and are regulated by BMPs, indicating the existence and need of local feedback mechanisms to temper BMP cellular activities...