Top-down suppression deficit underlies working memory impairment in normal agingAdam Gazzaley
Henry H Wheeler, Jr Brain Imaging Center, Helen Wills Neuroscience Institute and Department of Psychology, University of California Berkeley, Berkeley, California 94720, USA
Nat Neurosci 8:1298-300. 2005
..Moreover, this suppression-specific attention deficit correlated with impaired working memory performance...
Influence of early attentional modulation on working memoryAdam Gazzaley
Department of Neurology, Physiology and Psychiatry, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, USA
Neuropsychologia 49:1410-24. 2011
..Factors that affect attentional control at this stage include cognitive load, task practice, perceptual training, and aging. These developments highlight the complex and dynamic relationships among perception, attention, and memory...
- Top-down enhancement and suppression of the magnitude and speed of neural activity
Adam Gazzaley
University of California, Berkeley, CA, USA
J Cogn Neurosci 17:507-17. 2005
..We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits...
- Functional connectivity during working memory maintenance
Adam Gazzaley
University of California, Berkeley, California 94720, USA
Cogn Affect Behav Neurosci 4:580-99. 2004
..These findings support the notion that the coordinated functional interaction between nodes of a widely distributed network underlies the active maintenance of a perceptual representation...
- Early top-down control of visual processing predicts working memory performance
Aaron M Rutman
University of California, San Francisco, CA 94158, USA
J Cogn Neurosci 22:1224-34. 2010
..These results contribute to our evolving understanding of the mechanistic overlap between attention and memory...
- Mechanisms of working memory disruption by external interference
Wesley C Clapp
Department of Neurology and Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
Cereb Cortex 20:859-72. 2010
..These results elucidate the mechanisms of external interference on WM performance and highlight similarities and differences of distraction and multitasking...
- Delays in neural processing during working memory encoding in normal aging
Theodore P Zanto
Department of Neurology, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
Neuropsychologia 48:13-25. 2010
..These results suggest that the presence of both generalized feature-based and feature-specific deficits in the speed of selective encoding of information contributes to WM performance deficits in older adults...
- Top-down modulation of visual feature processing: the role of the inferior frontal junction
Theodore P Zanto
Departments of Neurology and Physiology, University of California San Francisco, San Fransisco, CA, USA
Neuroimage 53:736-45. 2010
..Furthermore, long-distance alpha (8-12Hz) phase coherence between the IFJ and visual cortices may serve as a mechanism underlying anticipatory, top-down modulation of color feature processing...
- Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory
Theodore P Zanto
Department of Neurology, University of California, San Francisco, San Francisco, California, USA
Nat Neurosci 14:656-61. 2011
..These results suggest that top-down modulation mediated by the prefrontal cortex is a causal link between early attentional processes and subsequent memory performance...
- Diminished top-down control underlies a visual imagery deficit in normal aging
Jonathan Kalkstein
WM Keck Center For Integrative Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, California 94158 2240, USA
J Neurosci 31:15768-74. 2011
..These results reveal that aging disrupts neural networks that subserve mental imagery and offers evidence of this as a factor in age-related memory decline...
- Dissociation of motor and sensory inhibition processes in normal aging
Joaquin A Anguera
Departments of Neurology, Physiology and Psychiatry, WM Keck Center For Integrative Neurosciences, University of California, San Francisco, CA 94158 2330, USA
Clin Neurophysiol 123:730-40. 2012
..In the present study, we hypothesized neural markers reflecting each type of inhibition may reveal a relationship across inhibitory domains in older adults...
- The effect of non-visual working memory load on top-down modulation of visual processing
Jesse Rissman
Henry H Wheeler Jr Brain Imaging Center, University of California, Berkeley, 94720, USA
Neuropsychologia 47:1637-46. 2009
..Cooney, J. W., Rissman, J., & D'Esposito, M. (2005). Top-down suppression deficit underlies working memory impairment in normal aging. Nature Neuroscience 8, 1298-1300], suggesting the possibility of a common underlying mechanism...
- Age-related changes in orienting attention in time
Theodore P Zanto
Departments of Neurology and Physiology, University of California San Francisco, San Francisco, California 94158, USA
J Neurosci 31:12461-70. 2011
..Overall, these results provide novel evidence that older adults do not use temporal cues to orient attention in time and support an expectation deficit in normal aging...
- Predictive knowledge of stimulus relevance does not influence top-down suppression of irrelevant information in older adults
Theodore P Zanto
Department of Neurology, University of California San Francisco, CA, USA
Cortex 46:564-74. 2010
..These results suggest that the inability to suppress irrelevant information early in the visual processing stream by older adults is related to mechanisms specific to top-down suppression...
- Expectation-driven changes in cortical functional connectivity influence working memory and long-term memory performance
Jacob Bollinger
W M Keck Center for Integrative Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
J Neurosci 30:14399-410. 2010
..g., FFA) can be dynamically linked or disconnected from different brain regions depending on prestimulus expectations, and the strength of distinct connections is associated with WM or LTM benefits...
- Neural mechanisms underlying the impact of visual distraction on retrieval of long-term memory
Peter E Wais
Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, California 94158 2330, USA
J Neurosci 30:8541-50. 2010
..We conclude that bottom-up influences from irrelevant visual information interfere with top-down selection of episodic details mediated by a capacity-limited frontal control region, resulting in impaired recollection...
- Reward modulation of prefrontal and visual association cortex during an incentive working memory task
Daniel C Krawczyk
Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, USA
Brain Res 1141:168-77. 2007
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- An expectation-based memory deficit in aging
Jacob Bollinger
Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA, USA
Neuropsychologia 49:1466-75. 2011
..This deficit may have broader consequences for the effective utilization of predictive cues to guide attention and engender optimal cognitive performance in older individuals...
- Age-related top-down suppression deficit in the early stages of cortical visual memory processing
Adam Gazzaley
Department of Neurology and Physiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 105:13122-6. 2008
..Thus, these data reconcile two cognitive aging hypotheses by revealing that an interaction of deficits in inhibition and processing speed contributes to age-related cognitive impairment...
- Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing
Adam Gazzaley
Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, CA 94143 2522, USA
Cereb Cortex 17:i125-35. 2007
..Although our correlation analyses do not permit assessment of directionality, these findings suggest that PFC biases activity levels in VAC by adjusting the strength of functional coupling in accordance with stimulus relevance...
- Practice-related improvement in working memory is modulated by changes in processing external interference
Anne S Berry
Department of Neurology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, 600 16th St, Genentech Hall, MC2240 Rm N472J, San Francisco, CA 94158, USA
J Neurophysiol 102:1779-89. 2009
....
- Differential coupling of visual cortex with default or frontal-parietal network based on goals
James Z Chadick
Department of Neurology, Physiology and Psychiatry, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, USA
Nat Neurosci 14:830-2. 2011
..This indicates that sensory cortical regions are differentially and dynamically coupled with distinct networks on the basis of task goals...
- Neural suppression of irrelevant information underlies optimal working memory performance
Theodore P Zanto
Department of Neurology and Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, California, 94158, USA
J Neurosci 29:3059-66. 2009
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- The influence of perceptual training on working memory in older adults
Anne S Berry
Departments of Neurology and Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California, USA
PLoS ONE 5:e11537. 2010
..These findings demonstrate the strength of the perceptual discrimination training approach by offering clear psychophysical evidence of transfer-of-benefit and a neural mechanism underlying cognitive improvement...
- Measuring functional connectivity during distinct stages of a cognitive task
Jesse Rissman
Henry H Wheeler Jr Brain Imaging Center, University of California, Berkeley, Berkeley, CA 94720, USA
Neuroimage 23:752-63. 2004
..Distinct functional connectivity maps were generated during the component stages of this task, illustrating how important and novel observations of neural networks within the isolated stages of a cognitive task can be obtained...
- Attention distributed across sensory modalities enhances perceptual performance
Jyoti Mishra
Department of Neurology, Physiology and Psychiatry, Keck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, California 94158, USA
J Neurosci 32:12294-302. 2012
..These results highlight a novel neural mechanism for top-down driven performance benefits via enhanced efficacy of sensory neural processing during distributed audiovisual attention relative to focused visual attention...
- Top-down modulation: bridging selective attention and working memory
Adam Gazzaley
Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA
Trends Cogn Sci 16:129-35. 2012
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- Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
Judy Pa
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Ann Neurol 65:414-23. 2009
..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI...
- Dynamic adjustments in prefrontal, hippocampal, and inferior temporal interactions with increasing visual working memory load
Jesse Rissman
Henry H Wheeler, Jr Brain Imaging Center, Department of Psychology, University of California Berkeley, Berkeley, CA 94720, USA
Cereb Cortex 18:1618-29. 2008
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- Age-related deficits in component processes of working memory
Adam Gazzaley
Department of Neurology, University of California, CA 94143 2522, USA
Neuropsychology 21:532-9. 2007
..These results suggest that when working memory maintenance systems are taxed, faulty recognition processes may underlie cognitive aging deficits in healthy older individuals...
- The impact of visual distraction on episodic retrieval in older adults
Peter E Wais
Departments of Neurology, Physiology and Psychiatry, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, USA
Brain Res 1430:78-85. 2012
..More generally, these findings explicate a mechanistic basis for selective impairment of recollection in normal aging...
- Reducing vascular variability of fMRI data across aging populations using a breathholding task
Daniel A Handwerker
Henry H Wheeler Jr Brain Imaging Center, Helen Wills Neuroscience Institute, University of California, Berkeley, USA
Hum Brain Mapp 28:846-59. 2007
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- Distinct mechanisms for the impact of distraction and interruption on working memory in aging
Wesley C Clapp
Departments of Neurology and Physiology, WM Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, United States
Neurobiol Aging 33:134-48. 2012
..These results suggest that distinct underlying mechanisms mediate the impact of different types of external interference on WM in normal aging...
- Top-down modulation and normal aging
Adam Gazzaley
Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143 2522, USA
Ann N Y Acad Sci 1097:67-83. 2007
..We are now further characterizing the basis of these age-related alterations in top-down modulation and investigating interventions to remedy them...
- Distractibility during episodic retrieval is exacerbated by perturbation of left ventrolateral prefrontal cortex
Peter E Wais
Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94158, USA
Cereb Cortex 22:717-24. 2012
....
The impact of auditory distraction on retrieval of visual memoriesPeter E Wais
Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94158 2330, USA
Psychon Bull Rev 18:1090-7. 2011
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- Deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults
Wesley C Clapp
Department of Neurology, The W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:7212-7. 2011
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- Is the prefrontal cortex necessary for delay task performance? Evidence from lesion and FMRI data
MARK D'ESPOSITO
Helen Wills Neuroscience Institute, University of California Berkeley, 132 Barker Hall, Berkeley, CA 94720 3190, USA
J Int Neuropsychol Soc 12:248-60. 2006
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- Subjective aspects of cognitive control at different stages of processing
Ezequiel Morsella
Department of Psychology, San Francisco State University, 1600 Holloway Avenue, EP 301, San Francisco, CA 94132 4168, USA
Atten Percept Psychophys 71:1807-24. 2009
..In addition, these data have implications for the study of response interference in affect and self-control, and they begin to address theories regarding the function of consciousness...
- Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
Leon Y Deouell
Henry H. Wheeler Jr. Brain Imaging Center, Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, Berkeley, California 94720-1650, USA
Nat Rev Neurosci 4:863-72. 2003
- The contribution of functional brain imaging to our understanding of cognitive aging
Adam Gazzaley
Henry H. Wheeler, Jr. Brain Imaging Center at the Helen Wills Neuroscience Institute and the Department of Psychology at the University of California, Berkeley, CA 94720, USA
Sci Aging Knowledge Environ 2003:PE2. 2003
..New methods in functional brain imaging are beginning to provide possible answers to questions regarding age-related cognitive decline...
- Response bias and aging on a recognition memory task
Terri J Huh
Department of Psychiatry, Memory and Aging Center, University of California San Francisco, California 94143, USA
J Int Neuropsychol Soc 12:1-7. 2006
..In the light of reported relationships between frontal regions and both aging and response bias, we hypothesize that frontal changes may be the underlying mechanism explaining the increase in liberal response bias with age...
