Adipose tissue inflammation and insulin resistance: all obese humans are not created equalMarie Soleil Gauthier
Diabetes and Metabolism Unit, Department of Medicine, Section of Endocrinology, Boston University Medical Center, Boston, MA 02118, U S A
Biochem J 430:e1-4. 2010
..Further studies will be required for this purpose, as well as to identify the pathogenetic factors that determine whether or not adipose tissue of an obese individual becomes inflamed...
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humansMarie Soleil Gauthier
Diabetes and Metabolism Unit, Section of Endocrinology, Boston University School of Medicine, Boston, MA 02118, USA
Biochem Biophys Res Commun 404:382-7. 2011
..Whether adipose tissue AMPK dysregulation is a causal factor for the development of the inflammation and insulin resistance remains to be determined...
- Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
X Julia Xu
Diabetes and Metabolism Unit, Section of Endocrinology, Boston University School of Medicine, Boston, MA 02118, USA
J Lipid Res 53:792-801. 2012
..However, most changes in gene expression appear to be depot-specific...
- A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
Lauren E Nelson
Endocrinology, Diabetes, and Nutrition Section, Department of Medicine, Boston University School of Medicine, Massachusetts, USA
Am J Physiol Cell Physiol 303:C4-C13. 2012
..Collectively, these findings suggest the existence of a novel reciprocal interaction between AMPK/SIRT1 and p53 that may have implications for the pathogenesis and treatment of metabolic diseases...
- Acute exercise activates AMPK and eNOS in the mouse aorta
Jose M Cacicedo
Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Physiol Heart Circ Physiol 301:H1255-65. 2011
..The results also suggest that AMPK likely is the principal activator of eNOS in this setting and that its own activation may be mediated by both SIRT1-LKB1 and CaMKKβ...
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
Gabriela Suchankova
Department of Medicine, Section of Endocrinology, Boston Medical Center, Boston, MA 02118, USA
Biochem Biophys Res Commun 378:836-41. 2009
..Collectively, these findings raise the possibility that glucose-induced changes in AMPK are linked to alterations in SIRT1 abundance and activity and possibly cellular redox state...
- AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance
Marie Soleil Gauthier
Diabetes and Metabolism Unit, Department of Medicine Section of Endocrinology, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 283:16514-24. 2008
..Finally, this AMPK activation appears to restrain the energy depletion and oxidative stress caused by lipolysis...
