The effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parametersEsteban Martinez
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, C Villarroel 170, 08036 Barcelona, Spain
AIDS 24:353-63. 2010
..To assess the effects of decreased antiretroviral therapy exposure on body fat and metabolic parameters...
Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL studyEsteban Martinez
Infectious Diseases Unit, Hospital Clínic Institut d Investigaciones Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS 24:1697-707. 2010
..Switching to raltegravir in selected patients treated with ritonavir-boosted protease inhibitors may result in similar efficacy and lower plasma lipids...
- The use of integrase inhibitors in treatment-experienced patients
Jose M Gatell
Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Eur J Med Res 14:30-5. 2009
..Most likely explanation was the presence of archived resistance mutationts to background therapy leading to a functional monotherapy with raltegravir...
- When and why to start antiretroviral therapy?
Jose M Gatell
Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
J Antimicrob Chemother 65:383-5. 2010
..Willingness to be treated and to adhere to the prescribed medication still remains the key to success...
[Efficacy of raltegravir: from healthy volunteers to phase III trials]Jose M Gatell
Servicio de Infecciones, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Barcelona, Espana
Enferm Infecc Microbiol Clin 26:29-33. 2008
..For all these reasons, raltegravir is an attractive option in treatment-naive and pretreated patients and in those receiving simplification regimens...
- Efficacy and safety of atazanavir-based highly active antiretroviral therapy in patients with virologic suppression switched from a stable, boosted or unboosted protease inhibitor treatment regimen: the SWAN Study (AI424-097) 48-week results
Jose Gatell
Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Clin Infect Dis 44:1484-92. 2007
..Limited data are available on the usefulness of switching from a PI-based regimen to a regimen based on a different PI, such as atazanavir, in HIV-infected patients experiencing virologic suppression but seeking regimen simplification...
- Management of dyslipidaemia in HIV-infected patients receiving antiretroviral therapy
Esteban Martinez
Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Antivir Ther 9:649-63. 2004
..Development of new PIs with more favourable effects on the lipid profile should be of benefit...
- [Secondary effects associated with raltegravir]
Jose M Gatell
Servicio de Infecciones, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Barcelona, Espana
Enferm Infecc Microbiol Clin 26:34-9. 2008
..The most notable were diarrhea, nausea and headache. The lipid profile of raltegravir was better than that of efavirenz. In view of the above, the risk-benefit ratio for raltegravir is positive...
- Immunological and virological factors at baseline may predict response to structured therapy interruption in early stage chronic HIV-1 infection
Felipe Garcia
Clinic Institute of Infections and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
AIDS 16:1761-5. 2002
..The objective was to analyse which baseline factors could predict a favourable outcome after structured therapy interruption (STI)...
- A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study
Felipe Garcia
Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
AIDS 17:43-51. 2003
....
- Influence of a vaccination schedule on viral load rebound and immune responses in successfully treated HIV-infected patients
Pedro Castro
Medical Intensive Care Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 25:1249-59. 2009
..However, it induced an increase in T cell activation and a drop in CD4(+) T cells, although these changes did not influence the VL rebound dynamics after HAART interruption...
- Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction
Esteban Martinez
Infectious Diseases Unit, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, C Villarroel 170, 08036 Barcelona, Spain
AIDS 24:F1-9. 2010
..To assess the effects of initiating abacavir-containing therapy on plasma lipids and cardiovascular biomarkers...
- A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression
Esteban Martinez
Hospital Clinic Institut d Investigaciones Biomediques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
J Acquir Immune Defic Syndr 51:290-7. 2009
..We compared 48-week efficacy and safety of these combinations as substitutes of nucleosides in patients with virological suppression...
- Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients
Esteban Martinez
Hospital Clinic, Barcelona, Spain
AIDS 21:367-9. 2007
..In contrast, abacavir showed a lower incidence of adverse effects leading to drug discontinuation...
- Phenotypic and functional characteristics of HIV-specific CD8 T cells and gag sequence variability after autologous dendritic cells based therapeutic vaccine
Anna Lopez
Retrovirology and Viral Immunopathology Laboratory, Hospital Clinic, University of Barcelona, Barcelona, Spain
Vaccine 27:6166-78. 2009
..Taken together, heterogeneity in the maturation status of HIV-specific CD8 T cells may be partially involved in the drop of peptide-specific IFN-gamma production during immunizations...
- Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor
Jose L Blanco
Infectious Diseases Service, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
AIDS 19:829-31. 2005
..Only one of the 66 patients developed changes in their pattern of mutations able to generate or increase resistance to new drugs...
- Immune restoration in HIV-positive, antiretroviral-naive patients after 1 year of zidovudine/lamivudine plus nelfinavir or nevirapine
Montserrat Plana
Institut Clinic d Infeccions i Immunologia, Immunology, Infectious Diseases and Microbiology Units, Institut de Investigació Biomèdica Agusti Pi i Suñer, Hospital Clinic, University of Barcelona, Barcelona, Spain
Antivir Ther 9:197-204. 2004
..To evaluate the immunological response in HIV-1-infected, antiretroviral-naive patients receiving highly active antiretroviral therapy regimen of two nucleosides plus a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor...
- Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz T
Jose M Miro
Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 26:747-57. 2010
..At 1 and 3 years, the immune reconstitution induced by an efavirenz-based regimen in very immunosuppressed patients was at least as potent as that induced by a ritonavir-boosted protease inhibitor-based antiretroviral regimen...
- Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patients
Miriam J Alvarez-Martinez
Hospital Clínic IDIBAPS Institut d Investigació August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Diagn Microbiol Infect Dis 68:60-5. 2010
..However, their presence did not worsen prognosis of PcP. The response to TMP-SMX with therapeutic doses was successful in most cases...
- Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV
Nuria Climent
Hospital Clinic, Barcelona, Spain
Immunol Cell Biol 87:634-9. 2009
..As IFN-gamma, TNF-alpha and IL-6 promote the Th1 versus Th2 phenotype and improve T helper proliferation responses and antigen-specific CTL responses ADA may be considered a promising candidate for therapeutic vaccine adjuvant...
- Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients
Agnes Libois
Infectious Diseases Unit, School of Medicine, University of Barcelona, Spain
AIDS Res Hum Retroviruses 22:657-66. 2006
..Conversely, higher and longer viral replication after cessation of HAART overwhelms the immune system. These data may help to guide future immune-based therapies...
- Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavir
Olga Millán
Servei Immunologia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
Clin Pharmacokinet 44:525-38. 2005
..Due to the low doses involved, pharmacokinetic-pharmacodynamic monitoring is recommended...
- Efficacy and safety of switching from boosted lopinavir to boosted atazanavir in patients with virological suppression receiving a LPV/r-containing HAART: the ATAZIP study
Josep Mallolas
Hospital Clinic Universitari IDIBAPS, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 51:29-36. 2009
..To evaluate the efficacy and safety of switching from boosted lopinavir (LPV/r) to boosted atazanavir (ATV/r) in virologically suppressed HIV-1-infected patients versus continuing LPV/r...
- HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infection
Marta Garrido
Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 46:268-74. 2007
..Our main objective was to study ICAM-1 expression in LT from HIV-1-infected persons and to correlate this expression with LT viral load and the immunoarchitecture alteration before and after highly active antiretroviral therapy (HAART)...
- Clinicoimmunological progression and response to treatment of long-term nonprogressor HIV-hepatitis C virus-coinfected patients
Pedro Castro
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
AIDS Res Hum Retroviruses 23:863-7. 2007
..HCV-treated LTNP could have a worse HIV progression than HIV-HCV-treated NP or untreated coinfected LTNP. HCV infection does not have a deleterious effect on the progression of LTNP...
- Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression
Marta Rodríguez-García
Service of Immunology, Hospital Clinic de Barcelona, Barcelona, Spain
PLoS ONE 5:e9436. 2010
..Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of alpha-defensins1-3 production by DC on disease progression...
- Tacrolimus treatment of plasmacytoid dendritic cells inhibits dinucleotide (CpG-)-induced tumour necrosis factor-alpha secretion
Mar Naranjo-Gómez
Laboratory of Immunobiology for Research and Diagnosis, Blood and Tissue Bank BST, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain
Immunology 119:488-98. 2006
..These results show that tacrolimus treatment of PDCs impairs CpG-induced activation, which could affect the outcome of the immune response...
- Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation
José M Martinez-Navio
Department of Biochemistry and Molecular Biology, Faculty of Biology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Immunology 128:393-404. 2009
....
- Efficacy and safety of outpatient parenteral antibiotic therapy for infective endocarditis: a ten-year prospective study
Carlos Cervera
Service of Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Enferm Infecc Microbiol Clin 29:587-92. 2011
....
- Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation
Anna Suy
Gynecology Department, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Infect Dis 196:1191-201. 2007
....
- Lymphoid tissue collagen deposition in HIV-infected patients correlates with the imbalance between matrix metalloproteinases and their inhibitors
Alba Diaz
Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
J Infect Dis 203:810-3. 2011
..047). To our knowledge, this is the first time that MMP/TIMP imbalance has been correlated with lymphoid tissue collagen deposition and incomplete immune recovery in HIV-infected patients, even after long-term antiretroviral treatment...
- Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells
José M Martinez-Navio
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Spain
J Leukoc Biol 89:127-36. 2011
..These data suggest that ADA is a relevant modulator of CD4+ T cell differentiation, even in cells from immunologically compromised individuals...
- Influence of repeated cycles of structured therapy interruption on the rate of recovery of CD4+ T cells after highly active antiretroviral therapy resumption
Agathe Leon
Infectious Diseases Department, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
J Antimicrob Chemother 63:184-8. 2009
..CD4+ T cell recovery dynamics were analysed during the 'on treatment' periods in structured therapy interruption (STI) as well as the long-term immune reconstitution with highly active antiretroviral therapy (HAART) after finishing STI...
- Short Communication: Natural killer cells and expression of KIR receptors in chronic HIV type 1-infected patients after different strategies of structured therapy interruption
Gabriel Mestre
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 24:1485-95. 2008
..This finding suggests that STI could decrease the number of NK subsets, which is related to the worst clinical development in these patients...
- Long-term CD4+ T-cell response to highly active antiretroviral therapy according to baseline CD4+ T-cell count
Felipe Garcia
Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
J Acquir Immune Defic Syndr 36:702-13. 2004
..It seems that the immune recovery slows down after approximately 3 years of HAART and reaches a plateau after 4-5 years of HAART...
- The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients
Ana Milinkovic
Infectious Diseases Unit, Hospital Clinic Barcelona, Barcelona, Spain
Antivir Ther 12:407-15. 2007
..We assessed the safety and efficacy of reducing the dose of stavudine compared with switching to tenofovir or maintaining the standard dose of d4T...
- Less lipoatrophy and better lipid profile with abacavir as compared to stavudine: 96-week results of a randomized study
Daniel Podzamczer
Infectious Disease Service, Hospital Universitari de Bellvitge, Barcelona, Spain
J Acquir Immune Defic Syndr 44:139-47. 2007
..To assess lipoatrophy, other toxicities, and efficacy associated with abacavir as compared with stavudine in HIV-infected antiretroviral-naive patients...
- Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus
Francesc Marco
Microbiology Service, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
Antimicrob Agents Chemother 52:2538-43. 2008
..01). No statistically significant difference between the vancomycin HD and the vancomycin RD for MRSA treatment was noted. These results support the use of daptomycin for the treatment of aortic valve endocarditis caused by GISA and MRSA...
- Assessment of migration of HIV-1-loaded dendritic cells labeled with 111In-oxine used as a therapeutic vaccine in HIV-1-infected patients
Alba Ruiz
Infectious Diseases Unit, Hospital Clinic, Villarroel 170, Barcelona, Spain
Immunotherapy 1:347-54. 2009
..92, p = 0.03). If more than 20,000 ILDCs had migrated, they could have been detected. In future trials, a higher number of DCs or alternative methods should be used to assess the migration of DCs to lymph nodes...
- Restoration of T cell responses to toxoplasma gondii after successful combined antiretroviral therapy in patients with AIDS with previous toxoplasmic encephalitis
Marylène Lejeune
Immunology Service, Hospital Clinic Institut d Investigacions Biomèdiques Augustí Pi i Suñer, University of Barcelona, Barcelona, Spain
Clin Infect Dis 52:662-70. 2011
..It is unknown whether a Toxoplasma gondii-specific T cell response is restored after successful combined antiretroviral therapy (cART) in patients with AIDS and current or previous toxoplasmic encephalitis (TE)...
- Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence
Llucia Alos
Department of Pathology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
Mod Pathol 18:127-36. 2005
..However, these parameters studied in lymphoid tissue are not re-established completely, even after 36 months of highly active antiretroviral therapy...
- Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection: a randomized pilot study
Felipe Garcia
Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
J Acquir Immune Defic Syndr 36:823-30. 2004
..005) after 6 months off HAART. We found that combining MMF and HAART delayed VL rebound and improved control of viral replication without HAART but only when inhibition of lymphocyte proliferation was achieved...
- Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3
Montserrat Plana
Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
J Acquir Immune Defic Syndr 36:791-9. 2004
..To analyze the dynamics of both HIV-1-specific CD4 and CD8 T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point achieved...
- Pharmacokinetic study of saquinavir 500 mg plus ritonavir (1000/100 mg twice a day) in HIV-positive pregnant women
María Martínez-Rebollar
Infectious Diseases Service, IDIBAPS, Hospital Clinic, Barcelona, Spain
Ther Drug Monit 33:772-7. 2011
..No vertical transmissions were reported. Therapeutic drug monitoring of SQV during pregnancy should be considered, mainly during the third trimester, to ensure adequate drug exposure throughout the entire pregnancy...
- Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patients
Alba Diaz
Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS 24:2029-39. 2010
..The factors associated with fibrosis in lymphoid tissue in long-term treated HIV-infected patients and their correlation with immune reconstitution were assessed...
- Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults
Esteban Martinez
Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Calle Villarroel 170, 08036 Barcelona, Spain
Lancet 364:65-7. 2004
..666, 95% CI 1.246-91.294, p=0.031). These results suggest that the risk of pancreatitis is heightened when didanosine and tenofovir are given together...
- Health-related quality of life in HIV patients switching to twice-daily indinavir/ritonavir regimen or continuing with three-times-daily indinavir-based therapy
Xavier Badia
Department of Clinical Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Antivir Ther 9:979-85. 2004
..To evaluate health-related quality of life (HRQoL) changes in patients treated with indinavir three-times daily after switching to a twice-daily indinavir/ritonavir regimen or continuing with the same regimen...
- Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality
Miriam J Alvarez-Martinez
Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
Diagn Microbiol Infect Dis 62:34-43. 2008
..03 and P < 0.001, respectively). The prevalence of DHPS mutants in Spain is low and is not associated with a worse outcome. Severe respiratory failure at admission is the strongest predictor of PCP outcome...
- [Clinical management of acute and chronic human immunodeficiency virus infection before starting antiretroviral treatment]
Jose M Miro
Servicio de Enfermedades Infecciosas, Hospital Clinico IDIBAPS, Universidad de Barcelona, Barcelona, Spain
Enferm Infecc Microbiol Clin 29:759-72. 2011
..No less important is the psychological support, as these patients must learn to live with a chronic infection, which managed properly can ensure a very good long-term prognosis and quality of life...
- Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection
Felipe Garcia
Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
J Infect Dis 191:1680-5. 2005
..This response was associated with changes in HIV-1-specific CD4(+) lymphoproliferative and CD8(+) T cell responses. These changes were not observed in a group of nonimmunized control patients...
- Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a Phase II study
Jose M Gatell
University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 53:456-63. 2010
..Raltegravir in combination therapy has demonstrated potent suppression of HIV-1 with a favorable safety profile. This report provides 96-week efficacy and safety data from Protocol 005, a Phase II study...
- Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects
Marta Rodríguez-García
Service of Immunology, Hospital Clinic Universitari de Barcelona, School of Medicine, University of Barcelona, Barcelona, Spain
Clin Immunol 131:374-84. 2009
..Results suggest that alpha-defensins1-3 might modulate the maturation and differentiation of MDDCs in vivo and therefore could be of special interest in the field of vaccine development...
- [Specialized home care for infectious disease. Experience from 1995 to 2002]
Juan Pablo Horcajada
Servicio de Enfermedades Infecciosas, Hospital Clinic IDIBAPS, Universidad de Barcelona, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Espana
Enferm Infecc Microbiol Clin 25:429-36. 2007
..This study reviews the experience of this service from 1995 to 2002 using prospectively recorded data...
- Influence of episodes of intermittent viremia ("blips") on immune responses and viral load rebound in successfully treated HIV-infected patients
Pedro Castro
Medical Intensive Care Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 29:68-76. 2013
..After treatment interruption, they showed greater specific immune responses against HIV, which did not prevent a higher virological rebound. EIV between 20 and 200 copies/ml did not have this deleterious effect...
- Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia
Carlos Cervera
Services of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
Eur J Haematol 87:87-91. 2011
..Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia...
- Metabolic and immunological effects of antiretroviral agents in healthy individuals receiving post-exposure prophylaxis
Felipe Garcia
Infectious Diseases Unit, University of Barcelona, Barcelona, Spain
Antivir Ther 7:195-7. 2002
..This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens...
- Renal dysfunction in the setting of HIV/AIDS
Jose M Miro
Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Curr HIV/AIDS Rep 9:187-99. 2012
..This review focuses on clinical and epidemiological issues, treatment strategies (including dialysis and kidney transplantation), and recent advances among kidney disease in the HIV population...
- Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals
Víctor Casanova
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
PLoS ONE 7:e51287. 2012
..Taken together, these findings suggest that ADA would promote enhanced and correctly polarized T-cell responses in strategies targeting asymptomatic HIV-infected individuals...
- Changes in cardiovascular biomarkers in HIV-infected patients switching from ritonavir-boosted protease inhibitors to raltegravir
Esteban Martinez
Hospital Clinic IDIBAPS, Universitat de Barcelona, Spain
AIDS 26:2315-26. 2012
..Switching from boosted protease inhibitors (PI/r) to raltegravir (RAL) results in a better plasma lipid profile than continuing PI/r. Whether this strategy affects plasma biomarkers associated with atherosclerosis is unknown...
- Effects of metformin or gemfibrozil on the lipodystrophy of HIV-infected patients receiving protease inhibitors
Esteban Martinez
Hospital Clinic IDIBAPS, Barcelona, Spain
Antivir Ther 8:403-10. 2003
..Whether a therapeutic approach addressed to those metabolic abnormalities may have any impact on body fat is not clear...
- Gynecomastia among HIV-infected patients is associated with hypogonadism: a case-control study
Alejandra Biglia
Infectious Diseases Unit, Hospital Clinic-Institut d'Investigaciones Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Clin Infect Dis 39:1514-9. 2004
..8-32.2; P=.003) were independent factors associated with gynecomastia. CONCLUSIONS: The data suggest that gynecomastia among HIV-infected patients is related to hypogonadism, rather than to an adverse effect of antiretroviral drugs...
- [Inflammatory response in elderly patients with bacteremia]
Luis Marti
Servicio de Infecciones, Hospital Clinico IDIBAPS, Universidad de Barcelona, Barcelona, Spain
Enferm Infecc Microbiol Clin 26:146-9. 2008
....
- Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3
Marta Rodríguez García
Service of Immunology, Hospital Clinic Universitari de Barcelona, Villarroel 170, 08036, Barcelona, Spain
J Leukoc Biol 82:1143-6. 2007
....
- Sensitivity and specificity of nested and real-time PCR for the detection of Pneumocystis jiroveci in clinical specimens
Miriam J Alvarez-Martinez
Microbiology Department, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona 08036, Spain
Diagn Microbiol Infect Dis 56:153-60. 2006
..Real-time PCR has a statistically significantly better specificity than nested PCR (P = .015) and is likely to generate fewer false positives...
- Expression and function of the IL-2 receptor in activated human plasmacytoid dendritic cells
Mar Naranjo-Gómez
Laboratory of Immunobiology for Research and Applications to Diagnosis, Blood and Tissue Bank, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Barcelona, Spain
Eur J Immunol 37:1764-72. 2007
..Finally, CD25 expression may be considered as a useful early activation marker for human PDC...
- Evaluation of the Roche COBAS® TaqMan® HIV-1 test for quantifying HIV-1 RNA in infected cells and lymphoid tissue
Cristina Gil
AIDS Research Group IDIBAPS, Hospital Clinic, University of Barcelona, Spain
J Virol Methods 174:69-76. 2011
..The Roche COBAS® TaqMan® HIV-1 (HPS) test thereby proved to be a helpful tool for measuring the HIV-1 viral load in infected cells and lymphoid tissue reservoirs...
- Randomized trial comparing pegylated interferon alpha-2b versus pegylated interferon alpha-2a, both plus ribavirin, to treat chronic hepatitis C in human immunodeficiency virus patients
Montserrat Laguno
Infectious Diseases Service, Hospital Clinic, Barcelona, Spain
Hepatology 49:22-31. 2009
..47). Conclusion: In patients with HIV, HCV therapy with PEG 2b or PEG 2a plus RBV had no significant differences in efficacy and safety...
- Inflammatory responses in blood samples of human immunodeficiency virus-infected patients with pulmonary infections
Natividad Benito
Service of Infectious Diseases, Institut Clínic de Infeccions i Inmunologia, Clinic Hospital IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
Clin Diagn Lab Immunol 11:608-14. 2004
..An elevated IL-8 level (>61 pg/ml) at the time of admission was an independent factor associated with higher mortality (odds ratio, 12; 95% confidence interval, 1.2 to 235.5)...
- Immunologic reconstitution after 1 year of highly active antiretroviral therapy, with or without protease inhibitors
Montserrat Plana
Institut Clínic de Infeccions i Immunologia ICII, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
J Acquir Immune Defic Syndr 29:429-34. 2002
....
- Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection
Esteban Martinez
Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
N Engl J Med 349:1036-46. 2003
..We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved...
- Effect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection
Elena Herrera
Unit of Synthesis and Biomedical Applications of Peptides IQAC CSIC, Barcelona, Spain
J Med Chem 53:6054-63. 2010
..We also show how GBV-C E2 domains notably decrease cellular membrane fusion and interfere with the HIV-1 infectivity in a dose-dependent manner, highlighting their potential utility in future anti-HIV-1 therapies...
- Health care-associated native valve endocarditis: importance of non-nosocomial acquisition
Natividad Benito
Hospital de Santa Creu i Sant Pau, University Autonoma of Barcelona, and Hospital Clínic IDIBAPS, University of Barcelona, Barcelona, Spain
Ann Intern Med 150:586-94. 2009
..The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined...
- Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS
Alex Soriano
Service of Infectious Diseases and AIDS Unit, Hospital Clinic de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
Immunogenetics 57:644-54. 2005
..Further studies are required to confirm these findings...
- Cardiovascular disease and HIV infection: host, virus, or drugs?
Esteban Martinez
Infectious Diseases Unit, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
Curr Opin Infect Dis 22:28-34. 2009
..We review the risk of cardiovascular disease in HIV-infected persons compared with that in uninfected persons and discuss the relative contributions of host, HIV, and antiretroviral therapy in the light of current knowledge...
- Efficacy of telavancin in the treatment of experimental endocarditis due to glycopeptide-intermediate Staphylococcus aureus
Jose M Miro
Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Antimicrob Agents Chemother 51:2373-7. 2007
..All isolates from vegetations remained susceptible to telavancin after therapy. The results suggest that telavancin may be an effective treatment for endocarditis caused by glycopeptide-intermediate S. aureus...
