Gilles Gasser

Summary

Publications

  1. doi Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
  2. doi The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
  3. doi Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
  4. doi Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
  5. doi [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
  6. doi In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
  7. doi DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
  8. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013
  9. doi A bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) complex with anticancer action upon photodeprotection
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    Angew Chem Int Ed Engl 53:2960-3. 2014
  10. doi Metal-containing peptide nucleic acid conjugates
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Dalton Trans 40:7061-76. 2011

Collaborators

  • Matthew H Todd
  • Robin B Gasser
  • Ingo Ott
  • Bernhard Spingler
  • Malay Patra
  • Vanessa Pierroz
  • Stefano Ferrari
  • Tanmaya Joshi
  • Anna Leonidova
  • Jennifer Keiser
  • Katrin Ingram
  • Anu Naik
  • Jeannine Hess
  • Riccardo Rubbiani
  • Cristina Mari
  • Leone Spiccia
  • Jakob Heier
  • Sandro Konatschnig
  • Sandra Morard
  • Lea Gemperle
  • Marcel Kaiser
  • Murray N Robertson
  • Julia Schur

Detail Information

Publications18

  1. doi Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
    ..In particular, Re-Bombesin was found to be at least 20-fold more toxic after light irradiation. DNA photo-cleavage studies demonstrated that all compounds damaged DNA via singlet oxygen and, to a minor extent, superoxide production...
  2. doi The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
    ..Furthermore, using specific examples, we illustrate how these particular properties can be put to good use in medicinal chemistry. The examples we present have an emphasis on, but are not restricted to, anti-cancer activity...
  3. doi Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
    ..Furthermore, Re-PNA could be detected in living cells using fluorescent microscopy...
  4. doi Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
    ..26 ± 0.1 SUV, 1h p.i.) and modest accumulation in the kidneys (5.45 ± 0.45 SUV, 1h p.i.). There was no significant activity in the thyroid and the stomach, demonstrating a high in vivo stability of the (99m)Tc-labeled Dpa-PNA conjugate...
  5. doi [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
    ..Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines...
  6. doi In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
    ..The in vivo activity of 1 and 2 was then studied in mice harboring a chronic S. mansoni infection. A single dose of 1 and 2 (400 mg/kg) resulted in low worm burden reductions of 24% and 29% (p > 0.05). ..
  7. doi DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
    ..It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes. ..
  8. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013
    ....
  9. doi A bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) complex with anticancer action upon photodeprotection
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    Angew Chem Int Ed Engl 53:2960-3. 2014
    ..This is the first substitutionally inert cytotoxic metal complex to be used as a light-triggered prodrug candidate...
  10. doi Metal-containing peptide nucleic acid conjugates
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Dalton Trans 40:7061-76. 2011
    ....
  11. ncbi Bis(dipyridophenazine)(2-(2'-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) Hexafluorophosphate: A Lesson in Stubbornness
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    ChemMedChem 9:1419-27. 2014
    ..The results of this important structure-activity relationship strongly support our initial hypothesis that accumulation in mitochondria is crucial for 1 to exert its cytotoxic action. ..
  12. ncbi Novel, mercury-free synthetic pathway for trifluoromethylthio-substituted metallocenes
    Jeannine Hess
    Department of Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse190, CH 8057 Zurich, Switzerland
    Inorg Chem 53:3662-7. 2014
    ..All organometallic compounds were found either to be nontoxic or to have a moderate toxicity toward the cell lines used in this study. ..
  13. doi Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid
    Vanessa Pierroz
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Chem Soc 134:20376-87. 2012
    ..It was demonstrated that the mitochondrial membrane potential in HeLa was impaired by 3 as early as 2 h after its introduction and even more with increasing time...
  14. doi Ferrocenyl derivatives of the anthelmintic praziquantel: design, synthesis, and biological evaluation
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 55:8790-8. 2012
    ..It was also demonstrated using two compounds of the series as models (8A and 8B) that the complexes were stable when incubated for 24 h at 37 °C in human plasma...
  15. ncbi Visible-light-induced annihilation of tumor cells with platinum-porphyrin conjugates
    Anu Naik
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zürich Switzerland
    Angew Chem Int Ed Engl 53:6938-41. 2014
    ..All of these favorable characteristics imply that tetraplatinated porphyrin complexes are worthy of exploration as novel PDT anticancer agents in vivo. ..
  16. ncbi Preparation of metal-containing peptide nucleic acid bioconjugates on the solid phase
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 1050:55-72. 2014
    ..In this book chapter, we report on the recent synthetic advances towards the preparation of these "(multi-)metallic PNAs" on the solid phase...
  17. doi Organometallic compounds: an opportunity for chemical biology?
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chembiochem 13:1232-52. 2012
    ..We also demonstrate that these recent discoveries are only a beginning and that many other organometallic complexes are likely to be found useful in this field of research in the near future...