Gilles Gasser

Summary

Publications

  1. doi request reprint Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
  2. doi request reprint The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
  3. doi request reprint Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
  4. doi request reprint Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
  5. doi request reprint [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
  6. doi request reprint In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
  7. doi request reprint DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
  8. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013
  9. doi request reprint A Bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) Complex with Anticancer Action upon Photodeprotection
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    Angew Chem Int Ed Engl 53:2960-3. 2014
  10. doi request reprint Metal-containing peptide nucleic acid conjugates
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Dalton Trans 40:7061-76. 2011

Collaborators

  • Bernhard Spingler
  • Robin B Gasser
  • Ingo Ott
  • Malay Patra
  • Vanessa Pierroz
  • Stefano Ferrari
  • Tanmaya Joshi
  • Anna Leonidova
  • Katrin Ingram
  • Jennifer Keiser
  • Cristina Mari
  • Leone Spiccia
  • Riccardo Rubbiani
  • Jakob Heier
  • Lea Gemperle
  • Marcel Kaiser
  • Matthew H Todd
  • Murray N Robertson
  • Julia Schur

Detail Information

Publications13

  1. doi request reprint Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
    ..In particular, Re-Bombesin was found to be at least 20-fold more toxic after light irradiation. DNA photo-cleavage studies demonstrated that all compounds damaged DNA via singlet oxygen and, to a minor extent, superoxide production...
  2. doi request reprint The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
    ..Furthermore, using specific examples, we illustrate how these particular properties can be put to good use in medicinal chemistry. The examples we present have an emphasis on, but are not restricted to, anti-cancer activity...
  3. doi request reprint Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
    ..Furthermore, Re-PNA could be detected in living cells using fluorescent microscopy...
  4. doi request reprint Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
    ..26 ± 0.1 SUV, 1h p.i.) and modest accumulation in the kidneys (5.45 ± 0.45 SUV, 1h p.i.). There was no significant activity in the thyroid and the stomach, demonstrating a high in vivo stability of the (99m)Tc-labeled Dpa-PNA conjugate...
  5. doi request reprint [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
    ..Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines...
  6. doi request reprint In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
    ..The in vivo activity of 1 and 2 was then studied in mice harboring a chronic S. mansoni infection. A single dose of 1 and 2 (400 mg/kg) resulted in low worm burden reductions of 24% and 29% (p > 0.05). ..
  7. doi request reprint DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
    ..It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes. ..
  8. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013
    ....
  9. doi request reprint A Bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) Complex with Anticancer Action upon Photodeprotection
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    Angew Chem Int Ed Engl 53:2960-3. 2014
    ..This is the first substitutionally inert cytotoxic metal complex to be used as a light-triggered prodrug candidate. ..
  10. doi request reprint Metal-containing peptide nucleic acid conjugates
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Dalton Trans 40:7061-76. 2011
    ....
  11. doi request reprint Ferrocenyl derivatives of the anthelmintic praziquantel: design, synthesis, and biological evaluation
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 55:8790-8. 2012
    ..It was also demonstrated using two compounds of the series as models (8A and 8B) that the complexes were stable when incubated for 24 h at 37 °C in human plasma...
  12. doi request reprint Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid
    Vanessa Pierroz
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Chem Soc 134:20376-87. 2012
    ..It was demonstrated that the mitochondrial membrane potential in HeLa was impaired by 3 as early as 2 h after its introduction and even more with increasing time...
  13. doi request reprint Organometallic compounds: an opportunity for chemical biology?
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chembiochem 13:1232-52. 2012
    ..We also demonstrate that these recent discoveries are only a beginning and that many other organometallic complexes are likely to be found useful in this field of research in the near future...