Guilherme J M Garcia

Summary

Publications

  1. doi request reprint Septal deviation and nasal resistance: an investigation using virtual surgery and computational fluid dynamics
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Am J Rhinol Allergy 24:e46-53. 2010
  2. doi request reprint Computational model for the regulation of extracellular ATP and adenosine in airway epithelia
    Guilherme J M Garcia
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:51-74. 2011
  3. doi request reprint Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 21:1165-75. 2009
  4. pmc Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report
    Julia S Kimbell
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Am J Rhinol Allergy 26:e94-8. 2012
  5. doi request reprint A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 22:277-86. 2010
  6. doi request reprint Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 21:607-18. 2009
  7. pmc Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities
    Guilherme J M Garcia
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biophys J 104:716-26. 2013
  8. pmc A mechanochemical model for auto-regulation of lung airway surface layer volume
    Gregory Herschlag
    Department of Mathematics, University of North Carolina, Chapel Hill, NC, USA
    J Theor Biol 325:42-51. 2013
  9. ncbi request reprint Interindividual variability in nasal filtration as a function of nasal cavity geometry
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA
    J Aerosol Med Pulm Drug Deliv 22:139-55. 2009
  10. ncbi request reprint Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Dr, P O Box 12137, Research Triangle Park, NC 27709, USA
    J Appl Physiol 103:1082-92. 2007

Detail Information

Publications10

  1. doi request reprint Septal deviation and nasal resistance: an investigation using virtual surgery and computational fluid dynamics
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Am J Rhinol Allergy 24:e46-53. 2010
    ..Second, we test whether computer simulations are consistent with rhinomanometry studies in predicting that anterior septal deviations increase nasal resistance more than posterior deviations...
  2. doi request reprint Computational model for the regulation of extracellular ATP and adenosine in airway epithelia
    Guilherme J M Garcia
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:51-74. 2011
    ..This study shows that computational modeling, coupled to experimental validation, provides a powerful approach for the identification of key therapeutic targets for the improvement of airway clearance in obstructive respiratory diseases...
  3. doi request reprint Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 21:1165-75. 2009
    ....
  4. pmc Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report
    Julia S Kimbell
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Am J Rhinol Allergy 26:e94-8. 2012
    ..The goal of this study was to develop methods for comparing nasal resistance computed by computational fluid dynamics (CFD) models with patient-reported symptoms of NAO using early data from a 4-year prospective study...
  5. doi request reprint A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 22:277-86. 2010
    ..These preliminary results suggest that differences in nasal anatomy and ventilation among adults and children do not have a significant effect on H(2)S dosimetry in the olfactory region...
  6. doi request reprint Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 21:607-18. 2009
    ..6-fold among the 7 individuals studied. Children and adults displayed very similar patterns of nasal gas uptake; no significant differences were noted between the two age groups...
  7. pmc Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities
    Guilherme J M Garcia
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biophys J 104:716-26. 2013
    ..By providing a method to quantify all the ion permeabilities of respiratory epithelia, the model may aid us in understanding the physiology that regulates normal airway surface hydration...
  8. pmc A mechanochemical model for auto-regulation of lung airway surface layer volume
    Gregory Herschlag
    Department of Mathematics, University of North Carolina, Chapel Hill, NC, USA
    J Theor Biol 325:42-51. 2013
    ....
  9. ncbi request reprint Interindividual variability in nasal filtration as a function of nasal cavity geometry
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA
    J Aerosol Med Pulm Drug Deliv 22:139-55. 2009
    ..Such a relationship is needed to (1) devise nasal drug delivery systems and (2) define limits of exposure to PM that are effective for the human population at large...
  10. ncbi request reprint Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Dr, P O Box 12137, Research Triangle Park, NC 27709, USA
    J Appl Physiol 103:1082-92. 2007
    ..We conclude that the main goals of a surgery to treat atrophic rhinitis should be 1) to restore the original surface area of the nose, 2) to restore the physiological airflow distribution, and 3) to create symmetric cavities...