Algorithms for the diagnosis and treatment of restless legs syndrome in primary careDiego Garcia-Borreguero
Sleep Research Institute, Madrid, Spain
BMC Neurol 11:28. 2011
..Restless legs syndrome (RLS) is a neurological disorder with a lifetime prevalence of 3-10%. in European studies. However, the diagnosis of RLS in primary care remains low and mistreatment is common...
Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck InstituteDiego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
Sleep Med 8:520-30. 2007
..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification...
- Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
Diego Garcia-Borreguero
Fundacion Jimenez Diaz, Madrid, Spain
Sleep Med 8:455-63. 2007
..The changes in each dimension are summed to give an ASRS total score...
Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (Willis-Ekbom disease): results from a prospective, multicenter study over 66 weeksDiego Garcia-Borreguero
Sleep Research Institute, Madrid, Spain
Mov Disord 27:277-83. 2012
..The incidence of augmentation was 3.1% higher with ropinirole than with placebo. New patients with first episodes of augmentation continued to cumulate at a stable rate over the duration of this study...
- Decreased phasic EMG activity during rapid eye movement sleep in treatment-naïve Parkinson's disease: effects of treatment with levodopa and progression of illness
Diego Garcia-Borreguero
Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
Mov Disord 17:934-41. 2002
..Potential implications for the understanding of the relationship between RBD and PD are discussed...
- Circadian variation in neuroendocrine response to L-dopa in patients with restless legs syndrome
Diego Garcia-Borreguero
Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
Sleep 27:669-73. 2004
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- European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society
Diego Garcia-Borreguero
Sleep Research Institute, Madrid, Spain
Eur J Neurol 19:1385-96. 2012
..These guidelines were undertaken by the EFNS in collaboration with the European Neurological Society and the European Sleep Research Society...
- Parkinson's disease and sleep
Diego Garcia-Borreguero
Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
Sleep Med Rev 7:115-29. 2003
..An adequate education of the PD patients in sleep hygiene measures and a skilled use of the medication seem necessary to prevent sleep disturbance...
- Time to REST: epidemiology and burden
Diego Garcia-Borreguero
Sleep Research Institute, Madrid, Spain
Eur J Neurol 13:15-20. 2006
..Given the significant burden of morbidity associated with RLS, there is a strong case for treatment in patients with troublesome symptoms...
- Epidemiology of restless legs syndrome: the current status
Diego Garcia-Borreguero
Department of Neurology, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain
Sleep Med Rev 10:153-67. 2006
..In summary, epidemiological evidence suggests that RLS is a common neurological disorder-with high impact on many aspects of the life of those affected...
- Did Immanuel Kant have dementia with Lewy bodies and REM behavior disorder?
Marcelo Miranda
Department of Neurology, Clinica Las Condes, Chile
Sleep Med 11:586-8. 2010
..His cognitive decline was strongly associated with a parasomnia compatible with a severe rapid eye movement (REM) behavior disorder (RBD) and dementia with Lewy bodies...
- Dopaminergic augmentation of restless legs syndrome
Diego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, Madrid, Spain
Sleep Med Rev 14:339-46. 2010
..RLS is treated by maintaining low doses of dopaminergic agents and ensuring iron sufficiency. Non-dopaminergics and opiates can be used when patients experience augmentation with more than one dopaminergic agent...
- Augmentation as a treatment complication of restless legs syndrome: concept and management
Diego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
Mov Disord 22:S476-84. 2007
..The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition...
- Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study
Diego Garcia-Borreguero
Department of Neurology, Fundacion Jimenez Diaz, Sleep Disorders Unit, Universidad Autonoma de Madrid, Madrid, Spain
Sleep Med 8:119-27. 2007
..To compare the efficacy, safety and tolerability of sumanirole with placebo in patients with idiopathic restless legs syndrome (RLS)...
- A 52-week open-label study of the long-term safety of ropinirole in patients with restless legs syndrome
Diego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
Sleep Med 8:742-52. 2007
..To assess the long-term safety and efficacy of ropinirole in the treatment of patients with restless legs syndrome (RLS) over 52 weeks...
