Marcelo Ganzella

Summary

Publications

  1. doi request reprint Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos, 2600, Anexo, Santana, Porto Alegre, RS 90035 003, Brazil
    Neurol Sci 33:985-97. 2012
  2. pmc Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Purinergic Signal 8:49-58. 2012
  3. doi request reprint Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 100:271-4. 2011
  4. doi request reprint Systemic administration of GMP induces anxiolytic-like behavior in rats
    Roberto Farina Almeida
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 96:306-11. 2010
  5. doi request reprint Effects of depressive-like behavior of rats on brain glutamate uptake
    Roberto Farina Almeida
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 35:1164-71. 2010
  6. ncbi request reprint Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Res 55:397-402. 2006
  7. pmc Intranasal guanosine administration presents a wide therapeutic time window to reduce brain damage induced by permanent ischemia in rats
    Denise Barbosa Ramos
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Santana, 90035 003, Porto Alegre, RS, Brazil
    Purinergic Signal 12:149-59. 2016
  8. ncbi request reprint Amnesic effect of GMP depends on its conversion to guanosine
    Jonas Alex Morales Saute
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 Anexo CEP 90 035 003, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 85:206-12. 2006
  9. doi request reprint Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterations
    Julia D Moreira
    Biochemistry Department, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Int 56:753-9. 2010
  10. ncbi request reprint NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice
    Carina R Boeck
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Epilepsia 45:745-50. 2004

Collaborators

Detail Information

Publications11

  1. doi request reprint Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos, 2600, Anexo, Santana, Porto Alegre, RS 90035 003, Brazil
    Neurol Sci 33:985-97. 2012
    ..In conclusion, GUO treatment did not prevent the cognitive impairment observed in 2VO animals, but our data suggest that GUO could be neuroprotective against hippocampal damage induced by 2VO...
  2. pmc Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Purinergic Signal 8:49-58. 2012
    ..Altogether, these findings suggest a potential modulatory role of GMP on neocortex glutamatergic system by promoting functional and plastic changes associated to more resistance of mice neocortex against an in vitro excitotoxicity event...
  3. doi request reprint Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 100:271-4. 2011
    ..In conclusion, this study demonstrated that INO exert anticonvulsant effect against hyperactivity of the glutamatergic system independently of BZ or ADO receptors activation...
  4. doi request reprint Systemic administration of GMP induces anxiolytic-like behavior in rats
    Roberto Farina Almeida
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 96:306-11. 2010
    ..Thus, this study suggests that acute administration of GMP was able to decrease the levels of anxiety in classical behavioral tasks...
  5. doi request reprint Effects of depressive-like behavior of rats on brain glutamate uptake
    Roberto Farina Almeida
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 35:1164-71. 2010
    ..These results may contribute to better understand the role of the glutamatergic system on the depressive-like behavior...
  6. ncbi request reprint Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Res 55:397-402. 2006
    ..The present study may, therefore, contribute to elucidate the mechanism of the brain dysfunction in patients with several neurological disorders involving elevation of QA in the CSF...
  7. pmc Intranasal guanosine administration presents a wide therapeutic time window to reduce brain damage induced by permanent ischemia in rats
    Denise Barbosa Ramos
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Santana, 90035 003, Porto Alegre, RS, Brazil
    Purinergic Signal 12:149-59. 2016
    ..Therefore, we showed that the IN route is an efficient way to promptly deliver GUO to the CNS and that IN GUO treatment prevented behavioral and brain impairment caused by ischemia in a therapeutically wide time window. ..
  8. ncbi request reprint Amnesic effect of GMP depends on its conversion to guanosine
    Jonas Alex Morales Saute
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 Anexo CEP 90 035 003, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 85:206-12. 2006
    ....
  9. doi request reprint Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterations
    Julia D Moreira
    Biochemistry Department, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Int 56:753-9. 2010
    ..The putative correlation among the neurochemical and behavioral alterations caused by dietary omega3 deficiency is discussed...
  10. ncbi request reprint NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice
    Carina R Boeck
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Epilepsia 45:745-50. 2004
    ..The purpose of this study was to investigate the potential neuroprotective effects of NMDA preconditioning against QA-induced seizures and hippocampal damage in vivo...
  11. doi request reprint Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida)
    Viviane M Linck
    Laboratorio de Etnofarmacologia, Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Avenida Sarmento Leite, 500, 90050 170, Porto Alegre, RS, Brazil Programa de Pós graduação em Ciências Biológicas Bioquímica Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Avenida Sarmento Leite, 500, 90050 170, Porto Alegre, RS, Brazil Electronic address
    Phytomedicine 22:52-5. 2015
    ..These results may represent an innovation in the antipsychotic development field. ..