Use of activated recombinant factor VII for severe coagulopathy post ventricular assist device or orthotopic heart transplantManish J Gandhi
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
J Cardiothorac Surg 2:32. 2007
..We report here our experience with rFVIIa as a rescue therapy to achieve hemostasis in patients undergoing orthotopic heart transplant (OHT) and/or VAD implantation...
Donor derived malignancy following transplantation: a reviewManish J Gandhi
Department of Pathology and Immunology, Washington University, 660 S Euclid Ave 8118, St Louis, MO 63110, USA
Cell Tissue Bank 8:267-86. 2007
..Further, we will briefly review the methods for detection and management of these donor related malignancies...
- Prestorage leukoreduction does not increase hemolysis of stored red cell concentrates
Manish J Gandhi
Puget Sound Blood Center, Seattle, WA 98104, USA
Transfus Apher Sci 36:17-22. 2007
..The purpose of this study was to determine the level of hemolysis seen in RC produced by our center...
- Congenital amegakaryocytic thrombocytopenia in three siblings: molecular analysis of atypical clinical presentation
Manish J Gandhi
Puget Sound Blood Center, Seattle, WAash, USA Division of Hematology, University of Washington School of Medicine, Seattle, WA 98104, USA
Exp Hematol 33:1215-21. 2005
..We evaluated this pedigree to understand the unusually late presentation of congenital amegakaryocytic thrombocytopenia (CAMT)...
- Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation
Paula G Heller
Division of Hematology, Instituto de Investigaciones Medicas Alfredo Lanari, University of Buenos Aires, Argentina
Blood 105:4664-70. 2005
..In conclusion, we identified a C-terminal AML1 mutation that leads to a decrease in Mpl receptor expression, providing a potential explanation for thrombocytopenia in this FPD/AML pedigree...
- X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)
Jennifer N Luthi
Puget Sound Blood Center and Program, 921 Terry Avenue, Seattle, WA 98104, USA
Exp Hematol 31:150-8. 2003
..Despite the absence of eczema or immunodeficiency, a mutation of the Wiskott-Aldrich syndrome (WAS) gene was suspected because of the presence of microthrombocytes...
- Cardiovascular tissues for transplantation
Manish J Gandhi
Puget Sound Blood Center/Northwest Tissue Center, Seattle, WA, USA
Clin Lab Med 25:571-85. 2005
- A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cells
Manish J Gandhi
Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104, USA
Blood Cells Mol Dis 35:70-3. 2005
..These studies provide evidence that SU6656 promotes megakaryocytic differentiation and thrombopoiesis in vitro...
- In vivo inactivation of MASTL kinase results in thrombocytopenia
H Jan Johnson
Puget Sound Blood Center, Seattle, Wash 98104 1256, USA
Exp Hematol 37:901-8. 2009
..We wanted to determine the expression and localization of MASTL, as well as its role in developing thrombocytes using an in vivo model system...
- FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10
Manish J Gandhi
Puget Sound Blood Center, Seattle, Wash 98104, USA
Hum Hered 55:66-70. 2003
..A substitution of cytosine for guanidine (G to C) at nucleotide position 565 was present in all thrombocytopenic family members, causing a predicted substitution of aspartic acid for glutamic acid (E167D) in exon four...
