D Games

Summary

Publications

  1. ncbi request reprint Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42
    D Games
    Elan Pharmaceuticals, 800 Gateway Blvd, So San Francisco, CA 94080, USA
    Ann N Y Acad Sci 920:274-84. 2000
  2. ncbi request reprint Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    F Bard
    Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA
    Nat Med 6:916-9. 2000
  3. ncbi request reprint Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999
  4. ncbi request reprint Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization
    D Schenk
    Elan Pharmaceuticals, San Francisco, CA 94080, USA
    J Mol Neurosci 17:259-67. 2001
  5. ncbi request reprint Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    D Games
    Athena Neurosciences, Inc, South San Francisco, California 94080
    Nature 373:523-7. 1995
  6. ncbi request reprint Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 79:1059-64. 2001
  7. ncbi request reprint Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease
    F Gonzalez-Lima
    Behavioral Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neuroreport 12:2375-9. 2001
  8. ncbi request reprint Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neurology 64:129-31. 2005
  9. ncbi request reprint Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    E Masliah
    Department of Neurosciences, University of California San Diego, La Jolla 92093-0624, USA
    J Neuropathol Exp Neurol 60:357-68. 2001
  10. ncbi request reprint A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    G Chen
    Department of Neuroscience, University of Edinburgh, UK
    Nature 408:975-9. 2000

Collaborators

  • D Schenk
  • M Lee
  • Eliezer Masliah
  • Stephen J Martin
  • R G Morris
  • Juebin Huang
  • F Gonzalez-Lima
  • J Valla
  • E M Reiman
  • J D Berndt
  • N Oshima
  • S L Roberds
  • E A Thomas
  • S B Freedman
  • K Johnson-Wood
  • L McConlogue
  • K Khan
  • K Hu
  • R Motter
  • K S Chen
  • G Chen
  • F Bard
  • S R Cherry
  • K Chen
  • G Basi
  • S Sugihara
  • J Anderson
  • L N Sautkulis
  • W Liu
  • J E Valla
  • K E Kappenman
  • R Kuehn
  • I Kola
  • J Wijsman
  • M Morishima-Kawashima
  • J G Sutcliffe
  • S Wright
  • T T Kawabe
  • D G Branstetter
  • S Sinha
  • N L Frigon
  • N F Nichols
  • M Power
  • J R Criado
  • G Tatsuno
  • D W Robertson
  • G M Shopp
  • M J Bienkowski
  • M Yoshimura
  • M E Shuck
  • H Tintrup
  • H Yamaguchi
  • Y Ihara
  • K A Svensson
  • M Schoor
  • H Grajeda
  • A Bernard
  • D Kholodenko
  • M Nguyen
  • K Weiss
  • N Vasquez
  • J Inglis
  • I Lieberburg
  • P Seubert
  • A Justice
  • J Knox
  • R L Burke
  • T Guido
  • B Welch
  • C Cannon
  • R Barbour
  • T Yednock
  • F Soriano

Detail Information

Publications13

  1. ncbi request reprint Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42
    D Games
    Elan Pharmaceuticals, 800 Gateway Blvd, So San Francisco, CA 94080, USA
    Ann N Y Acad Sci 920:274-84. 2000
    ..A beta immunization appears to increase clearance of amyloid plaques, and may therefore be a novel and effective approach for the treatment of AD...
  2. ncbi request reprint Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    F Bard
    Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA
    Nat Med 6:916-9. 2000
    ....
  3. ncbi request reprint Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999
    ..Our results raise the possibility that immunization with amyloid-beta may be effective in preventing and treating Alzheimer's disease...
  4. ncbi request reprint Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization
    D Schenk
    Elan Pharmaceuticals, San Francisco, CA 94080, USA
    J Mol Neurosci 17:259-67. 2001
    ..These findings have stimulated several approaches to develop novel therapeutic strategies to treat Alzheimer's disease that either are about or have entered the clinic...
  5. ncbi request reprint Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    D Games
    Athena Neurosciences, Inc, South San Francisco, California 94080
    Nature 373:523-7. 1995
    ..These mice support a primary role for APP/A beta in the genesis of AD and could provide a preclinical model for testing therapeutic drugs...
  6. ncbi request reprint Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 79:1059-64. 2001
    ..These findings suggest that, although increases in apoD expression are a normal feature of brain aging, super-increases may represent a glial cell compensatory response to beta-amyloid deposition in Alzheimer's disease...
  7. ncbi request reprint Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease
    F Gonzalez-Lima
    Behavioral Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neuroreport 12:2375-9. 2001
    ..These findings, which might account for the early, nonprogressive behavioral abnormalities observed in these animals, have implications for the study of AD...
  8. ncbi request reprint Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neurology 64:129-31. 2005
    ..This case illustrates the effects of an Abeta-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy...
  9. ncbi request reprint Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    E Masliah
    Department of Neurosciences, University of California San Diego, La Jolla 92093-0624, USA
    J Neuropathol Exp Neurol 60:357-68. 2001
    ..However, no paired helical filaments were observed. Taken together, these studies indicate that the PDAPP tg model recapitulates early cytoskeletal pathology similar to that observed in AD...
  10. ncbi request reprint A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    G Chen
    Department of Neuroscience, University of Edinburgh, UK
    Nature 408:975-9. 2000
    ....
  11. ncbi request reprint BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
    S L Roberds
    Department of Genomics, Pharmacia Corp, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Hum Mol Genet 10:1317-24. 2001
    ....
  12. ncbi request reprint Effects of image resolution on autoradiographic measurements of posterior cingulate activity in PDAPP mice: implications for functional brain imaging studies of transgenic mouse models of Alzheimer's Disease
    J Valla
    Alzheimer s Disease Research Laboratory, Harrington Arthritis Research Center, USA
    Neuroimage 16:1-6. 2002
    ..It remains possible that these imaging techniques will prove useful in transgenic mouse lines that do not exhibit the same morphological abnormalities in neighboring white matter regions...
  13. pmc Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain
    N Oshima
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 158:2209-18. 2001
    ..These observations indicate that the Abeta42 associated with low-density membrane domains is tightly coupled with the process of extracellular Abeta deposition...