Changes in high molecular weight kininogen levels during and after cardiopulmonary bypass surgery measured using a chromogenic peptide substrate assayM J Gallimore
Kent Haemophilia Centre, Kent and Canterbury Hospital, UK
Blood Coagul Fibrinolysis 13:561-8. 2002
..HK levels fell significantly during CPB (P = 0.0014) and were significantly higher (P = 0.016) 6 days after CPB, suggesting that HK may be a positive acute-phase reacting protein...
- Plasma levels of factor XII, prekallikrein and high molecular weight kininogen in normal blood donors and patients having suffered venous thrombosis
Michael J Gallimore
Kent Haemophilia Centre, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, Kent CT1 3NG, UK
Thromb Res 114:91-6. 2004
....
- Reduced factor XII levels in patients with the antiphospholipid syndrome are associated with antibodies to factor XII
D W Jones
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, United Kingdom
Br J Haematol 110:721-6. 2000
..Four of the 21 patients with antibodies to FXII were found to have FXII levels below the laboratory normal range. Antibodies to FXII are present in significant numbers of patients with APS and may lead to acquired FXII deficiency...
- Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome
D W Jones
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK
Br J Haematol 113:550-2. 2001
..4, p = 0.025)...
- An automated chromogenic peptide substrate assay for coagulation factor XII
D W Jones
Haemophilia Comprehensive Care Centre, Kent and Canterbury Hospitals NHS Trust, Canterbury, Kent, UK
Blood Coagul Fibrinolysis 9:183-7. 1998
..FXIIag levels corresponded with FXIIcs. The automated FXIIcs assay is therefore lupus anticoagulant insensitive and allows us to measure FXII levels accurately and routinely in large numbers of patient samples...
- The antigenic binding site(s) of antibodies to factor XII associated with the antiphospholipid syndrome
S L Harris
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK
J Thromb Haemost 3:969-75. 2005
..Two regions were identified as possible antigenic binding site(s) for FXIIab: one in the growth factor domain and the other in the catalytic domain...
- Urokinase induced fibrinolysis in thromboelastography: a model for studying fibrinolysis and coagulation in whole blood
M J Gallimore
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK
J Thromb Haemost 3:2506-13. 2005
..Most studies on fibrinolysis have used plasma or euglobulin assays, ignoring the influence of cellular elements of blood on the fibrinolytic process...
- Antibodies to factor XII: a possible predictive marker for recurrent foetal loss
David Wynne Jones
Kent Haemophilia Centre, Kent and Canterbury Hospital, Kent, UK
Immunobiology 207:43-6. 2003
..While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, p = 0.025)...
- The role of endogenous kallikrein inhibition in perioperative transfusion and adverse outcome in cardiac surgical patients
Robert J Frumento
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cardiothorac Vasc Anesth 21:23-7. 2007
..The goal of this study was to explore the relationship among endogenous plasma kallikrein inhibition (KI), perioperative bleeding, and adverse outcomes in cardiac surgery...
