Morgan Gallazzini

Summary

Publications

  1. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
  2. pmc High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Mol Biol Cell 22:703-14. 2011
  3. pmc Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP
    Carlos E Irarrazabal
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 107:906-11. 2010
  4. pmc GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20982, USA
    Proc Natl Acad Sci U S A 105:11026-31. 2008
  5. pmc What's new about osmotic regulation of glycerophosphocholine
    Morgan Gallazzini
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Physiology (Bethesda) 24:245-9. 2009
  6. pmc Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP
    Margarita Kunin
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12108. 2010
  7. pmc Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 103:15260-5. 2006

Collaborators

Detail Information

Publications7

  1. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
    ..Thus, c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143, which contributes to its increased activity...
  2. pmc High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Mol Biol Cell 22:703-14. 2011
    ....
  3. pmc Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP
    Carlos E Irarrazabal
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 107:906-11. 2010
    ....
  4. pmc GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20982, USA
    Proc Natl Acad Sci U S A 105:11026-31. 2008
    ..We conclude that GDPD5 is a GPC-PDE that contributes to osmotic regulation of cellular GPC...
  5. pmc What's new about osmotic regulation of glycerophosphocholine
    Morgan Gallazzini
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Physiology (Bethesda) 24:245-9. 2009
    ..We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance...
  6. pmc Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP
    Margarita Kunin
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12108. 2010
    ..Hypertonicity, such as induced by high NaCl, increases the activity of the transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins...
  7. pmc Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 103:15260-5. 2006
    ....