Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999A C Gales
University of Iowa College of Medicine, Iowa City, Iowa, USA, and Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Clin Infect Dis 32:S104-13. 2001
..maltophilia isolates observed in this study emphasize the importance of local surveillance in determining the most adequate therapy for acinetobacter and S. maltophilia infections and the possible clonal, epidemic nature of occurrence...
- Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis
Ana C Gales
Laboratório ALERTA, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Int J Antimicrob Agents 27:300-2. 2006
..Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance...
- In vitro activity of tigecycline, a new glycylcycline, tested against 1,326 clinical bacterial strains isolated from Latin America
Ana C Gales
Department of Medicine, Division of Infectious Diseases, University of Sao Paulo, Rua Leandro Dupret 188, Sao Paulo, Brazil
Braz J Infect Dis 9:348-56. 2005
..The in vitro activity of tigecycline (former GAR-936), a new semisynthetic tetracycline, was evaluated in comparison with tetracycline and other antimicrobial agents...
- Antimicrobial susceptibility patterns of unusual nonfermentative gram-negative bacilli isolated from Latin America: report from the SENTRY Antimicrobial Surveillance Program (1997-2002)
Ana C Gales
Departamento de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP 04025 010, Brasil
Mem Inst Oswaldo Cruz 100:571-7. 2005
..Since selection of the most appropriate antimicrobial agents for testing and reporting has not been established by the NCCLS for many of NF-GNB species, results from large multicenter studies may help to guide the best empiric therapy...
- Antimicrobial activity of dalbavancin tested against Gram-positive clinical isolates from Latin American medical centres
A C Gales
Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Clin Microbiol Infect 11:95-100. 2005
..and Listeria spp. Dalbavancin may provide an important therapeutic option for Gram-positive infections, excluding those caused by enterococci with VanA-type resistance...
- Genotypic characterization of carbapenem-nonsusceptible Acinetobacter spp. isolated in Latin America
Ana Cristina Gales
Laboratório Especial de Microbiologia Clínica and Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Microb Drug Resist 10:286-91. 2004
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- Carbapenem-resistant Pseudomonas aeruginosa outbreak in an intensive care unit of a teaching hospital
Ana C Gales
Division of Infectious Diseases, Sao Francisco University, Braganca Paulista, SP, Brazil
Braz J Infect Dis 8:267-71. 2004
..aeruginosa strains. Interestingly, a similar PFGE pattern was encountered in a P. aeruginosa strain isolated from Hospital São Paulo that was used as a PFGE control...
- Activity of mupirocin and 14 additional antibiotics against staphylococci isolated from Latin American hospitals: report from the SENTRY antimicrobial surveillance program
A C Gales
Universidade Federal de Sao Paulo, Division of Infectious Diseases, Department of Medicine, Sao Paulo, Brazil
J Chemother 16:323-8. 2004
..5%) and varied widely (10.0 to 48.9%) among the monitored Latin American medical centers. Mupirocin resistance rates appear to be increasing and routine monitoring for potential resistance seems prudent...
- Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999
A C Gales
University of Iowa College of Medicine, Iowa City, Iowa, USA, and Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Clin Infect Dis 32:S146-55. 2001
..Isolates showing unique ribogroups were found in Europe, Latin America, and the United States, but clonal spread was documented in several medical centers...
- Urinary tract infection trends in Latin American hospitals: report from the SENTRY antimicrobial surveillance program (1997-2000)
Ana C Gales
Division of Infectious Diseases, Universidade Federal de, Sao Paulo, SP, Brazil
Diagn Microbiol Infect Dis 44:289-99. 2002
..Carbapenem-resistant P. aeruginosa, ciprofloxacin-resistant E. coli, ESBL-producing K. pneumoniae constitute serious problem in this geographic region...
- Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia in Latin America: frequency of occurrence and antimicrobial susceptibility profile: results from the SENTRY Antimicrobial Surveillance Program (1997-2000)
Ana C Gales
Laboratório Especial de Microbiologia Clínica, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brazil
Diagn Microbiol Infect Dis 44:301-11. 2002
..Our results emphasize the importance of local surveillance programs in correctly guiding empiric therapy and local intervention programs in attempt to reduce antimicrobial resistance...
- Salmonella spp. isolates causing bloodstream infections in Latin America: report of antimicrobial activity from the SENTRY Antimicrobial Surveillance Program (1997-2000)
Ana C Gales
Laboratório Especial de Microbiologia Clínica, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
Diagn Microbiol Infect Dis 44:313-8. 2002
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- Emergence of an IMP-like metallo-enzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital
Ana C Gales
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Diagn Microbiol Infect Dis 45:77-9. 2003
..This manuscript reports the first appearance of an IMP-like metallo-beta-lactamase encountered in a clinical isolate of A. baumannii from a Brazilian teaching hospital...
- Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-beta-lactamase
Ana C Gales
Laboratório ALERTA, Universidade Federal de Sao Paulo, SP, Brazil
J Antimicrob Chemother 52:699-702. 2003
..In Brazil, carbapenem use has been limited by high carbapenem-resistance rates among Pseudomonas aeruginosa isolates...
Nosocomial bloodstream infections caused by Klebsiella pneumoniae: impact of extended-spectrum beta-lactamase (ESBL) production on clinical outcome in a hospital with high ESBL prevalenceAlexandre R Marra
Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brasil UNIFESP EPM Hospital São Paulo HSP, Brasil
BMC Infect Dis 6:24. 2006
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- Increased resistance to first-line agents among bacterial pathogens isolated from urinary tract infections in Latin America: time for local guidelines?
Soraya S Andrade
Laboratório Especial de Microbiologia Clínica, Universidade Federal de Sao Paulo, 04025 010 São Paulo, SP, Brazil
Mem Inst Oswaldo Cruz 101:741-8. 2006
..Our results highlight the need for developing specific CA-UTI guidelines in geographic regions where elevated resistance to new and old compounds may influence prescribing decisions...
- Tigecycline activity tested against 11808 bacterial pathogens recently collected from US medical centers
Ana C Gales
Division of Infectious Diseases, Department of Medicine, Universidade Federal de Sao Paulo, Sao Paulo, SP 04025 010, Brazil
Diagn Microbiol Infect Dis 60:421-7. 2008
..9% susceptible) was as active as imipenem. This study demonstrated the sustained potency of tigecycline against contemporary clinically relevant Gram-positive and Gram-negative pathogens; tigecycline resistance was rare (0.3%)...
Efflux pumps expression and its association with porin down-regulation and beta-lactamase production among Pseudomonas aeruginosa causing bloodstream infections in BrazilDanilo E Xavier
Division of Infectious Diseases, Universidade Federal de Sao Paulo, Rua Pedro de Toledo 781, 04039 032 Sao Paulo, Brazil
BMC Microbiol 10:217. 2010
..aeruginosa. We have investigated the expression level of efflux systems among clinical isolates of P. aeruginosa, regardless of their antimicrobial susceptibility profile...
- Ability of Latin America laboratories to detect antimicrobial resistance patterns: experience of the SENTRY Antimicrobial Surveillance Program (1997-2000)
Rodrigo E Mendes
Special Laboratory of Clinical Microbiology Federal University of São Paulo, SP, Brazil
Braz J Infect Dis 7:282-9. 2003
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- Changing antimicrobial susceptibility patterns among Streptococcus pneumoniae and Haemophilus influenzae from Brazil: Report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
Mariana Castanheira
Division of Infectious Diseases, , , Brazil
Microb Drug Resist 12:91-8. 2006
..The continued emerging antimicrobial resistances found in these pathogens (mainly S. pneumoniae) highlight the need for alternative agents for the treatment of infections caused by these species...
- SENTRY antimicrobial surveillance program report: Latin American and Brazilian results for 1997 through 2001
Helio S Sader
Special Laboratory of Clinical Microbiology, Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
Braz J Infect Dis 8:25-79. 2004
..This report allows the evaluation of the activities numerous antimicrobial agents against clinical isolates collected in Latin American countries...
- Prevalence and clinical outcomes of episodes of ventilator-associated pneumonia caused by SPM-1-producing and non-producing imipenem-resistant Pseudomonas aeruginosa
Guilherme Henrique Campos Furtado
Divisão de Doenças Infecciosas, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Rev Soc Bras Med Trop 44:604-6. 2011
..The presence of metallo-β-lactamases (MBL) has been pointed out as a major mechanism of resistance among these strains. No previous study addressed outcomes of respiratory infections caused by these strains...
- Antimicrobial susceptibility of gram-positive bacteria isolated in Brazilian hospitals participating in the SENTRY Program (2005-2008)
Ana C Gales
Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
Braz J Infect Dis 13:90-8. 2009
..Although vancomycin resistance rates in Brazil appears to be relatively low compared to those reported in the USA, VRE has emerged and rapidly disseminated in some Brazilian medical centers...
- In71, an Enterobacter cloacae blaVIM-1-carrying integron related to In70.2 from Italian Pseudomonas aeruginosa isolates: a SENTRY Antimicrobial Surveillance Program report
Mariana Castanheira
Laboratório ALERTA, Infectious Diseases Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Microb Drug Resist 13:130-4. 2007
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- Influence of disk preparation on detection of metallo-beta-lactamase-producing isolates by the combined disk assay
Soraya S Andrade
Laboratório Especial de Microbiologia Clínica, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Clin Microbiol 45:2058-60. 2007
..Among the 10 beta-lactam/IMBL combinations tested, only the imipenem/EDTA combination produced similar results...
- Dissemination of IMP-1 metallo- beta -lactamase-producing Acinetobacter species in a Brazilian teaching hospital
Maria C B Tognim
Division of Infectious Diseases, , , Brazil
Infect Control Hosp Epidemiol 27:742-7. 2006
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- Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study
Ana Cristina Gales
Escola Paulista de Medicina Universidade Federal de Sao Paulo, Rua Leandro Dupret 188, Sao Paulo, SP, Brazil
Braz J Infect Dis 15:513-20. 2011
..0%). In this study, doripenem showed similar in vitro activity to that of meropenem and retained some activity against imipenem-resistant P. aeruginosa isolated from Brazilian medical centers...
- Intravenous polymyxin B for the treatment of nosocomial pneumonia caused by multidrug-resistant Pseudomonas aeruginosa
Guilherme Henrique Campos Furtado
Hospital Epidemiology Committee, Division of Infectious Diseases, Federal University of Sao Paulo, Brazil
Int J Antimicrob Agents 30:315-9. 2007
..aeruginosa. Our study demonstrated that polymyxin B is a reliable antimicrobial drug, but only as salvage therapy, for nosocomial pneumonia caused by MDR P. aeruginosa...
- Bloodstream infections with metallo-beta-lactamase-producing Pseudomonas aeruginosa: epidemiology, microbiology, and clinical outcomes
Alexandre R Marra
Divsion of Infectious Diseases, Universidade Federal de Sao Paulo, Brasil UNIFESP EPM Hospital São Paulo, Escola Paulista de Medicina, Rua Napoleao de Barros, 715 7th andar, CEP 04023 062, Sao Paulo, SP, Brazil
Antimicrob Agents Chemother 50:388-90. 2006
..We evaluated the epidemiological and microbiological characteristics of monomicrobial bloodstream infections caused by MBL-producing P. aeruginosa isolates, as well as the clinical outcomes in patients with these infections...
Dissemination of bla(IMP-1)-carrying integron In86 among Klebsiella pneumoniae isolates harboring a new trimethoprim resistance gene dfr23Andréia P Penteado
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de Sao Paulo, São Paulo 04039 032, Brazil
Diagn Microbiol Infect Dis 63:87-91. 2009
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- Metallo-beta-lactamase detection: comparative evaluation of double-disk synergy versus combined disk tests for IMP-, GIM-, SIM-, SPM-, or VIM-producing isolates
Renata C Picão
Laboratório ALERTA, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Clin Microbiol 46:2028-37. 2008
..Our results indicate that both phenotypic methods to detect MBL-producing isolates should be based on the genera to be tested, regardless of the enzyme produced by such isolates, as well as on the local prevalence of MBL producers...
- Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
Elisa Maria Beirão
Departamento de Infectologia, Hospital Heliopolis, Rua Conego Xavier 276, Sao Paulo, SP, Brazil
Braz J Infect Dis 15:69-73. 2011
..The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center...
- Evaluation of the susceptibility profiles, genetic similarity and presence of qnr gene in Escherichia coli resistant to ciprofloxacin isolated in Brazilian hospitals
Andrea S Pereira
Special Laboratory of Microbiology, Federal University of Sao Paulo, SP, Brazil
Braz J Infect Dis 11:40-3. 2007
..The great genomic variability found among the ciprofloxacin-resistant Escherichia coli highlights the importance of the appropriate use of quinolone to restrict the selection of resistant isolates...
- Cloverleaf test (modified Hodge test) for detecting carbapenemase production in Klebsiella pneumoniae: be aware of false positive results
Cecilia G Carvalhaes
Laboratório ALERTA, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Antimicrob Chemother 65:249-51. 2010
..The aim of this study was to evaluate the presence of carbapenemases in a Klebsiella pneumoniae collection and the performance of the modified Hodge test (MHT) to correctly identify this phenotype...
- Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis
Rodrigo E Mendes
Division of Infectious Diseases, Federal University of Sao Paulo, Rua Leandro Dupret, 188, Sao Paulo, SP, Brazil CEP 04025 010
J Clin Microbiol 45:544-7. 2007
..This assay could be suitable for identification of MbetaL-producing gram-negative bacteria by molecular diagnostic laboratories...
- Molecular typing and antimicrobial susceptibility of vancomycin-resistant Enterococcus faecium in Brazil
Rosangela F Cereda
Division of Infectious Diseases, Universidade Federal Sao Paulo, Sao Paulo, Brazil
Infect Control Hosp Epidemiol 23:19-22. 2002
..A unique PFGE pattern with 4 subtypes was detected in 17 isolates from 4 different hospitals. CONCLUSION: The results of our study indicate the occurrence of intra- and interhospital dissemination of VRE in Sao Paulo, Brazil...
- First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America
Mariana Castanheira
Laboratório ALERTA, Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 781 6o Andar, Sao Paulo, SP, and Unidade de Microbiologia, Serviço de Patologia Clínica, Hospital de Clinicas, Porto Alegre, RS, Brazil
Antimicrob Agents Chemother 51:1527-9. 2007
..This is the first report of a qnrA-carrying isolate in a Latin American country...
- Metallo-β-lactamase-production in meropenem-susceptible Pseudomonas aeruginosa isolates: risk for silent spread
Renata Cristina Picão
Laboratório ALERTA, Departamento de Infectologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Mem Inst Oswaldo Cruz 107:747-51. 2012
..MBL-producing P. aeruginosa that are not resistant to meropenem may represent a risk for therapeutic failure and act as silent reservoirs of MBL-encoding genes...
- Resistance trends of Acinetobacter spp. in Latin America and characterization of international dissemination of multi-drug resistant strains: five-year report of the SENTRY Antimicrobial Surveillance Program
Maria Cristina Bronharo Tognim
, , , CEP 04025-010, Brazil
Int J Infect Dis 8:284-91. 2004
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