James E Galagan

Summary

Publications

  1. doi request reprint ChIP-Seq and the complexity of bacterial transcriptional regulation
    James Galagan
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Curr Top Microbiol Immunol 363:43-68. 2013
  2. pmc A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data
    Desmond S Lun
    Phenomics and Bioinformatics Research Centre, School of Mathematics and Statistics, and Australian Centre for Plant Functional Genomics, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, SA 5095, Australia
    Genome Biol 10:R142. 2009
  3. pmc The Mycobacterium tuberculosis regulatory network and hypoxia
    James E Galagan
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Nature 499:178-83. 2013
  4. ncbi request reprint Genomic insights into tuberculosis
    James E Galagan
    Department of Biomedical Engineering, Bioinformatics program and National Emerging Infectious Diseases Laboratory, Boston University, 34 Cummington Mall 1002, Boston, Massachusetts 02215 and Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 15:307-20. 2014

Collaborators

Detail Information

Publications4

  1. doi request reprint ChIP-Seq and the complexity of bacterial transcriptional regulation
    James Galagan
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Curr Top Microbiol Immunol 363:43-68. 2013
    ..Finally, we discuss two aspects of the binding discovered by ChIP-Seq that were unexpected given the canonical model: the substantial binding outside the proximal promoter region and the large number of weak binding sites...
  2. pmc A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data
    Desmond S Lun
    Phenomics and Bioinformatics Research Centre, School of Mathematics and Statistics, and Australian Centre for Plant Functional Genomics, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, SA 5095, Australia
    Genome Biol 10:R142. 2009
    ..We apply CSDeconv to novel ChIP-seq data for DosR binding in Mycobacterium tuberculosis and to existing data for GABP in humans and show that it can discriminate binding sites separated by as few as 40 bp...
  3. pmc The Mycobacterium tuberculosis regulatory network and hypoxia
    James E Galagan
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Nature 499:178-83. 2013
    ..The regulatory network reveals transcription factors underlying these changes, allows us to computationally predict expression changes, and indicates that Rv0081 is a regulatory hub. ..
  4. ncbi request reprint Genomic insights into tuberculosis
    James E Galagan
    Department of Biomedical Engineering, Bioinformatics program and National Emerging Infectious Diseases Laboratory, Boston University, 34 Cummington Mall 1002, Boston, Massachusetts 02215 and Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 15:307-20. 2014
    ..tuberculosis, as well as the molecular basis for its pathogenicity. These have important implications for our perspective of the disease, development of new drugs and vaccines, and treatment of patients using existing therapeutics. ..