John L Gainer

Summary

Publications

  1. ncbi request reprint Trans-sodium crocetinate for treating hypoxia/ischemia
    John L Gainer
    Diffusion Pharmaceuticals LLC, 2020 Avon Court, 4, Charlottesville, VA 22902, USA
    Expert Opin Investig Drugs 17:917-24. 2008
  2. ncbi request reprint trans-Sodium crocetinate and diffusion enhancement
    Amanda K Stennett
    Department of Chemical Engineering, University of Virginia, 102 Engineers Way, Charlottesville, VA 22904 4741, USA
    J Phys Chem B 110:18078-80. 2006
  3. ncbi request reprint TSC for hemorrhagic shock: effects on cytokines and blood pressure
    Amanda K Stennett
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 4741, USA
    Shock 22:569-74. 2004
  4. ncbi request reprint TSC and hemorrhagic shock
    Lisa J Giassi
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Adv Exp Med Biol 540:55-60. 2003
  5. pmc Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation
    Hiroaki Manabe
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 113:802-9. 2010
  6. ncbi request reprint Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy
    Lisa J Giassi
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 4741, USA
    Shock 18:585-8. 2002
  7. ncbi request reprint Trans-sodium crocetinate and hemorrhagic shock
    Amanda K Stennett
    Fresenius Medical Care, Lexington, Massachusetts, USA
    Shock 28:339-44. 2007

Collaborators

  • David O Okonkwo
  • Amanda K Stennett
  • Lisa J Giassi
  • Hiroaki Manabe
  • Kevin S Lee
  • Ryon H Clarke
  • James W Roy
  • Robert J Murray
  • Gail L Dempsey
  • A Kennon Poynter

Detail Information

Publications7

  1. ncbi request reprint Trans-sodium crocetinate for treating hypoxia/ischemia
    John L Gainer
    Diffusion Pharmaceuticals LLC, 2020 Avon Court, 4, Charlottesville, VA 22902, USA
    Expert Opin Investig Drugs 17:917-24. 2008
    ..Animal toxicology studies have demonstrated that high levels of TSC are well-tolerated, and a Phase I clinical study has shown that TSC is also safe in humans...
  2. ncbi request reprint trans-Sodium crocetinate and diffusion enhancement
    Amanda K Stennett
    Department of Chemical Engineering, University of Virginia, 102 Engineers Way, Charlottesville, VA 22904 4741, USA
    J Phys Chem B 110:18078-80. 2006
    ..TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, and molecular simulations suggest that the increase in diffusivity occurs only in these ordered regions...
  3. ncbi request reprint TSC for hemorrhagic shock: effects on cytokines and blood pressure
    Amanda K Stennett
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 4741, USA
    Shock 22:569-74. 2004
    ..Again, similar effects on other cytokines have been seen with 100% oxygen. These results support the hypothesis that the effects of TSC on hemorrhagic shock are mediated via an effect on oxygen...
  4. ncbi request reprint TSC and hemorrhagic shock
    Lisa J Giassi
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Adv Exp Med Biol 540:55-60. 2003
  5. pmc Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation
    Hiroaki Manabe
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 113:802-9. 2010
    ..The present study examined the ability of TSC to modify oxygenation in ischemic neural tissue and tested the potential neuroprotective effects of TSC in permanent and temporary models of focal cerebral ischemia...
  6. ncbi request reprint Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy
    Lisa J Giassi
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 4741, USA
    Shock 18:585-8. 2002
    ..The dosing regimen must be different, however, presumably because of the blood acidosis that develops after hemorrhage. The results also suggest that TSC may be protective against secondary liver damage resulting from trauma...
  7. ncbi request reprint Trans-sodium crocetinate and hemorrhagic shock
    Amanda K Stennett
    Fresenius Medical Care, Lexington, Massachusetts, USA
    Shock 28:339-44. 2007
    ..Pharmacokinetics data are presented for different modes of administration. Initial studies suggest that instillation of TSC into the trachea or intramuscular injection may provide useful alternative treatment routes...