Trans-sodium crocetinate for treating hypoxia/ischemiaJohn L Gainer
Diffusion Pharmaceuticals LLC, 2020 Avon Court, 4, Charlottesville, VA 22902, USA
Expert Opin Investig Drugs 17:917-24. 2008
..Animal toxicology studies have demonstrated that high levels of TSC are well-tolerated, and a Phase I clinical study has shown that TSC is also safe in humans...
- trans-Sodium crocetinate and diffusion enhancement
Amanda K Stennett
Department of Chemical Engineering, University of Virginia, 102 Engineers Way, Charlottesville, VA 22904-4741, USA
J Phys Chem B 110:18078-80. 2006
..TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, and molecular simulations suggest that the increase in diffusivity occurs only in these ordered regions...
- TSC for hemorrhagic shock: effects on cytokines and blood pressure
Amanda K Stennett
Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904-4741, USA
Shock 22:569-74. 2004
..Again, similar effects on other cytokines have been seen with 100% oxygen. These results support the hypothesis that the effects of TSC on hemorrhagic shock are mediated via an effect on oxygen...
- TSC and hemorrhagic shock
Lisa J Giassi
Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
Adv Exp Med Biol 540:55-60. 2003
Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigationHiroaki Manabe
Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 113:802-9. 2010
..The present study examined the ability of TSC to modify oxygenation in ischemic neural tissue and tested the potential neuroprotective effects of TSC in permanent and temporary models of focal cerebral ischemia...
- Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy
Lisa J Giassi
Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904-4741, USA
Shock 18:585-8. 2002
..The dosing regimen must be different, however, presumably because of the blood acidosis that develops after hemorrhage. The results also suggest that TSC may be protective against secondary liver damage resulting from trauma...
- Trans-sodium crocetinate and hemorrhagic shock
Amanda K Stennett
Fresenius Medical Care, Lexington, Massachusetts, USA
Shock 28:339-44. 2007
..Pharmacokinetics data are presented for different modes of administration. Initial studies suggest that instillation of TSC into the trachea or intramuscular injection may provide useful alternative treatment routes...
