Takashi Furuta

Summary

Publications

  1. pmc DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription
    Takashi Furuta
    Department of Molecular Medicine, Graduate School of Pharmaceutical Science, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 862 0973, Japan
    BMC Mol Biol 9:39. 2008
  2. ncbi request reprint Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    FASEB J 20:782-4. 2006
  3. ncbi request reprint Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Leuk Res 31:1721-8. 2007
  4. ncbi request reprint Membrane-anchored CD14 is required for LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Kumamoto University, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 338:1402-9. 2005

Collaborators

  • Akiko Uehara
  • Tsuyoshi Shuto
  • Hirofumi Kai
  • Mary Ann Suico
  • Dieter C Gruenert
  • Judy Cheung
  • Tsukasa Okiyoneda
  • Mariko Oba
  • Shogo Shimasaki
  • Yuko Ohira
  • Keizo Sato
  • Jian dong Li
  • Haidong Xu
  • Kosuke Kato
  • Hidetoshi Arima
  • Yoko Mori
  • Suganya Viriyakosol

Detail Information

Publications4

  1. pmc DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription
    Takashi Furuta
    Department of Molecular Medicine, Graduate School of Pharmaceutical Science, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 862 0973, Japan
    BMC Mol Biol 9:39. 2008
    ..However, the molecular mechanisms underlying DNA hypomethylation-dependent enhancement of TLR2 expression in CF cells remain unknown...
  2. ncbi request reprint Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    FASEB J 20:782-4. 2006
    ....
  3. ncbi request reprint Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Leuk Res 31:1721-8. 2007
    ..Thus, the data demonstrate a higher responsiveness of dHL-60 cells to TLR2 and TLR4 ligands because of increased TLR2 and MD2/CD14 gene expression...
  4. ncbi request reprint Membrane-anchored CD14 is required for LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells
    Tsuyoshi Shuto
    Department of Molecular Medicine, Kumamoto University, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 338:1402-9. 2005
    ..Thus, our data indicate that caveolae-dependent endocytosis pathway is involved in LPS-induced TLR4 downregulation and that this is dependent on membrane-anchored CD14 expression...