Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, et al
. miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation. Sci Rep. 2019;9:3445 pubmed publisher
..Taken together, the current study suggests that miR-124 dosage modulates PFC function through repressing the Drd2 pathway, suggesting a critical role of miR-124 in normal PFC function. ..
Irie S, Sanuki R, Muranishi Y, Kato K, Chaya T, Furukawa T. Rax Homeoprotein Regulates Photoreceptor Cell Maturation and Survival in Association with Crx in the Postnatal Mouse Retina. Mol Cell Biol. 2015;35:2583-96 pubmed publisher
..Taken together, these results suggest that Rax plays essential roles in the maturation of both cones and rods and in the survival of cones by regulating photoreceptor gene expression with Crx in the postnatal mouse retina. ..
Ueno A, Omori Y, Sugita Y, Watanabe S, Chaya T, Kozuka T, et al
. Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018;22:3548-3561 pubmed publisher
..These results suggest that the Frmpd2-Lrit1-mGluR6 axis regulates selective synapse formation in cone photoreceptors and is essential for normal visual function. ..
Tsutsumi R, Chaya T, Furukawa T. Enriched expression of the ciliopathy gene Ick in cell proliferating regions of adult mice. Gene Expr Patterns. 2018;29:18-23 pubmed publisher
..These results suggest that Ick is expressed in proliferating regions in the adult mouse brain, testis, and intestine. ..
Chaya T, Omori Y, Kuwahara R, Furukawa T. ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014;33:1227-42 pubmed publisher
..Our results suggest that ICK is a Kif3a kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia. ..
Sanuki R, Watanabe S, Sugita Y, Irie S, Kozuka T, Shimada M, et al
. Protein-4.1G-Mediated Membrane Trafficking Is Essential for Correct Rod Synaptic Location in the Retina and for Normal Visual Function. Cell Rep. 2015;10:796-808 pubmed publisher
..Taken together, the data in this study provide insight into the mechanism and importance of proper synapse location in neural circuit formation. ..
Watanabe S, Sanuki R, Sugita Y, Imai W, Yamazaki R, Kozuka T, et al
. Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity. J Neurosci. 2015;35:8004-20 pubmed publisher
..Our current study provides new insights into mechanisms of the diversification of amacrine cells and their function in vision. ..
Okamoto S, Chaya T, Omori Y, Kuwahara R, Kubo S, Sakaguchi H, et al
. Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function. J Neurosci. 2017;37:2073-2085 pubmed publisher
..Our study defines the association of ciliary transport regulation with PCP formation in HCs and hearing function. ..
Chaya T, Matsumoto A, Sugita Y, Watanabe S, Kuwahara R, Tachibana M, et al
. Versatile functional roles of horizontal cells in the retinal circuit. Sci Rep. 2017;7:5540 pubmed publisher
..Taken together, our current study suggests multiple functional aspects of HCs crucial for visual processing. ..