Takehiko Fujisawa

Summary

Publications

  1. ncbi request reprint The evaluation of lymph node metastasis by endobronchial ultrasound-guided transbronchial needle aspiration: crucial for selection of surgical candidates with metastatic lung tumors
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 134:1485-90. 2007
  2. ncbi request reprint Beginning and development of lung cancer surgery in Japan
    Takehiko Fujisawa
    Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Gen Thorac Cardiovasc Surg 58:387-92. 2010
  3. doi request reprint Endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with non-small cell lung cancer in non-operable patients pursuing radiotherapy as a primary treatment
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Oncol 5:606-11. 2010
  4. doi request reprint Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation
    Lei Tian
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 113:1396-403. 2008
  5. ncbi request reprint Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Ann Surg Oncol 14:2636-42. 2007
  6. ncbi request reprint Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Ann Thorac Surg 82:254-60. 2006
  7. ncbi request reprint Prognostic implications of cell cycle-related proteins in primary resectable pathologic N2 nonsmall cell lung cancer
    Sherif Mohamed
    Department of Thoracic Surgery Graduate School of Medicine Chiba University, Chiba, Japan
    Cancer 109:2506-14. 2007
  8. ncbi request reprint Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 13:6087-92. 2007
  9. ncbi request reprint A solitary metastatic lung tumor from thyroid papillary carcinoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): report of a case
    Yuichi Sakairi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 38:46-8. 2008
  10. ncbi request reprint Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Chest 132:597-602. 2007

Collaborators

Detail Information

Publications65

  1. ncbi request reprint The evaluation of lymph node metastasis by endobronchial ultrasound-guided transbronchial needle aspiration: crucial for selection of surgical candidates with metastatic lung tumors
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 134:1485-90. 2007
    ....
  2. ncbi request reprint Beginning and development of lung cancer surgery in Japan
    Takehiko Fujisawa
    Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Gen Thorac Cardiovasc Surg 58:387-92. 2010
    ..This article reviews the beginning and development of lung cancer surgery in Japan from a historical point of view...
  3. doi request reprint Endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with non-small cell lung cancer in non-operable patients pursuing radiotherapy as a primary treatment
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Oncol 5:606-11. 2010
    ..The aim of this study was to evaluate the effectiveness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for lymph node staging in patients with non-small cell lung cancer before CIRT...
  4. doi request reprint Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer: association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation
    Lei Tian
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 113:1396-403. 2008
    ..The expression of prostaglandin E receptor 2 (PTGER2) affects the biologic behavior of various types of malignant tumors. Recently, transactivation of both PTGER2 and epidermal growth factor receptor (EGFR) has been reported in some tumors...
  5. ncbi request reprint Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Ann Surg Oncol 14:2636-42. 2007
    ..The aim of this study was to determine whether IL-12Rbeta2 methylation is a common feature in human lung cancer...
  6. ncbi request reprint Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Ann Thorac Surg 82:254-60. 2006
    ..We sought to identify poor prognostic factors preoperatively and to retrospectively evaluate preoperative clinical indications for surgery...
  7. ncbi request reprint Prognostic implications of cell cycle-related proteins in primary resectable pathologic N2 nonsmall cell lung cancer
    Sherif Mohamed
    Department of Thoracic Surgery Graduate School of Medicine Chiba University, Chiba, Japan
    Cancer 109:2506-14. 2007
    ..For the current study, to select an appropriate therapeutic strategy for each patient, patients with N2 NSCLC were stratified into homogenous subgroups according to the expression profiles of cell cycle-related markers...
  8. ncbi request reprint Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 13:6087-92. 2007
    ..Although the details of each cascade are understood, very little is known about their collective effects in non-small cell lung cancer (NSCLC)...
  9. ncbi request reprint A solitary metastatic lung tumor from thyroid papillary carcinoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): report of a case
    Yuichi Sakairi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 38:46-8. 2008
    ..We performed right lower lobectomy with lymph node sampling, and the final pathological diagnosis was papillary carcinoma without lymph node metastasis...
  10. ncbi request reprint Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Chest 132:597-602. 2007
    ..EBUS-TBNA enables the sampling of histologic cores, which can be used for genetic analysis...
  11. ncbi request reprint Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    J Thorac Oncol 2:916-26. 2007
    ..On the basis on the results, a phase II study using a regimen of four fractions during 1 week was performed. The purpose of the present study was to determine the local control and 5-year survival rates...
  12. ncbi request reprint Histological diagnosis of mediastinal lymph node metastases from renal cell carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respirology 12:302-3. 2007
    ..This current study reports a case of mediastinal lymph node metastases from renal cell carcinoma successfully diagnosed histologically by endobronchial ultrasound-guided transbronchial needle aspiration...
  13. ncbi request reprint Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Cancer 106:2200-7. 2006
    ..Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event...
  14. ncbi request reprint Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 14:1397-404. 2007
    ..Although loss of expression of RRAD in breast cancer cells has been reported and it may act as an oncogene, the mechanism of silencing is unknown...
  15. ncbi request reprint Indications for mediastinoscopy and comparison of lymph node dissections in candidates for lung cancer surgery
    Hideki Kimura
    Division of Thoracic Diseases, Chiba Cancer Center, 666 2 Nitona cho, Chuo Ku, Chiba 260 8717, Japan
    Lung Cancer 56:349-55. 2007
    ..3 and 89.9%. The more favorable Group A outcomes indicated both successful selection by these criteria of patients not requiring mediastinal examination, and the superfluity of complete lymph node dissection in early stage cancer...
  16. ncbi request reprint Lymphangioleiomyomatosis with a giant bulla: report of a case
    Taiki Fujiwara
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 35:247-9. 2005
    ..She was commenced on progesterone, which improved her condition even further. This case report retrospectively follows the progression of her disease from the onset of symptoms 5 years before she was referred to us for treatment...
  17. ncbi request reprint Characteristics of tumor extension requiring bronchoplasty and pneumonectomy in patients with lung cancer and positive bronchoscopic findings
    Yasuo Sekine
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Surg Today 36:491-8. 2006
    ..We investigated how the characteristics of tumor extension determined the operative methods and the surgical outcomes...
  18. ncbi request reprint Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Cardiovasc Surg 132:312-5. 2006
    ..However, if significant negative prognostic factors become evident in patients with pathologic stage Ia non-small cell lung carcinoma, patients with negative prognostic factors should have adjuvant treatment after surgery...
  19. ncbi request reprint Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 82:1802-7. 2006
    ..We performed a prospective analysis of adjuvant chemotherapy for patients with completely resected pulmonary LCNECs to assess the effect of adjuvant chemotherapy...
  20. ncbi request reprint Association of chronic obstructive pulmonary disease and tumor recurrence in patients with stage IA lung cancer after complete resection
    Yasuo Sekine
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 84:946-50. 2007
    ..We sought to determine the impact of this disease on long-term survival after surgical resection and to identify prognostic factors in pathological stage IA lung cancer...
  21. ncbi request reprint Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Japan
    Surg Today 35:968-71. 2005
    ..A right upper lobectomy with SVC reconstruction was performed. The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type...
  22. doi request reprint Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, orotate phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration: a
    Takahiro Nakajima
    Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Lung Cancer 12:293-7. 2011
    ....
  23. ncbi request reprint Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Chest 130:710-8. 2006
    ....
  24. ncbi request reprint Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis
    Kenzo Hiroshima
    Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mod Pathol 19:1358-68. 2006
    ....
  25. doi request reprint Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer
    Yasumitsu Moriya
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Lung Cancer 64:86-91. 2009
    ..The findings of this study showed that pathological diagnosis combined with molecular classification clearly distinguished patients with good prognoses from patients with poor prognoses...
  26. ncbi request reprint LKB1 protein expression in neuroendocrine tumors of the lung
    Randa Mahmoud Sobhi Amin
    Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Pathol Int 58:84-8. 2008
    ..Although a few previous studies indicated rare genetic alterations of LKB1 in SCLC, further studies including analysis of other NE tumors and focusing on epigenetic abnormalities of LKB1 gene are warranted...
  27. ncbi request reprint Long-term management of polychondritis with serial tracheobronchial stents
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 81:e24-6. 2006
    ..Dramatic improvement of dyspnea was obtained each time. The patient survived during this period without oxygen inhalation or mechanical ventilation before she suddenly died due to suffocation caused by difficulty of sputum discharge...
  28. ncbi request reprint Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 50:347-54. 2005
    ..The procedure was uneventful without complications. EBUS-TBNA is a safe and sensitive method for lymph node staging in patients with lung cancer. It spares invasive staging procedures which has a major impact on patient management...
  29. ncbi request reprint Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease
    Yasuo Sekine
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Jpn J Thorac Cardiovasc Surg 53:237-43. 2005
    ..The purpose of this study was to investigate the impact of pulmonary rehabilitation on surgical morbidity and lung function in lung cancer patients with chronic obstructive pulmonary disease (COPD)...
  30. doi request reprint A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer
    Shinichiro Motohashi
    Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 182:2492-501. 2009
    ..These results are encouraging and warrant further evaluation for survival benefit of this immunotherapy...
  31. ncbi request reprint Endobronchial ultrasonography: current status and future directions
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Thorac Oncol 2:970-9. 2007
    ..The aim of this review is to highlight the current status of the different EBUS techniques available and to discuss the future direction of EBUS...
  32. ncbi request reprint Histological diagnosis of spinal chondrosarcoma by endobronchial ultrasound-guided transbronchial needle aspiration
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respirology 12:308-10. 2007
    ..A very rare case of spinal chondrosarcoma due to hereditary multiple exostoses successfully diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration and by immunohistochemistry with genetic analysis is reported...
  33. ncbi request reprint Double primary lung carcinoma consisting of large cell neuroendocrine carcinoma and squamous cell carcinoma: report of a case
    Yoshito Yamada
    Department of Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Thorac Cardiovasc Surg 11:397-400. 2005
    ..The patient had right supraclavicular lymph node metastases of LCNEC and died of multiple pulmonary metastases 10 months after the operation...
  34. ncbi request reprint Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Oncol 33:113-9. 2008
    ..Analysis for CXCL12 may provide novel opportunities for prognosis and therapy of resected NSCLCs...
  35. ncbi request reprint A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer
    Shinichiro Motohashi
    Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 12:6079-86. 2006
    ..We did a phase I study with autologous activated Valpha24 NKT cell therapy...
  36. ncbi request reprint Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells
    Masako Chiyo
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Anticancer Res 24:3763-7. 2004
    ..The parent tumor growth influenced by the cytokine producers was similar to each other. Combinatory antitumor effects were not produced by the cytokine producers and application of the cytokines did not show any synergistic effects...
  37. doi request reprint Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer
    Eitetsu Koh
    Department of Thoracic Surgery, Tokyo Women s Medical University Yachiyo Medical Center, Owada Shinden Yachiyo City, Chiba, Japan
    Int J Surg Pathol 20:233-9. 2012
    ..The aims of the study were to identify the significance of interleukin (IL)-6 production and to determine whether IL-6 production influences long-term survival in patients with non-small-cell lung cancer (NSCLC)...
  38. ncbi request reprint Surgical treatment of a superior sulcus tumor in a patient with idiopathic thrombocytopenic purpura: report of a case
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Japan
    Surg Today 35:1078-80. 2005
    ..The patient remained in good condition for 20 months following the surgery; however, he eventually died due to bone metastases...
  39. ncbi request reprint Aberrant methylation: common in thymic carcinomas, rare in thymomas
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, 1 8 1 Inohana, Chuoh ku, Chiba 260 8677, Japan
    Oncol Rep 14:1621-4. 2005
    ..0053). No tumors showed a mutation of EGFR, KRAS, and HER2. Thymic carcinoma is distinct from thymoma not only with respect to clinicopathological features, but also aberrant methylation patterns of the tumor suppressor genes...
  40. ncbi request reprint Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 84:702-7. 2007
    ....
  41. ncbi request reprint Staging and diagnosis of non-small cell lung cancer: invasive modalities
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Respirology 12:173-83. 2007
    ..In addition, the current advances in diagnostic bronchoscopy for lung cancer will be reviewed...
  42. ncbi request reprint A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population
    Toshihiko Iizasa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Oncol Rep 14:919-23. 2005
    ..We conclude that the A4/A4 genotype of the 5'-flanking region of CYP2E1 was significantly more frequent in lung adenocarcinoma cases than in healthy controls and, therefore, may be involved in the development of lung adenocarcinoma...
  43. doi request reprint Early detection of COPD is important for lung cancer surveillance
    Yasuo Sekine
    Depts of Thoracic Surgery, Tokyo Women s Medical University Yachiyo Medical Center, Chiba, Japan
    Eur Respir J 39:1230-40. 2012
    ..We propose that, for the prevention of both diseases, COPD screening in smokers should be initiated as early as possible, so they can stop smoking and so that candidates for an efficient lung cancer screening programme can be identified...
  44. ncbi request reprint Effective detection of bronchial preinvasive lesions by a new autofluorescence imaging bronchovideoscope system
    Masako Chiyo
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 48:307-13. 2005
    ..0005). We conclude that AFI appears to represent a significant advance in distinguishing preinvasive and malignant lesions from bronchitis or hyperplasia under circumstances where LIFE would identify these all as abnormal lesions...
  45. ncbi request reprint Inhibition of potential lethal damage repair and related gene expression after carbon-ion beam irradiation to human lung cancer grown in nude mice
    Tomoyasu Yashiro
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba
    J Radiat Res 48:377-83. 2007
    ..We conclude that PCNA could be a likely candidate gene for PLD repair...
  46. ncbi request reprint Epidermal growth factor receptor expression status in lung cancer correlates with its mutation
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Hum Pathol 36:1127-34. 2005
    ..In conclusion, EGFR and HER2 overexpression is frequent in lung cancer, and EGFR overexpression correlates with the EGFR TK domain mutations...
  47. ncbi request reprint Rapid regression of stage IVb invasive thymoma under palliative corticosteroid administration
    Taiki Fujiwara
    Department of Chest Surgery, Matsudo City Hospital, Chiba, Japan
    Gen Thorac Cardiovasc Surg 55:180-3. 2007
    ..After 1 month of antipyretic therapy, whole-body eruption disappeared and we encountered rapid regression of the thymoma. Unfortunately she died of interstitial pneumonitis only 2 months after the regression...
  48. ncbi request reprint The efficacy of partial liquid ventilation in lung protection during hypotension and cardiac arrest: preliminary study of lung transplantation using non-heart-beating donors
    Shigetoshi Yoshida
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Heart Lung Transplant 24:723-9. 2005
    ..However, no effective lung protection method has been developed. In this study, we preliminarily investigated the protective effect of partial liquid ventilation (PLV) on a non-heart-beating rabbit lung...
  49. ncbi request reprint Endobronchial ultrasound-guided transbronchial needle aspiration for the treatment of central airway stenosis caused by a mediastinal cyst
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Eur J Cardiothorac Surg 32:538-40. 2007
    ..We herein report a rare case of central airway stenosis caused by mediastinal cyst successfully treated by EBUS-TBNA with no regrowth after 1 year. A total of 80 ml of fluid content was aspirated, resulting in patency of the trachea...
  50. ncbi request reprint A strategy of sequential therapy with a bronchoscopic excision and thoracotomy for intra- and extrabronchial wall schwannoma: report of a case
    Teruaki Mizobuchi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Surg Today 35:778-81. 2005
    ..The pathologic diagnosis of the tumor was benign schwannoma. There were no complications and no evidence of disease recurrence has been observed after the surgery...
  51. ncbi request reprint Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases
    Hidemi Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Surg Today 35:243-6. 2005
    ..We also review 23 reported cases of endobronchial neurogenic tumors and discuss the efficacy of endoscopic treatments for endobronchial neurogenic tumors...
  52. ncbi request reprint Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung
    Randa M S Amin
    Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Pathol Int 58:38-44. 2008
    ..These data imply that aberrant mTOR signaling may play a role in the development of SH, and its vascular nature may be due partially to high levels of VEGF caused by dysregulation of mTOR signaling...
  53. ncbi request reprint Does perioperative high-dose prednisolone have clinical benefits for generalized myasthenia gravis?
    Yasuo Sekine
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur J Cardiothorac Surg 29:908-13. 2006
    ....
  54. ncbi request reprint Pulmonary artery leiomyosarcoma expressing Epstein-Barr virus in an immunocompetent individual
    Sana Yokoi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 81:1897-9. 2006
    ..We document a case of pulmonary artery leiomyosarcoma expressing Epstein-Barr virus DNA sequences in an immunocompetent patient 4 years after symptomatic Epstein-Barr virus infection...
  55. ncbi request reprint Early open thoracotomy and mediastinopleural irrigation for severe descending necrotizing mediastinitis
    Takekazu Iwata
    Department of Thoracic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur J Cardiothorac Surg 28:384-8. 2005
    ..Since DNM is uncommon, few reports of large series of patients with DNM (i.e. more than 10 cases) have been published. The present aim was to evaluate our treatment strategy for DNM by retrospective chart review...
  56. ncbi request reprint A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer
    Aki Ishikawa
    Department of Immunology and Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Cancer Res 11:1910-7. 2005
    ..We did a phase I dose escalation study with alphaGalCer-pulsed DCs in lung cancer patients...
  57. ncbi request reprint Dose-volume factors predicting radiation pneumonitis in patients receiving salvage radiotherapy for postlobectomy locoregional recurrent non-small-cell lung cancer
    Takashi Uno
    Department of Radiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba, 260 8670, Japan
    Int J Clin Oncol 11:55-9. 2006
    ..The correlation between treatment-related factors and lung toxicity has not been sufficiently evaluated in salvage radiotherapy...
  58. ncbi request reprint Diffuse malignant pleural mesothelioma: a multi-institutional clinicopathological study
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Surg Today 38:993-8. 2008
    ..Thus, we performed a multiinstitutional study to evaluate the current status of diagnosis and treatment in Japan...
  59. ncbi request reprint Surgical technique of experimental lung transplantation in rabbits
    Shigetoshi Yoshida
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Cardiovasc Surg 11:7-11. 2005
    ..The purpose of this study was to establish a lung allotransplantation model for the evaluation of acute lung rejection in the rabbit and to investigate the transplantation techniques in the rabbit...
  60. ncbi request reprint Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 67:750-8. 2007
    ..Second, a Phase II study using the optimal dose was performed. The purpose of the present study was to clarify the local control and 5-year survival rates...
  61. ncbi request reprint Dramatic improvement of respiratory condition after lobectomy for localized bullous emphysema
    Hironobu Wada
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Cardiovasc Surg 10:293-6. 2004
    ..His dyspnea immediately disappeared and the respiratory function improved dramatically. We concluded that lobectomy could be considered as one of surgical options in case of complete lobar destruction in emphysema patients...
  62. ncbi request reprint Papillary carcinoma of the thymus gland
    Mitsuru Yoshino
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 80:741-2. 2005
    ..In this study we report on a case of papillary thymic carcinoma in a 29-year-old woman. Histologically, the tumor consisted of a papillary component admixed with a solid component, a component that is commonly found in type A thymoma...
  63. ncbi request reprint Thyroid cancer with massive invasion into the neck and mediastinal great veins
    Shinichiro Motohashi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Jpn J Thorac Cardiovasc Surg 53:55-7. 2005
    ..The patient has survived for more than two years after surgery, with good general condition...
  64. ncbi request reprint Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
    Masako Chiyo
    Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
    Int J Cancer 115:437-42. 2005
    ..These data collectively suggest that expressed IL-27 in tumors produces T cell-dependent and-independent antitumor effects and is a possible therapeutic strategy for cancer...
  65. ncbi request reprint Clinicopathological analysis of pulmonary sclerosing hemangioma
    Akira Iyoda
    Department of Thoracic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    Ann Thorac Surg 78:1928-31. 2004
    ..Sclerosing hemangiomas of the lung are uncommon tumors and are thought to be benign. However, the histogenesis and clinicopathological features of these tumors have not been elucidated...