Cheryl A Frye

Summary

Publications

  1. pmc Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice
    Cheryl A Frye
    The Departments of Psychology and Biology and Centers for Life Science and Neuroscience Research, The University at Albany State University of New York, Albany, NY 12222, United States
    Neurosci Lett 472:38-42. 2010
  2. pmc Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Physiol Behav 100:264-7. 2010
  3. pmc Progesterone enhances performance of aged mice in cortical or hippocampal tasks
    Cheryl A Frye
    Department of Psychology and Centers for Life Science and Neuroscience Research, University at Albany SUNY, Albany, NY 12222, United States
    Neurosci Lett 437:116-20. 2008
  4. pmc Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 33:1049-61. 2008
  5. pmc Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Behav Brain Res 187:88-99. 2008
  6. ncbi Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects
    Alicia A Walf
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Stress 10:251-60. 2007
  7. ncbi Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Neurosci 118:1352-64. 2004
  8. pmc Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, NY 12222, USA
    Horm Behav 54:726-34. 2008
  9. ncbi Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1288-301. 2005
  10. ncbi Progestins' effects on sexual behaviour of female rats and hamsters involving D1 and GABA(A) receptors in the ventral tegmental area may be G-protein-dependent
    Cheryl A Frye
    Department of Psychology, Life Sciences 1058, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 172:286-93. 2006

Collaborators

Detail Information

Publications97

  1. pmc Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice
    Cheryl A Frye
    The Departments of Psychology and Biology and Centers for Life Science and Neuroscience Research, The University at Albany State University of New York, Albany, NY 12222, United States
    Neurosci Lett 472:38-42. 2010
    ..PRKO, compared to wildtype, mice performed better in the inhibitory avoidance task, irrespective of progesterone. Thus, progesterone to aged mice enhances performance across a variety of tasks and this may not require actions at PRs...
  2. pmc Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Physiol Behav 100:264-7. 2010
    ..Levels of 3alpha,5alpha-THP in the hypothalamus of BTBR mice were significantly higher compared to C57/J and 129S1 mice. These findings suggest that neuroendocrine dysregulation among BTBR mice extends to 3alpha,5alpha-THP...
  3. pmc Progesterone enhances performance of aged mice in cortical or hippocampal tasks
    Cheryl A Frye
    Department of Psychology and Centers for Life Science and Neuroscience Research, University at Albany SUNY, Albany, NY 12222, United States
    Neurosci Lett 437:116-20. 2008
    ..Thus, progesterone improved learning and memory in tasks mediated by the prefrontal cortex and/or hippocampus of aged mice...
  4. pmc Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 33:1049-61. 2008
    ..Similar patterns were seen among young, adult GDX but not in intact mice. Thus, 3alpha-diol can enhance affective and cognitive behavior of male mice...
  5. pmc Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Behav Brain Res 187:88-99. 2008
    ..Thus, 3alpha,5alpha-THP infusions to the VTA, but not SN or CG, can enhance socio-sexual behaviors and increase levels in midbrain, hippocampus, and diencephalon...
  6. ncbi Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects
    Alicia A Walf
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Stress 10:251-60. 2007
    ..Thus, estradiol and gestational stress can have opposite effects on anxiety and inhibitory avoidance performance...
  7. ncbi Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Neurosci 118:1352-64. 2004
    ..Only 3alpha-diol levels in the hippocampus were consistently elevated in conjunction with these behavioral effects...
  8. pmc Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, NY 12222, USA
    Horm Behav 54:726-34. 2008
    ..Thus, actions at ERbeta may be required for T's anxiety-reducing and cognitive-enhancing effects...
  9. ncbi Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1288-301. 2005
    ..Together, these data suggest that E(2) may have dose-dependent effects on anxiety and depressive behavior of female rodents, which may depend on the tone of the hypothalamic-pituitary-adrenal axis...
  10. ncbi Progestins' effects on sexual behaviour of female rats and hamsters involving D1 and GABA(A) receptors in the ventral tegmental area may be G-protein-dependent
    Cheryl A Frye
    Department of Psychology, Life Sciences 1058, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 172:286-93. 2006
    ..Thus, progestins' actions in the VTA for lordosis that involve D(1) and/or GBRs may also include recruitment of G-proteins...
  11. pmc Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze
    Alicia A Walf
    Dept of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Behav Brain Res 196:254-60. 2009
    ..Thus, enhanced performance in cognitive tasks and anti-anxiety-like behavior of proestrous mice may require actions of ERbeta in the hippocampus and/or cortex...
  12. pmc Estradiol reduces anxiety- and depression-like behavior of aged female mice
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Physiol Behav 99:169-74. 2010
    ..Thus, an acute E(2) regimen produced specific anti-anxiety and anti-depressant effects, independent of effects on motor behavior, when administered to aged female C57BL/6 mice...
  13. ncbi Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 6:320-7. 2005
    ..These data suggest that actions of progesterone at GABA(A) receptors in the hippocampus are important for progesterone's antiseizure effects...
  14. ncbi Administration of estrogen receptor beta-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:407-14. 2007
    ..Administration of ERalpha-specific SERMs produced similar effects as vehicle administration. Thus, E(2)'s anti-anxiety and anti-depressive effects may involve ERbeta in the hippocampus...
  15. pmc Nociceptive and anxiety-like behavior in reproductively competent and reproductively senescent middle-aged rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Gend Med 6:235-46. 2009
    ..Changes in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect...
  16. pmc Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice
    Carolyn J Koonce
    Department of aPsychology, University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 20:1047-50. 2009
    ..Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects...
  17. ncbi In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABA A receptors
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Horm Behav 50:332-7. 2006
    ..There were no effects on motor behavior. Thus, in the VTA, GBR activity modulates D1-mediated actions for lordosis of hamsters and rats...
  18. ncbi Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 32:522-30. 2007
    ..Thus, E(2)'s rewarding effects may involve actions at ERs in the nucleus accumbens...
  19. ncbi ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1598-609. 2005
    ..Coadministration of tamoxifen (10 mg/kg) blocked the antianxiety behavior produced by 17beta-E2, DPN, or coumestrol. Together, these data suggest that actions at ERbeta may underlie some of E2's antianxiety effects...
  20. pmc Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res Bull 77:91-7. 2008
    ..Effects on lordosis were not solely due to changes in general motor behavior. Thus, 3alpha,5alpha-THP's actions in the ventral tegmental area through membrane receptors may require activity of protein kinase C...
  21. pmc Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, NY 12222, USA
    Pharmacol Biochem Behav 93:474-81. 2009
    ..Thus, actions at GABA(A) receptors in the midbrain VTA are essential for appetitive and consummatory aspects of sexual receptivity among rats...
  22. pmc Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice
    Carolyn J Koonce
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 253:232-9. 2013
    ..Thus, metabolism of P4 by the 5α-reductase enzyme may be essential for enhancement of these behaviors. ..
  23. ncbi Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area
    Kanako Sumida
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 161:1-7. 2005
    ..The D(2) agonist, quinpirole and the D(2) antagonist, sulpiride, had no significant effects on P-facilitated lordosis. These data suggest that, in hamsters, P's actions for lordosis may involve D(1) receptors in the VTA...
  24. pmc Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks
    Alicia A Walf
    Department of Psychology, The University at Albany, State University of New York, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:513-21. 2008
    ..Thus, actions at ERbeta may be important for E(2) or SERMs to enhance cognitive performance of female mice in the object recognition and placement tasks...
  25. ncbi In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A
    Sandra M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Neuroendocrinology 84:405-14. 2006
    ..Thus, in the VTA, progestins' membrane actions involving D1 or GBRs are mediated, in part, by PKA...
  26. pmc Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 186:302-11. 2006
    ....
  27. pmc Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 193:269-76. 2008
    ..These findings suggest that actions of 3alpha,5alpha-THP in the VTA are important for mediating aspects of exploration, anxiety, and social behavior related to mating...
  28. pmc Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 21:590-5. 2010
    ..Thus, formation of 3alpha,5alpha-THP may be required for progesterone's cognitive-enhancing effects...
  29. ncbi Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsy Behav 6:140-6. 2005
    ..These data suggest that formation of 3alpha,5alpha-THP in the hippocampus is important for progesterone's antiseizure effects...
  30. ncbi Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Epilepsia 45:1531-8. 2004
    ..The present studies were designed to characterize the effects of progestins to modulate pentylenetetrazole (PTZ)-induced seizures in female rats...
  31. pmc Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Life Sciences Research 1058, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:909-16. 2009
    ..Thus, E(2)-replacement reduced anxiety and depression behavior and improved cognitive performance of aged female rats; however, delay in E(2) treatment influenced whether there were favorable effects of E(2) in some tasks...
  32. pmc 6-hydroxydopamine lesions enhance progesterone-facilitated lordosis of rats and hamsters, independent of effects on motor behavior
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Physiol Behav 99:218-24. 2010
    ..This suggests that the dopaminergic output neurons of midbrain VTA may play an important role in modulation of P(4)-facilitated sexual lordosis among rodents...
  33. ncbi In the ventral tegmental area, G-proteins mediate progesterone's actions at dopamine type 1 receptors for lordosis of rats and hamsters
    Sandra M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY, 12222, USA
    Psychopharmacology (Berl) 186:133-42. 2006
    ..Previous reports indicate that the ventral tegmental area (VTA) and/or progesterone (P) can modulate the reinforcing effects of drugs of abuse, food, and sexual behavior...
  34. doi Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 16:418-22. 2009
    ..Estrogens with activity at ERbeta, but not those selective for ERalpha, produced antiseizure effects. Actions at ERbeta may underlie some antiseizure effects of T's metabolites...
  35. pmc Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 83:336-47. 2006
    ..Whether endogenous levels of 3alpha,5alpha-THP modulate and/or are increased in response to affective and/or reproductively-relevant behaviors was investigated...
  36. ncbi Androgens' performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the dorsal hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:201-8. 2007
    ....
  37. pmc Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of naturally cycling and ovariectomized rats
    Danielle C Llaneza
    Dept of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 93:337-42. 2009
    ..Thus, progesterone and/or estrogen may mediate impulsive and/or avoidant behavior...
  38. pmc Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, New York, USA
    Reproduction 133:663-74. 2007
    ..Thus, paced mating enhances concentrations of 5alpha-reduced progestins in brain areas associated with reproduction (midbrain), as well as exploration/anxiety (hippocampus and striatum) and social behavior (cortex)...
  39. pmc In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C
    Cheryl A Frye
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1230:218-23. 2008
    ..Thus, progestogens' non-traditional actions in the VTA to enhance lordosis through D1 and/or GABA(A) include activity of PLC...
  40. pmc Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats
    Cheryl A Frye
    Department of Psychology, The Centers for Neuroscience Life Sciences Research 1058, The University at Albany SUNY, Albany, New York 12222, USA
    Reproduction 137:119-28. 2009
    ..These findings suggest that 3alpha,5alpha-THP formation in the midbrain VTA may influence appetitive, as well as consummatory, aspects of mating behavior...
  41. ncbi Sexual experience of male rats influences anxiety-like behavior and androgen levels
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, United States
    Physiol Behav 92:443-53. 2007
    ..Thus, sexual experience is associated with lower levels of anxiety-like behavior and higher levels of androgen secretion...
  42. ncbi Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:17-26. 2008
    ....
  43. ncbi Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively
    Alicia A Walf
    Department of Psychology, Research The University at Albany Suny, Albany, NY 12222, USA
    Neuropsychopharmacology 33:431-40. 2008
    ..Thus, ERbeta and ERalpha may be required for E(2)'s modulation of affective and sexual behavior, respectively...
  44. pmc Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice
    Carolyn J Koonce
    Dept Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 226:376-80. 2012
    ..Thus, 5α-reductase may be required for the estrous cycle variations in affective behavior and 3α,5α-THP levels of female mice...
  45. pmc Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    Neurobiol Learn Mem 86:35-46. 2006
    ..Together, these results suggest that E2 and progestins can have mnemonic effects through actions in the cortex and/or hippocampus...
  46. pmc Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY, USA
    Neurobiol Learn Mem 90:171-7. 2008
    ..Compared to vehicle, P(4) treatment increased freezing in contextual and cued fear testing. Thus, acute P(4) treatment to OVX mice can improve cognitive performance across a variety of tasks...
  47. pmc Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites
    Cheryl A Frye
    Department of Psychology, Research, The University at Albany, State University of New York, Albany, New York 12222, USA
    Physiol Behav 97:266-9. 2009
    ..Together, these data suggest that T and its 5alpha-reduced and aromatized metabolites have anti-depressant-like effects in aged male and female mice...
  48. ncbi Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 30:418-30. 2005
    ..These findings suggest that T's anti-anxiety effects may be due in part to actions of its 5alpha-reduced metabolites in the dorsal hippocampus...
  49. pmc Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Behav Pharmacol 21:530-9. 2010
    ..Therefore, effects of CEE to reduce anxiety-like behavior of middle-aged rats may be owing, in part, to its capacity to enhance levels of 3alpha,5alpha-THP in the hippocampus...
  50. ncbi ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Social Sciences 369, Albany, NY 12222, USA
    Neurobiol Learn Mem 85:183-91. 2006
    ....
  51. pmc Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 213:93-103. 2011
    ..Some actions of 3α,5α-THP may occur via positive modulation of GABA(A) receptors (GBRs), or negative modulation of N-methyl-D: -aspartate receptors (NMDARs), to influence anxiety-like behavior; but this is not known...
  52. ncbi Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Horm Behav 50:237-44. 2006
    ..Progestin- or progestin plus SKF38393-or muscimol-mediated increases in lordosis were blocked by DDA pretreatment. Thus, in the VTA, progestins' membrane action may involve adenylyl cyclase...
  53. pmc Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex
    Cheryl A Frye
    Dept of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neurosci Lett 551:53-7. 2013
    ..Levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and hippocampus were lowest among mice administered MPA. Thus, some of P4s effects to enhance cognitive performance may be incumbent upon its 5α-reduction. ..
  54. ncbi In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3alpha,5alpha-THP's actions at dopamine type 1 receptors for lordosis of rats
    Sandra M Petralia
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 80:233-43. 2004
    ..Thus, in the VTA, 3alpha,5alpha-THP's actions for lordosis may involve activation of D1 and initiation of the G-protein-mediated second messenger cAMP...
  55. pmc Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring
    Jason J Paris
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Stress 14:652-64. 2011
    ..Thus, immune stress during late pregnancy reduced gestational length and negatively impacted birth outcomes, hippocampal function and central neurosteroid formation in the offspring...
  56. ncbi Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats
    Cheryl A Frye
    Department of Psychology, University at Albany State University of New York, Albany, NY 12222, USA
    Behav Neurosci 118:306-13. 2004
    ..Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses...
  57. pmc Parity and estrogen-administration alter affective behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Physiol Behav 93:351-6. 2008
    ..Together, these data suggest that E(2) can alter affective behavior and rats with greater reproductive experience have decreased anxiety-like behavior in the elevated plus maze, irrespective of E(2)-priming...
  58. pmc Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout, mice
    Danielle M Osborne
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 16:411-4. 2009
    ..Thus, some of the anticonvulsive effects of E(2) may involve formation of 3alpha,5alpha-THP in the hippocampus...
  59. ncbi Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 81:907-16. 2005
    ..BDNF levels in the hippocampus were increased by estrogen-priming, but reduced by progesterone administration. Thus, estrogen may have anti-seizure effects by enhancing formation of allopregnanolone...
  60. pmc Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, United States
    Neurobiol Learn Mem 88:208-16. 2007
    ..Thus, performance in the object placement task is better when E(2) and/or P are naturally elevated or when E(2), the ERalpha selective ER modulator PPT, P, or its metabolite, 3alpha,5alpha-THP, are administered post-training...
  61. ncbi In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters
    Sandra M Petralia
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 178:174-82. 2005
    ..Thus, if, in the VTA, MBR-mediated increases in 3alpha,5alpha-THP enhance sexual responses via actions at GBRs, then blocking GBRs with picrotoxin will reduce FGIN 1-27-induced increases in sexual behavior of female rodents...
  62. ncbi Progesterone's 5 alpha-reduced metabolite, 3 alpha,5 alpha-THP, mediates lateral displacement of hamsters
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1038:59-68. 2005
    ..These data suggest that lateral displacement is progestin-sensitive and requires the formation of 3 alpha,5 alpha-THP in the midbrain VTA...
  63. pmc II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus
    Jason J Paris
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Brain Res 1379:149-63. 2011
    ..Neither estradiol nor corticosterone levels significantly contributed to cognitive performance. Thus, the capacity for cortico-limbic P(4) utilization may influence cognitive performance in aging...
  64. pmc Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Dev Neurobiol 71:142-52. 2011
    ..Thus, these data suggest that a physiological regimen of P₄ can prevent some of the deficits in water maze performance produced by kainic acid...
  65. pmc Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 99:525-31. 2011
    ..Together these data demonstrate that P decreases depressive behavior of young and older adult C57/BL6, wildtype and PRKO mice, which suggest that acute anti-depressant effects of P may occur independent of actions at "classic" PRs...
  66. pmc Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1036:101-8. 2005
    ..These findings suggest that E2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task...
  67. ncbi Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:551-8. 2004
    ..Together, these data suggest that estrogen can have positive mnemonic effects in the inhibitory avoidance task...
  68. ncbi 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 29:1019-27. 2004
    ..These results suggest that 5alpha-reduced androgens may have actions in the hippocampus to improve cognitive performance...
  69. ncbi Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Ave, Albany, NY 12222, USA
    Brain Res 956:285-93. 2002
    ....
  70. pmc Communication, interventions, and scientific advances in autism: a commentary
    Danielle C Llaneza
    Department of Psychology, University at Albany, State University of New York, Albany, NY 12222, United States
    Physiol Behav 100:268-76. 2010
    ..This reciprocity is one of the hallmarks of the scientific method, such that research may inform behavioral treatments, and observations made during treatment may inform subsequent research...
  71. ncbi Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the conditioned fear and inhibitory avoidance tasks
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:559-68. 2004
    ..These data indicate that androgens effects to enhance learning may be mediated in part by actions of 5alpha-reduced metabolites in the hippocampus...
  72. ncbi Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta
    Allicia Ryan
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 13:32-5. 2008
    ..This pattern of effects was observed in wild-type or betaERKO mice. Thus, for these mice, the antiseizure effects of 3*-diol for the chemoconvulsant PTZ occur independent of actions at ERbeta...
  73. pmc Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:S143-61. 2009
    ..Further understanding of these neurobiological and/or behavioral factors may lead to findings that ultimately can promote health and prevent disease...
  74. pmc Early postnatal stimulation alters pregnane neurosteroids in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany, Albany, NY 12222, and Division of Neurology, The Children s Hospital of Philadelphia, PA, USA
    Psychopharmacology (Berl) 186:343-50. 2006
    ..Early postnatal stimulation is a developmental stressor that can produce pervasive endocrine effects...
  75. pmc Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats
    Amy S Kohtz
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Horm Behav 57:474-80. 2010
    ..However, cocaine's disruption of sexual behaviors was similar among males and proestrous females. These data suggest a complex interaction between hormonal milieu and the neuroendocrine and behavioral effects of cocaine...
  76. ncbi Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5alpha-reductase
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsia 43:14-7. 2002
    ..To investigate the importance of progesterone (P4) metabolism by the 5alpha-reductase type I enzyme in mitigating P4 antiseizure effects...
  77. ncbi Prenatal stress alters reproductive responses of rats in behavioral estrus and paced mating of hormone-primed rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Horm Behav 42:472-83. 2002
    ....
  78. ncbi Androgens in the hippocampus can alter, and be altered by, ictal activity
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:483-93. 2004
    ..Thus, this paper will review data in support of androgens' antiseizure effects. Further understanding of androgens' role in seizure processes is important for potential therapeutic effects...
  79. ncbi Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats
    Cheryl A Frye
    The University at Albany SUNY, Department of Psychology, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 28:657-73. 2003
    ..Together, these data are consistent with the hypothesis that olanzapine reduces fear, has anxiolytic effects, and may enhance social interaction in part due to increasing progestin concentrations...
  80. pmc Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building Rm 1058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:78-85. 2007
    ..Together, these findings suggest that T's effects to enhance learning and memory may take place, in part, through actions of its metabolite, 3alpha-diol, at ERbeta in the dorsal hippocampus...
  81. ncbi Anti-nociception following exposure to trimethylthiazoline, peripheral or intra-amygdala estrogen and/or progesterone
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 144:77-85. 2003
    ..These data suggest that following exposure to predator odor, pain sensitivity in the tailflick task is decreased and that E(2) and/or P may have actions in the amygdala to produce similar anti-nociceptive effects...
  82. ncbi Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase
    Cheryl A Frye
    Department of Psychology and Center for Neurobiology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 1004:116-24. 2004
    ..Thus, these data suggest metabolism by the 5 alpha-reductase type I enzyme may mitigate P(4)'s effects on some tasks of motor, anxiety, nociception, and depression behavior...
  83. ncbi Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats
    Cheryl A Frye
    Department of Psychology, State University of New York at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:473-81. 2004
    ..These data indicate that T's 5alpha-reduced metabolite, DHT, can reduce anxiety behavior and that blocking metabolism to 3alpha-diol in the hippocampus can attenuate these effects...
  84. ncbi 3alpha,5alpha-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:505-12. 2004
    ..Together, these data suggest that progestins can protect against ADX-induced cell death and that the actions of the progesterone metabolite, 3alpha,5alpha-THP, may underlie these effects...
  85. pmc A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 31:1097-111. 2006
    ..It is particularly important to investigate the putative receptor mechanisms and brain targets for E2 to determine whether mood-enhancing effects of E2 can occur without deleterious proliferative effects in reproductive tissues...
  86. pmc Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse
    Cheryl A Frye
    Department of Psychology, Centers for Neuroscience and Life Sciences Research, The University at Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:209-19. 2007
    ..How progestins' effects on these processes may underlie response to drugs of abuse is considered and new findings which demonstrate interactions between progestins and cocaine are presented...
  87. ncbi Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, New York, 12222, USA
    Horm Behav 41:306-15. 2002
    ..Together these data suggest that variations in 3alpha,5alpha-THP levels in the hippocampus may mitigate proestrous changes in anxiety and depressive behavior of cycling rats...
  88. pmc Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Steroids 73:997-1007. 2008
    ..Thus, there may be a convergence of E(2)'s actions through rapid, membrane-mediated effects and intracellular ERs in the hippocampus for these functional effects...
  89. ncbi Seizure exacerbation associated with inhibition of progesterone metabolism
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Neurol 53:390-1. 2003
    ..We report a case in which efficacy was eliminated during concomitant treatment with a reductase inhibitor. The observation suggests that a reduced metabolite, rather than progesterone itself, was responsible for improved seizure control...
  90. ncbi Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats
    Cheryl A Frye
    Department of Psychology, Social Science 220, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:531-40. 2004
    ..Together, these data suggest that 3alpha,5alpha-THP in the hippocampus may mediate antidepressive behavior of female rats...
  91. ncbi Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Horm Behav 50:216-22. 2006
    ..Together, these findings suggest that androgens can decrease anxiety-like behavior of male rats in part through DHT's actions at androgen receptors in the hippocampus...
  92. pmc Conjugated equine estrogen enhances rats' cognitive, anxiety, and social behavior
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 19:789-92. 2008
    ..Thus, CEE can enhance cognitive, antianxiety, and social behavior of middle-aged rats...
  93. ncbi 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia
    Charles D Smith
    Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536 0098, USA
    Psychopharmacology (Berl) 186:481-5. 2006
    ..Recent literature suggests that neurosteroid metabolism may be altered in Alzheimer's disease (AD)...
  94. pmc MK-801 infusions to the ventral tegmental area and ventromedial hypothalamus produce opposite effects on lordosis of hormone-primed rats
    Sandra M Petralia
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:377-85. 2007
    ..These data suggest NMDARs may be important in the mediation of hormonal actions in both the ventral tegmental area and the ventromedial hypothalamus for sexual receptivity of rodents, but in different ways...
  95. ncbi Differences in affective behaviors and hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations
    Betty Zimmerberg
    Department of Psychology, Williams College, 18 Hoxsey Street, Williamstown, MA 01267, USA
    Behav Brain Res 159:301-11. 2005
    ....
  96. ncbi Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats
    Deborah F Frisone
    Department of Psychology, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA
    Behav Brain Res 128:153-60. 2002
    ..These results are discussed in light of research on the effects of CORT on the developing hippocampus...
  97. ncbi Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective
    Iratxe Ciriza
    Instituto Cajal, C S I C, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    J Neurobiol 66:916-28. 2006
    ....