Physical activity and breast cancer: review of the epidemiologic evidence and biologic mechanismsChristine M Friedenreich
Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, Alberta, T2N 4N2, Canada
Recent Results Cancer Res 188:125-39. 2011
..The purpose of this chapter is to review both the epidemiologic evidence and hypothesized biologic mechanisms whereby physical activity may influence breast cancer risk...
Case-control study of markers of insulin resistance and endometrial cancer riskChristine M Friedenreich
Division of Cancer Care, Alberta Health Services, Department of Population Health Research, Calgary, Canada
Endocr Relat Cancer 19:785-92. 2012
..Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk...
Hours spent and energy expended in physical activity domains: results from the Tomorrow Project cohort in Alberta, CanadaIlona Csizmadi
Department of Population Health Research, Alberta Health Services Cancer Care, 1331 29 Street NW, Calgary, Alberta, Canada
Int J Behav Nutr Phys Act 8:110. 2011
..We describe domain-specific hours of activity and energy expended among participants in a prospective cohort in Alberta, Canada...
Case-control study of the metabolic syndrome and metabolic risk factors for endometrial cancerChristine M Friedenreich
Department of Population Health Research, Division of Cancer Care, Alberta Health Services Cancer Care Tom Baker Cancer Centre, 1331 29 Street N W Calgary, Alberta T2N 4N2, Canada
Cancer Epidemiol Biomarkers Prev 20:2384-95. 2011
..Metabolic syndrome may predict endometrial cancer risk better than diabetes, hypertension, dyslipidemia, dysglycemia, or weight alone, but few studies have examined this issue...
Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal womenChristine M Friedenreich
Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, Alberta, Canada T2N 4N2
Endocr Relat Cancer 18:357-69. 2011
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Mediators and moderators of the effects of a year-long exercise intervention on endogenous sex hormones in postmenopausal womenChristine M Friedenreich
Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, AB, T2N 4N2, Canada
Cancer Causes Control 22:1365-73. 2011
..To identify factors that mediate or moderate the effects of exercise on postmenopausal sex hormone concentrations...
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trialC M Friedenreich
Department of Population Health Research, Alberta Health Services, Calgary, Alberta, Canada
Int J Obes (Lond) 35:427-35. 2011
..We examined the effects of an aerobic exercise intervention on adiposity outcomes that may be involved in the association between physical activity and breast cancer risk...
Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal womenChristine M Friedenreich
Alberta Health Services, 1331 29 St NW, Calgary, Alberta, Canada
Cancer Prev Res (Phila) 5:98-108. 2012
..Further trials are needed to corroborate our findings about the optimal dose of exercise required to lower CRP levels and effect modification of CRP changes by levels of body fatness and fitness...
Case-control study of lifetime total physical activity and endometrial cancer riskChristine M Friedenreich
Alberta Health Services, 1331 29 St NW, Calgary, AB T2N 4N2, Canada
Cancer Causes Control 21:1105-16. 2010
..This study provides evidence for a decreased risk between lifetime physical activity and endometrial cancer risk and a possible increased risk associated with sedentary behavior...
Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal womenChristine M Friedenreich
Alberta Health Services, Calgary, Alberta, Canada
J Clin Oncol 28:1458-66. 2010
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State of the epidemiological evidence on physical activity and cancer preventionChristine M Friedenreich
Department of Population Health Research, Alberta Health Services, 1331 29 St NW, Calgary, Alberta, Canada
Eur J Cancer 46:2593-604. 2010
..Physical activity is a modifiable lifestyle risk factor that has the potential to reduce the risk of most major cancer sites...
Case-control study of lifetime physical activity and breast cancer riskC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Alberta, Canada
Am J Epidemiol 154:336-47. 2001
..22, 95% CI: 0.07, 0.70) when they compared the highest with the lowest quartile of lifetime total physical activity. This study provides evidence that lifetime total activity reduces risk of postmenopausal breast cancer...
Relation between intensity of physical activity and breast cancer risk reductionC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Alberta, Canada
Med Sci Sports Exerc 33:1538-45. 2001
..To examine the influence of frequency, duration, and intensity of physical activity on risk of breast cancer and to compare breast cancer risks associated with self-reported versus assigned intensity levels of activity...
Prevalence of meeting physical activity guidelines for cancer prevention in AlbertaF E Aparicio-Ting
Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, Alberta, Canada
Chronic Dis Inj Can 32:216-26. 2012
..S. Department of Health and Human Services (USDHHS) for health benefits and by the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) for cancer prevention benefits...
Review of anthropometric factors and breast cancer riskC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
Eur J Cancer Prev 10:15-32. 2001
..Recommendations for future research on anthropometric factors and breast cancer are provided. Sufficient evidence exists to support strategies to avoid weight gain throughout life as a means of reducing postmenopausal breast cancer risk...
Influence of physical activity in different age and life periods on the risk of breast cancerC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Edmonton, Alberta, Canada
Epidemiology 12:604-12. 2001
..58 (95% confidence interval = 0.41-0.83). This study suggests that sustained activity throughout life and particularly activity done later in life may have the most benefit in reducing breast cancer risk...
The lifetime total physical activity questionnaire: development and reliabilityC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
Med Sci Sports Exerc 30:266-74. 1998
..To develop and test the intra-rater reliability of an interview-administered questionnaire that assesses lifetime patterns of total physical activity including occupational, household, and exercise/sports activities...
Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effectsC M Friedenreich
Division of Population Health and Information, Alberta Cancer Board, 1331 29 St NW, Calgary, Alberta, Canada
Br J Sports Med 42:636-47. 2008
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Physical activity and cancer: lessons learned from nutritional epidemiologyC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
Nutr Rev 59:349-57. 2001
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Physical activity and cancer prevention: from observational to intervention researchC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Alberta, T2N 4N2 Canada
Cancer Epidemiol Biomarkers Prev 10:287-301. 2001
..This review concludes with detailed recommendations for future research in this field...
The role of physical activity in breast cancer etiologyChristine M Friedenreich
Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, Alberta, Canada
Semin Oncol 37:297-302. 2010
..These additional data will be useful in improving public health recommendations regarding physical activity for breast cancer risk reduction...
Medical, demographic and social cognitive correlates of physical activity in a population-based sample of colorectal cancer survivorsA E Speed-Andrews
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
Eur J Cancer Care (Engl) 21:187-96. 2012
..43; P < 0.001), affective attitude (β= 0.25; P < 0.001) and instrumental attitude (β= 0.15; P < 0.001). The TPB may be a useful framework for developing population-based interventions to increase PA in CRC survivors...
A review of physical activity and prostate cancer riskC M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
Cancer Causes Control 12:461-75. 2001
..The purpose was to review the etiologic role and the possible biologic mechanisms for physical activity in the primary prevention of prostate cancer and to identify future research priorities...
An analysis of the effect of selection bias on the association of hormone replacement therapy and breast cancer riskIlona Csizmadi
Division of Population Health and Information, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alberta T2N 4N2, Canada
Chronic Dis Can 26:73-9. 2005
..02 - 2.40), respectively, following re-sampling of the controls. This sensitivity analysis illustrates the extent to which differential participation rates between HRT users and nonusers may affect estimates of measures of effect...
Physical activity and cancer prevention: etiologic evidence and biological mechanismsChristine M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Alberta, Canada, T2N 1N3
J Nutr 132:3456S-3464S. 2002
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Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future researchHeather K Neilson
Division of Population Health, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alberta, Canada T2N 4N2
Cancer Epidemiol Biomarkers Prev 18:11-27. 2009
..Future etiologic studies should consider interactions among biomarkers, whereas exercise trials should explore exercise effects independently of weight loss, different exercise prescriptions, and effects on central adiposity...
Case-control study of anthropometric measures and breast cancer riskChristine M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
Int J Cancer 99:445-52. 2002
..These effects were independent of dietary intake and lifetime total physical activity...
Case-control study of lifetime total physical activity and prostate cancer riskC M Friedenreich
Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada
Am J Epidemiol 159:740-9. 2004
..70, 95% CI: 0.54, 0.92). This study provides inconsistent evidence for the association between physical activity and prostate cancer risk...
Estimating activity energy expenditure: how valid are physical activity questionnaires?Heather K Neilson
Division of Population Health and Information, Alberta Cancer Board, Calgary, Canada
Am J Clin Nutr 87:279-91. 2008
..Small sample sizes, use of correlation coefficients, and limited information on individual validity were problematic. Future research should address these issues to clarify the true validity of PAQs for estimating AEE...
Case-control study of anthropometric measures and prostate cancer riskChristine M Friedenreich
Division of Population Health and Information, Alberta Cancer Board, Calgary, Canada
Int J Cancer 110:278-83. 2004
..89 (0.69-1.16). Our study provides evidence for no association between any measures of anthropometry including several derived measures of changes in weight over lifetime and prostate cancer risk...
Physical activity and breast cancer risk: the effect of menopausal statusChristine M Friedenreich
Division of Population Health and Information, Alberta Cancer Board, Calgary, Canada
Exerc Sport Sci Rev 32:180-4. 2004
..This review examines potential reasons for the differences in effect by menopausal status, including possible underlying biologic mechanisms...
Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trialKerry S Courneya
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
J Clin Oncol 25:4396-404. 2007
..We evaluated the relative merits of aerobic and resistance exercise in blunting these effects...
Prospective cohort study of lifetime physical activity and breast cancer survivalChristine M Friedenreich
Division of Population Health, Alberta Cancer Board, Calgary, AB, Canada
Int J Cancer 124:1954-62. 2009
..Prediagnosis recreational activity conferred a benefit for survival after breast cancer. Moderate intensity recreational activity was particularly protective...
Barriers to supervised exercise training in a randomized controlled trial of breast cancer patients receiving chemotherapyKerry S Courneya
University of Alberta, E 488 Van Vliet Center, Edmonton, Alberta, Canada
Ann Behav Med 35:116-22. 2008
..Exercise adherence is a challenge for breast cancer patients receiving chemotherapy but few studies have identified the key barriers...
Commentary: improving pooled analyses in epidemiologyChristine M Friedenreich
Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, AB, Canada
Int J Epidemiol 31:86-7. 2002
Six-month follow-up of patient-rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapyKerry S Courneya
University of Alberta, Edmonton, Alberta, Canada
Cancer Epidemiol Biomarkers Prev 16:2572-8. 2007
..Few exercise trials in cancer patients have reported longer-term follow-up. Here, we report a 6-month follow-up of exercise behavior and patient-rated outcomes from an exercise trial in breast cancer patients...
Moderators of the effects of exercise training in breast cancer patients receiving chemotherapy: a randomized controlled trialKerry S Courneya
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
Cancer 112:1845-53. 2008
..In this study, the authors examined personal and clinical factors that may predict exercise training responses...