Kevin J French

Summary

Publications

  1. ncbi request reprint Discovery and evaluation of inhibitors of human sphingosine kinase
    Kevin J French
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Res 63:5962-9. 2003
  2. pmc Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases
    Lynn W Maines
    Apogee Biotechnology Corporation, Hershey, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 47:5022-31. 2006
  3. pmc Antitumor activity of sphingosine kinase inhibitors
    Kevin J French
    Apogee Biotechnology Company, P O Box 916, Hershey, PA 17033, USA
    J Pharmacol Exp Ther 318:596-603. 2006
  4. ncbi request reprint Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein
    Brian D Lee
    Department of Pharmacology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Med Chem 47:1413-22. 2004
  5. pmc Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
    Charles E Ducker
    Apogee Biotechnology Corporation, Hershey, PA, USA
    Mol Cancer Res 3:463-76. 2005
  6. pmc Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase
    Lynn W Maines
    Apogee Biotechnology Corporation, PO Box 916, Hershey, PA 17033, USA
    Dig Dis Sci 53:997-1012. 2008
  7. ncbi request reprint Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1
    Kevin J French
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Pharmacol Exp Ther 309:340-7. 2004
  8. ncbi request reprint Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008
    Brian D Lee
    Integrative Biosciences Graduate Program, The Penn State College of Medicine, Hershey, PA 17033, USA
    Oncol Res 14:49-60. 2003
  9. doi request reprint Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase
    Leo R Fitzpatrick
    Department of Pharmacology, Penn State College of Medicine, Hershey, Hummelstown, PA 17036, USA
    Inflammopharmacology 19:75-87. 2011
  10. pmc Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase
    Charles E Ducker
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive Hershey, PA 17033, USA
    Oncogene 23:9230-7. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Discovery and evaluation of inhibitors of human sphingosine kinase
    Kevin J French
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Res 63:5962-9. 2003
    ..These compounds are the first examples of nonlipid inhibitors of SK with in vivo antitumor activity and so provide leads for additional development of inhibitors of this important molecular target...
  2. pmc Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases
    Lynn W Maines
    Apogee Biotechnology Corporation, Hershey, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 47:5022-31. 2006
    ..This study was undertaken to examine the effects of SK inhibitors on the responses of retinal endothelial cells (RECs) to VEGF and TNFalpha and their therapeutic efficacy in a diabetic retinopathy model...
  3. pmc Antitumor activity of sphingosine kinase inhibitors
    Kevin J French
    Apogee Biotechnology Company, P O Box 916, Hershey, PA 17033, USA
    J Pharmacol Exp Ther 318:596-603. 2006
    ..These compounds are the first examples of nonlipid selective inhibitors of SK with in vivo antitumor activity and provide leads for further development of inhibitors of this important molecular target...
  4. ncbi request reprint Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein
    Brian D Lee
    Department of Pharmacology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Med Chem 47:1413-22. 2004
    ..Because of their enhanced selectivity toward Pgp, these substituted dihydropyrroloquinolines may be effective MDR modulators in a clinical setting...
  5. pmc Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
    Charles E Ducker
    Apogee Biotechnology Corporation, Hershey, PA, USA
    Mol Cancer Res 3:463-76. 2005
    ..Overall, the data indicate that NMT1 and NMT2 have only partially overlapping functions and that NMT1 is critical for tumor cell proliferation...
  6. pmc Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase
    Lynn W Maines
    Apogee Biotechnology Corporation, PO Box 916, Hershey, PA 17033, USA
    Dig Dis Sci 53:997-1012. 2008
    ..Together, these data indicate that SK is a critical component in inflammation and that inhibitors of this enzyme may be useful in treating inflammatory bowel diseases...
  7. ncbi request reprint Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1
    Kevin J French
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Pharmacol Exp Ther 309:340-7. 2004
    ..Overall, these studies establish an efficient assay for screening for inhibitors of human NMT and identify a novel family of inhibitors that compete at the peptide-binding site and have activity in intact cells...
  8. ncbi request reprint Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008
    Brian D Lee
    Integrative Biosciences Graduate Program, The Penn State College of Medicine, Hershey, PA 17033, USA
    Oncol Res 14:49-60. 2003
    ..This should allow improved prediction of the clinical utility of these compounds...
  9. doi request reprint Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase
    Leo R Fitzpatrick
    Department of Pharmacology, Penn State College of Medicine, Hershey, Hummelstown, PA 17036, USA
    Inflammopharmacology 19:75-87. 2011
    ..Pro-inflammatory cytokines like TNF-α activate sphingosine kinase (SK). Therefore, inhibition of SK is a potential molecular target for the treatment of rheumatoid arthritis...
  10. pmc Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase
    Charles E Ducker
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive Hershey, PA 17033, USA
    Oncogene 23:9230-7. 2004
    ..Activity of the enzyme and its ability to transform cells is dependent on critical residues in the active site of the enzyme...