Rafael C Freire

Summary

Publications

  1. ncbi request reprint The panic disorder respiratory ratio: a dimensional approach to the respiratory subtype
    Rafael Christophe Freire
    Laboratory of Panic and Respiration, Universidade Federal do Rio de Janeiro, Brazil
    Rev Bras Psiquiatr 35:57-62. 2013
  2. ncbi request reprint Panic disorder and the respiratory system: clinical subtype and challenge tests
    Rafael C Freire
    Laboratory of Panic and Respiration, National Institute for Translational Medicine Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Rev Bras Psiquiatr 34:S32-41. 2012
  3. doi request reprint Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment
    Rafael C Freire
    Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
    Harv Rev Psychiatry 18:220-9. 2010
  4. doi request reprint Anxiogenic properties of a computer simulation for panic disorder with agoraphobia
    Rafael C Freire
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Affect Disord 125:301-6. 2010
  5. ncbi request reprint A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Rio de Janeiro, Brazil
    Depress Anxiety 25:847-53. 2008
  6. ncbi request reprint Caffeine challenge test in panic disorder and depression with panic attacks
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro RJ 22410 003, Brazil
    Compr Psychiatry 48:257-63. 2007
  7. ncbi request reprint Demographic and clinical features of panic disorder comorbid with bipolar I disorder: a 3-year retrospective study
    Antonio Egidio Nardi
    Laboratory of Panic and Respiration, Federal University of Rio de Janeiro, Brazil
    J Affect Disord 106:185-9. 2008
  8. ncbi request reprint Caffeine and 35% carbon dioxide challenge tests in panic disorder
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
    Hum Psychopharmacol 22:231-40. 2007
  9. doi request reprint Double-blind comparison of 30 and 60 mg tranylcypromine daily in patients with panic disorder comorbid with social anxiety disorder
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702 Rio de Janeiro, Brazil
    Psychiatry Res 175:260-5. 2010
  10. doi request reprint Panic disorder and social anxiety disorder subtypes in a caffeine challenge test
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702, Rio de Janeiro, RJ 22410 003 Brazil
    Psychiatry Res 169:149-53. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint The panic disorder respiratory ratio: a dimensional approach to the respiratory subtype
    Rafael Christophe Freire
    Laboratory of Panic and Respiration, Universidade Federal do Rio de Janeiro, Brazil
    Rev Bras Psiquiatr 35:57-62. 2013
    ..The objective of our study was to determine whether the respiratory ratio is correlated with CO₂-induced panic attacks and other clinical and demographic features...
  2. ncbi request reprint Panic disorder and the respiratory system: clinical subtype and challenge tests
    Rafael C Freire
    Laboratory of Panic and Respiration, National Institute for Translational Medicine Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Rev Bras Psiquiatr 34:S32-41. 2012
    ..Investigators hypothesized that there is a fundamental abnormality in the physiological mechanisms that control breathing in PD...
  3. doi request reprint Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment
    Rafael C Freire
    Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
    Harv Rev Psychiatry 18:220-9. 2010
    ..Our objective is to summarize the new findings concerning the respiratory subtype (RS) of panic disorder (PD) since its first description...
  4. doi request reprint Anxiogenic properties of a computer simulation for panic disorder with agoraphobia
    Rafael C Freire
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Affect Disord 125:301-6. 2010
    ..There are several useful methods to induce anxiety in patients with panic disorder with agoraphobia (PDA). Our aim was to ascertain if a computer simulation (CS) could induce anxiety and physiologic alterations in PDA patients...
  5. ncbi request reprint A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Rio de Janeiro, Brazil
    Depress Anxiety 25:847-53. 2008
    ..There is a clear differentiation of PD patients and their first-degree relatives by a caffeine test from the healthy group...
  6. ncbi request reprint Caffeine challenge test in panic disorder and depression with panic attacks
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro RJ 22410 003, Brazil
    Compr Psychiatry 48:257-63. 2007
    ..85, P = .026). Our data suggest that there is an association between panic attacks, no matter if associated with PD or MDP, and hyperreactivity to an oral caffeine challenge test...
  7. ncbi request reprint Demographic and clinical features of panic disorder comorbid with bipolar I disorder: a 3-year retrospective study
    Antonio Egidio Nardi
    Laboratory of Panic and Respiration, Federal University of Rio de Janeiro, Brazil
    J Affect Disord 106:185-9. 2008
    ....
  8. ncbi request reprint Caffeine and 35% carbon dioxide challenge tests in panic disorder
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
    Hum Psychopharmacol 22:231-40. 2007
    ..42, df=1, p<0.001), and had more previous depressive episodes (chi2=27.35, df=1, p<0.001). Our data suggest that there is an association between respiratory PD subtype and hyperreactivity to challenge tests: CO2 and oral caffeine...
  9. doi request reprint Double-blind comparison of 30 and 60 mg tranylcypromine daily in patients with panic disorder comorbid with social anxiety disorder
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702 Rio de Janeiro, Brazil
    Psychiatry Res 175:260-5. 2010
    ..Tranylcypromine--60 mg daily--was found effective in the treatment of panic disorder and social anxiety disorder comorbidity...
  10. doi request reprint Panic disorder and social anxiety disorder subtypes in a caffeine challenge test
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702, Rio de Janeiro, RJ 22410 003 Brazil
    Psychiatry Res 169:149-53. 2009
    ..The PD and PSAD patients had a higher number of induced panic attacks, some specific anxiety symptoms, and a more severe anxiety response than GSAD patients and normal volunteers...
  11. ncbi request reprint 35% Carbon dioxide and breath-holding challenge tests in panic disorder: a comparison with spontaneous panic attacks
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Depress Anxiety 23:236-44. 2006
    ..001). Our data suggest that there is an association between respiratory PD subtype and the response to respiratory challenge tests: CO(2)and breath-holding. The CPA may be confirmed as a subgroup of respiratory PD subtype...
  12. ncbi request reprint Personality traits spectrum in panic disorder and major depression
    Rafael C Freire
    Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Rev Bras Psiquiatr 29:31-4. 2007
    ..Our aim was to identify the personality traits in patients with panics disorder, major depression and with both disorders (comorbidity)...
  13. ncbi request reprint Comparison between hyperventilation and breath-holding in panic disorder: patients responsive and non-responsive to both tests
    Antonio E Nardi
    Laboratory of Panic and Respiration, Federal University of Rio de Janeiro, Brazil
    Psychiatry Res 142:201-8. 2006
    ..The panic attack may be a final common pathway for different types of stimuli, and respiratory tests may characterize different PD subgroups...
  14. ncbi request reprint Panic disorder respiratory subtype: a comparison between responses to hyperventilation and CO2 challenge tests
    Rafael C Freire
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Visconde de Pirajá, 407 702, 22410 003, Rio de Janeiro, Brazil
    Psychiatry Res 157:307-10. 2008
    ..The respiratory subtype patients were observed to be more sensitive to the 35% CO(2) inhalation challenge test and the hyperventilation test than the non-respiratory subtype patients...
  15. ncbi request reprint Diurnal panic attacks with and without nocturnal panic attacks: are there some phenomenological differences?
    Fabiana L Lopes
    Panic and Respiration Laboratory, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Rev Bras Psiquiatr 27:216-21. 2005
    ..To compare nocturnal and diurnal panic attacks in a cross-sectional study and in a longitudinal prospective short-term follow-up...
  16. ncbi request reprint Psychopathological profile of 35% CO2 challenge test-induced panic attacks: a comparison with spontaneous panic attacks
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22410 003, Brazil
    Compr Psychiatry 47:209-14. 2006
    ..The responders may be a subgroup of respiratory PD subtype with future diagnostic and therapeutic implications...
  17. doi request reprint A randomized, naturalistic, parallel-group study for the long-term treatment of panic disorder with clonazepam or paroxetine
    Antonio E Nardi
    Panic and Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, National Institute for Translational Medicine INCT TM, Niteroi, Rio de Janeiro, Brazil
    J Clin Psychopharmacol 32:120-6. 2012
    ..There was a significant advantage with clonazepam over paroxetine with respect to the frequency and nature of adverse events...
  18. ncbi request reprint Freezing reaction in panic disorder patients associated with anticipatory anxiety
    Fabiana L Lopes
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, INCT Translational Medicine, Rio de Janeiro, Brazil
    Depress Anxiety 26:917-21. 2009
    ..The purpose of this study was to assess the postural control analysis and autonomic activation in panic disorder (PD) patients presented with visual stimuli...
  19. ncbi request reprint A three-year follow-up study of patients with the respiratory subtype of panic disorder after treatment with clonazepam
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702, Rio de Janeiro RJ 22410 003, Brazil
    Psychiatry Res 137:61-70. 2005
    ..The respiratory subgroup had a faster response after 8 weeks of treatment and an equivalent response in the 3-year follow-up period. Clonazepam had a sustained therapeutic effect over the entire treatment period...
  20. doi request reprint Tapering clonazepam in patients with panic disorder after at least 3 years of treatment
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, INCT Translational Medicine CNPq, Rio de Janeiro, Brazil
    J Clin Psychopharmacol 30:290-3. 2010
    ..Clonazepam can be successfully discontinued without any major withdrawal symptoms if the dose is reduced gradually. We recommend reducing the dosage of clonazepam after intermediate-term use by 0.25 mg/wk...
  21. ncbi request reprint Demographic and clinical features of schizoaffective (schizobipolar) disorder--a 5-year retrospective study. Support for a bipolar spectrum disorder
    Antonio E Nardi
    Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702, Rio de Janeiro, RJ 22410 003, Brazil
    J Affect Disord 89:201-6. 2005
    ....
  22. ncbi request reprint Clinical features of respiratory and nocturnal panic disorder subtypes
    Rafael C Freire
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Visconde de Pirajá, 407 702, 22410 003, Rio de Janeiro, Brazil
    Psychiatry Res 152:287-91. 2007
    ..The non-nocturnal subtype was significantly associated with agoraphobia, and the respiratory subtype was not associated with these variables...
  23. ncbi request reprint Alpha absolute power measurement in panic disorder with agoraphobia patients
    Marcele Regine de Carvalho
    Laboratory of Panic and Respiration, Institute of Psychiatry of Federal University of Rio de Janeiro IPUB UFRJ, Rio de Janeiro, Brazil
    J Affect Disord 151:259-64. 2013
    ..The objective of this study was to measure frontal absolute alpha-power with qEEG in 24 subjects with panic disorder and agoraphobia (PDA) compared to 21 healthy controls...
  24. ncbi request reprint Clonazepam for the treatment of panic disorder
    Antonio E Nardi
    Panic and Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, National Institute for Translational Medicine INCT TM, Rio de Janeiro, Brazil
    Curr Drug Targets 14:353-64. 2013
    ....
  25. doi request reprint Virtual reality as a mechanism for exposure therapy
    Marcele Regine de Carvalho
    Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro RJ, Brazil
    World J Biol Psychiatry 11:220-30. 2010
    ..Throughout the process of elaboration and investigation, clinical experiences in virtual environments must be related to real experiences in a flexible context that combines relevant cultural, physical and cognitive aspects...
  26. doi request reprint Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients
    Fabiana L Lopes
    Panic and Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, INCT Translational Medicine CNPq, Rio de Janeiro, RJ, Brazil
    World J Biol Psychiatry 11:357-63. 2010
    ..Those findings corroborate the Neuroanatomical hypothesis of PD...
  27. ncbi request reprint The relationship between the severity of asthma and comorbidities with anxiety and depressive disorders
    Alexandre M Valenca
    Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rua Visconde de Pirajá 407 702, Tijuca, 22410 003 Rio de Janeiro, RJ, Brazil
    Rev Bras Psiquiatr 28:206-8. 2006
    ..Our aim was to assess the frequency of anxiety and depressive disorders in a sample of asthmatic outpatients and observe if there is any relationship between this comorbidity and the severity of asthma...
  28. doi request reprint New treatment options for panic disorder: clinical trials from 2000 to 2010
    Rafael C Freire
    National Institute for Translational Medicine INCT TM, Federal University of Rio de Janeiro, Institute of Psychiatry, Laboratory of Panic and Respiration, Brazil
    Expert Opin Pharmacother 12:1419-28. 2011
    ..PD should be treated effectively as soon as the symptoms emerge because the longer these patients remain without treatment, the worse the prognosis will be...
  29. ncbi request reprint Panic disorder and control of breathing
    Antonio E Nardi
    Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
    Respir Physiol Neurobiol 167:133-43. 2009
    ....
  30. ncbi request reprint Do social anxiety disorder patients belong to a bipolar spectrum subgroup?
    Alexandre M Valenca
    Institute of Psychiatry, Federal University of Rio de Janeiro, R Visconde de Piraja, 407 702, Rio de Janeiro RJ 22410 003, Brazil
    J Affect Disord 86:11-8. 2005
    ....