Hypertension and chronic kidney disease: controversies in pathogenesis and treatmentJ L Pirkle
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
Minerva Urol Nefrol 65:37-50. 2013
..As such, many of the controversial aspects of hypertension management will likely be clarified in the near future...
Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetesThomas C Register
Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 98:E60-5. 2013
..Plasma DKK1, BMD in the spine, and CP in three arterial beds were assessed in African-Americans (AAs) to determine relationships of serum DKK1 with atherosclerotic vascular calcification...
- Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
Barry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 82:805-11. 2012
..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
Effect of race and genetics on vitamin D metabolism, bone and vascular healthBarry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
Nat Rev Nephrol 8:459-66. 2012
..Ultimately, in our opinion, a new mechanistic understanding of the relationships between bone mineralization and vascular calcification will produce novel approaches for disease prevention in aging populations...
- A critical evaluation of glycated protein parameters in advanced nephropathy: a matter of life or death: time to dispense with the hemoglobin A1C in end-stage kidney disease
Barry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
Diabetes Care 35:1621-4. 2012
..In the counterpoint narrative following Dr. Freedman's contribution, Dr. Kalantar-Zadeh defends the use of A1C as the unquestioned gold standard for glycemic management in dialysis subjects...
- Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
Barry I Freedman
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
PLoS Genet 7:e1002150. 2011
..These analyses reveal a role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes...
- Target organ damage in African American hypertension: role of APOL1
Barry I Freedman
Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
Curr Hypertens Rep 14:21-8. 2012
..Discovery of APOL1-associated nephropathy was a major success of the genetics revolution, demonstrating that secondary hypertension is typically present in nondiabetic African Americans with nephropathy...
- Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans
Barry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
Nephrol Dial Transplant 26:3805-10. 2011
..Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease...
- Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
Keith L Keene
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hum Genet 123:333-41. 2008
..We have identified a novel region of the ESR1 gene that may contain important functional polymorphisms in relation to susceptibility to T2DM and/or diabetic nephropathy...
- A genome scan for ESRD in black families enriched for nondiabetic nephropathy
Barry I Freedman
Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
J Am Soc Nephrol 15:2719-27. 2004
..1 and 13q33.3 as contributing to early-onset ESRD and ESRD in the presence of increased BMI, respectively. These regions should receive priority in the search for loci that contribute susceptibility to nondiabetic nephropathy...
- Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
Tennille S Leak
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hum Genet 124:63-71. 2008
..This study confirms known diabetic nephropathy loci and identifies potentially novel susceptibility variants located within 6q24-27 in AA...
- Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
Jasmin Divers
Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
J Clin Endocrinol Metab 95:5382-9. 2010
..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
- Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study
Allison B Lehtinen
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Ann Noninvasive Electrocardiol 14:72-9. 2009
..It is unclear whether these genetic variants remain relevant in subjects with underlying conditions such as diabetes that are associated with prolonged QT interval...
- Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans
Pamela J Hicks
Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 27157 1053
Kidney Int 80:1339-43. 2011
..05) in dominant models. In addition, no evidence of APOL1 or MYH9 interactions with sickle cell trait was detected. Hence, sickle cell trait is not associated with diabetic or non-diabetic ESRD in a large sample of African Americans...
- Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
Keith L Keene
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 57:1057-62. 2008
..Our objective was to comprehensively evaluate variants in ENPP1 for association with type 2 diabetic end-stage renal disease (ESRD)...
- Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
Tennille S Leak
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
BMC Med Genet 11:22. 2010
..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
- Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Diab Vasc Dis Res 5:128-34. 2008
..057 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small...
- Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease
Keith L Keene
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hum Genet 124:147-54. 2008
..This study presents exploratory analyses of the impact of admixture on studies of AA with T2DM-ESRD and supports the use of ancestral proportions as a means of reducing confounding effects due to admixture...
- Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
Barry I Freedman
1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
Nephrol Dial Transplant 24:3366-71. 2009
....
- Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
Jessica N Cooke
Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
Nephrol Dial Transplant 27:1505-11. 2012
..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated...
- Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes
Yongmei Liu
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
Am J Kidney Dis 52:242-50. 2008
..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy...
- Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
Joshua P Lewis
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 57:2220-5. 2008
..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
- Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy
Michele M Sale
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 56:2638-42. 2007
..Our objective was to investigate the importance of TCF7L2 in a larger African-American case-control population...
- Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
Barry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
J Bone Miner Res 24:1719-27. 2009
..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
- Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study
Donald W Bowden
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes 55:1985-94. 2006
....
- Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
J Jeffrey Carr
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Bone 42:43-52. 2008
..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
- Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Mediators Inflamm 2010:170153. 2010
..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
- Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
Tennille S Leak
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Mol Genet Metab 92:145-50. 2007
..028), rs4814597 (Pa=0.039) and rs2269023 (Pa=0.043). None of the PCSK2 SNPs were associated with age at T2DM diagnosis. A variant in the PCKS2 gene, rs2021785, appears to play a role in susceptibility to T2DM in this AA population...
- Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
Barry I Freedman
Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 75:736-45. 2009
..Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease...
- Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
Allison B Lehtinen
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 92:345-52. 2007
....
- Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
Barry I Freedman
Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 29:626-32. 2009
....
- Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study
Megan E Rudock
From the Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Atherosclerosis 203:459-65. 2009
..We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population...
- Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study
Ryan L McKimmie
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Am J Gastroenterol 103:3029-35. 2008
....
- Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes 55:651-8. 2006
..53 +/- 0.1 to 0.57 +/- 0.1 (P = 8.1 x 10(-10)), suggesting a modest but detectable effect of this gene on the phenotype of CorCP in type 2 diabetic patients...
- Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
Leslie A Lange
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Ann Hum Genet 70:717-25. 2006
..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
- Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations
Carla J Gallagher
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Diabetes 56:675-84. 2007
..033) were associated with type 2 diabetes and/or ESRD. Results suggest that intron 1 and intron 2 of the ESR1 gene may contain functionally important regions related to type 2 diabetes or ESRD risk...
- Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease
Meredith A Bostrom
David H Murdoch Research Institute, Kannapolis, NC, USA
Am J Nephrol 36:252-60. 2012
..Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis...
- A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q
Michele M Sale
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 53:830-7. 2004
..009 for interaction, DeltaP = 0.070 for OSA). These results provide evidence that genes predisposing African-American individuals to type 2 diabetes are located in the 6q and 7p regions of the genome...
- Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am Heart J 151:706-11. 2006
..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
- Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report
Amber M Reeves-Daniel
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Kidney Dis 55:e21-4. 2010
..Collapsing C1q nephropathy with rapid progression to end-stage renal disease appears to reside in the MYH9-associated disease spectrum...
- Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans
Jessica N Cooke
Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
Diabetes Care 35:287-92. 2012
..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans...
- Genome-wide association of BMI in African Americans
Maggie C Y Ng
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 20:622-7. 2012
..Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations...
- Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants
Isai Gopalakrishnan
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Hum Pathol 42:291-4. 2011
....
- Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA
Meredith A Bostrom
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Hum Genet 128:195-204. 2010
..This is the first GWAS for non-DM ESRD in African Americans using pooled DNA. We demonstrate strong association between non-DM ESRD in African Americans with MYH9, and have identified additional candidate loci...
- Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
Allison B Lehtinen
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes 57:1108-14. 2008
..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry...
- Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
Pamela J Hicks
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 28:914-20. 2008
..Interactions between the ephrin-B2 receptor and ephrin-B2 ligand play essential roles in renal angiogenesis, blood vessel maturation, and kidney disease...
- The spectrum of MYH9-associated nephropathy
Meredith A Bostrom
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Clin J Am Soc Nephrol 5:1107-13. 2010
..MYH9 risk variants exhibit the most impressive association with any common complex kidney disease yet identified...
- The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans
Caitrin W McDonough
Center for Diabetes Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Hum Genet 126:265-75. 2009
..Protection from diabetic nephropathy afforded by 5L-5L homozygosity in CNDP1 may be masked by the effects of additional risk haplotypes in CNDP1 and CNDP2...
- A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans
Barry I Freedman
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
Nephrol Dial Transplant 22:1131-5. 2007
..A trinucleotide repeat sequence in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently associated with DN in European Caucasians and Arabs...
- P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study
Yongmei Liu
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Kidney Int 68:741-6. 2005
..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)...
- Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study
Anita M Saran
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 28:366-71. 2008
..The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown...
- A genome-wide association search for type 2 diabetes genes in African Americans
Nicholette D Palmer
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
PLoS ONE 7:e29202. 2012
..These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations...
- Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes
Jasmin Divers
Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
J Bone Miner Res 26:1554-60. 2011
..This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes...
- Sickle cell trait and development of microvascular complications in diabetes mellitus
Anthony J Bleyer
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Clin J Am Soc Nephrol 5:1015-20. 2010
..The objective of this study was to determine whether individuals with diabetes mellitus and SCT have higher rates of microvascular complications relative to those without SCT...
- Glycated albumin and risk of death and hospitalizations in diabetic dialysis patients
Barry I Freedman
Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
Clin J Am Soc Nephrol 6:1635-43. 2011
..We determined the association between GA, HbA(₁c), and glucose levels with survival and hospitalizations in diabetic dialysis patients...
- The impact of pedigree structure on heritability estimates for pulse pressure in three studies
Fang Chi Hsu
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Hum Hered 60:63-72. 2005
....
- T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study
Yongmei Liu
Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Am Soc Nephrol 16:1085-90. 2005
..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members...
- Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
Joshua P Lewis
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Genomics 96:211-9. 2010
..0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans...
- Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy
Meredith A Bostrom
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 58:499-504. 2009
..Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations...
- A genome scan for diabetic nephropathy in African Americans
Donald W Bowden
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
Kidney Int 66:1517-26. 2004
..There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes...
- Genetic determinants of albuminuria and renal disease in diabetes mellitus
Michele M Sale
Center for Human Genomics and Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
Nephrol Dial Transplant 21:13-6. 2006
- Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy
Meredith A Bostrom
Wake Forest School of Medicine, Winston Salem, NC, USA
Am J Kidney Dis 59:210-21. 2012
..African Americans have increased susceptibility to nondiabetic nephropathy relative to European Americans...
- Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease
Judith A Engeler Dusel
Department of Internal Medicine, Center for Human Genomics, Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 68:256-62. 2005
..Evidence for linkage of end-stage renal disease (ESRD) to chromosome 1q25-31 in the region of NPHS2 has been identified in a genome-wide scan in African American (AA) siblings...
- A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study
Yongmei Liu
Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Eur J Cardiovasc Prev Rehabil 13:655-7. 2006
..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families...
- Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population
Carla J Gallagher
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Mol Genet Metab 87:54-60. 2006
..046). Significant, but rare, risk and protective haplotypes were identified as driving these associations with T2DM (P=0.034-0.047). These associations suggest that the OPRM1 gene plays a role in T2DM susceptibility in African Americans...
- Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study
Matthew R Nelson
Department of Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
Pacing Clin Electrophysiol 31:314-21. 2008
..We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants...
- Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping
Caitrin W McDonough
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Hum Genet 126:805-17. 2009
..0017; OR (95% CI) = 0.65 (0.50-0.85)]. Collectively, these results suggest that multiple genes in this region may influence diabetic nephropathy susceptibility in AAs...
- Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart study
Jasmin Divers
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 18:2004-9. 2010
..004). As in European Americans, PAT is associated with CP in African Americans with type 2 diabetes. Ethnic differences in the relationships between organ-specific adipose tissue depots and atherosclerosis require further study...
- Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease
Barry I Freedman
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA bfreedma wfubmc edu
Am J Nephrol 31:375-9. 2010
..These assays have yet to be compared in patients with advanced chronic kidney disease (CKD)...
- Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
Nicholette D Palmer
Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
Diabetes 60:662-8. 2011
..The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans...
- The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans
Barry I Freedman
Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 32:66-72. 2010
..Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN...
- A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
Lynne E Wagenknecht
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Epidemiol 166:340-7. 2007
..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another...
- Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
Jennifer L Bento
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
BMC Med Genet 6:42. 2005
..GLUT10 (gene symbol SLC2A10) is a facilitative glucose transporter within the type 2 diabetes (T2DM)-linked region on chromosome 20q12-13.1. Therefore, we evaluated GLUT10 as a positional candidate gene for T2DM in Caucasian Americans...
- Coronary calcium score and prediction of all-cause mortality in diabetes: the diabetes heart study
Subhashish Agarwal
Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston Salem, North Carolina, USA
Diabetes Care 34:1219-24. 2011
..In diabetes, it remains unclear whether the coronary artery calcium (CAC) score provides additional information about total mortality risk beyond traditional risk factors...
- A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients
Trudye A Young
Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Dermatolog Treat 20:76-81. 2009
..The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients...
- Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study
Jasmin Divers
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes Care 33:131-8. 2010
..We explored ethnicity-specific relationships between albuminuria and calcified plaque involving the infrarenal aorta, coronary artery, and carotid artery in 835 European American and 393 African American subjects with type 2 diabetes...
- The relationship between albuminuria and hormone therapy in postmenopausal women
Mamta Agarwal
Department of Internal Medicine Nephrology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Am J Kidney Dis 45:1019-25. 2005
..Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women...
- Susceptibility genes in common complex kidney disease
Jasmin Divers
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Curr Opin Nephrol Hypertens 19:79-84. 2010
..A brief overview of methods for identifying gene variants is provided, along with genetic associations and new avenues under exploration...
- A genome scan for all-cause end-stage renal disease in African Americans
Barry I Freedman
Department of Internal Medicine Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
Nephrol Dial Transplant 20:712-8. 2005
....
- Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus
Barry I Freedman
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1053, USA
Hypertension 48:8-13. 2006
- Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes
Jennifer L Bento
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes 53:3007-12. 2004
..These results suggest that PTPN1 is a significant contributor to type 2 diabetes susceptibility in the Caucasian population. This risk is likely due to noncoding polymorphisms...
- Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes
Barry I Freedman
Section on Nephrology, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Semin Dial 23:244-7. 2010
..MYH9 polymorphisms may affect treatment outcomes in severe kidney disease and such gene effects are rarely encountered in practice...
- Relationship between albuminuria and cardiovascular disease in Type 2 diabetes
Barry I Freedman
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
J Am Soc Nephrol 16:2156-61. 2005
..004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function...
- Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster
Jeannette T Bensen
The Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Genomics 82:194-217. 2003
..0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD...
- Renal artery calcified plaque associations with subclinical renal and cardiovascular disease
Barry I Freedman
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 65:2262-7. 2004
..The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown...
