Barry I Freedman

Summary

Publications

  1. pmc Genotypic variation and outcomes in kidney transplantation: donor and recipient effects
    Michael D Gautreaux
    Department of General Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 84:431-3. 2013
  2. pmc Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, NC, USA Electronic address
    J Diabetes Complications 28:56-60. 2014
  3. pmc Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC Center for Human Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    Am J Kidney Dis 62:1165-75. 2013
  4. pmc Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study
    Laura M Raffield
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:95. 2013
  5. pmc Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:68. 2013
  6. pmc Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study
    Jeremy N Adams
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Cardiovasc Diabetol 12:31. 2013
  7. ncbi request reprint Hypertension and chronic kidney disease: controversies in pathogenesis and treatment
    J L Pirkle
    SectioDepartment of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Minerva Urol Nefrol 65:37-50. 2013
  8. pmc Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:E60-5. 2013
  9. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
  10. doi request reprint Effect of race and genetics on vitamin D metabolism, bone and vascular health
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Nat Rev Nephrol 8:459-66. 2012

Detail Information

Publications100

  1. pmc Genotypic variation and outcomes in kidney transplantation: donor and recipient effects
    Michael D Gautreaux
    Department of General Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 84:431-3. 2013
    ..Genomics breakthroughs in nephrology and immunology will likely revolutionize the field of transplant medicine. ..
  2. pmc Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, NC, USA Electronic address
    J Diabetes Complications 28:56-60. 2014
    ..Since neuropathy and nephropathy are microvascular Type 2 diabetes (T2D) complications, relationships between skin conductance, estimated glomerular filtration rate (eGFR), and urine albumin:creatinine ratio (UACR) were assessed...
  3. pmc Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC Center for Human Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    Am J Kidney Dis 62:1165-75. 2013
    ..The present era of precision medicine will couple one's genetic makeup with specific therapies to reduce rates of disease based on the presence of disease-specific alleles. ..
  4. pmc Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study
    Laura M Raffield
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:95. 2013
    ..This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for CVD risk prediction in European Americans with T2D enrolled in the Diabetes Heart Study (DHS)...
  5. pmc Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:68. 2013
    ....
  6. pmc Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study
    Jeremy N Adams
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Cardiovasc Diabetol 12:31. 2013
    ..HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM)...
  7. ncbi request reprint Hypertension and chronic kidney disease: controversies in pathogenesis and treatment
    J L Pirkle
    SectioDepartment of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Minerva Urol Nefrol 65:37-50. 2013
    ..As such, many of the controversial aspects of hypertension management will likely be clarified in the near future...
  8. pmc Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:E60-5. 2013
    ..Plasma DKK1, BMD in the spine, and CP in three arterial beds were assessed in African-Americans (AAs) to determine relationships of serum DKK1 with atherosclerotic vascular calcification...
  9. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
  10. doi request reprint Effect of race and genetics on vitamin D metabolism, bone and vascular health
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Nat Rev Nephrol 8:459-66. 2012
    ..Ultimately, in our opinion, a new mechanistic understanding of the relationships between bone mineralization and vascular calcification will produce novel approaches for disease prevention in aging populations...
  11. pmc A critical evaluation of glycated protein parameters in advanced nephropathy: a matter of life or death: time to dispense with the hemoglobin A1C in end-stage kidney disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Diabetes Care 35:1621-4. 2012
    ..In the counterpoint narrative following Dr. Freedman's contribution, Dr. Kalantar-Zadeh defends the use of A1C as the unquestioned gold standard for glycemic management in dialysis subjects...
  12. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    ..These analyses reveal a role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes...
  13. pmc Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 26:3805-10. 2011
    ..Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease...
  14. pmc Target organ damage in African American hypertension: role of APOL1
    Barry I Freedman
    Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Curr Hypertens Rep 14:21-8. 2012
    ..Discovery of APOL1-associated nephropathy was a major success of the genetics revolution, demonstrating that secondary hypertension is typically present in nondiabetic African Americans with nephropathy...
  15. ncbi request reprint A genome scan for ESRD in black families enriched for nondiabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 15:2719-27. 2004
    ..1 and 13q33.3 as contributing to early-onset ESRD and ESRD in the presence of increased BMI, respectively. These regions should receive priority in the search for loci that contribute susceptibility to nondiabetic nephropathy...
  16. pmc Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 123:333-41. 2008
    ..We have identified a novel region of the ESR1 gene that may contain important functional polymorphisms in relation to susceptibility to T2DM and/or diabetic nephropathy...
  17. pmc Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:63-71. 2008
    ..This study confirms known diabetic nephropathy loci and identifies potentially novel susceptibility variants located within 6q24-27 in AA...
  18. pmc Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann Noninvasive Electrocardiol 14:72-9. 2009
    ..It is unclear whether these genetic variants remain relevant in subjects with underlying conditions such as diabetes that are associated with prolonged QT interval...
  19. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  20. pmc Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans
    Pamela J Hicks
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 27157 1053
    Kidney Int 80:1339-43. 2011
    ..05) in dominant models. In addition, no evidence of APOL1 or MYH9 interactions with sickle cell trait was detected. Hence, sickle cell trait is not associated with diabetic or non-diabetic ESRD in a large sample of African Americans...
  21. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
    ..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
  22. doi request reprint Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diab Vasc Dis Res 5:128-34. 2008
    ..057 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small...
  23. doi request reprint Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:1057-62. 2008
    ..Our objective was to comprehensively evaluate variants in ENPP1 for association with type 2 diabetic end-stage renal disease (ESRD)...
  24. pmc Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:147-54. 2008
    ..This study presents exploratory analyses of the impact of admixture on studies of AA with T2DM-ESRD and supports the use of ancestral proportions as a means of reducing confounding effects due to admixture...
  25. ncbi request reprint Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study
    Donald W Bowden
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:1985-94. 2006
    ....
  26. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
    ..Adipokines vary in relation to changes in body composition and may play roles in regulation of BMD and risk of cardiovascular disease...
  27. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    ..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated...
  28. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    ....
  29. pmc Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes
    Yongmei Liu
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
    Am J Kidney Dis 52:242-50. 2008
    ..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy...
  30. ncbi request reprint Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy
    Michele M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2638-42. 2007
    ..Our objective was to investigate the importance of TCF7L2 in a larger African-American case-control population...
  31. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  32. pmc Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study
    Thomas C Register
    Departments of Pathology T C R, Public Health Sciences J D, L E W, C D L, Radiology T C R, J J C, R C H, and Internal Medicine Nephrology B I F and Center for Genomics and Personalized Medicine Research D W B, N D P, J X, S C S, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 and Department of Pediatric Nephrology K A H, D J D, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Endocrinol Metab 99:315-21. 2014
    ..Sclerostin, an endogenous regulator of the Wnt pathway and bone formation, has been associated with impaired osteoblast activation and may play a role in vascular calcification...
  33. ncbi request reprint P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study
    Yongmei Liu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 68:741-6. 2005
    ..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)...
  34. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
    ..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
  35. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  36. ncbi request reprint Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 92:345-52. 2007
    ....
  37. pmc Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
    Barry I Freedman
    Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 75:736-45. 2009
    ..Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease...
  38. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    ..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
  39. pmc Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Mol Genet Metab 92:145-50. 2007
    ..028), rs4814597 (Pa=0.039) and rs2269023 (Pa=0.043). None of the PCSK2 SNPs were associated with age at T2DM diagnosis. A variant in the PCKS2 gene, rs2021785, appears to play a role in susceptibility to T2DM in this AA population...
  40. doi request reprint Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 57:1108-14. 2008
    ..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry...
  41. pmc Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 29:626-32. 2009
    ....
  42. pmc Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study
    Megan E Rudock
    From the Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 203:459-65. 2009
    ..We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population...
  43. ncbi request reprint Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
    Leslie A Lange
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 70:717-25. 2006
    ..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
  44. pmc Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study
    Ryan L McKimmie
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Gastroenterol 103:3029-35. 2008
    ....
  45. ncbi request reprint Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:651-8. 2006
    ..53 +/- 0.1 to 0.57 +/- 0.1 (P = 8.1 x 10(-10)), suggesting a modest but detectable effect of this gene on the phenotype of CorCP in type 2 diabetic patients...
  46. ncbi request reprint Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations
    Carla J Gallagher
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Diabetes 56:675-84. 2007
    ..033) were associated with type 2 diabetes and/or ESRD. Results suggest that intron 1 and intron 2 of the ESR1 gene may contain functionally important regions related to type 2 diabetes or ESRD risk...
  47. doi request reprint Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the diabetes heart study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, North Carolina, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, North Carolina, USA Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 21:E456-62. 2013
    ....
  48. ncbi request reprint The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ....
  49. ncbi request reprint T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study
    Yongmei Liu
    Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Soc Nephrol 16:1085-90. 2005
    ..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members...
  50. pmc An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects
    Lijun Ma
    Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e56193. 2013
    ..The T allele also associated with higher hepatic triglyceride levels. These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to DN...
  51. pmc Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease
    Meredith A Bostrom
    David H Murdoch Research Institute, Kannapolis, NC, USA
    Am J Nephrol 36:252-60. 2012
    ..Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis...
  52. ncbi request reprint A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q
    Michele M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 53:830-7. 2004
    ..009 for interaction, DeltaP = 0.070 for OSA). These results provide evidence that genes predisposing African-American individuals to type 2 diabetes are located in the 6q and 7p regions of the genome...
  53. ncbi request reprint Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    ..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
  54. pmc Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report
    Amber M Reeves-Daniel
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Kidney Dis 55:e21-4. 2010
    ..Collapsing C1q nephropathy with rapid progression to end-stage renal disease appears to reside in the MYH9-associated disease spectrum...
  55. pmc Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 35:287-92. 2012
    ..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans...
  56. pmc Genome-wide association of BMI in African Americans
    Maggie C Y Ng
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 20:622-7. 2012
    ..Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations...
  57. pmc Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants
    Isai Gopalakrishnan
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Pathol 42:291-4. 2011
    ....
  58. pmc Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Genet 128:195-204. 2010
    ..This is the first GWAS for non-DM ESRD in African Americans using pooled DNA. We demonstrate strong association between non-DM ESRD in African Americans with MYH9, and have identified additional candidate loci...
  59. ncbi request reprint The spectrum of MYH9-associated nephropathy
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 5:1107-13. 2010
    ..MYH9 risk variants exhibit the most impressive association with any common complex kidney disease yet identified...
  60. ncbi request reprint A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans
    Barry I Freedman
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 22:1131-5. 2007
    ..A trinucleotide repeat sequence in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently associated with DN in European Caucasians and Arabs...
  61. pmc The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans
    Caitrin W McDonough
    Center for Diabetes Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Hum Genet 126:265-75. 2009
    ..Protection from diabetic nephropathy afforded by 5L-5L homozygosity in CNDP1 may be masked by the effects of additional risk haplotypes in CNDP1 and CNDP2...
  62. pmc Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
    Pamela J Hicks
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 28:914-20. 2008
    ..Interactions between the ephrin-B2 receptor and ephrin-B2 ligand play essential roles in renal angiogenesis, blood vessel maturation, and kidney disease...
  63. ncbi request reprint Evaluation of genetic variation and association in the matrix metalloproteinase 9 (MMP9) gene in ESRD patients
    Shohei Hirakawa
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Kidney Dis 42:133-42. 2003
    ..Expression of the matrix metalloproteinase 9 (MMP9) gene is increased in a variety of renal diseases. Several genetic studies have associated MMP9 with end-stage renal disease (ESRD)...
  64. pmc Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Acta Diabetol 50:391-9. 2013
    ..Further understanding the mechanisms underpinning these relationships may prove important in predicting and managing CVD complications in T2DM...
  65. ncbi request reprint Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes
    Allison M Bagwell
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 54:1185-90. 2005
    ..0% of chromosomes) accounting for the evidence of association. Our results suggest that type 2 diabetes linked to 20q12-13 is a heterogeneous disease in which different populations may have different type 2 diabetes susceptibility loci...
  66. pmc Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
    Mariana Murea
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1053, USA
    BMC Nephrol 13:148. 2012
    ..Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D)...
  67. pmc Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study
    Anita M Saran
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 28:366-71. 2008
    ..The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown...
  68. pmc A genome-wide association search for type 2 diabetes genes in African Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e29202. 2012
    ..These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations...
  69. doi request reprint Glycated albumin and risk of death and hospitalizations in diabetic dialysis patients
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 6:1635-43. 2011
    ..We determined the association between GA, HbA(₁c), and glucose levels with survival and hospitalizations in diabetic dialysis patients...
  70. doi request reprint Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes
    Jasmin Divers
    Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 26:1554-60. 2011
    ..This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes...
  71. pmc Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 96:211-9. 2010
    ..0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans...
  72. pmc Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:499-504. 2009
    ..Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations...
  73. ncbi request reprint A genome scan for diabetic nephropathy in African Americans
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Kidney Int 66:1517-26. 2004
    ..There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes...
  74. pmc Sickle cell trait and development of microvascular complications in diabetes mellitus
    Anthony J Bleyer
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin J Am Soc Nephrol 5:1015-20. 2010
    ..The objective of this study was to determine whether individuals with diabetes mellitus and SCT have higher rates of microvascular complications relative to those without SCT...
  75. ncbi request reprint Genetic determinants of albuminuria and renal disease in diabetes mellitus
    Michele M Sale
    Center for Human Genomics and Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 21:13-6. 2006
  76. pmc Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy
    Meredith A Bostrom
    Wake Forest School of Medicine, Winston Salem, NC, USA
    Am J Kidney Dis 59:210-21. 2012
    ..African Americans have increased susceptibility to nondiabetic nephropathy relative to European Americans...
  77. ncbi request reprint Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease
    Judith A Engeler Dusel
    Department of Internal Medicine, Center for Human Genomics, Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 68:256-62. 2005
    ..Evidence for linkage of end-stage renal disease (ESRD) to chromosome 1q25-31 in the region of NPHS2 has been identified in a genome-wide scan in African American (AA) siblings...
  78. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
    ..GLUT10 (gene symbol SLC2A10) is a facilitative glucose transporter within the type 2 diabetes (T2DM)-linked region on chromosome 20q12-13.1. Therefore, we evaluated GLUT10 as a positional candidate gene for T2DM in Caucasian Americans...
  79. doi request reprint Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study
    Matthew R Nelson
    Department of Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pacing Clin Electrophysiol 31:314-21. 2008
    ..We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants...
  80. ncbi request reprint A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 166:340-7. 2007
    ..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another...
  81. pmc Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping
    Caitrin W McDonough
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 126:805-17. 2009
    ..0017; OR (95% CI) = 0.65 (0.50-0.85)]. Collectively, these results suggest that multiple genes in this region may influence diabetic nephropathy susceptibility in AAs...
  82. pmc Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart study
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 18:2004-9. 2010
    ..004). As in European Americans, PAT is associated with CP in African Americans with type 2 diabetes. Ethnic differences in the relationships between organ-specific adipose tissue depots and atherosclerosis require further study...
  83. doi request reprint Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA bfreedma wfubmc edu
    Am J Nephrol 31:375-9. 2010
    ..These assays have yet to be compared in patients with advanced chronic kidney disease (CKD)...
  84. pmc The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 32:66-72. 2010
    ..Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN...
  85. pmc Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes 60:662-8. 2011
    ..The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans...
  86. ncbi request reprint A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study
    Yongmei Liu
    Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Eur J Cardiovasc Prev Rehabil 13:655-7. 2006
    ..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families...
  87. ncbi request reprint Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population
    Carla J Gallagher
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Genet Metab 87:54-60. 2006
    ..046). Significant, but rare, risk and protective haplotypes were identified as driving these associations with T2DM (P=0.034-0.047). These associations suggest that the OPRM1 gene plays a role in T2DM susceptibility in African Americans...
  88. pmc Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 33:131-8. 2010
    ..We explored ethnicity-specific relationships between albuminuria and calcified plaque involving the infrarenal aorta, coronary artery, and carotid artery in 835 European American and 393 African American subjects with type 2 diabetes...
  89. pmc Coronary calcium score and prediction of all-cause mortality in diabetes: the diabetes heart study
    Subhashish Agarwal
    Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes Care 34:1219-24. 2011
    ..In diabetes, it remains unclear whether the coronary artery calcium (CAC) score provides additional information about total mortality risk beyond traditional risk factors...
  90. doi request reprint A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients
    Trudye A Young
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Dermatolog Treat 20:76-81. 2009
    ..The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients...
  91. ncbi request reprint The relationship between albuminuria and hormone therapy in postmenopausal women
    Mamta Agarwal
    Department of Internal Medicine Nephrology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Kidney Dis 45:1019-25. 2005
    ..Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women...
  92. pmc Susceptibility genes in common complex kidney disease
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Curr Opin Nephrol Hypertens 19:79-84. 2010
    ..A brief overview of methods for identifying gene variants is provided, along with genetic associations and new avenues under exploration...
  93. ncbi request reprint Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hypertension 48:8-13. 2006
  94. ncbi request reprint Relationship between albuminuria and cardiovascular disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 16:2156-61. 2005
    ..004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function...
  95. ncbi request reprint Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 53:3007-12. 2004
    ..These results suggest that PTPN1 is a significant contributor to type 2 diabetes susceptibility in the Caucasian population. This risk is likely due to noncoding polymorphisms...
  96. pmc Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Semin Dial 23:244-7. 2010
    ..MYH9 polymorphisms may affect treatment outcomes in severe kidney disease and such gene effects are rarely encountered in practice...
  97. ncbi request reprint A genome scan for all-cause end-stage renal disease in African Americans
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 20:712-8. 2005
    ....
  98. ncbi request reprint Renal artery calcified plaque associations with subclinical renal and cardiovascular disease
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 65:2262-7. 2004
    ..The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown...
  99. ncbi request reprint Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster
    Jeannette T Bensen
    The Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Genomics 82:194-217. 2003
    ..0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD...