Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserineS Courtney Frasch
Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
J Biol Chem 288:4583-93. 2013
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- Emerging roles for lysophosphatidylserine in resolution of inflammation
S Courtney Frasch
Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Prog Lipid Res 51:199-207. 2012
..This article will review our current knowledge of lysoPS biology including receptor signaling and mechanisms of generation as well as summarize the more recent evidence of its expanding roles in inflammation...
- Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity
S Courtney Frasch
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Biol Chem 286:12108-22. 2011
..Together, these data support the hypothesis that lyso-PS presented on the surface of activated and dying neutrophils provides a tightly controlled, proresolution signal for high capacity clearance of neutrophils in acute inflammation...
- NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
S Courtney Frasch
Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
J Biol Chem 283:33736-49. 2008
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- PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease
Ruby Fernandez-Boyanapalli
Department of Pediatrics, National Jewish Health, Denver, CO, USA
Blood 116:4512-22. 2010
..As such, PPARγ may be a therapeutic target for CGD, and possibly other inflammatory conditions where aberrant macrophage programming and impaired efferocytosis delay resolution of inflammation...
Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent mannerRuby Fernandez-Boyanapalli
National Jewish Health, Denver, CO 80206, USA
J Immunol 185:4030-41. 2010
..These data support the hypothesis that in addition to correcting immunodeficiency in CGD, IFN-γ priming of Ms restores clearance of apoptotic cells and may thereby contribute to resolution of exaggerated CGD inflammation...
- Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
Ruby F Fernandez-Boyanapalli
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Blood 113:2047-55. 2009
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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyteShyra J Gardai
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
Cell 123:321-34. 2005
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- Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A
S Courtney Frasch
Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 178:6540-8. 2007
..Together, these data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secretory vesicles and result in G2A receptor/Galphai/phospholipase C signaling for calcium flux in neutrophils...
- Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil
Michael B Fessler
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biol Chem 279:39989-98. 2004
..In sum, these findings provide evidence for an important regulatory role of cholesterol in both transmission of the lipopolysaccharide signal and the inflammatory phenotype of the human neutrophil...
- Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
S Courtney Frasch
Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biol Chem 279:17625-33. 2004
..Of note, PS exposure, phospholipid uptake, and FM 1-43 staining also localized to the uropod following stimulation demonstrating that both PLSCR1 and phospholipid flip-flop characterize this specialized domain of polarized neutrophils...
- Modulation of macrophage efferocytosis in inflammation
Darlynn Korns
Division of Cell Biology, Department of Pediatrics, National Jewish Health Denver, CO, USA
Front Immunol 2:57. 2011
..This review summarizes the current knowledge of the multiple factors that modulate macrophage efferocytic ability and highlights emerging therapeutic targets with significant potential for limiting chronic inflammation...
- Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
Shyra J Gardai
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Biol Chem 279:21085-95. 2004
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- SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice
Fabienne Gally
Department of Medicine, National Jewish Health, Denver, Colorado, USA
Am J Pathol 178:2159-67. 2011
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