S Courtney Frasch

Summary

Publications

  1. pmc Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 288:4583-93. 2013
  2. pmc Emerging roles for lysophosphatidylserine in resolution of inflammation
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Prog Lipid Res 51:199-207. 2012
  3. pmc Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Biol Chem 286:12108-22. 2011
  4. pmc NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 283:33736-49. 2008
  5. pmc PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease
    Ruby Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Health, Denver, CO, USA
    Blood 116:4512-22. 2010
  6. doi Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner
    Ruby Fernandez-Boyanapalli
    National Jewish Health, Denver, CO 80206, USA
    J Immunol 185:4030-41. 2010
  7. pmc Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    Ruby F Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 113:2047-55. 2009
  8. ncbi Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    Cell 123:321-34. 2005
  9. ncbi Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:6540-8. 2007
  10. ncbi Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:39989-98. 2004

Collaborators

Detail Information

Publications15

  1. pmc Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 288:4583-93. 2013
    ....
  2. pmc Emerging roles for lysophosphatidylserine in resolution of inflammation
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Prog Lipid Res 51:199-207. 2012
    ..This article will review our current knowledge of lysoPS biology including receptor signaling and mechanisms of generation as well as summarize the more recent evidence of its expanding roles in inflammation...
  3. pmc Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Biol Chem 286:12108-22. 2011
    ..Together, these data support the hypothesis that lyso-PS presented on the surface of activated and dying neutrophils provides a tightly controlled, proresolution signal for high capacity clearance of neutrophils in acute inflammation...
  4. pmc NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 283:33736-49. 2008
    ....
  5. pmc PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease
    Ruby Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Health, Denver, CO, USA
    Blood 116:4512-22. 2010
    ..As such, PPARγ may be a therapeutic target for CGD, and possibly other inflammatory conditions where aberrant macrophage programming and impaired efferocytosis delay resolution of inflammation...
  6. doi Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner
    Ruby Fernandez-Boyanapalli
    National Jewish Health, Denver, CO 80206, USA
    J Immunol 185:4030-41. 2010
    ..These data support the hypothesis that in addition to correcting immunodeficiency in CGD, IFN-γ priming of Ms restores clearance of apoptotic cells and may thereby contribute to resolution of exaggerated CGD inflammation...
  7. pmc Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    Ruby F Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 113:2047-55. 2009
    ....
  8. ncbi Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    Cell 123:321-34. 2005
    ....
  9. ncbi Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:6540-8. 2007
    ..Together, these data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secretory vesicles and result in G2A receptor/Galphai/phospholipase C signaling for calcium flux in neutrophils...
  10. ncbi Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:39989-98. 2004
    ..In sum, these findings provide evidence for an important regulatory role of cholesterol in both transmission of the lipopolysaccharide signal and the inflammatory phenotype of the human neutrophil...
  11. ncbi Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17625-33. 2004
    ..Of note, PS exposure, phospholipid uptake, and FM 1-43 staining also localized to the uropod following stimulation demonstrating that both PLSCR1 and phospholipid flip-flop characterize this specialized domain of polarized neutrophils...
  12. pmc Induction of TGF-β1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36
    Weipeng Xiong
    Department of Pediatrics, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e72772. 2013
    ..However, the PS receptor(s) responsible for this induction has not been clearly determined...
  13. pmc Modulation of macrophage efferocytosis in inflammation
    Darlynn Korns
    Division of Cell Biology, Department of Pediatrics, National Jewish Health Denver, CO, USA
    Front Immunol 2:57. 2011
    ..This review summarizes the current knowledge of the multiple factors that modulate macrophage efferocytic ability and highlights emerging therapeutic targets with significant potential for limiting chronic inflammation...
  14. ncbi Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Biol Chem 279:21085-95. 2004
    ....
  15. pmc SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice
    Fabienne Gally
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Am J Pathol 178:2159-67. 2011
    ....