Philippe Zizzari

Summary

Country: France

Publications

  1. pmc Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents
    Philippe Zizzari
    Unite Mixte de Recherche, 549 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Endocrinology 148:1648-53. 2007
  2. doi request reprint Physiological roles of preproghrelin-derived peptides in GH secretion and feeding
    Philippe Zizzari
    UMR894 INSERM, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, 2 ter rue d Alesia, 75014 Paris, France
    Peptides 32:2274-82. 2011
  3. pmc A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice
    Rim Hassouna
    UMR S 894 Inserm, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 7:e51135. 2012
  4. ncbi request reprint Delayed age-associated decrease in growth hormone pulsatile secretion and increased orexigenic peptide expression in the Lou C/JaLL rat
    Laurent Kappeler
    INSERM U549, IFR Broca Ste Anne, Universite Paris 5, Paris, France
    Neuroendocrinology 80:273-83. 2004
  5. pmc Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity
    Rim Hassouna
    UMR S 894 Inserm, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, Sorbonne Paris Cité Paris, France
    Front Endocrinol (Lausanne) 4:25. 2013
  6. ncbi request reprint Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release
    Annabelle Reaux-Le Goazigo
    Institut National de la Sante et de la Recherche Medicale, Unité 691, College de France, 11 place Marcelin Berthelot, Paris, France
    Am J Physiol Endocrinol Metab 292:E7-15. 2007
  7. ncbi request reprint Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset
    Roland M Dardennes
    Universite Paris Descartes, Faculte de Medecine, Hopital Sainte Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France
    Psychoneuroendocrinology 32:106-13. 2007
  8. doi request reprint Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis
    Jacques Epelbaum
    Centre de Psychiatrie and Neurosciences, UMR 894 INSERM, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Mol Cell Endocrinol 314:244-7. 2010
  9. ncbi request reprint Novel analogs of ghrelin: physiological and clinical implications
    Heather A Halem
    IPSEN, 27 Maple Street, Milford, Massachusetts 01757, USA
    Eur J Endocrinol 151:S71-5. 2004
  10. ncbi request reprint Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats
    Virginie Tolle
    Institut National de la Santé et de la Recherche Médicale U549, 75014 Paris, France
    Endocrinology 143:1353-61. 2002

Collaborators

  • Jacques Epelbaum
  • Virginie Tolle
  • Odile Viltart
  • Laurent Kappeler
  • Bruno Estour
  • Josette Alliot
  • Heather A Halem
  • F Rubino
  • Rim Hassouna
  • Marie Thérèse Bluet-Pajot
  • Catherine Videau
  • Peter Kamenicky
  • Roland M Dardennes
  • Annabelle Reaux-Le Goazigo
  • Michael Culler
  • Alexandra Labarthe
  • Robert Gardette
  • Seung Kwon Yang
  • Emilio Badoer
  • Martine Imbert-Teboul
  • Anne Blanchard
  • Geri Meduri
  • Philippe Chanson
  • Alain Doucet
  • Marc Lombes
  • Say Viengchareun
  • Pierre Marie Sinet
  • Julien Daniel Guelfi
  • Lucia Romo
  • Christine Foulon
  • Catherine Llorens-Cortes
  • Dana Iancu-Gontard
  • Marie Christine Mouren
  • Claudette Boni
  • Marie Thérèse Bluet
  • Rodrigo Alvear-Perez
  • Frederic Rouillon
  • Philip Gorwood
  • Amelie Kipman
  • Catherine Tomasetto
  • Dominique Grouselle

Detail Information

Publications14

  1. pmc Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents
    Philippe Zizzari
    Unite Mixte de Recherche, 549 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Endocrinology 148:1648-53. 2007
    ..It remains to be determined whether obestatin modulates endogenous ghrelin actions...
  2. doi request reprint Physiological roles of preproghrelin-derived peptides in GH secretion and feeding
    Philippe Zizzari
    UMR894 INSERM, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, 2 ter rue d Alesia, 75014 Paris, France
    Peptides 32:2274-82. 2011
    ..Data obtained from pharmacological approaches, mutant models and evaluation of the hormones in animal and human models are discussed...
  3. pmc A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice
    Rim Hassouna
    UMR S 894 Inserm, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 7:e51135. 2012
    ..In the present study, we tested the activity of native and Q90L obestatin to modulate ghrelin-induced food intake, GH secretion, cFos activity in GHRH and Neuropeptide Y (NPY) neurons and γ-aminobutyric-acid activity onto GHRH neurons...
  4. ncbi request reprint Delayed age-associated decrease in growth hormone pulsatile secretion and increased orexigenic peptide expression in the Lou C/JaLL rat
    Laurent Kappeler
    INSERM U549, IFR Broca Ste Anne, Universite Paris 5, Paris, France
    Neuroendocrinology 80:273-83. 2004
    ..In conclusion, ageing in Lou C/Jall rats is associated with a delayed decrease in pulsatile GH secretion in the presence of a lower IGF-1 tone and an increase in the expression of orexigenic neuropeptides in the hypothalamus...
  5. pmc Actions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity
    Rim Hassouna
    UMR S 894 Inserm, Centre de psychiatrie et Neurosciences, Universite Paris Descartes, Sorbonne Paris Cité Paris, France
    Front Endocrinol (Lausanne) 4:25. 2013
    ..A better understanding of the molecular pathways activated by these compounds could be useful in devising future therapeutic applications, such as for cachexia and anorexia...
  6. ncbi request reprint Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release
    Annabelle Reaux-Le Goazigo
    Institut National de la Sante et de la Recherche Medicale, Unité 691, College de France, 11 place Marcelin Berthelot, Paris, France
    Am J Physiol Endocrinol Metab 292:E7-15. 2007
    ....
  7. ncbi request reprint Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset
    Roland M Dardennes
    Universite Paris Descartes, Faculte de Medecine, Hopital Sainte Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France
    Psychoneuroendocrinology 32:106-13. 2007
    ....
  8. doi request reprint Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis
    Jacques Epelbaum
    Centre de Psychiatrie and Neurosciences, UMR 894 INSERM, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Mol Cell Endocrinol 314:244-7. 2010
    ..This review is focussed on the possible implication of the ghrelin/obestatin system in psychiatric diseases with particular emphasis on eating disorders...
  9. ncbi request reprint Novel analogs of ghrelin: physiological and clinical implications
    Heather A Halem
    IPSEN, 27 Maple Street, Milford, Massachusetts 01757, USA
    Eur J Endocrinol 151:S71-5. 2004
    ..These studies demonstrate the feasibility of creating ghrelin analogs that are selective for specific activities, as well as their utility in dissecting the role of ghrelin in both normal physiology and specific pathologies...
  10. ncbi request reprint Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats
    Virginie Tolle
    Institut National de la Santé et de la Recherche Médicale U549, 75014 Paris, France
    Endocrinology 143:1353-61. 2002
    ..Moreover, ghrelin secretion is pulsatile and directly related to feeding behavior only...
  11. ncbi request reprint [Ghrelin: a striking example of neuroendocrine peptide pleiotropy]
    Marie Thérèse Bluet-Pajot
    IFR Broca Sainte Anne, INSERM U 549, 2 ter, rue d Alesia, 75014 Paris, France
    Med Sci (Paris) 21:715-21. 2005
    ..Thus, the continuation of the fascinating ghrelin story as well as its potential pathophysiological implications in endocrinology and internal medicine remain open avenues for future investigations...
  12. ncbi request reprint The role of the small bowel in the regulation of circulating ghrelin levels and food intake in the obese Zucker rat
    Francesco Rubino
    Institut de Recherche Contre les Canceurs de l Appareil Digestif European Institute of Telesurgery, 1 Place de l Hopital, 67091 Strasbourg, France
    Endocrinology 146:1745-51. 2005
    ....
  13. pmc Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly
    Peter Kamenicky
    Institut National de la Santé et de la Recherche Médicale Unité 693, Faculte de Medecine Paris Sud, 63 rue Gabriel Peri, Le Kremlin Bicetre Cedex, France
    Endocrinology 149:3294-305. 2008
    ..Our findings provide the first evidence that GH, in concert with IGF-I, stimulates ENaC-mediated sodium transport in the late distal nephron, accounting for the pathogenesis of sodium retention in acromegaly...
  14. ncbi request reprint Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women
    Virginie Tolle
    INSERM, U 549, 75014 Paris, France
    J Clin Endocrinol Metab 88:109-16. 2003
    ..Even though endogenous ghrelin is not strictly correlated with basal GH secretion, it may be involved in the magnitude of GHRH-induced GH release in AN patients...