Luc Zimmer

Summary

Country: France

Publications

  1. ncbi request reprint Positron emission tomography neuroimaging for a better understanding of the biology of ADHD
    Luc Zimmer
    Laboratory of Neuropharmacology, EAC CNRS 5006, University of Lyon 1, Lyon, France PET Department, CERMEP imagerie du vivant, 69003 Lyon, France
    Neuropharmacology 57:601-7. 2009
  2. ncbi request reprint PET radiotracers for molecular imaging of serotonin 5-HT1A receptors
    T Billard
    CERMEP Imaging Platform, University Hospital of Lyon Hospices Civils de Lyon, 59 Boulevard Pinel, F 69003 Lyon, France
    Curr Med Chem 21:70-81. 2014
  3. doi request reprint PET radiotracers for molecular imaging in the brain: past, present and future
    Luc Zimmer
    University Hospital of Lyon, 59 Boulevard Pinel, Lyon, France
    Neuroimage 61:363-70. 2012
  4. ncbi request reprint Can positron emission tomography facilitate paediatric drug development?
    Luc Zimmer
    PET Department, CERMEP imagerie du vivant, Lyon, France
    Fundam Clin Pharmacol 22:595-8. 2008
  5. ncbi request reprint Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors
    Laura Lambas-Senas
    Universite de Lyon, F 69008, Lyon, France
    Prog Neuropsychopharmacol Biol Psychiatry 33:262-8. 2009
  6. ncbi request reprint A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus
    Luc Zimmer
    Centre d Exploration et de Recherche Médicales par Emission de Positons, Biomedical Cyclotron, Lyon, France
    J Nucl Med 44:1495-501. 2003
  7. ncbi request reprint A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging
    Nicolas Costes
    Imagerie du vivant, PET Centre, Centre d Etude et de Recherche Multimodales et Pluridisciplinaires, Lyon, France
    J Nucl Med 46:1980-9. 2005
  8. ncbi request reprint Looking for a 5-HT7 radiotracer for positron emission tomography
    Julien Andriès
    Universite de Lyon, Universite Lyon 1, CNRS, ICBMS UMR CNRS 5246, Lyon, France
    Bioorg Med Chem Lett 20:3730-3. 2010
  9. doi request reprint Comparison of 4 radiolabeled antagonists for serotonin 5-HT(7) receptor neuroimaging: toward the first PET radiotracer
    Laetitia Lemoine
    CERMEP imagerie du vivant, Lyon, France
    J Nucl Med 52:1811-8. 2011
  10. ncbi request reprint Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging
    Laetitia Lemoine
    University of Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
    J Nucl Med 53:969-76. 2012

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Positron emission tomography neuroimaging for a better understanding of the biology of ADHD
    Luc Zimmer
    Laboratory of Neuropharmacology, EAC CNRS 5006, University of Lyon 1, Lyon, France PET Department, CERMEP imagerie du vivant, 69003 Lyon, France
    Neuropharmacology 57:601-7. 2009
    ....
  2. ncbi request reprint PET radiotracers for molecular imaging of serotonin 5-HT1A receptors
    T Billard
    CERMEP Imaging Platform, University Hospital of Lyon Hospices Civils de Lyon, 59 Boulevard Pinel, F 69003 Lyon, France
    Curr Med Chem 21:70-81. 2014
    ....
  3. doi request reprint PET radiotracers for molecular imaging in the brain: past, present and future
    Luc Zimmer
    University Hospital of Lyon, 59 Boulevard Pinel, Lyon, France
    Neuroimage 61:363-70. 2012
    ..In the last part, we highlight some applications presenting a potential for novel functional explorations of the brain...
  4. ncbi request reprint Can positron emission tomography facilitate paediatric drug development?
    Luc Zimmer
    PET Department, CERMEP imagerie du vivant, Lyon, France
    Fundam Clin Pharmacol 22:595-8. 2008
    ..Although placing this technique in a unique position to potentially contribute to the process of drug development and evaluation in paediatrics, several ethical and methodological aspects should be considered...
  5. ncbi request reprint Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors
    Laura Lambas-Senas
    Universite de Lyon, F 69008, Lyon, France
    Prog Neuropsychopharmacol Biol Psychiatry 33:262-8. 2009
    ..These results suggest that 5-HT(1A) receptors are not substantially affected in adult Sprague-Dawley rats that were subjected to a maternal deprivation 3 h daily during the neonatal period...
  6. ncbi request reprint A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus
    Luc Zimmer
    Centre d Exploration et de Recherche Médicales par Emission de Positons, Biomedical Cyclotron, Lyon, France
    J Nucl Med 44:1495-501. 2003
    ..Because endogenous serotonin is significantly decreased in some pathologies, the aim of this study was to determine whether (18)F-MPPF is sensitive to depletion of this neurotransmitter...
  7. ncbi request reprint A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging
    Nicolas Costes
    Imagerie du vivant, PET Centre, Centre d Etude et de Recherche Multimodales et Pluridisciplinaires, Lyon, France
    J Nucl Med 46:1980-9. 2005
    ..Our study reports, to our knowledge, the first large normative imaging database of 18F-MPPF binding potential (BP) over aging, for both males and females...
  8. ncbi request reprint Looking for a 5-HT7 radiotracer for positron emission tomography
    Julien Andriès
    Universite de Lyon, Universite Lyon 1, CNRS, ICBMS UMR CNRS 5246, Lyon, France
    Bioorg Med Chem Lett 20:3730-3. 2010
    ..After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation...
  9. doi request reprint Comparison of 4 radiolabeled antagonists for serotonin 5-HT(7) receptor neuroimaging: toward the first PET radiotracer
    Laetitia Lemoine
    CERMEP imagerie du vivant, Lyon, France
    J Nucl Med 52:1811-8. 2011
    ..Because no radioligand has yet been successfully used to study this receptor by PET neuroimaging, the objective of the present study was to develop a 5-HT(7) (18)F-labeled radiotracer...
  10. ncbi request reprint Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging
    Laetitia Lemoine
    University of Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
    J Nucl Med 53:969-76. 2012
    ..In this study, we radiolabeled the high-affinity 5-HT(1A) receptor agonist (18)F-F13714 and investigated its potential as a PET tracer...
  11. ncbi request reprint A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment
    Nicolas Aznavour
    Laboratoire de Neuropharmacologie, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Neuroimage 33:834-42. 2006
    ..If the decrease in [(18)F]MPPF binding at the onset of SSRI treatment was detectable by PET imaging, it could potentially serve as a biological index of efficacy...
  12. ncbi request reprint Synthesis and biological evaluation in rat and cat of [18F]12ST05 as a potential 5-HT6 PET radioligand
    Sandrine Tang
    Institut de Chimie et Biochimie Moleculaires et Supramoleculaires, UMR CNRS 5246, Universite Lyon 1, Universite de Lyon, Lyon, 69677 Cermep, France
    Nucl Med Biol 34:995-1002. 2007
    ..However, no 5-HT6 positron emission tomography (PET) radiotracer is currently used in clinical imaging studies. The purpose of this study was to propose the first fluorinated PET radiotracer for this brain receptor...
  13. ncbi request reprint Test-retest reproducibility of 18F-MPPF PET in healthy humans: a reliability study
    Nicolas Costes
    CERMEP imagerie du vivant, PET Department, Lyon, France
    J Nucl Med 48:1279-88. 2007
    ..The aim of this study was to assess the reliability of 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine (18F-MPPF) PET binding parameter's quantification via a test-retest study over a long-term period...
  14. doi request reprint [18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging
    Laetitia Lemoine
    Laboratory of Neuropharmacology, Universite de Lyon, EAC CNRS 5006, Lyon, France
    Eur J Nucl Med Mol Imaging 37:594-605. 2010
    ..Since all clinical PET 5-HT(1A) radiopharmaceuticals are antagonists, it is of great interest to develop a( 18)F labelled agonist...
  15. doi request reprint MPTP animal model of Parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? A study using PET imaging, autoradiography, and immunohistochemistry in the cat
    Nicolas Aznavour
    CERMEP Imaging Platform, Hospices Civils de Lyon, Lyon, France
    CNS Neurosci Ther 18:934-41. 2012
    ..This raises the question as whether MPTP causes a cell death with a decrease in dopamine transporter or a simple impairment of TH...
  16. doi request reprint Effects of amyloid-β peptides on the serotoninergic 5-HT1A receptors in the rat hippocampus
    Mathieu Verdurand
    Laboratory of Neuropharmacology, FRE CNRS 3006, Univ Lyon 1, Universite de Lyon, France
    Neurobiol Aging 32:103-14. 2011
    ..Exploration of the functional consequences of these serotoninergic modifications during the neurodegenerative process may have an impact on therapeutics targeting 5-HT(1A) receptors in AD...
  17. doi request reprint 5-HT7 receptor antagonists as a new class of antidepressants
    Ouissame Mnie-Filali
    Laboratory of Neuropharmacology FRE CNRS 3006, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Drug News Perspect 20:613-8. 2007
    ..The use of such ligands seems very promising to elaborate novel generations of antidepressants that surpass the efficacy and onset of action limitations of existing antidepressants...
  18. ncbi request reprint Displacement of the PET ligand 18F-MPPF by the electrically evoked serotonin release in the rat hippocampus
    Latifa Rbah
    CERMEP Biomedical Cyclotron, 59 Boulevard Pinel, F 69003 Lyon, France
    Synapse 49:239-45. 2003
    ..This compartment, explored by the beta-microprobe, is probably distinct from the extracellular compartment, explored by microdialysis...
  19. ncbi request reprint Current status of positron emission tomography radiotracers for serotonin receptors in humans
    Luc Zimmer
    Hospices Civils de Lyon, CERMEP Imaging Platform, Lyon, France University of Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Centre, Lyon, France
    J Labelled Comp Radiopharm 56:105-13. 2013
    ....
  20. ncbi request reprint R-citalopram prevents the neuronal adaptive changes induced by escitalopram
    Ouissame Mnie-Filali
    Laboratory of Neuropharmacology, Faculty of Pharmacy, University Lyon 1, Lyon Cedex, France
    Neuroreport 18:1553-6. 2007
    ....
  21. ncbi request reprint A comparison of in vivo and in vitro neuroimaging of 5-HT 1A receptor binding sites in the cat brain
    Nicolas Aznavour
    CERMEP Biomedical Cyclotron, Lyon, France
    J Chem Neuroanat 31:226-32. 2006
    ..Our study also shows the advantages of combining complementary neuroimaging techniques such as in vivo PET imaging and in vitro autoradiography to visualize the distribution of the 5-HT 1A receptors...
  22. ncbi request reprint Carbon-11 labelling of 8[[3-[4-(2-[(11)C]methoxyphenyl)piperazin-1-yl]-2-hydroxypropyl]oxy]thiochroman, a presynaptic 5-HT(1A) receptor agonist, and its in vivo evaluation in anaesthetised rat and in awake cat
    Luc Zimmer
    CERMEP, Biomedical Cyclotron, 59 Bd Pinel, 69003 Lyon, France
    Nucl Med Biol 30:541-6. 2003
    ..In both in vivo techniques, the new ligand did not reveal any specific binding in hippocampus indicating that this radiotracer is not suitable for mapping 5HT(1A) receptors using positron emission tomography...
  23. ncbi request reprint Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer
    Mathieu Verdurand
    CERMEP imagerie du vivant, PET Department, Universite Lyon 1, Lyon, France
    Nucl Med Commun 29:920-6. 2008
    ..An increasing number of PET centres schedule its transfer for clinical studies and therefore are interested in its automated synthesis...
  24. ncbi request reprint [18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain
    Nicolas Aznavour
    Laboratoire de Neuropharmacologie, Universite Lyon 1, Lyon, France
    Neuropharmacology 52:695-707. 2007
    ....
  25. ncbi request reprint In-capillary derivatization and capillary electrophoresis separation of amino acid neurotransmitters from brain microdialysis samples
    Luc Denoroy
    Universite de Lyon, F 69008 Lyon, France
    J Chromatogr A 1205:144-9. 2008
    ..This new single-step methodology allows the analysis of amino acid neurotransmitters in rat brain microdialysis samples...
  26. doi request reprint Behaviour of a genetic mouse model of depression in the learned helplessness paradigm
    Laure Bougarel
    Centre de Recherche en Neurosciences de Lyon, CNRS UMR 5292 INSERM U1028 Physiopathologie des réseaux neuronaux du cycle veille sommeil, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Psychopharmacology (Berl) 215:595-605. 2011
    ..Learned helplessness (LH), in which footshock stress induces a coping deficit, models some aspects of depression in rodents, but so far, fewer LH studies have been performed in mice than in rats...
  27. ncbi request reprint Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis
    Luc Zimmer
    CERMEP Biomedical Cyclotron, Lyon, France
    J Neurochem 80:278-86. 2002
    ..After modelization, 18F-MPPF binding could constitute an interesting radiotracer for positron emission tomography in evaluating the serotonin endogenous levels in limbic areas of the human brain...
  28. doi request reprint Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging
    Julie Colomb
    University Lyon 1, CNRS, Institute of Chemistry and Biochemistry UMR 5246, Villeurbanne, France CERMEP Imagerie du vivant, Lyon, France
    Nucl Med Biol 41:330-7. 2014
    ..Although these results were promising, it appeared that the radiotracer-candidates suffered, among other drawbacks, from too low a 5-HT7 receptor affinity...
  29. pmc Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex
    Cynthia El Hage
    INSERM, U1028, Lyon Neuroscience Research Center, Physiopathology of the Neuronal Network Responsible for the Sleep Waking Cycle Team, Lyon, France
    PLoS ONE 7:e43535. 2012
    ..The present study provides new insights into the neuroanatomical regions and neuronal cell types that may underlie pathological anxiety during cocaine withdrawal...
  30. ncbi request reprint PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow
    Wadad Hassoun
    CERMEP, Lyon, France
    Eur J Nucl Med Mol Imaging 30:141-8. 2003
    ..These results are the first to be obtained on this topic in awake cats, and show that the BP(raclo) is greatly dependent on alterations in the CBF...
  31. doi request reprint Outcome of poor-grade subarachnoid hemorrhage as determined by biomarkers of glucose cerebral metabolism
    Gleicy K Barcelos
    BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France
    Neurocrit Care 18:234-44. 2013
    ....
  32. ncbi request reprint Modeling [18 F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection
    Nicolas Costes
    Centre d Exploration et de Recherche Médicales par Emission de Positons, Lyon, France
    J Cereb Blood Flow Metab 22:753-65. 2002
    ..This study confirms the value of MPPF in the investigation of normal and pathologic systems involving the limbic network and 5-HT1A receptors. Standard values can be used for the simulation of simplified protocols...
  33. ncbi request reprint Short- and long-term effects of p-ethynylphenylalanine on brain serotonin levels
    Luc Zimmer
    CERMEP Biomedical Cyclotron, Lyon, France
    Neurochem Res 27:269-75. 2002
    ..These results demonstrated that p-EPA is a useful pharmacological tool which powerfully, acutely and irreversibly reduces the 5-HT levels...
  34. ncbi request reprint SIC, an intracerebral beta(+)-range-sensitive probe for radiopharmacology investigations in small laboratory animals: binding studies with (11)C-raclopride
    Luc Zimmer
    Centre d Exploration et de Recherche Médicales par Emission de Positons, Biomedical Cyclotron, Lyon, France
    J Nucl Med 43:227-33. 2002
    ..Our aim was to show the ability of a recently developed beta(+)-range-sensitive intracerebral probe (SIC) to measure, in vivo, the binding of radioligands in small animals...