Maria Christina Zennaro

Summary

Country: France

Publications

  1. ncbi request reprint Mineralocorticoid receptors in the metabolic syndrome
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 75015 Paris, France
    Trends Endocrinol Metab 20:444-51. 2009
  2. pmc A network perspective on metabolic inconsistency
    Nikolaus Sonnenschein
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    BMC Syst Biol 6:41. 2012
  3. doi request reprint Aldosterone resistance: structural and functional considerations and new perspectives
    Maria Christina Zennaro
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Mol Cell Endocrinol 350:206-15. 2012
  4. doi request reprint KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale INSERM, U970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Mol Cell Endocrinol 371:221-7. 2013
  5. doi request reprint Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers
    Sheerazed Boulkroun
    Institut National de la Santé et de la Recherche Médicale Unité 970, PARCC, 56 rue Leblanc, 75015 Paris, France
    Endocrinology 152:4753-63. 2011
  6. doi request reprint Genetics of mineralocorticoid excess: an update for clinicians
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, 56 rue Leblanc, 75015 Paris, France
    Eur J Endocrinol 169:R15-25. 2013
  7. doi request reprint Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations
    Brigitte Escoubet
    Assistance Publique Hopitaux de Paris, Hopital Bichat Claude Bernard, Paris, France
    Circ Cardiovasc Genet 6:381-90. 2013
  8. pmc Mineralocorticoid receptor mutations and a severe recessive pseudohypoaldosteronism type 1
    Edwige Ludiwyne Hubert
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 22:1997-2003. 2011
  9. doi request reprint Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Scientifique 970, Paris Cardiovascular Research Center, Paris, France
    Hypertension 59:592-8. 2012
  10. doi request reprint Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1
    Fabio L Fernandes-Rosa
    Department of Puericulture and Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040 900, Brazil
    J Clin Endocrinol Metab 96:E519-27. 2011

Collaborators

  • Decio Armanini
  • Pierre Francois Plouin
  • Herve Lefebvre
  • Marcus Quinkler
  • Enzo Lalli
  • Gilberta Giacchetti
  • Laurence Mangin
  • Florence Tubach
  • Sheerazed Boulkroun
  • Jerome Fagart
  • Bruno Feve
  • Ursula Kuhnle
  • Franco Veglio
  • Véronique Abadie
  • Claudio Letizia
  • Xavier Jeunemaitre
  • Brigitte Escoubet
  • Fabio L Fernandes-Rosa
  • Edwige Ludiwyne Hubert
  • Fábio Luiz Fernandes-Rosa
  • Karim Sacre
  • Nikolaus Sonnenschein
  • Arndt Benecke
  • Marie Edith Rafestin-Oblin
  • Marc Lombes
  • Say Viengchareun
  • Lucie Pujo
  • Laurent Pascual Le Tallec
  • Paola Sartorato
  • Olivier Steichen
  • Mauro Maccario
  • Martin Reincke
  • Tchao Meatchi
  • Tim M Strom
  • Maria Verena Cicala
  • Felix Beuschlein
  • Thomas Papo
  • Silvia Monticone
  • Paolo Mulatero
  • Marie Paule Chauveheid
  • Giampaolo Bernini
  • Tracy Ann Williams
  • Blandine Pasquet
  • Francesco Fallo
  • Anna Riester
  • Franco Mantero
  • Laurence Amar
  • Bruno Allolio
  • Jean Michel Serfaty
  • Jean Pierre Laisy
  • Cédric Laouénan
  • France Mentre
  • Sylvie Chillon
  • Camille Couffignal
  • Sebastian Eilebrecht
  • Jose Felipe Golib Dzib
  • Marc Thorsten Hütt
  • Annick Lesne
  • Debora Gomes
  • Chantal Metz
  • Sonir R Antonini
  • Michel Fay
  • Nicolas Tchitchek
  • Raphaël Teissier
  • Elodie Jouanno
  • Françoise Gary
  • Aurélie Claës
  • Dimitris T Papadimitriou
  • Christiane De Gennes
  • Véronique Poulet-Young
  • Remi Salomon
  • Arturo Naselli
  • Elodie Poisson
  • Marie Christine Lecomte
  • Patrick Niaudet
  • Alain Racine
  • Anne Laure Lapeyraque
  • Massimiliano Caprio
  • Olivier Kirsh
  • Yasmina Khaldi
  • Eliana di Battista
  • Anna Maria Fusco
  • Marie Hélène Lecornec
  • Paola Loli
  • Maurizio Bosio
  • Jean Pierre Chabrolle
  • Anne Dejean
  • Laurent Pascual-Le Tallec

Detail Information

Publications18

  1. ncbi request reprint Mineralocorticoid receptors in the metabolic syndrome
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 75015 Paris, France
    Trends Endocrinol Metab 20:444-51. 2009
    ....
  2. pmc A network perspective on metabolic inconsistency
    Nikolaus Sonnenschein
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    BMC Syst Biol 6:41. 2012
    ..A network-driven interpretation of gene expression data has the potential of suggesting novel classifiers for pathological cellular states and of contributing to a general theoretical understanding of gene regulation...
  3. doi request reprint Aldosterone resistance: structural and functional considerations and new perspectives
    Maria Christina Zennaro
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Mol Cell Endocrinol 350:206-15. 2012
    ..We will also discuss genotype-phenotype correlations and new clinical and genetic entities that may prove relevant for patient's care in neonates with renal salt losing syndromes and/or failure to thrive...
  4. doi request reprint KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale INSERM, U970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Mol Cell Endocrinol 371:221-7. 2013
    ..The cell composition of APA was not significantly different between groups. These results indicate that KCNJ5 mutations are not correlated with adrenal cortex remodeling in APA...
  5. doi request reprint Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers
    Sheerazed Boulkroun
    Institut National de la Santé et de la Recherche Médicale Unité 970, PARCC, 56 rue Leblanc, 75015 Paris, France
    Endocrinology 152:4753-63. 2011
    ..Our data suggest that both APA and adjacent ZG present characteristics of stem/precursor cells; the reexpression of genes involved in fetal adrenal development could underlie excessive ZG cell proliferation and APA formation...
  6. doi request reprint Genetics of mineralocorticoid excess: an update for clinicians
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, 56 rue Leblanc, 75015 Paris, France
    Eur J Endocrinol 169:R15-25. 2013
    ..Finally, we outline the cardiovascular, renal, and metabolic consequences of mineralocorticoid excess beyond blood pressure regulation...
  7. doi request reprint Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations
    Brigitte Escoubet
    Assistance Publique Hopitaux de Paris, Hopital Bichat Claude Bernard, Paris, France
    Circ Cardiovasc Genet 6:381-90. 2013
    ..We aimed to assess the cardiovascular outcomes in adults carrying NR3C2 mutations...
  8. pmc Mineralocorticoid receptor mutations and a severe recessive pseudohypoaldosteronism type 1
    Edwige Ludiwyne Hubert
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 22:1997-2003. 2011
    ..This might prove relevant for patient's care in neonatal salt losing disorders and may affect renal salt handling and blood pressure in the general population...
  9. doi request reprint Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Scientifique 970, Paris Cardiovascular Research Center, Paris, France
    Hypertension 59:592-8. 2012
    ..KCNJ5 mutation carriers are more likely to be females; younger age and higher aldosterone levels at diagnosis suggest that KCNJ5 mutations may be associated with a more florid phenotype of primary aldosteronism...
  10. doi request reprint Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1
    Fabio L Fernandes-Rosa
    Department of Puericulture and Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040 900, Brazil
    J Clin Endocrinol Metab 96:E519-27. 2011
    ..Type 1 pseudohypoaldosteronism (PHA1), a primary form of mineralocorticoid resistance, is due to inactivating mutations of the NR3C2 gene, coding for the mineralocorticoid receptor (MR)...
  11. ncbi request reprint Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism
    Paola Sartorato
    Institut National de la Sante et de la Recherche Medicale, Unité 478, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Clin Endocrinol Metab 88:2508-17. 2003
    ..Their absence in some families underscores the importance of an extensive investigation of the hMR gene and the role of precise diagnostic procedures to allow for identification of other genes potentially involved in the disease...
  12. ncbi request reprint Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma
    Fábio Luiz Fernandes-Rosa
    From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France F L F R, S B, L A, T M, X J, M C Z University Paris Descartes, Sorbonne Paris Cité, Paris, France F L F R, S B, L A, T M, X J, M C Z Service de Génétique F L F R, X J, M C Z, Unité Hypertension artérielle L A, and Service d Anatomie Pathologique T M, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France Divisions of Internal Medicine and Hypertension, Department of Medical Sciences T A W, S M, P M and Endocrinology, Diabetes, and Metabolism, Department of Medical Sciences M M, University of Torino, Torino, Italy Medizinische Klinik und Poliklinik IV
    Hypertension 64:354-61. 2014
    ..Young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options. ..
  13. ncbi request reprint Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification
    Laurent Pascual Le Tallec
    Institut National de la Sante et de la Recherche Medicale, U478, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Mol Endocrinol 17:2529-42. 2003
    ..Taken together, our results identify a novel function for PIAS1 which interacts with the N-terminal domain of hMR and represses its ligand-dependent transcriptional activity, at least in part, through SUMO modifications...
  14. ncbi request reprint Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism
    Lucie Pujo
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Genetics, Paris, France
    Hum Mutat 28:33-40. 2007
    ..The other patients without MR mutations might have different diseases resembling to PHA1 in the neonatal period, which could be identified by extensive clinical and functional exploration...
  15. pmc Increased arterial stiffness in systemic lupus erythematosus (SLE) patients at low risk for cardiovascular disease: a cross-sectional controlled study
    Karim Sacre
    Departement de Medecine Interne, Hopital Bichat, Universite Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Paris, France INSERM U1149, Paris, France Département Hospitalo Universitaire FIRE Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases, Paris, France
    PLoS ONE 9:e94511. 2014
    ..In conclusion, arterial stiffness is increased in SLE patients despite a low risk for CVD according to Framingham score and is associated with systolic blood pressure and glucocorticoid therapy. ..
  16. doi request reprint Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism
    Sheerazed Boulkroun
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Hypertension 56:885-92. 2010
    ..Transcriptional phenotyping is not in favor of this being an intermediate step toward the formation of aldosterone-producing adenoma...
  17. ncbi request reprint Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin
    Say Viengchareun
    INSERM U478, Institut Fédératif de Recherche Claude Bernard, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    FEBS Lett 532:345-50. 2002
    ....
  18. ncbi request reprint Mineralocorticoid resistance
    Maria Christina Zennaro
    Institut National de la Sante et de la Recherche Medicale, Unité 478, Faculte de Medecine, Xavier Bichat, B P 416, 16 rue H Huchard, 75870 Paris 18, France
    Trends Endocrinol Metab 15:264-70. 2004
    ..Precise clinical diagnosis and establishment of intermediate phenotypes should be helpful for identifying other genes involved in PHA1 and gaining new insight into the regulation of sodium homeostasis...