Maria Christina Zennaro
Zennaro M, Caprio M, Feve B. Mineralocorticoid receptors in the metabolic syndrome. Trends Endocrinol Metab. 2009;20:444-51 pubmed publisher
Koyama R, Mannic T, Ito J, Amar L, Zennaro M, Rossier M, et al
. MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes. Int J Mol Sci. 2018;19: pubmed publisher
El Zein R, Boulkroun S, Fernandes Rosa F, Zennaro M. Molecular genetics of Conn adenomas in the era of exome analysis. Presse Med. 2018;47:e151-e158 pubmed publisher
Zennaro M, Boulkroun S, Fernandes Rosa F. An update on novel mechanisms of primary aldosteronism. J Endocrinol. 2015;224:R63-77 pubmed publisher
..We also address some of the foreseeable consequences that genetic knowledge may contribute to improve diagnosis and patient care. ..
Zennaro M, Boulkroun S, Fernandes Rosa F. Inherited forms of mineralocorticoid hypertension. Best Pract Res Clin Endocrinol Metab. 2015;29:633-45 pubmed publisher
..In this review we describe the different forms of inherited mineralocorticoid hypertension, providing an overview of their clinical and biochemical features, their underlying genetic defects and specific therapeutic options. ..
Zennaro M, Jeunemaitre X. SFE/SFHTA/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism. Ann Endocrinol (Paris). 2016;77:214-9 pubmed publisher
..In rare cases, PA may be associated with complex neurologic disorder involving epileptic seizures and cerebral palsy (Primary Aldosteronism, Seizures, and Neurologic Abnormalities [PASNA]) due to de novo germline CACNA1D mutations. ..
Daniil G, Fernandes Rosa F, Chemin J, Blesneac I, Beltrand J, Polak M, et al
. CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism. EBioMedicine. 2016;13:225-236 pubmed publisher
Fernandes Rosa F, Daniil G, Orozco I, GÃ¶ppner C, El Zein R, Jain V, et al
. A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet. 2018;50:355-361 pubmed publisher
..Our data indicate that CLCN2 mutations cause primary aldosteronism. They highlight the important role of chloride in aldosterone biosynthesis and identify ClC-2 as the foremost chloride conductor of resting glomerulosa cells. ..
Zennaro M, Hubert E, Fernandes Rosa F. Aldosterone resistance: structural and functional considerations and new perspectives. Mol Cell Endocrinol. 2012;350:206-15 pubmed publisher
..We will also discuss genotype-phenotype correlations and new clinical and genetic entities that may prove relevant for patient's care in neonates with renal salt losing syndromes and/or failure to thrive. ..