Maria Christina Zennaro

Summary

Country: France

Publications

  1. Zennaro M, Caprio M, Feve B. Mineralocorticoid receptors in the metabolic syndrome. Trends Endocrinol Metab. 2009;20:444-51 pubmed publisher
  2. Koyama R, Mannic T, Ito J, Amar L, Zennaro M, Rossier M, et al. MicroRNA-204 Is Necessary for Aldosterone-Stimulated T-Type Calcium Channel Expression in Cardiomyocytes. Int J Mol Sci. 2018;19: pubmed publisher
  3. El Zein R, Boulkroun S, Fernandes Rosa F, Zennaro M. Molecular genetics of Conn adenomas in the era of exome analysis. Presse Med. 2018;47:e151-e158 pubmed publisher
  4. Zennaro M, Boulkroun S, Fernandes Rosa F. An update on novel mechanisms of primary aldosteronism. J Endocrinol. 2015;224:R63-77 pubmed publisher
    ..We also address some of the foreseeable consequences that genetic knowledge may contribute to improve diagnosis and patient care. ..
  5. Zennaro M, Boulkroun S, Fernandes Rosa F. Inherited forms of mineralocorticoid hypertension. Best Pract Res Clin Endocrinol Metab. 2015;29:633-45 pubmed publisher
    ..In this review we describe the different forms of inherited mineralocorticoid hypertension, providing an overview of their clinical and biochemical features, their underlying genetic defects and specific therapeutic options. ..
  6. Zennaro M, Jeunemaitre X. SFE/SFHTA/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism. Ann Endocrinol (Paris). 2016;77:214-9 pubmed publisher
    ..In rare cases, PA may be associated with complex neurologic disorder involving epileptic seizures and cerebral palsy (Primary Aldosteronism, Seizures, and Neurologic Abnormalities [PASNA]) due to de novo germline CACNA1D mutations. ..
  7. Daniil G, Fernandes Rosa F, Chemin J, Blesneac I, Beltrand J, Polak M, et al. CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism. EBioMedicine. 2016;13:225-236 pubmed publisher
  8. Fernandes Rosa F, Daniil G, Orozco I, Göppner C, El Zein R, Jain V, et al. A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet. 2018;50:355-361 pubmed publisher
    ..Our data indicate that CLCN2 mutations cause primary aldosteronism. They highlight the important role of chloride in aldosterone biosynthesis and identify ClC-2 as the foremost chloride conductor of resting glomerulosa cells. ..
  9. Zennaro M, Hubert E, Fernandes Rosa F. Aldosterone resistance: structural and functional considerations and new perspectives. Mol Cell Endocrinol. 2012;350:206-15 pubmed publisher
    ..We will also discuss genotype-phenotype correlations and new clinical and genetic entities that may prove relevant for patient's care in neonates with renal salt losing syndromes and/or failure to thrive. ..

More Information

Publications12

  1. Fernandes Rosa F, Williams T, Riester A, Steichen O, Beuschlein F, Boulkroun S, et al. Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension. 2014;64:354-61 pubmed publisher
    ..Young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options. ..
  2. Fernandes Rosa F, Giscos Douriez I, Amar L, Gomez Sanchez C, Meatchi T, Boulkroun S, et al. Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma. Hypertension. 2015;66:1014-22 pubmed publisher
    ..In conclusion, different mutations are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified. ..
  3. Zennaro M, Fernandes Rosa F. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations. J Endocrinol. 2017;234:T93-T106 pubmed publisher
    ..We will also discuss the influence of rare MR variants on blood pressure and salt sensitivity as well as on stress and cognitive functions in the general population. ..