- Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cellsHaluk Yuzugullu
Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, 06800, Ankara, Turkey
Mol Cancer 8:90. 2009..To this aim, we characterized differentiation status of HCC cell lines and compared their expression status of Wnt pathway genes, and explored their activity of canonical Wnt signaling...
- Senescence and immortality in hepatocellular carcinomaMehmet Ozturk
Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey
Cancer Lett 286:103-13. 2009..Oncogene-induced senescence in premalignant lesions and reversible immortality of cancer cells including HCC offer new potentials for tumor prevention and treatment...
- The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneityMine Mumcuoglu
BilGen Genetics and Biotechnology Center, Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
PLoS ONE 5:e11288. 2010..The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation and senescence as a potential cause of heterogeneity...