Thierry Walzer

Summary

Country: France

Publications

  1. ncbi request reprint Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
    Nat Immunol 8:1337-44. 2007
  2. pmc Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:3384-9. 2007
  3. ncbi request reprint Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration
    Thierry Walzer
    Amgen, Seattle, WA 98119, USA
    J Immunol 174:51-9. 2005
  4. ncbi request reprint Natural-killer cells and dendritic cells: "l'union fait la force"
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Marseille, France
    Blood 106:2252-8. 2005
  5. ncbi request reprint Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells
    Charles A Stewart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, and Service d Immunologie, Hopital de Conception, Assistance Publique Hopitaux de Marseille, France
    Eur J Immunol 37:1442-52. 2007
  6. ncbi request reprint Dendritic cell function in mice lacking Plexin C1
    Thierry Walzer
    Amgen Inc, Department of Immune Regulation, 1201 Amgen Court West Seattle, WA 98119, USA
    Int Immunol 17:943-50. 2005
  7. ncbi request reprint Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule
    Laurent Galibert
    Department of Molecular Sciences, Amgen Inc, 1201 Amgen Court, Seattle, WA 98119 3105, USA
    J Biol Chem 280:21955-64. 2005
  8. ncbi request reprint Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils
    Thierry Walzer
    Amgen Inc, Seattle, WA 98119, USA
    Eur J Immunol 35:391-8. 2005
  9. doi request reprint Maturation of mouse NK cells is a 4-stage developmental program
    Laura Chiossone
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 113:5488-96. 2009
  10. doi request reprint Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 38:2076-84. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
    Nat Immunol 8:1337-44. 2007
    ..Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5...
  2. pmc Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:3384-9. 2007
    ..DT injection in these mice leads to a complete and selective NK cell ablation. This model paves a way for the in vivo characterization and preclinical assessment of NK cell biological function...
  3. ncbi request reprint Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration
    Thierry Walzer
    Amgen, Seattle, WA 98119, USA
    J Immunol 174:51-9. 2005
    ..Furthermore, A39R binding to plexin C1 inhibited chemokine-induced migration of DCs in vitro, suggesting that plexins and semaphorins could be involved in the regulation of leukocyte movement...
  4. ncbi request reprint Natural-killer cells and dendritic cells: "l'union fait la force"
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Marseille, France
    Blood 106:2252-8. 2005
    ..Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses...
  5. ncbi request reprint Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells
    Charles A Stewart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, and Service d Immunologie, Hopital de Conception, Assistance Publique Hopitaux de Marseille, France
    Eur J Immunol 37:1442-52. 2007
    ..Instead, it ascribes chronic TCRgammadelta engagement as a means of acquiring NK-like function...
  6. ncbi request reprint Dendritic cell function in mice lacking Plexin C1
    Thierry Walzer
    Amgen Inc, Department of Immune Regulation, 1201 Amgen Court West Seattle, WA 98119, USA
    Int Immunol 17:943-50. 2005
    ..These results suggest a role for Plexin C1 in DC migration or mobility within the LNs...
  7. ncbi request reprint Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule
    Laurent Galibert
    Department of Molecular Sciences, Amgen Inc, 1201 Amgen Court, Seattle, WA 98119 3105, USA
    J Biol Chem 280:21955-64. 2005
    ..We propose that Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system...
  8. ncbi request reprint Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils
    Thierry Walzer
    Amgen Inc, Seattle, WA 98119, USA
    Eur J Immunol 35:391-8. 2005
    ..In contrast, A39R had no effect on direct priming of CD8+ T cells by peptide-pulsed CD8alpha+ DC in vitro. These results suggest that poxviruses may use semaphorin homologs as a means to evade the immune system...
  9. doi request reprint Maturation of mouse NK cells is a 4-stage developmental program
    Laura Chiossone
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 113:5488-96. 2009
    ..This developmental program appears to be associated with a progressive acquisition of NK-cell effector functions...
  10. doi request reprint Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 38:2076-84. 2008
    ..This phenomenon ensures the segregation of NK cells outside of the white pulp and might contribute to the control of immunopathology...
  11. ncbi request reprint Natural killer cell-dendritic cell crosstalk in the initiation of immune responses
    Thierry Walzer
    1INSERM CNRS Univ, Centre d immunologie de Marseille Luminy, Méditerranée, Campus de Luminy, case 90, 13288 Marseille Cedex 09, France
    Expert Opin Biol Ther 5:S49-59. 2005
    ..Finally, we discuss the potential clinical implications of this new field...
  12. ncbi request reprint Differential in vivo persistence of two subsets of memory phenotype CD8 T cells defined by CD44 and CD122 expression levels
    Thierry Walzer
    Immuno Apoptose, Institut National de la Sante et de la Recherche Medicale, Unité 503, Center Européen de Recherche en Virologie et en Immunologie, Lyon, France
    J Immunol 168:2704-11. 2002
    ..These results show that acquisition of enhanced functional characteristics and long-term persistence by memory T cells are independent. This may have important consequences for the design of specific vaccine...
  13. ncbi request reprint Cutting edge: immediate RANTES secretion by resting memory CD8 T cells following antigenic stimulation
    Thierry Walzer
    Institut National de la Sante et de la Recherche Medicale, Unité 503, Centre d Etude et de Recherche en Virologie et Immunologie, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    J Immunol 170:1615-9. 2003
    ..As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-gamma, RANTES secretion is mainly due to the translation of the pre-existing mRNA...
  14. doi request reprint Mouse CD146/MCAM is a marker of natural killer cell maturation
    Nicolas Despoix
    UMR S608, INSERM Université de la Méditerranée, Faculte de Pharmacie, Marseille, France
    Eur J Immunol 38:2855-64. 2008
    ..These findings define CD146 as a marker of mouse NK cell maturation that may be used as an alternative to the combined use of CD27 and CD11b staining to detect final stages of NK cell maturation...
  15. pmc Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor
    Emilie Narni-Mancinelli
    Centre d immunologie de Marseille Luminy, Université de la Méditerranée UM 631, Campus de Luminy case 906, 13288 Marseille, France
    Proc Natl Acad Sci U S A 108:18324-9. 2011
    ..Finally, Nkp46(iCre) mice also represent a unique mouse model of conditional mutagenesis specifically in NKp46(+) cells, paving the way for further developments in the biology of NKp46(+) NK, T, and NKR(+)ROR-γt(+) cells...
  16. doi request reprint Functions of natural killer cells
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
    Nat Immunol 9:503-10. 2008
    ....
  17. pmc Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
    Scott H Robbins
    CIML Centre d Immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy Case 906, Marseille F 13288, France
    Genome Biol 9:R17. 2008
    ....
  18. ncbi request reprint Cutting edge: Priming of NK cells by IL-18
    Julie Chaix
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
    J Immunol 181:1627-31. 2008
    ..This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines...
  19. ncbi request reprint The trafficking of natural killer cells
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 220:169-82. 2007
    ..Here, we describe the tissue localization of NK cells, using NKp46 as an NK cell marker, and review the current knowledge on the mechanisms that govern their trafficking in humans and in mice...
  20. ncbi request reprint Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Curr Opin Immunol 19:365-72. 2007
    ..In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area...
  21. ncbi request reprint No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice
    Thierry Walzer
    Amgen Inc, Seattle, WA 98119, USA
    J Allergy Clin Immunol 115:192-9. 2005
    ..Fms-like tyrosine kinase 3 ligand (FLT3L) is a hematopoietic growth factor that drives the development of multiple subsets of DCs in the lymphoid organs...
  22. doi request reprint Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance
    Sophie Guia
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Sci Signal 4:ra21. 2011
    ..We propose that the confinement of activating receptors at the plasma membrane is pivotal to ensuring the self-tolerance of NK cells...
  23. ncbi request reprint Hyperproliferative response of a monoclonal memory CD8 T cell population is characterized by an increased frequency of clonogenic precursors
    Christophe Arpin
    Immuno Apoptose, Institut National de la Sante et de la Recherche Medicale, Unité 503, Centre d Etudes et de Recherche en Virologie et Immunologie, Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    J Immunol 168:2147-53. 2002
    ..e., lag time and intermitotic interval. Hence, these results suggest that the clonogenic potential of individual cells is imprinted before Ag encounter and that clonogenic precursors are selected or generated following in vivo activation...
  24. ncbi request reprint NK cell development: gas matters
    Thierry Walzer
    Nat Immunol 7:702-4. 2006
  25. ncbi request reprint In vivo impact of CpG1826 oligodeoxynucleotide on CD8 T cell primary responses and survival
    Laurent Beloeil
    Centre d Etude et de Recherche en Virologie et en Immunologie, Unité 503, Institut Fédératif de Recherche 128 BioSciences Lyon Gerland, Lyon, France
    J Immunol 171:2995-3002. 2003
    ..They also suggest that this adjuvant can modulate CD8 T cell responses in a system which is likely to be independent of CD4 T cell help...
  26. ncbi request reprint Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4
    Antoine Marcais
    Institut National de la Sante de la Recherche Medicale, Unité 503, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 177:4451-7. 2006
    ..Overall, these results indicate that the expression of CCL5 is an intrinsic property acquired by memory CD8 T cells that is regulated by environmental factors...
  27. ncbi request reprint Maintenance of CCL5 mRNA stores by post-effector and memory CD8 T cells is dependent on transcription and is coupled to increased mRNA stability
    Antoine Marcais
    INSERM, U503, Lyon, France
    Eur J Immunol 36:2745-54. 2006
    ..Finally, we show that these stores are spontaneously reconstituted when the inhibitory signal is removed, indicating that the transcription of ccl5 is a default feature of memory CD8 T cells imprinted in their genetic program...