Research Topics
Genomes and Genes
| Thierry WalzerSummaryCountry: France Publications
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Detail Information
Publications
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46Thierry Walzer
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
Proc Natl Acad Sci U S A 104:3384-9. 2007..DT injection in these mice leads to a complete and selective NK cell ablation. This model paves a way for the in vivo characterization and preclinical assessment of NK cell biological function...
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptorThierry Walzer
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
Nat Immunol 8:1337-44. 2007..Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5...- Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migrationThierry Walzer
Amgen, Seattle, WA 98119, USA
J Immunol 174:51-9. 2005..Furthermore, A39R binding to plexin C1 inhibited chemokine-induced migration of DCs in vitro, suggesting that plexins and semaphorins could be involved in the regulation of leukocyte movement... - Natural-killer cells and dendritic cells: "l'union fait la force"Thierry Walzer
Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Marseille, France
Blood 106:2252-8. 2005..Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses... - Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cellsCharles A Stewart
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, and Service d Immunologie, Hopital de Conception, Assistance Publique Hopitaux de Marseille, France
Eur J Immunol 37:1442-52. 2007..Instead, it ascribes chronic TCRgammadelta engagement as a means of acquiring NK-like function... - Dendritic cell function in mice lacking Plexin C1Thierry Walzer
Amgen Inc, Department of Immune Regulation, 1201 Amgen Court West Seattle, WA 98119, USA
Int Immunol 17:943-50. 2005..These results suggest a role for Plexin C1 in DC migration or mobility within the LNs... 
Maturation of mouse NK cells is a 4-stage developmental programLaura Chiossone
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Blood 113:5488-96. 2009..This developmental program appears to be associated with a progressive acquisition of NK-cell effector functions...- Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophilsThierry Walzer
Amgen Inc, Seattle, WA 98119, USA
Eur J Immunol 35:391-8. 2005..In contrast, A39R had no effect on direct priming of CD8+ T cells by peptide-pulsed CD8alpha+ DC in vitro. These results suggest that poxviruses may use semaphorin homologs as a means to evade the immune system... - Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated moleculeLaurent Galibert
Department of Molecular Sciences, Amgen Inc, 1201 Amgen Court, Seattle, WA 98119 3105, USA
J Biol Chem 280:21955-64. 2005..We propose that Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system... - Natural killer cell-dendritic cell crosstalk in the initiation of immune responsesThierry Walzer
1INSERM-CNRS-Univ, Centre d'Immunologie de Marseille-Luminy, , Campus de Luminy, case 90, 13288 Marseille Cedex 09, France
Expert Opin Biol Ther 5:S49-59. 2005..Finally, we discuss the potential clinical implications of this new field... - Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptorEmilie Narni-Mancinelli
Centre d immunologie de Marseille Luminy, Université de la Méditerranée UM 631, Campus de Luminy case 906, 13288 Marseille, France
Proc Natl Acad Sci U S A 108:18324-9. 2011..Finally, Nkp46(iCre) mice also represent a unique mouse model of conditional mutagenesis specifically in NKp46(+) cells, paving the way for further developments in the biology of NKp46(+) NK, T, and NKR(+)ROR-γt(+) cells... - Functions of natural killer cellsEric Vivier
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
Nat Immunol 9:503-10. 2008.... - Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammationClaude Gregoire
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Eur J Immunol 38:2076-84. 2008..This phenomenon ensures the segregation of NK cells outside of the white pulp and might contribute to the control of immunopathology... - Mouse CD146/MCAM is a marker of natural killer cell maturationNicolas Despoix
UMR S608, INSERM Université de la Méditerranée, Faculte de Pharmacie, Marseille, France
Eur J Immunol 38:2855-64. 2008..These findings define CD146 as a marker of mouse NK cell maturation that may be used as an alternative to the combined use of CD27 and CD11b staining to detect final stages of NK cell maturation... - Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profilingScott H Robbins
CIML Centre d Immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy Case 906, Marseille F 13288, France
Genome Biol 9:R17. 2008.... - Cutting edge: Priming of NK cells by IL-18Julie Chaix
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
J Immunol 181:1627-31. 2008..This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines... - The trafficking of natural killer cellsClaude Gregoire
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
Immunol Rev 220:169-82. 2007..Here, we describe the tissue localization of NK cells, using NKp46 as an NK cell marker, and review the current knowledge on the mechanisms that govern their trafficking in humans and in mice... - Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analysesThierry Walzer
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
Curr Opin Immunol 19:365-72. 2007..In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area... - Confinement of activating receptors at the plasma membrane controls natural killer cell toleranceSophie Guia
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Campus de Luminy, Marseille, France
Sci Signal 4:ra21. 2011..We propose that the confinement of activating receptors at the plasma membrane is pivotal to ensuring the self-tolerance of NK cells... - No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient miceThierry Walzer
Amgen Inc, Seattle, WA 98119, USA
J Allergy Clin Immunol 115:192-9. 2005..Fms-like tyrosine kinase 3 ligand (FLT3L) is a hematopoietic growth factor that drives the development of multiple subsets of DCs in the lymphoid organs... - In vivo impact of CpG1826 oligodeoxynucleotide on CD8 T cell primary responses and survivalLaurent Beloeil
Centre d'Etude et de Recherche en Virologie et en Immunologie, , , Lyon, France
J Immunol 171:2995-3002. 2003..They also suggest that this adjuvant can modulate CD8 T cell responses in a system which is likely to be independent of CD4 T cell help... - Cutting edge: immediate RANTES secretion by resting memory CD8 T cells following antigenic stimulationThierry Walzer
, , Centre d'Etude et de Recherche en Virologie et Immunologie, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
J Immunol 170:1615-9. 2003..As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-gamma, RANTES secretion is mainly due to the translation of the pre-existing mRNA... - Differential in vivo persistence of two subsets of memory phenotype CD8 T cells defined by CD44 and CD122 expression levelsThierry Walzer
Immuno-Apoptose, , , , Lyon, France
J Immunol 168:2704-11. 2002..These results show that acquisition of enhanced functional characteristics and long-term persistence by memory T cells are independent. This may have important consequences for the design of specific vaccine... - NK cell development: gas mattersThierry Walzer
Nat Immunol 7:702-4. 2006 - Maintenance of CCL5 mRNA stores by post-effector and memory CD8 T cells is dependent on transcription and is coupled to increased mRNA stabilityAntoine Marcais
INSERM, U503, Lyon, France
Eur J Immunol 36:2745-54. 2006..Finally, we show that these stores are spontaneously reconstituted when the inhibitory signal is removed, indicating that the transcription of ccl5 is a default feature of memory CD8 T cells imprinted in their genetic program... - Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4Antoine Marcais
Institut National de la Sante de la Recherche Medicale, Unité 503, 21 Avenue Tony Garnier, Lyon, France
J Immunol 177:4451-7. 2006..Overall, these results indicate that the expression of CCL5 is an intrinsic property acquired by memory CD8 T cells that is regulated by environmental factors... - Hyperproliferative response of a monoclonal memory CD8 T cell population is characterized by an increased frequency of clonogenic precursorsChristophe Arpin
Immuno-Apoptose, , , Centre d'Etudes et de Recherche en Virologie et Immunologie, Avenue Tony Garnier, 69365 Lyon Cedex 07, France
J Immunol 168:2147-53. 2002..e., lag time and intermitotic interval. Hence, these results suggest that the clonogenic potential of individual cells is imprinted before Ag encounter and that clonogenic precursors are selected or generated following in vivo activation...