Karim Wahbi

Summary

Country: France

Publications

  1. ncbi request reprint Brugada syndrome and abnormal splicing of SCN5A in myotonic dystrophy type 1
    Karim Wahbi
    Service de cardiologie, Universite Paris Descartes, Hopital Cochin, AP HP, 27, rue du Faubourg Saint Jacques, 75014 Paris, France Institut de Myologie, Universite Pierre et Marie Curie, Hopital Pitie Salpetriere, AP HP, 75013 Paris, France Electronic address
    Arch Cardiovasc Dis 106:635-43. 2013
  2. doi request reprint Electrophysiological study with prophylactic pacing and survival in adults with myotonic dystrophy and conduction system disease
    Karim Wahbi
    Pierre et Marie Curie Paris 6 University, Myology Institute, Pitie Salpetriere Hospital, 75013 Paris, France
    JAMA 307:1292-301. 2012
  3. ncbi request reprint Cardiac assessment of limb-girdle muscular dystrophy 2I patients: an echography, Holter ECG and magnetic resonance imaging study
    Karim Wahbi
    Myology Institute, Pitie Salpetriere Hospital, APHP, Paris, France
    Neuromuscul Disord 18:650-5. 2008
  4. ncbi request reprint Left ventricular non-compaction in a patient with myotonic dystrophy type 2
    Karim Wahbi
    Department of Cardiology, Cochin Hospital, Assistance Publique Hopitaux de Paris, Rene Descartes University, 27 rue du Fg St Jacques, 75014 Paris, France
    Neuromuscul Disord 18:331-3. 2008
  5. doi request reprint Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2 myotonic dystrophy: a case control study
    Karim Wahbi
    Myology Institute, Pitie Salpetriere Hospital, APHP, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Neuromuscul Disord 19:468-72. 2009
  6. doi request reprint Influence of age and renal function on high-sensitivity cardiac troponin T diagnostic accuracy for the diagnosis of acute myocardial infarction
    Camille Chenevier-Gobeaux
    Clinical Chemistry Laboratory, Groupe Hospitalier Cochin Broca Hôtel Dieu, Universite Paris Descartes, Assistance publique des Hôpitaux de Paris APHP, Paris, France
    Am J Cardiol 111:1701-7. 2013
  7. doi request reprint High cardiovascular morbidity and mortality in myofibrillar myopathies due to DES gene mutations: a 10-year longitudinal study
    Karim Wahbi
    Institut de Myologie, Hopital Pitie Salpetriere, APHP, Paris, France
    Neuromuscul Disord 22:211-8. 2012
  8. doi request reprint Blood glutathione decrease in subjects carrying lamin A/C gene mutations is an early marker of cardiac involvement
    Christophe Meune
    Universite Paris Descartes, AP HP, Departement de Cardiologie, Groupe Hospitalier Cochin, F 75014, France
    Neuromuscul Disord 22:252-7. 2012
  9. doi request reprint High risk of severe cardiac adverse events in patients with mitochondrial m.3243A>G mutation
    Edoardo Malfatti
    AP HP, Pitie Salpetriere Hospital, Reference Center for Muscle Diseases Paris Est, Myology Institute, Paris, France
    Neurology 80:100-5. 2013
  10. ncbi request reprint Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up
    Denis Duboc
    Department of Cardiology, Cochin Hospital, APHP, Paris V René Descartes University, Paris, France
    Am Heart J 154:596-602. 2007

Detail Information

Publications21

  1. ncbi request reprint Brugada syndrome and abnormal splicing of SCN5A in myotonic dystrophy type 1
    Karim Wahbi
    Service de cardiologie, Universite Paris Descartes, Hopital Cochin, AP HP, 27, rue du Faubourg Saint Jacques, 75014 Paris, France Institut de Myologie, Universite Pierre et Marie Curie, Hopital Pitie Salpetriere, AP HP, 75013 Paris, France Electronic address
    Arch Cardiovasc Dis 106:635-43. 2013
    ..In patients with myotonic dystrophy type 1 (DM1), the mechanisms underlying sudden cardiac death, which occurs in up to 1/3 of patients, are unclear...
  2. doi request reprint Electrophysiological study with prophylactic pacing and survival in adults with myotonic dystrophy and conduction system disease
    Karim Wahbi
    Pierre et Marie Curie Paris 6 University, Myology Institute, Pitie Salpetriere Hospital, 75013 Paris, France
    JAMA 307:1292-301. 2012
    ..Up to one-third of patients with myotonic dystrophy type 1 die suddenly. Thus far, no intervention has effectively prevented sudden death...
  3. ncbi request reprint Cardiac assessment of limb-girdle muscular dystrophy 2I patients: an echography, Holter ECG and magnetic resonance imaging study
    Karim Wahbi
    Myology Institute, Pitie Salpetriere Hospital, APHP, Paris, France
    Neuromuscul Disord 18:650-5. 2008
    ..Reduced contractility and cardiac magnetic resonance imaging morphological abnormalities are highly prevalent in LGMD2I patients suggesting that all patients should be referred for cardiac evaluation...
  4. ncbi request reprint Left ventricular non-compaction in a patient with myotonic dystrophy type 2
    Karim Wahbi
    Department of Cardiology, Cochin Hospital, Assistance Publique Hopitaux de Paris, Rene Descartes University, 27 rue du Fg St Jacques, 75014 Paris, France
    Neuromuscul Disord 18:331-3. 2008
    ..Left ventricular non-compaction diagnosis is often overlooked. Neurological examination should be performed in all patients with left ventricular non-compaction...
  5. doi request reprint Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2 myotonic dystrophy: a case control study
    Karim Wahbi
    Myology Institute, Pitie Salpetriere Hospital, APHP, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Neuromuscul Disord 19:468-72. 2009
    ..Our study suggests that systematic cardiac investigations should be recommended in these patients...
  6. doi request reprint Influence of age and renal function on high-sensitivity cardiac troponin T diagnostic accuracy for the diagnosis of acute myocardial infarction
    Camille Chenevier-Gobeaux
    Clinical Chemistry Laboratory, Groupe Hospitalier Cochin Broca Hôtel Dieu, Universite Paris Descartes, Assistance publique des Hôpitaux de Paris APHP, Paris, France
    Am J Cardiol 111:1701-7. 2013
    ..2 [1.2-3.9], p = 0.007). In conclusion, adapted thresholds of HScTnT are required for an accurate diagnosis of AMI/NSTEMI in patients aged ≥70 and in those with low eGFR...
  7. doi request reprint High cardiovascular morbidity and mortality in myofibrillar myopathies due to DES gene mutations: a 10-year longitudinal study
    Karim Wahbi
    Institut de Myologie, Hopital Pitie Salpetriere, APHP, Paris, France
    Neuromuscul Disord 22:211-8. 2012
    ..Our study underscores that in DES patients in-depth cardiac investigations are needed to prevent cardiac conduction system disease...
  8. doi request reprint Blood glutathione decrease in subjects carrying lamin A/C gene mutations is an early marker of cardiac involvement
    Christophe Meune
    Universite Paris Descartes, AP HP, Departement de Cardiologie, Groupe Hospitalier Cochin, F 75014, France
    Neuromuscul Disord 22:252-7. 2012
    ..90 [0.76-1.04]; p=0.01). Blood glutathione decrease may allow the detection of reduced contractility in muscular dystrophic LMNA-mutated patients with still preserved LVEF...
  9. doi request reprint High risk of severe cardiac adverse events in patients with mitochondrial m.3243A>G mutation
    Edoardo Malfatti
    AP HP, Pitie Salpetriere Hospital, Reference Center for Muscle Diseases Paris Est, Myology Institute, Paris, France
    Neurology 80:100-5. 2013
    ..To determine the long-term incidence of cardiac life-threatening complications and death in patients with the m.3243A>G mutation, and to identify cardiac prognostic factors...
  10. ncbi request reprint Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up
    Denis Duboc
    Department of Cardiology, Cochin Hospital, APHP, Paris V René Descartes University, Paris, France
    Am Heart J 154:596-602. 2007
    ....
  11. doi request reprint Mid-regional pro atrial natriuretic peptide allows the accurate identification of patients with atrial fibrillation of short time of onset: a pilot study
    Christophe Meune
    Universite Paris Descartes, Departement de Cardiologie, Groupe Hospitalier Cochin Broca Hôtel Dieu, Assistance Publique des Hopitaux de Paris, 27 rue du Fbg St Jacques, 75679 Paris Cedex 14, France
    Clin Biochem 44:1315-9. 2011
    ..A delay of AF onset >48 h is believed to be clinically significant. Mid-regional pro A-type natriuretic peptide (MR-proANP) could be of interest in the identification of the time from onset of AF to presentation...
  12. ncbi request reprint Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: A controlled study of 100 consecutive patients
    Christophe Meune
    Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:1803-9. 2008
    ..To assess the prevalence of primary cardiac complications in a large population of patients with systemic sclerosis (SSc), using recently developed echocardiographic techniques...
  13. doi request reprint N-terminal Pro brain natriuretic peptide is a reliable biomarker of reduced myocardial contractility in patients with lamin A/C gene mutations
    Christophe Meune
    Universite Paris Descartes, Departement de Cardiologie, Hopital Cochin, AP HP, Paris, France
    Int J Cardiol 151:160-3. 2011
    ..We examined the ability of the N-terminal brain natriuretic peptide (NT-proBNP) to detect LV or right ventricular (RV) dysfunction in patients with lamin A/C (LMNA) gene mutations...
  14. doi request reprint Performance of glycogen phosphorylase isoenzyme BB is weak in the detection of patients with non-ST-elevation acute coronary syndrome
    Christophe Meune
    Cardiology Department, Universite Paris Descartes, Groupe Hospitalier Cochin Broca Hôtel Dieu, APHP, Paris, France
    Clin Biochem 44:1343-5. 2011
    ..To examine the diagnostic performance of glycogen-phosphorylase-isoenzyme-BB (GPBB) combined with cardiac troponin I (cTnI) in acute coronary syndrome (ACS)...
  15. doi request reprint Neutral lipid storage disease with myopathy: a whole-body nuclear MRI and metabolic study
    Pascal Laforet
    AP HP, Centre de Référence de Pathologie Neuromusculaire Paris Est, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Mol Genet Metab 108:125-31. 2013
    ..Two patients had elevated triglycerides and low cholesterol-HDL. Based on these analyses, regular control of cardiometabolic risks appear mandatory in the clinical follow-up of these subjects...
  16. doi request reprint Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations
    Christophe Meune
    Paris Descartes University and Department of Rheumatology A, Cochin Hospital, AP HP, Paris, France
    Arthritis Rheum 63:2790-6. 2011
    ..To develop a score to estimate the risk of developing pulmonary hypertension (PH) in patients with systemic sclerosis (SSc)...
  17. ncbi request reprint Myocardial dysfunction in rheumatoid arthritis: a controlled tissue-Doppler echocardiography study
    Christophe Meune
    Department of Cardiology, Paris Descartes University, Medical School, Cochin Hospital, Paris, France
    J Rheumatol 34:2005-9. 2007
    ..To determine the sensitivity and accuracy of tissue-Doppler echocardiography (TDE) to assess myocardial contractility. Heart failure is one of the determinants of the excess in mortality in patients with rheumatoid arthritis (RA)...
  18. ncbi request reprint Meta-analysis of Renin-Angiotensin-aldosterone blockade for heart failure in presence of preserved left ventricular function
    Christophe Meune
    Cardiology Department, Cochin Hospital, APHP, Universite Paris Descartes, Paris, France
    J Cardiovasc Pharmacol Ther 16:368-75. 2011
    ..To overcome this limitation, we performed a meta-analysis of the randomized trials of ACE inhibitors or ARB in patients with HF and preserved LVEF...
  19. ncbi request reprint Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors
    Christophe Meune
    Department of Cardiology, Cochin Hospital, Paris, France
    Eur J Heart Fail 9:197-201. 2007
    ..By inhibiting prostaglandins, aspirin may be deleterious in heart failure (HF) and/or may counteract angiotensin-converting enzyme (ACE) inhibitor efficacy. Conversely, clopidogrel has no effect on prostaglandin metabolism...
  20. doi request reprint Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: a pilot study
    Christophe Meune
    Cardiology Department, Hopital Cochin, AP HP, Universite Paris Descartes, Paris Cedex 14, France
    Arch Cardiovasc Dis 104:4-10. 2011
    ..High-sensitivity cardiac troponin assays have improved the detection of acute coronary syndrome...
  21. ncbi request reprint A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis
    Pascal Laforet
    Institut de Myologie, Batiment Babinski, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Neuromuscul Disord 16:178-82. 2006
    ..Considering those results, PRKAG2 gene could be a potential candidate for unexplained muscle glycogenosis associated with cardiac abnormalities...