David H Volle


Country: France


  1. Baptissart M, Sèdes L, Holota H, Thirouard L, Martinot E, De Haze A, et al. Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways. Sci Rep. 2018;8:16875 pubmed publisher
    ..Tgr5 knock-out mice combined with in vitro strategies defined the critical role of paternal Tgr5 dependent pathways in the multigenerational impacts of ancestral CA exposure. ..
  2. Garcia M, Thirouard L, Sèdes L, Monrose M, Holota H, Caira F, et al. Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases. Int J Mol Sci. 2018;19: pubmed publisher
  3. Sèdes L, Desdoits Lethimonier C, Rouaisnel B, Holota H, Thirouard L, Lesné L, et al. Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders. Stem Cell Reports. 2018;11:944-958 pubmed publisher
    ..BPA and S act additively in human testis. Our data demonstrate that FXRα activity modulates the impact of BPA on male gonads and on undifferentiated germ cell population. ..
  4. Oumeddour A, Viennois E, Caira F, Decourbey C, Maqdasy S, Tahraoui A, et al. Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochem Biophys Res Commun. 2014;446:656-62 pubmed publisher
    ..Altogether, our study shows that both nuclear receptors Lxr? and Lxr? are not only basally important for testicular physiology but could also have a preventive effect against estrogen-like endocrine disruptors. ..
  5. Volle D. Nuclear receptors as pharmacological targets, where are we now?. Cell Mol Life Sci. 2016;73:3777-80 pubmed publisher
    ..The produced molecules could have either autocrine, paracrine stimulations, or even act on distant organs (endocrine signaling). ..
  6. Volle D, Decourteix M, Garo E, McNeilly J, Fenichel P, Auwerx J, et al. The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. J Clin Invest. 2009;119:3752-64 pubmed publisher
    ..Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis...
  7. Vega A, Baptissart M, Martinot E, Saru J, Baron S, Schoonjans K, et al. Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP. Expert Opin Ther Targets. 2014;18:1367-76 pubmed publisher
    ..In conclusion, we demonstrate that neonatal DES exposure alters adult hepatic physiology in an SHP-dependent manner. ..
  8. Martinot E, Sèdes L, Baptissart M, Lobaccaro J, Caira F, Beaudoin C, et al. Bile acids and their receptors. Mol Aspects Med. 2017;56:2-9 pubmed publisher
  9. Martinot E, Sèdes L, Baptissart M, Holota H, Rouaisnel B, Damon Soubeyrand C, et al. The Bile Acid Nuclear Receptor FXR? Is a Critical Regulator of Mouse Germ Cell Fate. Stem Cell Reports. 2017;9:315-328 pubmed publisher
    ..FXR? regulates the expression of several pluripotency factors. Among these, in vitro approaches show that FXR? controls the expression of the pluripotency marker Lin28 in the germ cells. ..

More Information


  1. Sèdes L, Martinot E, Baptissart M, Baron S, Caira F, Beaudoin C, et al. Bile acids and male fertility: From mouse to human?. Mol Aspects Med. 2017;56:101-109 pubmed publisher
    ..The studies on mouse models open perspectives to better understand the deleterious effects of bile acids on testicular pathophysiologies and fertility disorders. Additional studies are needed to corroborate these correlations in humans. ..