E Vivier

Summary

Country: France

Publications

  1. ncbi request reprint Early signaling via inhibitory and activating NK receptors
    M BlEry
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    Hum Immunol 61:51-64. 2000
  2. doi request reprint Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
  3. ncbi request reprint Cutting edge: Priming of NK cells by IL-18
    Julie Chaix
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
    J Immunol 181:1627-31. 2008
  4. ncbi request reprint Natural killer cells and malaria
    Sophie Roetynck
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 214:251-63. 2006
  5. ncbi request reprint KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
    Elena Tomasello
    Laboratory of NK cells and Innate Immunity, Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Marseille, France
    Eur J Immunol 35:1670-7. 2005
  6. pmc Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)
    Xavier Saulquin
    Centre d Immunologie INSERM CNRS, de Marseille Luminy, Case 906, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    J Exp Med 197:933-8. 2003
  7. pmc Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein
    Laura Chiossone
    Centre d immunologie de Marseille Luminy, INSERM, U 1104 Marseille, France
    Front Immunol 3:239. 2012
  8. doi request reprint Targeting natural killer cells and natural killer T cells in cancer
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite d Aix Marseille, Marseille, France
    Nat Rev Immunol 12:239-52. 2012
  9. pmc Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
    Scott H Robbins
    CIML Centre d Immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy Case 906, Marseille F 13288, France
    Genome Biol 9:R17. 2008
  10. ncbi request reprint Natural killer cell signaling pathways
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Science 306:1517-9. 2004

Detail Information

Publications93

  1. ncbi request reprint Early signaling via inhibitory and activating NK receptors
    M BlEry
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    Hum Immunol 61:51-64. 2000
    ..The second part of the review describes the known NK cell activating receptors. Most of them require association with ITAM-containing polypeptides in order to mediate cell activation...
  2. doi request reprint Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  3. ncbi request reprint Cutting edge: Priming of NK cells by IL-18
    Julie Chaix
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
    J Immunol 181:1627-31. 2008
    ..This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines...
  4. ncbi request reprint Natural killer cells and malaria
    Sophie Roetynck
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 214:251-63. 2006
    ..However, the in vivo functions of NK cells during malaria are still enigmatic, and many issues remain to be dissected, such as the molecular basis of the direct recognition of iRBCs by NK cells...
  5. ncbi request reprint KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
    Elena Tomasello
    Laboratory of NK cells and Innate Immunity, Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Marseille, France
    Eur J Immunol 35:1670-7. 2005
    ..Finally, bone remodeling and brain function are also dependent upon the integrity of KARAP/DAP12 signals, as shown by the analysis of KARAP/DAP12-deficient mice and KARAP/DAP12-deficient Nasu-Hakola patients...
  6. pmc Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)
    Xavier Saulquin
    Centre d Immunologie INSERM CNRS, de Marseille Luminy, Case 906, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    J Exp Med 197:933-8. 2003
    ..Therefore, the mode of recognition used by KIR largely differs from the conformational changes that characterize T cell receptor or NKG2D interaction with their respective ligands...
  7. pmc Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein
    Laura Chiossone
    Centre d immunologie de Marseille Luminy, INSERM, U 1104 Marseille, France
    Front Immunol 3:239. 2012
    ..These data suggest that IL-18BP is beneficial in an animal model of HLH and in combination with anti-infectious therapy may be a promising strategy to treat HLH patients...
  8. doi request reprint Targeting natural killer cells and natural killer T cells in cancer
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite d Aix Marseille, Marseille, France
    Nat Rev Immunol 12:239-52. 2012
    ..The rational use of these cells in cancer immunotherapies awaits a better understanding of their effector functions, migratory patterns and survival properties in humans...
  9. pmc Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
    Scott H Robbins
    CIML Centre d Immunologie de Marseille Luminy, Universite de la Mediterranee, Parc Scientifique de Luminy Case 906, Marseille F 13288, France
    Genome Biol 9:R17. 2008
    ....
  10. ncbi request reprint Natural killer cell signaling pathways
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Science 306:1517-9. 2004
    ..Understanding the integration of these multiple signals is central to the understanding and manipulation of NK cell effector signaling pathways...
  11. ncbi request reprint Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Nat Rev Immunol 4:190-8. 2004
  12. ncbi request reprint Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?
    Eric Vivier
    Centre d immunologie de Marseille Luminy, CNRS INSERM Université de la Méditerrannée, Parc Scientifique de Luminy, Case 906, 13288, Cedex 09, Marseille, France
    Curr Opin Immunol 14:306-11. 2002
    ....
  13. doi request reprint Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille 13288, France
    Cell Host Microbe 6:493-5. 2009
    ..Remarkably, this immunosuppressive activity only occurs during systemic infections...
  14. pmc Innate or adaptive immunity? The example of natural killer cells
    Eric Vivier
    Centre d Immunologie de Marseille Luminy CIML, Université de la Méditerranée UM 631, Campus de Luminy, 13288 Marseille, France
    Science 331:44-9. 2011
    ..NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response...
  15. ncbi request reprint Innate and adaptive immunity: specificities and signaling hierarchies revisited
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Nat Immunol 6:17-21. 2005
    ..Indeed, the level of specificity and mode of signaling integration used by the main cellular participants in the adaptive and innate immune systems are more similar than previously appreciated...
  16. doi request reprint Functions of natural killer cells
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
    Nat Immunol 9:503-10. 2008
    ....
  17. ncbi request reprint Good news, bad news for missing-self recognition by NK cells: autoimmune control but viral evasion
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille 13288, France
    Immunity 26:549-51. 2007
    ..2007) and Lu et al. (2007) extend the understanding of the consequences of missing-self recognition in immune evasion and immune cell regulation via NKRP-1 and CD94-NKG2A inhibitory receptors, respectively...
  18. ncbi request reprint Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Curr Opin Immunol 19:365-72. 2007
    ..In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area...
  19. ncbi request reprint What is natural in natural killer cells?
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Immunol Lett 107:1-7. 2006
    ..Therefore, the NK denomination does not reflect a genuine property of these lymphocytes that appear to more and more resemble T and B lymphocytes...
  20. ncbi request reprint Immunology. A pathogen receptor on natural killer cells
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Université Méditerranée, Marseille, France
    Science 296:1248-9. 2002
  21. ncbi request reprint Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells
    Charles A Stewart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, and Service d Immunologie, Hopital de Conception, Assistance Publique Hopitaux de Marseille, France
    Eur J Immunol 37:1442-52. 2007
    ..Instead, it ascribes chronic TCRgammadelta engagement as a means of acquiring NK-like function...
  22. ncbi request reprint Association of signal-regulatory proteins beta with KARAP/DAP-12
    E Tomasello
    Centre d Immunologie INSERM CNRS de Marseille Luminy CIML, Marseille, France
    Eur J Immunol 30:2147-56. 2000
    ....
  23. ncbi request reprint Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12
    E Tomasello
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Case 906, 13288 Marseille Cedex 09, France
    J Biol Chem 273:34115-9. 1998
    ....
  24. ncbi request reprint Outside-in signaling pathway linked to CD146 engagement in human endothelial cells
    F Anfosso
    INSERM EMI 00 19 Physiopathologie de l Endothélium, UFR Pharmacie, Universite de la Mediterranee, 13385 Marseille, France
    J Biol Chem 276:1564-9. 2001
    ..In addition to its role in cell-cell adhesion, CD146 is a signaling molecule involved in the dynamics of actin cytoskeleton rearrangement...
  25. ncbi request reprint Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells
    S Ugolini
    Centre d'Immunologie INSERM/CNRS de Marseille-Luminy, Case 906, 13288 Marseille, France
    Nat Immunol 2:430-5. 2001
    ..These results unveil an MHC class I-dependent pathway that promotes the survival of a subset of memory-phenotype CD8+ T cells and also reveal an unexpected biological function for inhibitory NKRs on T cells...
  26. ncbi request reprint Strategies of natural killer cell recognition and signaling
    C A Stewart
    Lab of NK Cells and Innate Immunity, Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, 13288 Marseille, France
    Curr Top Microbiol Immunol 298:1-21. 2006
    ..Recent approaches offer ways to unravel how the integration of complex signaling networks directs the NK response...
  27. pmc Multiplicity and plasticity of natural killer cell signaling pathways
    Sabrina Chiesa
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Marseille Cedex 09, France
    Blood 107:2364-72. 2006
    ....
  28. ncbi request reprint Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells
    Nicolas Anfossi
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale INSERM Centre National de la Recherche Scientifique CNRS Université de la Méditerranée, Marseille, France
    J Immunol 173:7223-9. 2004
    ....
  29. ncbi request reprint Natural killer cell-dendritic cell crosstalk in the initiation of immune responses
    Thierry Walzer
    1INSERM CNRS Univ, Centre d immunologie de Marseille Luminy, Méditerranée, Campus de Luminy, case 90, 13288 Marseille Cedex 09, France
    Expert Opin Biol Ther 5:S49-59. 2005
    ..Finally, we discuss the potential clinical implications of this new field...
  30. ncbi request reprint Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
    Pascale Andre
    Innate Pharma SA, Marseille, France
    Eur J Immunol 34:961-71. 2004
    ..These data thus show that target recognition via NKG2D or NCR triggers all aspects of NK activation, and pave the way for further dissection of the signaling pathways induced by NK cell recognition of ULBP-1 and MICA...
  31. pmc Natural killer cells promote early CD8 T cell responses against cytomegalovirus
    Scott H Robbins
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    PLoS Pathog 3:e123. 2007
    ..Thus, the extent to which NK cell responses benefit the host goes beyond their direct antiviral effects and extends to the prevention of innate cytokine shock and to the promotion of adaptive immunity...
  32. ncbi request reprint Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules
    Nicolas Anfossi
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale INSERM Centre National de la Recherche Scientifique CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
    J Immunol 173:3773-82. 2004
    ..They further suggest that the size of the Ly49+CD8+ T cell subset marks a history of CD8+ T cell activation that might preferentially result from endogenous inducers of inflammation rather than from microbial infections...
  33. ncbi request reprint Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice
    Mathias Lucas
    Centre d immunologie de Marseille Luminy, CNRS Inserm Université de la Méditerranée, Campus de Luminy, France
    Eur J Immunol 32:2653-63. 2002
    ....
  34. ncbi request reprint Biology of T memory type 1 cells
    N Anfossi
    Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Univ. Med, Marseille, France
    Immunol Rev 181:269-78. 2001
    ..Thus, sensing of self-MHC class I molecules by inhibitory NKR displayed on alphabeta T cells leads to the in vivo accumulation of Tm1 cells...
  35. pmc Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin
    P Andre
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Case 906, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 97:3400-5. 2000
    ..These results indicate that NK cell differentiation is accompanied by the acquisition of a unique carbohydrate, PEN5, that can serve as part of a combination code to deliver KIR(+) NK cells to specific tissues...
  36. doi request reprint Maturation of mouse NK cells is a 4-stage developmental program
    Laura Chiossone
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 113:5488-96. 2009
    ..This developmental program appears to be associated with a progressive acquisition of NK-cell effector functions...
  37. pmc Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum
    Myriam Baratin
    Centre d immunologie de Marseille Luminy, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Université delaMéditerranée, 13288 Marseille, France
    Proc Natl Acad Sci U S A 102:14747-52. 2005
    ..However, IL-18R expression on NK cells, IL-18 production by macrophages, and MyD88 on both cell types are essential components of this previously undescribed pathway of NK cell activation in response to a parasite infection...
  38. ncbi request reprint How to extinguish lymphocyte activation, immunotyrosine-based inhibition motif (ITIM)-bearing molecules a solution?
    M BlEry
    Centre d immunologie de Marseille Luminy, Marseille, France
    Clin Chem Lab Med 37:187-91. 1999
    ..These molecules are able to recruit phosphatases on their phosphorylated ITIM and thus mediate a localized inhibition of the transduction pathways. The molecular basis of this inhibitory pathway is discussed below...
  39. pmc Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:3384-9. 2007
    ..DT injection in these mice leads to a complete and selective NK cell ablation. This model paves a way for the in vivo characterization and preclinical assessment of NK cell biological function...
  40. ncbi request reprint Natural-killer cells and dendritic cells: "l'union fait la force"
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Marseille, France
    Blood 106:2252-8. 2005
    ..Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses...
  41. pmc Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors
    C Andrew Stewart
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université Méditerranée, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 102:13224-9. 2005
    ..We discuss how our results for KIR2DS1 and parallel studies on KIR2DS2 relate to the association between activating KIR genes and susceptibility to autoimmune disorders...
  42. doi request reprint Mouse CD146/MCAM is a marker of natural killer cell maturation
    Nicolas Despoix
    UMR S608, INSERM Université de la Méditerranée, Faculte de Pharmacie, Marseille, France
    Eur J Immunol 38:2855-64. 2008
    ..These findings define CD146 as a marker of mouse NK cell maturation that may be used as an alternative to the combined use of CD27 and CD11b staining to detect final stages of NK cell maturation...
  43. doi request reprint Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells
    Celine Cognet
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
    Clin Immunol 135:26-32. 2010
    ..As KIR2DS1 has been associated with autoimmunity and hematopoietic stem cell transplantation, these results pave the way to dissect the function of KIR2DS1 in these clinical conditions...
  44. ncbi request reprint Comparative analysis of NK cell subset distribution in normal and lymphoproliferative disease of granular lymphocyte conditions
    Veronique Pascal
    Centre d Immunologie Marseille Luminy, INSERM CNRS Université Méditerranée, Marseille, France
    Eur J Immunol 34:2930-40. 2004
    ....
  45. pmc Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    Francois Romagne
    Innate Pharma SA, Marseille, France
    Blood 114:2667-77. 2009
    ....
  46. ncbi request reprint Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, and Centre National de la Recherche Scientifique, UMR6102, Marseille, France
    Nat Immunol 8:1337-44. 2007
    ..Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5...
  47. pmc Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells
    Myriam Baratin
    Aix Marseille Universite, Faculte des Sciences de Luminy, Centre d Immunologie de Marseille Luminy CIML, Marseille, France
    PLoS ONE 2:e228. 2007
    ..PfEMP1 is expressed on parasitized-erythrocytes and participates to vascular obstruction through the binding to several host receptors. PfEMP1 is also a pivotal target for host antibody response to Pf infection...
  48. doi request reprint A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo
    Sophie Guia
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 111:5008-16. 2008
    ....
  49. doi request reprint Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies
    Karine Crozat
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 227:129-49. 2009
    ....
  50. ncbi request reprint Contrasting roles of DAP10 and KARAP/DAP12 signaling adaptors in activation of the RBL-2H3 leukemic mast cell line
    Nicolas Anfossi
    Centre d immunologie de Marseille Luminy, CNRS Inserm Université de la Méditerranée, Marseille, France
    Eur J Immunol 33:3514-22. 2003
    ..Therefore, we report here a cellular model in which the association of a cell surface receptor with various signaling adaptors dictates the co-stimulatory or the direct stimulatory properties of the complex...
  51. ncbi request reprint Distribution of killer-cell immunoglobulin-like receptor (KIR) in Comoros and Southeast France
    C Frassati
    Pôle Polymorphisme Génétique Humain, EFS Alpes Méditerranée, Marseille, France
    Tissue Antigens 67:356-67. 2006
    ..As KIR gene content is heterogeneous among ethnic groups, it can probably be used to assess the genetic relationships among populations from different geographic areas...
  52. ncbi request reprint [NK cells and innate immunity to malaria]
    Sophie Roetynck
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Med Sci (Paris) 22:739-44. 2006
    ..However, the molecular basis of Pf-E recognition by NK cells as well as the functional role of NK cell responses during the course of the disease remain to be adressed...
  53. doi request reprint Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, INSERM, U631, France
    Nat Rev Immunol 9:229-34. 2009
    ....
  54. ncbi request reprint Coordination of activating and inhibitory signals in natural killer cells
    Sabrina Chiesa
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Mol Immunol 42:477-84. 2005
    ..Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated...
  55. pmc Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor
    A Cambiaggi
    Centre d Immunologie Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique de Marseille Luminy, Case 906, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 94:8088-92. 1997
    ....
  56. pmc The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
    M BlEry
    Centre d Immunologie Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique de Marseille Luminy, Case 906, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 95:2446-51. 1998
    ..Tyrosine-phosphorylated ITIMs allow PIR-B to associate with SHP-1 but not with SHIP. Engagement of PIR-B thereby initiates a SHP-1-dependent inhibitory pathway that may play an important role in regulating B lymphocyte activation...
  57. ncbi request reprint The trafficking of natural killer cells
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 220:169-82. 2007
    ..Here, we describe the tissue localization of NK cells, using NKp46 as an NK cell marker, and review the current knowledge on the mechanisms that govern their trafficking in humans and in mice...
  58. doi request reprint Expression of the CD85j (leukocyte Ig-like receptor 1, Ig-like transcript 2) receptor for class I major histocompatibility complex molecules in idiopathic inflammatory myopathies
    Nicolas Schleinitz
    Department of Internal Medicine, CHU La Conception, Marseille, France
    Arthritis Rheum 58:3216-23. 2008
    ..The muscle lesions are characterized by leukocyte infiltration. We undertook this study to analyze the expression in muscle lesions of various class I MHC-specific receptors on leukocytes and natural killer (NK) cells...
  59. doi request reprint Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 38:2076-84. 2008
    ..This phenomenon ensures the segregation of NK cells outside of the white pulp and might contribute to the control of immunopathology...
  60. doi request reprint Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future
    Marc Daëron
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Immunol Rev 224:11-43. 2008
    ....
  61. ncbi request reprint Syk regulation of phosphoinositide 3-kinase-dependent NK cell function
    Kun Jiang
    Immunology Program, H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Immunol 168:3155-64. 2002
    ..Our results are the first report documenting the instrumental role of Syk in control of PI3K-dependent natural cytotoxicity...
  62. ncbi request reprint TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
    ..Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3...
  63. pmc Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
    Cheng Lung Ku
    Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    J Exp Med 204:2407-22. 2007
    ..Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria...
  64. doi request reprint Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways
    Jerome D Coudert
    Ludwig Institute for Cancer Research, Lausanne Branch and University of Lausanne, Switzerland
    Blood 111:3571-8. 2008
    ..The reversible suppression of the NK cells' cytolytic function probably reduces the NK cells' efficacy to control endogenous and exogenous stress yet may be needed to limit tissue damage...
  65. ncbi request reprint Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
    Francesco Colucci
    Laboratory for Cytokines and Lymphoid Development, The Pasteur Institute, Paris, France
    Nat Immunol 3:288-94. 2002
    ..This suggests that distinct and redundant signaling pathways act synergistically to trigger natural cytotoxicity...
  66. pmc Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus
    Pascal Trempat
    Department of Pathology and Inserm U563, Centre de Physiopathologie de Toulouse, Purpan, France
    J Virol 76:11139-42. 2002
    ..Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection...
  67. ncbi request reprint Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    Jerome D Coudert
    Ludwig Institute for Cancer Research, Lausanne Branch, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 106:1711-7. 2005
    ..Thus, the chronic exposure to tumor cells expressing NKG2D ligand alters NKG2D signaling and may facilitate the evasion of tumor cells from NK cell reactions...
  68. ncbi request reprint Expression of MHC class I receptors confers functional intraclonal heterogeneity to a reactive expansion of gammadelta T cells
    Xavier Lafarge
    CNRS UMR 5164, CIRID, IFR66, Universite Bordeaux 2, Bordeaux, France
    Eur J Immunol 35:1896-905. 2005
    ..In conclusion, heterogeneity of MHC-NKR expression confers a functional intraclonal diversity that may participate to induction of specific gammadelta T cell effector functions or proliferation upon pathogen challenge...
  69. ncbi request reprint The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells
    Tony Avril
    Division of Cell Biology and Immunology, The Wellcome Trust Biocentre, University of Dundee, Dundee, United Kingdom
    J Immunol 173:6841-9. 2004
    ..Finally, mutation of the membrane-proximal motif increased the sialic acid binding activity of Siglecs-7 and -9, raising the possibility that "inside-out" signaling may occur to regulate ligand binding...
  70. ncbi request reprint Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways
    Linda Oberg
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Eur J Immunol 34:1646-53. 2004
    ..However, activation of the effector or the target enhanced rejection and shifted the balance between different signaling pathways involved...
  71. ncbi request reprint IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules
    Magali Terme
    ERM0208 Institut National de la Sante et de la Recherche Medicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
    J Immunol 172:5957-66. 2004
    ..These data outline a novel role for Th2 cytokines in the regulation of innate immune responses through triggering receptors expressed on myeloid cells...
  72. pmc Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation
    Geraldine Ferjoux
    Institut National de la Santé et de la Recherche Médicale U531, IFR31, CHU Rangueil, 31403 Toulouse, France
    Mol Biol Cell 14:3911-28. 2003
    ..All these data suggest that Src acts upstream of SHP-2 in sst2 signaling and provide evidence for a functional role for Src and SHP-2 downstream of an inhibitory G protein-coupled receptor...
  73. pmc Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells
    Melissa R Snyder
    Department of Medicine Rheumatology and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 197:437-49. 2003
    ..Our data suggest that CD158j in T cells functions as a costimulatory molecule through the JNK pathway independent of KARAP/DAP12 and DAP10. Costimulation by CD158j may contribute to the autoreactivity of CD4(+)CD28(null) T cells in RA...
  74. ncbi request reprint Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 35:3111-8. 2005
    ..Increased resistance to experimental encephalomyelitis is observed in DAP12 knockin mice, which is dependent on IDO expression. Therefore, DAP12-related receptors act as negative regulators of IDO-mediated tolerance in vivo...
  75. pmc CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    Francois Ghiringhelli
    ERM 0208, Institut National de la Sante et de la Recherche Medicale INSERM, University of Paris XI, France
    J Exp Med 202:1075-85. 2005
    ..Human NK cell-mediated tumor recognition could also be restored by depletion of T reg cells from tumor-infiltrating lymphocytes. These findings support a role for T reg cells in blunting the NK cell arm of the innate immune system...
  76. ncbi request reprint A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
    ..In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response...
  77. pmc Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
    Karine Crozat
    The Scripps Research Institute TSRI, La Jolla, CA 92037, USA
    J Exp Med 204:853-63. 2007
    ..In contrast, neither Listeria monocytogenes nor MCMV induces the syndrome. In mice, the HLH phenotype is conditional, which suggests the existence of a specific infectious trigger of FHL3 in humans...
  78. ncbi request reprint Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
    Shlomo Nedvetzki
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3776-85. 2007
    ....
  79. pmc Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection
    Hanna Sjölin
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Exp Med 195:825-34. 2002
    ..Our results are discussed in relation to recent reports demonstrating that innate resistance to MCMV requires the presence of NK cells expressing the KARAP/DAP12-associated receptor Ly49H...
  80. ncbi request reprint Dendritic cells (DC) promote natural killer (NK) cell functions: dynamics of the human DC/NK cell cross talk
    Nadine C Fernandez
    Unite d immunologie, Departement de Biologie Clinique, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Eur Cytokine Netw 13:17-27. 2002
    ..While IL-12, IL-15 and IL-18 are not critical, a direct cell-to-cell contact is mandatory for NK activation by DC and required for optimal proliferation. These data imply that DC also modulate human NK cell innate effector functions...
  81. ncbi request reprint DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections
    Anthony R French
    Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:4981-90. 2006
    ..The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate...
  82. ncbi request reprint DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection
    Hanna Sjölin
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 177:2908-16. 2006
    ..The potential implications of the regulation of pDC functions by DAP12 for promoting health over disease are discussed...
  83. ncbi request reprint Human NK cell education by inhibitory receptors for MHC class I
    Nicolas Anfossi
    Innate Pharma, 13009 Marseille, France
    Immunity 25:331-42. 2006
    ..These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent "missing self" recognition...
  84. ncbi request reprint NK cell development: gas matters
    Thierry Walzer
    Nat Immunol 7:702-4. 2006
  85. ncbi request reprint Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    Andreas Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Nat Immunol 3:1142-9. 2002
    ..This strategy suggests a rationale for the multisubunit structure of stimulatory immunoreceptors...
  86. ncbi request reprint CD antigens 2002
    David Mason
    Blood 99:3877-80. 2002
  87. ncbi request reprint Natural killer cell receptor signaling pathway
    Frederic Vely
    INSERM U608, 13005 Marseille, France
    Sci STKE 2005:cm6. 2005
    ..Understanding the integration of these signals into the "canonical" PTK-PTP equilibrium represents the future challenge for the elucidation of NK cell effector signaling pathways...
  88. ncbi request reprint Natural killer cell receptor signaling pathway in mammals
    Frederic Vely
    INSERM U608, 13005 Marseille, France
    Sci STKE 2005:cm7. 2005
    ..We focus here on how recognition events are integrated to trigger distinct and graded effector functions...
  89. pmc Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages
    Serge Nataf
    INSERM U433, Faculte Laennec, Lyon, France
    Am J Pathol 166:275-86. 2005
    ..Our results confirm that KARAP/DAP12-mediated signals play an important role in the regulation of both brain and bone homeostasis. Yet, important differences exist between the symptoms observed in Nasu-Hakola patients and KDelta75 mice...
  90. ncbi request reprint Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes
    Celine Eidenschenk
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM Unité 550, Faculte de Medecine Necker, 156 rue de Vaugirard, 75015 Paris, France, European Union EU
    J Immunol 177:8835-43. 2006
    ..Impaired cytokine-mediated lymphocyte survival is likely to be the pathogenic mechanism underlying this novel form of inherited and selective NK deficiency in humans...
  91. ncbi request reprint Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C
    Paula Bonorino
    Institut National de la Santé et de la Recherche Médicale Unité 548, Departement Reponse et Dynamique Cellulaires, Commissariat a l Energie Atomique, Universite Joseph Fourier, Grenoble, France
    Hepatology 46:1375-86. 2007
    ..Both NKG2A and KIRs could inhibit the response of HCV-specific CD8(+) T cells ex vivo...