Research Topics
| Francesco VisioliSummaryCountry: France Publications
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Publications
Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patientsFrancesco Visioli
Dept. of Pharmacological Sciences, University of Milan, Milan, Italy
Eur J Nutr 44:121-7. 2005..CONCLUSIONS: EVOO consumption by mildly dyslipidemic patients is associated with favorable changes in circulating markers of cardiovascular condition. Based on current knowledge, these effects may be associated with cardioprotection...
Flavonoid characterization and in vitro antioxidant activity of Aconitum anthora L. (Ranunculaceae)Cristina Mariani
Dipartimento di Biologia, Universita di Milano, Via Celoria 26, 20133 Milano, Italy
Phytochemistry 69:1220-6. 2008..anthora. The antioxidant activity of the four identified flavonoids was screened by three in vitro tests...- Assessment of nutritional profiles: a novel system based on a comprehensive approachFrancesco Visioli
Laboratory of Micronutrients and Cardiovascular Disease, UMR7079, Universite Pierre et Marie Curie Paris 6, Bat A, 5 étage, 7 quai Saint Bernard, 75005 Paris, France
Br J Nutr 98:1101-7. 2007..Moreover, this approach allows for rapid modification and great flexibility to suit individual needs and gastronomic habits... - Nutritional strategies for healthy cardiovascular aging: focus on micronutrientsFrancesco Visioli
UMR 7079, Universite Paris 6 Pierre et Marie Curie, 7 quai Saint Bernard, Batiment A, 5eme etage, 75005 Paris, France
Pharmacol Res 55:199-206. 2007..In this article we review the known effects of micronutrients on the aging heart and we propose strategies for dietary improvements... - Chocolate, lifestyle, and healthFrancesco Visioli
Laboratory of Micronutrients and Cardiovascular Disease, UR7079, Universite Pierre et Marie Curie, Paris, France
Crit Rev Food Sci Nutr 49:299-312. 2009.... - Docosahexaenoic acid down-regulates endothelial Nox 4 through a sPLA2 signalling pathwayDoriane Richard
Laboratory of Micronutrients and Cardiovascular Disease, Universite Pierre et Marie Curie, Paris 6, France
Biochem Biophys Res Commun 389:516-22. 2009..Further, the use of specific inhibitors allowed demonstrating that group V sPLA(2) is involved in the down-regulation of Nox 4 expression and activity by DHA. This interplay is mediated by ERK and PKC... - Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approachAntonin Lamaziere
Laboratory of Mass Spectrometry APLIPID, ER7 UPMC, Paris, France
Prostaglandins Leukot Essent Fatty Acids 84:7-11. 2011..These data might in part explain the mixed therapeutic results obtained in neurological disorders, many of which are likely region-specific... - Polyunsaturated fatty acids and cardiovascular diseaseDoriane Richard
Laboratory of Micronutrients and Cardiovascular Disease, Universite Pierre et Marie Curie, Paris, France
Cell Mol Life Sci 66:3277-88. 2009..This article reviews the most up-to-date evidence of the association between PUFA consumption and reduced cardiovascular mortality... - Weight and plasma lipid control by decaffeinated green teaDoriane Richard
Laboratory of Micronutrients and Cardiovascular Disease, UR4, UPMC Univ 06, Paris, France
Pharmacol Res 59:351-4. 2009..In conclusion, administration of decaffeinated green tea might contribute to weight control and provides an opportunity for through-the-day consumption, without the excitatory effects of caffeine... - Olive phenolics increase glutathione levels in healthy volunteersFrancesco Visioli
UPMC Univ Paris 06, Paris, France
J Agric Food Chem 57:1793-6. 2009..Future studies on groups of individuals who may benefit from an increase in their glutathione levels, for example, the elderly, will further elucidate the biological activities of this formulation... - Polyunsaturated fatty acids as antioxidantsDoriane Richard
Laboratory of Micronutrients and Cardiovascular Disease, UMR7079, UPMC Univ 06, Paris, France
Pharmacol Res 57:451-5. 2008.... - Evolution of minor polar compounds and antioxidant capacity during storage of bottled extra virgin olive oilAnnalisa Romani
Department of Pharmaceutical Science, University of Florence, Sesto Fiorentino, Florence, Italy
J Agric Food Chem 55:1315-20. 2007..The tests on the stable free radical DPPH* confirmed the results on human LDL. We propose this as an additional parameter to evaluate olive oil quality and stability over time... - Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oilPaola Bogani
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Atherosclerosis 190:181-6. 2007..These data reinforce the notion that the Mediterranean diet reduces the incidence of coronary heart disease partially due to the protective role of its phenolic components, including those of extra virgin olive oil... - Wild artichoke prevents the age-associated loss of vasomotor functionGiuseppe Rossoni
Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
J Agric Food Chem 53:10291-6. 2005.... - Hypochlorous acid scavenging properties of local Mediterranean plant foodsSebastian Schaffer
Institute of Pharmacology (ZAFES, Biocenter Niederursel, University of Frankfurt, Frankfurt am Main, Germany
Lipids 39:1239-47. 2004..pulegioides. In synthesis, our study shows that local Mediterranean plant foods prevent HOCl toxicity in vitro and, thus, suggests further mechanisms responsible for the reported health-beneficial effect of the Mediterranean diet... - Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acidTory M Hagen
Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Ann N Y Acad Sci 959:491-507. 2002..Thus, ALCAR along with lipoic acid may be effective supplemental regimens to maintain myocardial function... - Biological properties of olive oil phytochemicalsFrancesco Visioli
University of Milan, Department of Pharmacological Sciences, Italy
Crit Rev Food Sci Nutr 42:209-21. 2002.... - n-3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive ratsLaura Raimondi
Dept of Pharmacology, University of Florence, Florence, Italy
Eur J Nutr 44:327-33. 2005..We hypothesised that ADMA reduction might be a part of EPA and DHA beneficial effects on the cardiovascular system... - Mediterranean diet as a nutrition education and dietary guide: misconceptions and the neglected role of locally consumed foods and wild green plantsYannis Manios
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Forum Nutr 59:154-70. 2006.... - The roller coaster of antioxidant therapyFrancesco Visioli
University of Milan, Department of Pharmacological Sciences, Italy
Curr Med Chem 11:3 p. preceeding 1085. 2004 - Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicalsMaria Annunziata Carluccio
C.N.R. Institute of Clinical Physiology, Lecce, Italy
Arterioscler Thromb Vasc Biol 23:622-9. 2003..CONCLUSIONS: Olive oil and red wine antioxidant polyphenols at nutritionally relevant concentrations transcriptionally inhibit endothelial adhesion molecule expression, thus partially explaining atheroprotection from Mediterranean diets... - Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activitySimona De Marino
Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, I 80131 Napoli, Ita
Molecules 13:1219-29. 2008..In vitro antioxidant activities were assessed by DPPH, total antioxidant capacity and lipid peroxidation assays. Flavan-3-ols derivatives (as major phenolic compounds in the latex) exhibited the highest antioxidant activity... - Phenolic glycosides from Foeniculum vulgare fruit and evaluation of antioxidative activitySimona De Marino
Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, I 80131 Naples, Italy
Phytochemistry 68:1805-12. 2007..Their structures were elucidated by spectral methods including 1D, 2D NMR and MS and chemical methods. Antioxidant activity was tested using three methods: DPPH(), total antioxidant capacity and assay of lipid peroxidation... - Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivoSebastian Schaffer
Institute of Pharmacology ZAFES, Biocenter Niederursel, University of Frankfurt, 60438 Frankfurt am Main, Germany
J Agric Food Chem 55:5043-9. 2007..In synthesis, the ex vivo data provide the first evidence of neuroprotective effects of oral hydroxytyrosol intake. Keywords: Hydroxytyrosol; olive mill wastewater; dissociated brain cells; oxidative stress; brain; Mediterranean diet... - Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetateMonica Deiana
Dipartimento di Biologia Sperimentale, Sezione di Patologia Sperimentale, Universita degli Studi di Cagliari, Cittadella Universitaria SS 554, 09042 Monserrato, Cagliari, Italy
Food Chem Toxicol 45:2434-40. 2007..In summary, MPC administration protects organs against lipid peroxidation and conserves the endogenous alpha-tocopherol... - Thiol supplementation inhibits metalloproteinase activity independent of glutathione statusPaola Bogani
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Biochem Biophys Res Commun 363:651-5. 2007..Although all thiols, these compounds have different properties and different cellular uptakes and metabolic characteristics, and this could explain, at least in part, their differential effects on MMPs... - Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesisMarika Massaro
Laboratory for Thrombosis and Vascular Research, C.N.R. Institute of Clinical Physiology, Pisa, Italy
Thromb Haemost 88:335-44. 2002..These results indicate that oleate may exert direct vascular atheroprotective effects by inhibiting endothelial activation through a quenching of stimuli-induced increase in ROS... - Antioxidants in the Mediterranean diets: An updatePaola Bogani
Institute of Pharmacological Sciences, University of Milan, Milan, Italy
World Rev Nutr Diet 97:162-79. 2007 - A multicenter, randomized, double-blind, placebo-controlled trial of long-term ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL): the study protocol [EudraCT no.: 2006-000032-27]Davide Pareyson
Department of Biochemistry and Genetics, C Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
Pharmacol Res 54:436-41. 2006..In consenting patients from three centers, skin biopsy is performed to evaluate PMP22 expression. The study will last 34 months, starting from March 2006... - Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with ageAnthony R Smith
Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Arch Biochem Biophys 454:100-5. 2006..These results suggest that age-dependent loss of NO may be partly caused by differences in eNOS subcellular distribution and its association with inhibitory proteins... - Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acidAnthony R Smith
Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
FASEB J 16:1102-4. 2002..Vitamin C supplementation should be considered when using cultured cells, especially when experimental endpoints are related to cellular redox status and eNOS activity... - The water-soluble vitamin E analogue Trolox protects against ischaemia/reperfusion damage in vitro and ex vivo. A comparison with vitamin EVadim F Sagach
A. A. Bogomolets Institute of Physiology, Kiev, Ukraine
Pharmacol Res 45:435-9. 2002..These differential effects are likely due to the scavenging, by Trolox, of reactive oxygen species generated in the water phase... - Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione statusFrancesco Visioli
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
Redox Rep 7:223-7. 2002..Thus, vitamin C and lipoic acid potentiate endothelial NO synthesis and bioactivity by mechanisms that appear to be independent of cellular GSH levels and redox environment... - Antioxidant activity of galloyl quinic derivatives isolated from P. lentiscus leavesMaria Camilla Baratto
Dipartimento di Chimica, , Via Aldo Moro, 1-53100 Siena, Italy
Free Radic Res 37:405-12. 2003..All the tested metabolites strongly reduced the oxidation of low-density lipoproteins (LDL), following a trend similar to that observed for the scavenger ability against OH radical... - Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acidsFrancesco Visioli
University of Milan, Department of Pharmacological Sciences, 20133 Milan, Italy
Lipids 38:415-8. 2003.... - Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administrationFrancesco Visioli
Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
J Nutr 133:2612-5. 2003..These data suggest that the rat is not the appropriate model for the study of HT metabolism and that HT-containing functional foods should be carefully formulated... - Protective activity of tomato products on in vivo markers of lipid oxidationFrancesco Visioli
Department of Pharmacological Science, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
Eur J Nutr 42:201-6. 2003..It has been suggested that regular consumption of tomato products improves antioxidant defenses due to their endogenous antioxidant compounds, notably lycopene... - Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patientsDeodato Assanelli
Institute of Internal Medicine, University of Brescia, Brescia, Italy
Pharmacol Res 49:79-84. 2004..Confirming previous reports, the effects of Vitamin E are still equivocal... - Vasomodulating potential of mediterranean wild plant extractsSimona Grande
Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Agric Food Chem 52:5021-6. 2004.... - Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protectionMarisa Porrini
Department of Food Science and Technology, Division of Human Nutrition, University of Milan, Milan, Italy
Br J Nutr 93:93-9. 2005..0001) in lymphocytes subjected to oxidative stress. In conclusion, the present study supports the fact that a low intake of carotenoids from tomato products improves cell antioxidant protection... - Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stressPatrizia Riso
Department of Food Science and Technology and Microbiology, Division of Human Nutrition, University of Milan, 21033 Milan, Italy
J Agric Food Chem 53:941-7. 2005.... - Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal womenSimonetta Salvini
Molecular and Nutritional Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologica CSPO, Scientific Institute of Tuscany, Florence, Italy
Br J Nutr 95:742-51. 2006..Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol... - The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformationGiulia Corona
Molecular Nutrition Group, School of Food Biosciences, University of Reading, UK
Free Radic Res 40:647-58. 2006..Our study provides additional information regarding the breakdown of complex olive oil polyphenols in the GI tract, in particular the stomach and the large intestine... - Local food and cardioprotection: the role of phytochemicalsFrancesco Visioli
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Forum Nutr 59:116-29. 2006..In synthesis, the data uniformly demonstrate that phytochemical components of the Mediterranean diet exert cardioprotective effects whose mechanisms are being progressively elucidated... - Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2AAnthony R Smith
Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Aging Cell 5:391-400. 2006..Taken together, these results suggest a novel mechanism that at least partly explains the persistent loss of eNOS activity and endothelial-derived NO availability in aging conduit arteries... - Antioxidant and other biological activities of phenols from olives and olive oilFrancesco Visioli
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Med Res Rev 22:65-75. 2002....