Bruno Vincent

Summary

Country: France

Publications

  1. ncbi request reprint Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochem Biophys Res Commun 271:82-5. 2000
  2. ncbi request reprint Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Eur J Neurosci 14:256-66. 2001
  3. ncbi request reprint p53-Dependent transcriptional control of cellular prion by presenilins
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 29:6752-60. 2009
  4. ncbi request reprint Regulation of betaAPP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560 Valbonne, France
    Curr Alzheimer Res 5:202-11. 2008
  5. ncbi request reprint ADAM proteases: protective role in Alzheimer's and prion diseases?
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, 06560 Valbonne, France
    Curr Alzheimer Res 1:165-74. 2004
  6. ncbi request reprint Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease
    Cristine Alves da Costa
    Institute of Molecular and Cellular Pharmacology, Coeducational Unit of Research 6097, National Center of Scientific Research Nice Sophia Antipolis University, 06560 Valbonne, France
    J Neurosci 26:6377-85. 2006
  7. ncbi request reprint Isoform-specific contribution of protein kinase C to prion processing
    Moustapha Alfa Cissé
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Sophia Antipolis, Valbonne, France
    Mol Cell Neurosci 39:400-10. 2008
  8. ncbi request reprint The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity
    Moustapha Alfa Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, du CNRS, UMR6097, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 280:40624-31. 2005
  9. pmc The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein
    Moustapha Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, Unite Mixte de Recherche, 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 286:29192-206. 2011
  10. ncbi request reprint The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53
    Frederic Checler
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097CNRS UNSA, Valbonne 06560, France
    Curr Alzheimer Res 4:423-6. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochem Biophys Res Commun 271:82-5. 2000
    ..Altogether, our data indicate that astrocytes interfere with estrogen in the regulation of sAPPalpha secretion, probably via secreted factor(s)...
  2. ncbi request reprint Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Eur J Neurosci 14:256-66. 2001
    ..Thus, apoE and astrocytic factor(s) may modulate the pathogenesis of Alzheimer's disease...
  3. ncbi request reprint p53-Dependent transcriptional control of cellular prion by presenilins
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 29:6752-60. 2009
    ..Furthermore, it adds support to previous reports linking secretase activities involved in betaAPP metabolism to the physiology of PrP(c)...
  4. ncbi request reprint Regulation of betaAPP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560 Valbonne, France
    Curr Alzheimer Res 5:202-11. 2008
    ....
  5. ncbi request reprint ADAM proteases: protective role in Alzheimer's and prion diseases?
    Bruno Vincent
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, 06560 Valbonne, France
    Curr Alzheimer Res 1:165-74. 2004
    ....
  6. ncbi request reprint Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease
    Cristine Alves da Costa
    Institute of Molecular and Cellular Pharmacology, Coeducational Unit of Research 6097, National Center of Scientific Research Nice Sophia Antipolis University, 06560 Valbonne, France
    J Neurosci 26:6377-85. 2006
    ..Thus our study shows that AICDs control p53 at a transcriptional level, in vitro and in vivo, and that FAD mutations increase p53 expression and activity in cells and human brains...
  7. ncbi request reprint Isoform-specific contribution of protein kinase C to prion processing
    Moustapha Alfa Cissé
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Sophia Antipolis, Valbonne, France
    Mol Cell Neurosci 39:400-10. 2008
    ....
  8. ncbi request reprint The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity
    Moustapha Alfa Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, du CNRS, UMR6097, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 280:40624-31. 2005
    ..ADAM9 could therefore represent, besides ADAM10, another potential therapeutic target to enhance the breakdown of the 106-126 and Abeta toxic domains of the prion and betaAPP proteins...
  9. pmc The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein
    Moustapha Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, Unite Mixte de Recherche, 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 286:29192-206. 2011
    ..Altogether, our data identify ERK1 as an important regulator of PrP(c) cellular homeostasis and indicate that this kinase exerts a dual control of PrP(c) levels through transcriptional and post-transcriptional mechanisms...
  10. ncbi request reprint The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53
    Frederic Checler
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097CNRS UNSA, Valbonne 06560, France
    Curr Alzheimer Res 4:423-6. 2007
    ..Our studies demonstrate that AICDs control p53 at a transcriptional level, in vitro and in vivo and unravel a still unknown function for presenilins...
  11. ncbi request reprint Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase
    Moustapha Alfa Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097 CNRS UNSA, Equipe labélisée Fondation pour la Recherche Médicale, Valbonne, France
    Biochem Biophys Res Commun 347:254-60. 2006
    ....
  12. ncbi request reprint The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation
    Claire Sunyach
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, université Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 282:1956-63. 2007
    ..Therefore, the nature of the proteolytic cleavage taking place on PrP(c) yielded C-terminal catabolites with distinct function and could be seen as a switch mechanism controlling the function of the PrP(c) in cell survival...
  13. ncbi request reprint Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP
    Raphaelle Pardossi-Piquard
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR6097 CNRS UNSA, Valbonne 06560, France
    Neuron 46:541-54. 2005
    ..The presenilin-dependent regulation of neprilysin, mediated by AICDs, provides a physiological means to modulate Abeta levels with varying levels of gamma-secretase activity...
  14. ncbi request reprint Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels
    Erwan Paitel
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, 06560 Valbonne, France
    J Biol Chem 279:612-8. 2004
    ..This phenotype likely occurs through up-regulation of p53 promoter transactivation as well as downstream by controlling p53 stability via Mdm2 expression...
  15. doi request reprint ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε
    Moustapha Cisse
    Universite de Nice Sophia Antipolis, Institut de Neuro Médecine Moléculaire, Unite Mixte de Recherche, 6097 Centre National de la Recherche Scientifique, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Mol Cell Neurosci 47:223-32. 2011
    ..This opens new potential therapeutic strategies aimed, in the context of Alzheimer's disease, at selectively activating ADAM17 towards βAPP without affecting the cleavages of its numerous other substrates...
  16. ncbi request reprint M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity
    Moustapha Alfa Cissé
    Institut de Pharmacologie Moleculaire et Cellulaire, 06560 Valbonne, France
    J Neurosci 27:4083-92. 2007
    ..Thus, our data provide strong evidence that muscarinic receptor activation increases the physiological processing of PrP(c) by upregulating the phosphorylation state and activity of ADAM17 protease...
  17. ncbi request reprint Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators
    Frederic Checler
    IPMC du CNRS, UMR6097, 660 route des Lucioles, 06560 Valbonne, France
    Trends Neurosci 25:616-20. 2002
    ..It is our opinion that targeting these disintegrins with specific 'activators' could be a suitable strategy to slow down, or even arrest, betaAPP and PrP(c)-related aggregation and toxicity...
  18. ncbi request reprint Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts
    M Armogida
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097 du CNRS, 660 route des Lucioles, 06560 Valbonne, France
    Nat Cell Biol 3:1030-3. 2001
    ....
  19. ncbi request reprint Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease
    Cristine Alves da Costa
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, 660 route des Lucioles, 06560 Valbonne, France
    J Biol Chem 277:50980-4. 2002
    ....
  20. pmc Intraneuronal Abeta42 accumulation in human brain
    G K Gouras
    Laboratory of Molecular and Cellular Neuroscience and Fisher Center for Research on Alzheimer s Disease, The Rockefeller University New York, New York 10021, USA
    Am J Pathol 156:15-20. 2000
    ..This study suggests that intracellular Abeta42 accumulation is an early event in neuronal dysfunction and that preventing intraneuronal Abeta42 aggregation may be an important therapeutic direction for the treatment of AD...