Jean Thomas Vilquin

Summary

Country: France

Publications

  1. ncbi Myoblast transplantation: clinical trials and perspectives. Mini-review
    J T Vilquin
    INSERM U582, Association Institut de Myologie, Universite Pierre et Marie Curie, Paris
    Acta Myol 24:119-27. 2005
  2. ncbi [Cell transplantation in heart failure management]
    Jean Thomas Vilquin
    INSERM U 582, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, Batiment Babinski, 75651 Paris Cedex 13, France
    Med Sci (Paris) 20:651-62. 2004
  3. ncbi Mesenchymal stem cells in bone and cartilage repair: current status
    Jean Thomas Vilquin
    Groupe Hospitalier Pitie Salpetriere, INSERM U582, Association Institut de Myologie, IFR14, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Regen Med 1:589-604. 2006
  4. ncbi Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy
    Albert A Hagege
    Assistance Publique Hopitaux de Paris, Department of Cardiology, Hôpital Européen Georges Pompidou and INSERM EMI 16, Necker Paris V University, Paris, France
    Lancet 361:491-2. 2003
  5. ncbi Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction
    Philippe Menasche
    Assistance Publique Hopitaux de Paris, Department of Cardiovascular Surgery B, Hopital Bichat, Paris, France
    J Am Coll Cardiol 41:1078-83. 2003
  6. pmc Myoblasts and embryonic stem cells differentially engraft in a mouse model of genetic dilated cardiomyopathy
    Cyril Catelain
    UPMC UM 76, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Mol Ther 21:1064-75. 2013
  7. ncbi Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat
    Nawwar Al Attar
    Department of Cardiovascular Surgery and INSERM U 572, Hopital Europeen Georges Pompidou, Paris, France
    Cardiovasc Res 58:142-8. 2003
  8. ncbi Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients
    Albert A Hagege
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Circulation 114:I108-13. 2006
  9. ncbi Characterization of distinct mesenchymal-like cell populations from human skeletal muscle in situ and in vitro
    Séverine Lecourt
    UPMC AIM UMR S 974, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Exp Cell Res 316:2513-26. 2010
  10. ncbi Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium?
    Agnes Maurel
    1 INSERM U633, Laboratoire d Etude des Greffes et Prothèses Cardiaques, Hopital Broussais, Paris, France
    Transplantation 80:660-5. 2005

Collaborators

Detail Information

Publications27

  1. ncbi Myoblast transplantation: clinical trials and perspectives. Mini-review
    J T Vilquin
    INSERM U582, Association Institut de Myologie, Universite Pierre et Marie Curie, Paris
    Acta Myol 24:119-27. 2005
    ..Some solutions are emerging, which recently allowed the set-up of new clinical trials in dedicated indications...
  2. ncbi [Cell transplantation in heart failure management]
    Jean Thomas Vilquin
    INSERM U 582, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, Batiment Babinski, 75651 Paris Cedex 13, France
    Med Sci (Paris) 20:651-62. 2004
    ..High quality clinical trials supported by strong pre-clinical data will help to evaluate the role of cell therapy as a potential treatment for heart failure...
  3. ncbi Mesenchymal stem cells in bone and cartilage repair: current status
    Jean Thomas Vilquin
    Groupe Hospitalier Pitie Salpetriere, INSERM U582, Association Institut de Myologie, IFR14, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Regen Med 1:589-604. 2006
    ..They also consider the stringent conditions, constraints and considerations necessary to take cell-mediated therapy from bench to bedside...
  4. ncbi Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy
    Albert A Hagege
    Assistance Publique Hopitaux de Paris, Department of Cardiology, Hôpital Européen Georges Pompidou and INSERM EMI 16, Necker Paris V University, Paris, France
    Lancet 361:491-2. 2003
    ..6%, respectively, in skeletal muscle). Myoblast grafts can survive and show a switch to slow-twitch fibres, which might allow sustained improvement in cardiac function...
  5. ncbi Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction
    Philippe Menasche
    Assistance Publique Hopitaux de Paris, Department of Cardiovascular Surgery B, Hopital Bichat, Paris, France
    J Am Coll Cardiol 41:1078-83. 2003
    ..This phase I trial was designed to assess the feasibility and safety of autologous skeletal myoblast transplantation in patients with severe ischemic cardiomyopathy...
  6. pmc Myoblasts and embryonic stem cells differentially engraft in a mouse model of genetic dilated cardiomyopathy
    Cyril Catelain
    UPMC UM 76, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Mol Ther 21:1064-75. 2013
    ..These data suggest that committed ESC fail to integrate in DCM where scar tissue is absent to provide the appropriate niche, whereas the functional benefits of Mb transplantation might extend to nonischemic cardiomyopathy...
  7. ncbi Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat
    Nawwar Al Attar
    Department of Cardiovascular Surgery and INSERM U 572, Hopital Europeen Georges Pompidou, Paris, France
    Cardiovasc Res 58:142-8. 2003
    ..The present experiments were designed to assess the long-term effects of the procedure...
  8. ncbi Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients
    Albert A Hagege
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Circulation 114:I108-13. 2006
    ..Short-term follow-up (FU) studies have suggested that a similar benefit could clinically occur despite an increased risk of LV arrhythmias...
  9. ncbi Characterization of distinct mesenchymal-like cell populations from human skeletal muscle in situ and in vitro
    Séverine Lecourt
    UPMC AIM UMR S 974, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Exp Cell Res 316:2513-26. 2010
    ..These results underline the diversity of human muscle cells, and the shared or restricted commitment abilities of the main lineages under defined conditions...
  10. ncbi Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium?
    Agnes Maurel
    1 INSERM U633, Laboratoire d Etude des Greffes et Prothèses Cardiaques, Hopital Broussais, Paris, France
    Transplantation 80:660-5. 2005
    ....
  11. ncbi Does the functional efficacy of skeletal myoblast transplantation extend to nonischemic cardiomyopathy?
    Julia Pouly
    INSERM U582, Institute of Myology, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Circulation 110:1626-31. 2004
    ..To address this issue, we tested SM transplantation in CHF147 Syrian hamsters, a strain characterized by a delta-sarcoglycan deficiency that phenotypically features the human setting of primary dilated cardiomyopathy...
  12. ncbi Skeletal myoblast transplantation through a catheter-based coronary sinus approach: an effective means of improving function of infarcted myocardium
    Camille Brasselet
    Assistance Publique Hopitaux de Paris, Department of Cardiology, Hôpital Européen Georges Pompidou et Faculté de Médecine René Descartes, Universite Paris V, Paris, France
    Eur Heart J 26:1551-6. 2005
    ..This study was designed to assess the functional effects of a transvenous coronary sinus technique of skeletal myoblast delivery in infarcted myocardium...
  13. doi Cell therapy for muscular dystrophies: advances and challenges
    Jean Thomas Vilquin
    UPMC UM 76, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Curr Opin Organ Transplant 16:640-9. 2011
    ..This article reviews recent problems including the identification of new putative cellular candidates, the combination of complementary genetic or pharmacological therapeutic approaches, and the set up of clinical trials...
  14. pmc Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacities
    Karine Vauchez
    Inserm U974, Paris, France
    Mol Ther 17:1948-58. 2009
    ..Our results suggest that ALDH activity is a novel marker for a population of new human skeletal muscle progenitors presenting a potential for cell biology and cell therapy...
  15. doi Distinction between two populations of islet-1-positive cells in hearts of different murine strains
    Patricia Khattar
    UPMC AIM UMR S 974, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Stem Cells Dev 20:1043-52. 2011
    ..Our studies demonstrate that islet-1-positive cells are relatively few in number in adult murine heart, being localized in restricted and rather inaccessible areas, and can represent both neural crest and cardiomyocyte lineages...
  16. ncbi Electrotransfer at MR imaging: tool for optimization of gene transfer protocols--feasibility study in mice
    Marion Paturneau-Jouas
    INSERM U 582, Institut de Myologie, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris, France
    Radiology 228:768-75. 2003
    ....
  17. ncbi Spontaneous muscular dystrophy caused by a retrotransposal insertion in the mouse laminin alpha2 chain gene
    Sylvie Besse
    INSERM U523, Institut de Myologie, IFR Coeur Muscle et Vaisseaux no 14, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Neuromuscul Disord 13:216-22. 2003
    ..The dy(Pas)/dy(Pas) mouse is thus the first spontaneous mutant with a complete laminin alpha2 chain deficiency in which the mutation has been identified...
  18. ncbi Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium
    Onnik Agbulut
    INSERM U572, Hopital Lariboisiere, Paris, France
    J Am Coll Cardiol 44:458-63. 2004
    ..The present study was designed as a face-to-face functional comparison of human skeletal myoblasts (SMs) and CD133(+) bone marrow-derived hematopoietic progenitors in an animal model of semichronic myocardial infarction...
  19. ncbi Ex vivo generation of mature and functional human smooth muscle cells differentiated from skeletal myoblasts
    Sophie Le Ricousse-Roussanne
    Institut des Vaisseaux et du Sang et Centre de Recherche Cardiovasculaire, INSERM U689, Paris, France
    Exp Cell Res 313:1337-46. 2007
    ..Based on the easily available tissue source and their differentiation into functional SMCs, these data argue that skeletal myoblasts might represent an important tool for SMCs-based cell therapy...
  20. ncbi Building the translational highway: toward new partnerships between academia and the private sector
    Ketty Schwartz
    Unité INSERM 582, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Nat Med 9:493-5. 2003
  21. ncbi Autologous myoblast transplantation for chronic ischemic mitral regurgitation
    Emmanuel Messas
    Universite Rene Descartes Paris 5, Faculté de médecine René Descartes Paris 5, Paris, France
    J Am Coll Cardiol 47:2086-93. 2006
    ..This study was designed to assess whether post-myocardial infarction (MI) in-scar transplantation of skeletal myoblasts (SM) could reduce chronic ischemic mitral regurgitation (MR) by decreasing left ventricular (LV) remodeling...
  22. doi Current advances in cell therapy strategies for muscular dystrophies
    Elisa Negroni
    Unité Thérapies des Maladies du muscle strié, UMRS974, UPMC Universite Paris 6, UM76, Inserm U974, CNRS UMR 7215, Institut de Myologie, Paris, France
    Expert Opin Biol Ther 11:157-76. 2011
    ..Cell therapy consists of delivering myogenic precursor cells to damaged tissue for the complementation of missing proteins and/or the regeneration of new muscle fibres...
  23. ncbi A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles
    Bruno Pitard
    INSERM U533, Faculte de Medecine, 44000 Nantes, France
    Hum Gene Ther 13:1767-75. 2002
    ..We propose that the PE6400 formulation could serve for the treatment of diseases primarily affecting muscle or for the expression of therapeutic proteins for local or systemic benefit...
  24. pmc Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host
    Bertrand Leobon
    Laboratory of Neurophysiology, Institut National de la Sante et de la Recherche Medicale, EPI 0002, Centre National de la Recherche Scientifique FRE2500, Ecole Superieure de Physique et Chimie Industrielles de la Ville de Paris, 75231 Paris, France
    Proc Natl Acad Sci U S A 100:7808-11. 2003
    ..We conclude that mechanisms other than electromechanical coupling between grafted and host cells are involved in the improvement of cardiac function...
  25. ncbi [The possible place of autologus cell therapy in facioscapulohumeral muscular dystrophy]
    Claude Desnuelle
    Centre de Reference pour les Maladies Neuromusculaires CHU de Nice Groupe Hospitalier l Archet, BP 3079, 06202 Nice cedex 03 et INSERM U 638
    Bull Acad Natl Med 189:697-713; discussion 713-4. 2005
    ..These results indicate that myoblasts taken from unaffected muscle of patients with FSHD warrant testing in a human cell therapy trial...
  26. ncbi Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction
    Said Ghostine
    Inserm EMI 0016, Necker Paris V University and Department of Cardiology 1, Hopital Europeen Georges Pompidou, France
    Circulation 106:I131-6. 2002
    ..Transplantation (Tx) of skeletal myoblasts (SM) within an infarcted myocardium improves global left ventricular (LV) function, although a direct systolic effect remains controversial...
  27. doi The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation
    Philippe Menasche
    Département de Chirurgie Cardio vasculaire, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France
    Circulation 117:1189-200. 2008
    ..Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to determine whether this procedure was functionally effective and arrhythmogenic...