Laurence Vico

Summary

Country: France

Publications

  1. pmc Impact of an obesogenic diet program on bone densitometry, micro architecture and metabolism in male rat
    Maude Gerbaix
    Laboratoire des Adaptations Métaboliques à l Exercice en conditions Physiologiques et Pathologiques, Clermont Universite, Universite Blaise Pascal, EA 3533, BP 80026, F 63171, Aubiere Cedex, France
    Lipids Health Dis 11:91. 2012
  2. doi request reprint Sex hormones and their receptors in bone homeostasis: insights from genetically modified mouse models
    L Vico
    Universite de Lyon, INSERM, U890, Université Jean Monnet, St Etienne, 42023, France
    Osteoporos Int 21:365-72. 2010
  3. ncbi request reprint Effects of gravitational changes on the bone system in vitro and in vivo
    L Vico
    LBTO Laboratoire de Biologie du Tissu Osseux, GIP Exercise, Faculte de Medecine, Saint Etienne, France
    Bone 22:95S-100S. 1998
  4. doi request reprint High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures
    Laurence Vico
    INSERM U890 IFR143, University of St Etienne, St Etienne, France
    J Bone Miner Res 23:1741-50. 2008
  5. ncbi request reprint What do we know about alteration in the osteoblast phenotype with microgravity?
    L Vico
    INSERM, E0366, Bone Biology Laboratory, University of St Etienne, France
    J Musculoskelet Neuronal Interact 6:317-8. 2006
  6. ncbi request reprint Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge
    Ndéye Marième Wade-Gueye
    INSERM U1059 SFR IFRESIS, F42023, Saint Etienne, France
    Bone 50:1064-73. 2012
  7. doi request reprint Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment
    Ndéye Marième Wade-Gueye
    Université de Lyon and Institut National de la Santé et de la Recherche Médicale Unité 890 Institut Fédératif de Recherche 143, Saint Etienne, France
    Endocrinology 151:5103-13. 2010
  8. doi request reprint Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain
    Valentin David
    INSERM U890, Laboratoire de Biologie du Tissu Osseux, IFR143, IFRESIS, Université Jean Monnet, St Etienne, F 42023, France
    Tissue Eng Part A 14:117-26. 2008
  9. ncbi request reprint Modulation of the responses of human osteoblast-like cells to physiologic mechanical strains by biomaterial surfaces
    Fabrice Di Palma
    Laboratoire de Biologie du Tissu Osseux, Faculté de Médecine 15 rue Ambroise Paré, Université Jean Monnet, Equipe INSERM E366, Saint Etienne 42023, Cedex 02, France
    Biomaterials 26:4249-57. 2005
  10. doi request reprint Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro
    Maya Boudiffa
    Universite de Lyon, Saint Etienne, France
    J Bone Miner Res 25:2669-79. 2010

Collaborators

Detail Information

Publications51

  1. pmc Impact of an obesogenic diet program on bone densitometry, micro architecture and metabolism in male rat
    Maude Gerbaix
    Laboratoire des Adaptations Métaboliques à l Exercice en conditions Physiologiques et Pathologiques, Clermont Universite, Universite Blaise Pascal, EA 3533, BP 80026, F 63171, Aubiere Cedex, France
    Lipids Health Dis 11:91. 2012
    ..An ANCOVA with global mass and global fat as covariates was used to determine the potential implication of the resulting mechanical loading on bone...
  2. doi request reprint Sex hormones and their receptors in bone homeostasis: insights from genetically modified mouse models
    L Vico
    Universite de Lyon, INSERM, U890, Université Jean Monnet, St Etienne, 42023, France
    Osteoporos Int 21:365-72. 2010
    ..More investigations are needed to fully understand the respective role of all these receptors in periosteal expansion in both sexes and the way they affect the mechanical sensitivity of the periosteum...
  3. ncbi request reprint Effects of gravitational changes on the bone system in vitro and in vivo
    L Vico
    LBTO Laboratoire de Biologie du Tissu Osseux, GIP Exercise, Faculte de Medecine, Saint Etienne, France
    Bone 22:95S-100S. 1998
    ..Data from the model confirmed the impairment of osteoblastic activity and showed an alteration in osteoblast recruitment with skeletal unloading. However, this model needs to be further validated...
  4. doi request reprint High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures
    Laurence Vico
    INSERM U890 IFR143, University of St Etienne, St Etienne, France
    J Bone Miner Res 23:1741-50. 2008
    ..Geometry parameters at the tibia displayed the greatest differences between healthy and fractured patients and between wrist and hip fractures...
  5. ncbi request reprint What do we know about alteration in the osteoblast phenotype with microgravity?
    L Vico
    INSERM, E0366, Bone Biology Laboratory, University of St Etienne, France
    J Musculoskelet Neuronal Interact 6:317-8. 2006
  6. ncbi request reprint Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge
    Ndéye Marième Wade-Gueye
    INSERM U1059 SFR IFRESIS, F42023, Saint Etienne, France
    Bone 50:1064-73. 2012
    ..These findings confirm the hypothesis of a crucial role for BSP in primary ossification, which has long been suspected for mineralization, but here extends to bone deposition and turnover...
  7. doi request reprint Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment
    Ndéye Marième Wade-Gueye
    Université de Lyon and Institut National de la Santé et de la Recherche Médicale Unité 890 Institut Fédératif de Recherche 143, Saint Etienne, France
    Endocrinology 151:5103-13. 2010
    ..Although up-regulation of one or several other SIBLINGs is a possible mechanism, further studies are needed to analyze the interplay and cross-regulation involved in compensating for the absence of BSP...
  8. doi request reprint Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain
    Valentin David
    INSERM U890, Laboratoire de Biologie du Tissu Osseux, IFR143, IFRESIS, Université Jean Monnet, St Etienne, F 42023, France
    Tissue Eng Part A 14:117-26. 2008
    ..Thus, in the ZetOS apparatus, we reproduce in vitro the osteogenic effects of mechanical strain known in vivo, making this system a unique and an essential laboratory aid for ex vivo testing of lamellar bone remodeling...
  9. ncbi request reprint Modulation of the responses of human osteoblast-like cells to physiologic mechanical strains by biomaterial surfaces
    Fabrice Di Palma
    Laboratoire de Biologie du Tissu Osseux, Faculté de Médecine 15 rue Ambroise Paré, Université Jean Monnet, Equipe INSERM E366, Saint Etienne 42023, Cedex 02, France
    Biomaterials 26:4249-57. 2005
    ..Our results suggest that the nature of the surface did not influence the up-regulation of alkaline phosphatase activity induced by IMS, but modulates specifically cell-substrate as well as cell-cell interactions in response to IMS...
  10. doi request reprint Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro
    Maya Boudiffa
    Universite de Lyon, Saint Etienne, France
    J Bone Miner Res 25:2669-79. 2010
    ..In conclusion, lack of BSP affects both osteoclast formation and activity, which is in accordance with in vivo findings. Our results also suggest at least some functional redundancy between BSP and OPN that remains to be clarified...
  11. ncbi request reprint Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis
    Valentin David
    Institut National de la Santé et de la Recherche Médicale Unité 890, Université Jean Monnet, F 42023 Saint Etienne Cedex 2, France
    Endocrinology 148:2553-62. 2007
    ..In conclusion, we provide evidence that mechanical stimuli are potential PPARgamma modulators counteracting adipocyte differentiation and inhibition of osteoblastogenesis...
  12. doi request reprint Imaging and quantitative assessment of long bone vascularization in the adult rat using microcomputed tomography
    Jia Fei
    Universite de Lyon, France
    Anat Rec (Hoboken) 293:215-24. 2010
    ..005), vessel separation increased by 27%, P < 0.01. SRmuCT could image sinusoid clusters in bone. muCT is an accurate and reproducible technique for 3D quantitative evaluation of long bone vascularisation in the rat...
  13. ncbi request reprint Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography
    Valentin David
    LBTO, INSERM E0366, University of Saint Etienne, Saint Etienne, France
    J Bone Miner Res 18:1622-31. 2003
    ..This prototype has a potential to detect three-dimensional trabecular microarchitectural changes induced by growth and unloading...
  14. ncbi request reprint Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences
    Valentin David
    Institut National de la Sante et de la Recherche Medicale, Laboratoire de Biologie du Tissu Osseux, University of Saint Etienne, Saint Etienne, France
    Am J Physiol Endocrinol Metab 290:E440-7. 2006
    ....
  15. doi request reprint Extracellular matrix produced by osteoblasts cultured under low-magnitude, high-frequency stimulation is favourable to osteogenic differentiation of mesenchymal stem cells
    Virginie Dumas
    Universite de Lyon, Saint Etienne, France
    Calcif Tissue Int 87:351-64. 2010
    ..LMHF stimulations of osteoblasts are therefore efficient and sufficient to generate osteogenic matrix...
  16. ncbi request reprint Focal contact clustering in osteoblastic cells under mechanical stresses: microgravity and cyclic deformation
    Alain Guignandon
    Laboratoire de Biologie du Tissu Osseux L B T O, INSERM E366, Faculte de Medecine, 15 rue Ambroise Paré, 42023 Saint Etienne Cedex 02, France
    Cell Commun Adhes 10:69-83. 2003
    ..8 osteoblastic cells...
  17. ncbi request reprint Interactions between estrogen and mechanical strain effects on U2OS human osteosarcoma cells are not influenced by estrogen receptor type
    Florence Lima
    LBTO Laboratoire de Biologie du Tissu Osseux, Rheumatology Department, INSERM E0366, University of Saint Etienne, France
    Bone 35:1127-35. 2004
    ..However, we were not able to demonstrate that interactions between E and MS were dependent on ER type in U2OS osteosarcoma cells...
  18. ncbi request reprint Lower bone cellular activities in male and female mature C3H/HeJ mice are associated with higher bone mass and different pyridinium crosslink profiles compared to C57BL/6J mice
    Daniel Amblard
    Laboratoire de Biologie du Tissu Osseux LBTO, GIP E2S, INSERM E0366, Faculte de Medecine, 15, rue Ambroise Pare, 42023 St Etienne 2, France
    J Bone Miner Metab 21:377-87. 2003
    ..In conclusion, we found that the lower cellular activities in C3H were associated with high cancellous bone mass and pyridinium crosslink levels, which might account for the more mineralized bone in C3H mice compared to that in B6 mice...
  19. ncbi request reprint Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells
    Alain Guignandon
    INSERM E366, St Etienne, F 42023, France
    Biochem Biophys Res Commun 343:407-14. 2006
    ....
  20. ncbi request reprint Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation
    Nadia Boutahar
    Laboratoire de Biologie du Tissu Osseux, INSERM, E366, 15 rue Ambroise Paré, 42023 Saint Etienne 02, France
    J Biol Chem 279:30588-99. 2004
    ..The latter was induced by ERK2 phosphorylation under the control of FAK and PYK2 phosphorylation orchestrated in a time-dependent manner...
  21. doi request reprint Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass
    Laurent Emmanuel Monfoulet
    INSERM, U577, and University Victor Segalen, Bordeaux, France
    J Bone Miner Res 26:2036-44. 2011
    ..These data shed new light on the respective roles of TRs in the control of bone metabolism by TH...
  22. doi request reprint Impaired energetic metabolism after central leptin signaling leads to massive appendicular bone loss in hindlimb-suspended rats
    Aline Martin
    INSERM U890, University Hospital of St Etienne, St Etienne, France
    J Bone Miner Res 23:2040-7. 2008
    ..In summary, our study supports the hypothesis of a concentration-dependent balance between peripheral and central control of leptin on bone...
  23. doi request reprint Validated Laser Doppler protocol for measurement of mouse bone blood perfusion - response to age or ovariectomy differs with genetic background
    Bernard Roche
    Inserm U1059, Universite de Lyon, Saint Etienne F 42023, France
    Bone 55:418-26. 2013
    ..This integrative structural and functional approach of bone vascularization showed that bone vascular adaptation occurs during aging or after ovariectomy and is affected by the genetic background...
  24. pmc Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice
    Cédric Gomez
    INSERM, E0366, Saint Etienne, France
    J Anat 210:259-71. 2007
    ..The altered morphological features of dd/ff mice and the increased bone resorption show the role of muscle activity in bone shaping and the consequences of bone unloading...
  25. doi request reprint Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation
    Céline Faure
    INSERM U890, St Etienne, F 42023, France
    Bone 42:1092-101. 2008
    ..Mechanically induced selection of soluble or matrix-bound VEGF production may modify osteoblast and endothelial cell crosstalk crucial during osteogenesis and fracture healing...
  26. doi request reprint Multiscale grooved titanium processed with femtosecond laser influences mesenchymal stem cell morphology, adhesion, and matrix organization
    Virginie Dumas
    Ecole Nationale d Ingénieurs de Saint Etienne Enise, LTDS, UMR 5513 CNRS, Universite de Lyon, 42023 Saint Etienne, France
    J Biomed Mater Res A 100:3108-16. 2012
    ..The ultrafast laser, as a new method for producing micro-nanohybrid surfaces, is a promising approach to promote desired tissue organization for tissue engineering...
  27. doi request reprint Pathophysiology of bone loss in disuse osteoporosis
    Christian Alexandre
    U Inserm 1059, Universite de Lyon, Saint Etienne, France
    Joint Bone Spine 78:572-6. 2011
    ..A better knowledge of these mechanisms should promote the development of preventive therapies for the often neglected osteoporotic fractures that occur in patients with spinal cord injury...
  28. doi request reprint Structure and quantification of microvascularisation within mouse long bones: what and how should we measure?
    Bernard Roche
    Universite de Lyon, F42023, Saint Etienne, France
    Bone 50:390-9. 2012
    ..Finally, we validate our technique by studying the effect of ovariectomy on mouse tibial vascular density...
  29. pmc Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis
    Luc Malaval
    Institut National de Santé et de Recherche Médicale U890, IFR 143, Université Jean Monnet, Saint Etienne, F42023, France
    J Exp Med 205:1145-53. 2008
    ..It does not, however, prevent the bone loss resulting from loss of mechanical stimulation, a phenotype that is clearly different from OPN(-/-) mice...
  30. ncbi request reprint Increase of both angiogenesis and bone mass in response to exercise depends on VEGF
    Zhenqiang Yao
    Faculte de Medecine, Laboratoire de Biologie du Tissu Osseux, Saint Etienne Cedex 02 42023, France
    J Bone Miner Res 19:1471-80. 2004
    ..VEGF blockade over 5 weeks of training fully prevented the exercise-induced bone mass gain...
  31. ncbi request reprint Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain
    Daniel Amblard
    Laboratoire de Biologie et Biochimie du Tissu Osseux, INSERM E9901, Faculté de Médecine 15, St Etienne, France
    J Bone Miner Res 18:561-9. 2003
    ....
  32. ncbi request reprint Physiological strains remodel extracellular matrix and cell-cell adhesion in osteoblastic cells cultured on alumina-coated titanium alloy
    Fabrice Di Palma
    Laboratoire de Biologie et de Biochimie du Tissu Osseux, Faculte de Medecine, Université Jean Monnet, Equipe de recherche INSERM E366, 15 rue Ambroise Paré, 42023 Saint Etienne Cedex 02, Loire, France
    Biomaterials 25:2565-75. 2004
    ..We concluded that reinforcement of cell-cell adhesion and remodelling of the FN network are important adaptive responses to physiological strains for human osteoblasts grown on alumina-coated biomaterials...
  33. doi request reprint Skeletal site-specific effects of whole body vibration in mature rats: from deleterious to beneficial frequency-dependent effects
    Marion Pasqualini
    INSERM U1059 LBTO, Université Jean Monnet, Universite de Lyon, Saint Etienne, France
    Bone 55:69-77. 2013
    ..We concluded that the skeleton is frequency-scalable, thus highlighting the importance of WBV regimen conditions and suggesting that cautions are required for frequencies less than 10 Hz, at least in rats...
  34. doi request reprint Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know
    Rhonda D Prisby
    Université Jean Monnet, INSERM U890, Saint Etienne F42023, France
    Ageing Res Rev 7:319-29. 2008
    ..e., the elderly, postmenopausal women, etc.) in hopes of eliciting multidisciplinary scientific inquiries into this potentially therapeutic aid which presumably has global ramifications...
  35. pmc Skeletal Development of Mice Lacking Bone Sialoprotein (BSP) - Impairment of Long Bone Growth and Progressive Establishment of High Trabecular Bone Mass
    Wafa Bouleftour
    Laboratoire de Biologie du Tissu Osseux and Institut National de la Santé et de la Recherche Médicale U1059, Université de Lyon Université Jean Monnet, Saint Etienne, France
    PLoS ONE 9:e95144. 2014
    ..Compensatory high Opn may allow normal endochondral development in BSP-/- mice, while impairing primary mineralization. ..
  36. ncbi request reprint Parathyroid hormone 1-84 targets bone vascular structure and perfusion in mice: impacts of its administration regimen and of ovariectomy
    Bernard Roche
    Inserm U1059, Lab Biologie Intégrée du Tissu Osseux, Universite de Lyon, Saint Etienne, France
    J Bone Miner Res 29:1608-18. 2014
    ..2014 American Society for Bone and Mineral Research. ..
  37. doi request reprint Absence of bone sialoprotein (BSP) impairs cortical defect repair in mouse long bone
    Luc Malaval
    Universite de Lyon, Saint Etienne, F42023, France
    Bone 45:853-61. 2009
    ..In conclusion, the absence of BSP delays bone repair at least in part by impairing both new bone formation and osteoclast activity...
  38. ncbi request reprint Plasticity of osteoprogenitor cells
    Marie Hélène Lafage-Proust
    LBTO INSERM 890, IFR 143, Jean Monnet University, 15 rue A Paré, 42023 Saint Etienne, France
    Joint Bone Spine 74:536-9. 2007
    ..New insights into the molecular mechanisms involved in controlling the osteoblast-adipocyte balance are unlocking doors to a vast array of innovative treatment strategies...
  39. ncbi request reprint Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells
    A Guignandon
    Laboratoire de Biologie du Tissu Osseux, Jean Monnet University, Saint Etienne, France
    Exp Cell Res 236:66-75. 1997
    ..We concluded that ROS 17/2.8 cells are sensitive to Gz switches and that their adaptation is at least dependent on microtubule function...
  40. ncbi request reprint MAPK and SRC-kinases control EGR-1 and NF-kappa B inductions by changes in mechanical environment in osteoblasts
    C Granet
    Laboratoire de Biologie et de Biochimie du Tissu Osseux LBBTO, INSERM E9901, Faculte de Medecine, 15 rue A Paré, 42023 Saint Etienne cedex 2, France
    Biochem Biophys Res Commun 284:622-31. 2001
    ..These could partially explain the later alterations of proliferation observed...
  41. ncbi request reprint Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions
    A Guignandon
    Laboratoire de Biologie et de Biochimie du Tissu Osseux Equipe Mixte INSERM E9901, Université Jean Monnet, Saint Etienne, 15 rue Ambroise Paré, F 42023 Saint Etienne Cedex 2, Grenoble, France
    FASEB J 15:2036-8. 2001
    ..ROS17/2.8 cells responded differently, whether or not they were cycling by reorganizing adhesion plaque topography or morphology. In ROS 17/2.8, this reorganization did not impair osteoblastic phenotype...
  42. ncbi request reprint Rotating-wall vessels, promising bioreactors for osteoblastic cell culture: comparison with other 3D conditions
    C Granet
    Laboratoire de Biologie du Tissu Osseux, Faculté de Médecine J Lisfranc, Saint Etienne, France
    Med Biol Eng Comput 36:513-9. 1998
    ..Therefore the bioreactor may be a suitable tissue culture model for investigation of growth and differentiation processes in tissue engineering...
  43. doi request reprint Young male soccer players exhibit additional bone mineral acquisition during the peripubertal period: 1-year longitudinal study
    Mohamed Zouch
    INSERM, Research Unit UMR 1059, University of Lyon, 42023, Saint Etienne, France
    Eur J Pediatr 173:53-61. 2014
    ....
  44. ncbi request reprint High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis
    Odile Barou
    Laboratoire de Biologie et de Biochimie du Tissu Osseux, Equipe Mixte INSERM 9901, Faculte de Medecine, Saint Etienne, France
    Invest Radiol 37:40-6. 2002
    ....
  45. pmc Synchrotron radiation micro-CT at the micrometer scale for the analysis of the three-dimensional morphology of microcracks in human trabecular bone
    Aymeric Larrue
    CREATIS, INSERM U1044, CNRS 5220, INSA Lyon, Université Lyon I, Universite de Lyon, Villeurbanne, France
    PLoS ONE 6:e21297. 2011
    ..In conclusion, this technique opens new perspective for the 3D investigation of microcracks and the impact of age, disease or treatment...
  46. doi request reprint Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix
    A Perrier
    Universite de Lyon, F42023, Saint Etienne, France
    Bone 47:23-33. 2010
    ..This particular surface activation was probably done firstly to reinforce cell survival (VEGF-A) and adhesion (OPN, FN) and secondly to recruit and prepare surfaces for subsequent bone cell activity...
  47. ncbi request reprint Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation
    C Gomez
    INSERM, Unit 403, Lyon, France
    Dev Dyn 234:393-403. 2005
    ..Expression patterns suggest Plexin-A3/Neuropilin-1 as a candidate receptor in target cells for the regulation of bone innervation by Semaphorin-3A...
  48. ncbi request reprint Space flight: a challenge for normal bone homeostasis
    G Carmeliet
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Belgium
    Crit Rev Eukaryot Gene Expr 11:131-44. 2001
    ..It is hoped that as the mechanisms by which bone responds to mechanical (un)loading are further understood, this insight will influence the treatment of other etiologies of osteoporosis...
  49. ncbi request reprint Regulation of ubiquitin-proteasome system, caspase enzyme activities, and extracellular proteinases in rat soleus muscle in response to unloading
    P Berthon
    Laboratoire de Physiologie et de Biomécanique de l Exercice Musculaire, Université Rennes 2, Rennes F 35000, France
    Pflugers Arch 454:625-33. 2007
    ..Overall, these data suggest that time-dependent regulation of intracellular and extracellular proteinases are important in setting the new phenotype of rat soleus muscle in response to HS...
  50. ncbi request reprint Osteobiology, strain, and microgravity. Part II: studies at the tissue level
    L Vico
    INSERM E9901, LBBTO, , France
    Calcif Tissue Int 68:1-10. 2001
    ..In Part II, we have considered the data on the alterations induced by unloading and microgravity on the skeleton and the mechanisms that are involved at the tissue level in animals and humans...
  51. ncbi request reprint Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures
    M Grano
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Calcif Tissue Int 70:176-85. 2002
    ..They also indicate for the first time that a possible mediator responsible for the increased osteoclastogenesis could be represented by the IL-6 whose secretion by bone marrow cells was significantly enhanced by unloading...