Catherine Vergely

Summary

Country: France

Publications

  1. doi request reprint Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension
    Sebastien Amoureux
    LPPCE, IFR Santé STIC 100, Facultes de Medecine et de Pharmacie, Dijon, France
    Fundam Clin Pharmacol 26:227-34. 2012
  2. pmc Forgotten radicals in biology
    Rochette Luc
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    Int J Biomed Sci 4:255-9. 2008
  3. ncbi request reprint Vitamin C deficiency exerts paradoxical cardiovascular effects in osteogenic disorder Shionogi (ODS) rats
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, IFR n degrees 100, Facultés de Médecine et Pharmacie, 21000 Dijon, France
    J Nutr 134:729-35. 2004
  4. ncbi request reprint Effect of two new PBN-derived phosphorylated nitrones against postischaemic ventricular dysrhythmias
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales LPPCE, facultés de médecine and pharmacie, Dijon, France
    Fundam Clin Pharmacol 17:433-42. 2003
  5. ncbi request reprint Postischemic recovery and oxidative stress are independent of nitric-oxide synthases modulation in isolated rat heart
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharamacie, Dijon, France
    J Pharmacol Exp Ther 303:149-57. 2002
  6. ncbi request reprint Isolated perfused rat hearts release secondary free radicals during ischemia reperfusion injury: cardiovascular effects of the spin trap alpha-phenyl N-tert-butylnitrone
    C Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Faculties of Medicine and Pharmacy, Dijon, France
    Free Radic Res 35:475-89. 2001
  7. ncbi request reprint Postischemic myocardial recovery and oxidative stress status of vitamin C deficient rat hearts
    C Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Facultés de Médecine et Pharmacie, 7 Boulevard Jeanne d Arc, 21000 Dijon, France
    Cardiovasc Res 51:89-99. 2001
  8. ncbi request reprint Acute administration of epirubicin induces myocardial depression in isolated rat heart and production of radical species evaluated by electron spin resonance spectroscopy
    Stephanie Delemasure
    Laboratory of Cardiovascular Experimental Pharmacology and Physiopathology, IFR N 100, Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France
    J Cardiovasc Pharmacol 50:647-53. 2007
  9. ncbi request reprint After four hours of cold ischemia and cardioplegic protocol, the heart can still be rescued with postconditioning
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expérimental, Facultés de Médecine et Pharmacie, Dijon, France
    Transplantation 84:1474-82. 2007
  10. doi request reprint Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats
    Pierre Sicard
    Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, Faculties of Medicine and Pharmacy, Dijon, France
    Free Radic Res 42:226-36. 2008

Collaborators

Detail Information

Publications60

  1. doi request reprint Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension
    Sebastien Amoureux
    LPPCE, IFR Santé STIC 100, Facultes de Medecine et de Pharmacie, Dijon, France
    Fundam Clin Pharmacol 26:227-34. 2012
    ....
  2. pmc Forgotten radicals in biology
    Rochette Luc
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    Int J Biomed Sci 4:255-9. 2008
    ..In conclusion, there is solid evidence supporting the formation of many free radicals by cells leading which may play an important role in their homeostasis...
  3. ncbi request reprint Vitamin C deficiency exerts paradoxical cardiovascular effects in osteogenic disorder Shionogi (ODS) rats
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, IFR n degrees 100, Facultés de Médecine et Pharmacie, 21000 Dijon, France
    J Nutr 134:729-35. 2004
    ..These unexpected results suggest that unidentified compensatory mechanisms play a role in maintaining normal cardiac function and vascular reactivity in vitamin C-deficient rats...
  4. ncbi request reprint Effect of two new PBN-derived phosphorylated nitrones against postischaemic ventricular dysrhythmias
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales LPPCE, facultés de médecine and pharmacie, Dijon, France
    Fundam Clin Pharmacol 17:433-42. 2003
    ....
  5. ncbi request reprint Postischemic recovery and oxidative stress are independent of nitric-oxide synthases modulation in isolated rat heart
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharamacie, Dijon, France
    J Pharmacol Exp Ther 303:149-57. 2002
    ..These results may indicate that, in our experimental conditions, cardiac NOS might not be a major factor implicated in the oxidative burst that follows a global myocardial ischemia...
  6. ncbi request reprint Isolated perfused rat hearts release secondary free radicals during ischemia reperfusion injury: cardiovascular effects of the spin trap alpha-phenyl N-tert-butylnitrone
    C Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Faculties of Medicine and Pharmacy, Dijon, France
    Free Radic Res 35:475-89. 2001
    ..Moreover, we demonstrated that the persistent post-ischemic dysfunction was associated with a sustained production and release of free radical species...
  7. ncbi request reprint Postischemic myocardial recovery and oxidative stress status of vitamin C deficient rat hearts
    C Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Facultés de Médecine et Pharmacie, 7 Boulevard Jeanne d Arc, 21000 Dijon, France
    Cardiovasc Res 51:89-99. 2001
    ....
  8. ncbi request reprint Acute administration of epirubicin induces myocardial depression in isolated rat heart and production of radical species evaluated by electron spin resonance spectroscopy
    Stephanie Delemasure
    Laboratory of Cardiovascular Experimental Pharmacology and Physiopathology, IFR N 100, Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France
    J Cardiovasc Pharmacol 50:647-53. 2007
    ..Further investigations are now needed to determine whether new cardioprotective agents targeting oxidative stress may reduce the incidence of anthracycline-induced cardiotoxicity...
  9. ncbi request reprint After four hours of cold ischemia and cardioplegic protocol, the heart can still be rescued with postconditioning
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expérimental, Facultés de Médecine et Pharmacie, Dijon, France
    Transplantation 84:1474-82. 2007
    ..We tested the impact of postconditioning on hearts maintained in the cold for a long period of total global ischemia and we compared the results with those obtained with pyruvate, a cardioprotective molecule...
  10. doi request reprint Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats
    Pierre Sicard
    Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, Faculties of Medicine and Pharmacy, Dijon, France
    Free Radic Res 42:226-36. 2008
    ..These results demonstrate the beneficial effects of ROSU in SHR, independently of any lowering of cholesterol levels...
  11. doi request reprint Atrial and vascular oxidative stress in patients with heart failure
    Luc Rochette
    Laboratoire de Physiologie et Pharmacologie Cardiovasculaires Expérimentales, Facultes de Medecine et de Pharmacie, 7 bd Jeanne d Arc, Dijon Cedex, France
    Cell Physiol Biochem 27:497-502. 2011
    ..These findings could give further insights into the relationship between iron metabolism disturbances and the severity of cardiovascular diseases...
  12. ncbi request reprint Are Zucker obese rats a useful model for cardiovascular complications in metabolic syndrome? Physical, biochemical and oxidative stress considerations
    Régine Debin
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, IFR No100, Facultes de Medecine et de Pharmacie, 7 bd Jeanne d Arc BP87900, 21079 Dijon, France
    Fundam Clin Pharmacol 23:59-67. 2009
    ..Dihydroethidium staining showed higher superoxide production in the coronary vessels of ZO rats than in ZL and Wistar rats. Our results show that ZO might only correspond to early-stage cardiovascular complications associated with MS...
  13. doi request reprint Beneficial effects of myocardial postconditioning are associated with reduced oxidative stress in a senescent mouse model
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    Transplantation 85:1802-8. 2008
    ..We studied (1) senescence in vessels and hearts and (2) the ability of the senescent heart to adapt to an ischemia-reperfusion (I/R) sequence in the context of PostC...
  14. pmc Postnatal overfeeding causes early shifts in gene expression in the heart and long-term alterations in cardiometabolic and oxidative parameters
    Ahmed Habbout
    Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio Métaboliques LPPCM, Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France
    PLoS ONE 8:e56981. 2013
    ..However, the repercussions of postnatal OF on cardiac gene expression, cardiac metabolism and nitro-oxidative stress are less well known...
  15. doi request reprint Effect of a chronic cholesterol-rich diet on vascular structure and oxidative stress in LDLR-/- mice
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, IFR santé STIC n 100, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    Cell Physiol Biochem 27:31-6. 2011
    ..There is conflicting evidence regarding the relationship between hypercholesterolemia and oxidative stress in vessels. To test the potential relationship, a mouse model of hypercholesterolemia was used...
  16. ncbi request reprint A cholesterol-rich diet improves resistance to ischemic insult in mouse hearts but suppresses the beneficial effect of post-conditioning
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expérimentale, Faculte de Medecine et Pharmacie, Dijon, France
    J Heart Lung Transplant 28:821-6. 2009
    ..The study examined the effect of Post-Con cardiac recovery after the ischemia-reperfusion sequence and the effect of Post-Con on low-density lipoprotein receptor-deficient (LDLR(-/-)) mice and control animals...
  17. ncbi request reprint NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging
    Alexandra Oudot
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, IFR No 100, Facultés de Médecine et Pharmacie, 7 Boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Free Radic Biol Med 40:2214-22. 2006
    ..One of the regulators of vascular NADPH oxidase activity, the renin-angiotensin system, may be involved in the modulation of vascular superoxide production during the aging process...
  18. ncbi request reprint Dissociation between vascular oxidative stress and cardiovascular function in Wistar Kyoto and spontaneously hypertensive rats
    Pierre Sicard
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, IFR No 100, Facultes de Medecine et de Pharmacie, 7, boulevard Jeanne d Arc, 21000 Dijon, France
    Vascul Pharmacol 45:112-21. 2006
    ..Dissociation between vascular oxidative stress and cardiovascular function may be evoked...
  19. doi request reprint Oxidative stress and myocardial gene alterations associated with Doxorubicin-induced cardiotoxicity in rats persist for 2 months after treatment cessation
    Carole Richard
    Laboratoire de Physiopathologie and Pharmacologie Cardiovasculaires Expérimentales, EA 2979, IFR Santé STIC, facultés de médecine and pharmacie, 7 bd Jeanne d Arc, 21000 Dijon, France
    J Pharmacol Exp Ther 339:807-14. 2011
    ....
  20. doi request reprint Smoking and FOS expression from blood leukocyte transcripts in patients with coronary artery disease
    Sébastien Saliques
    IFR 100 Santé STIC, Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, UFR Medecine, Université de Bourgogne EA2979, Dijon, France
    Atherosclerosis 219:931-6. 2011
    ..We aimed to analyze the relationship between smoking status and c-Fos expression in circulating leukocytes of patients with CAD...
  21. doi request reprint Plasma antioxidant status in septic critically ill patients: a decrease over time
    Jean Marc Doise
    Service de Reanimation Medicale, Facultes de Medecine et de Pharmacie, IFR No100, Dijon, France
    Fundam Clin Pharmacol 22:203-9. 2008
    ..TAC, unaffected at first, deteriorated over time whatever the severity of the infection in these critically ill patients. TAC, unable to distinguish severe sepsis and septic shock, is unlikely to be a particularly useful outcome measure...
  22. ncbi request reprint Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model
    Bertrand Collin
    Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, Faculty of Medicine, University of Burgundy, 7, boulevard Jeanne d Arc, 21079, Dijon Cedex, BP 87900, France
    Mol Cell Biochem 294:225-35. 2007
    ..As HC could generate an alteration in the oxidative status, we studied the effects of a 1-month cholesterol diet on cardiovascular oxidative stress...
  23. doi request reprint Circulating leukocyte telomere length and oxidative stress: a new target for statin therapy
    Sébastien Saliques
    IFR Santé STIC, Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, UFR Medecine, Université de Bourgogne EA2979, Dijon, France
    Atherosclerosis 219:753-60. 2011
    ....
  24. doi request reprint Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential
    Luc Rochette
    Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio Métaboliques, Universite de Bourgogne, Facultés de Médecine et Pharmacie, 21000 Dijon, France
    Mol Nutr Food Res 57:114-25. 2013
    ..The complex and intimate association between increased oxidative stress and increased inflammation in related disorders such as diabetes, makes it difficult to establish the temporal sequence of the relationship...
  25. ncbi request reprint Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts
    Ségolène Gambert
    Faculties of Medicine and Pharmacy, Dijon, France
    Mol Cell Biochem 283:147-52. 2006
    ..The novel conclusion is that adverse effects of fatty acids on ischemic-reperfusion injury may be mediated, at least in part, by oxygen-derived free radicals...
  26. ncbi request reprint Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusion
    Alexandra Oudot
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Faculties of Medicine and Pharmacy, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Eur J Pharmacol 462:145-54. 2003
    ..Our study demonstrates that ischaemia-reperfusion induces adaptative cardiac modifications, which allow exogenously added angiotensin II to stimulate myocardial NADPH oxidase through angiotensin AT(1) receptor activation...
  27. ncbi request reprint Pharmacological concentration of angiotensin-(1-7) activates NADPH oxidase after ischemia-reperfusion in rat heart through AT1 receptor stimulation
    Alexandra Oudot
    Laboratoire de Physiopathologie et Pharmacologie, Cardio vasculaires Expérimentales, IFR No 100, Facultés de Médecine et Pharmacie, 7, Boulevard Jeanne d Arc BP 87900, 21079 Dijon, France
    Regul Pept 127:101-10. 2005
    ..This is the first time that it has been shown that, in the heart, angiotensin-(1-7) at pharmacological concentration activates NADPH oxidase, an enzyme thought to be involved in several angiotensin II effects...
  28. doi request reprint Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant properties
    Jean Pierre Berne
    Laboratoire de Physiopathologie et Pharmacologie Cardio Métaboliques, Inserm UMR866, Universite de Bourgogne, Dijon, France
    Cell Physiol Biochem 29:475-84. 2012
    ..These results suggest that the production of CO is a necessary factor in the cardioprotective and antioxidant actions of CO-releasing compound. These results may open up new ground for a novel class of cardioprotective compounds...
  29. doi request reprint Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats
    Carole Richard
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, IFR 100, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    J Cardiovasc Pharmacol 52:278-85. 2008
    ..P did not improve cardiac performance, but it modulated kinin receptor expression and enhanced antioxidant defense...
  30. doi request reprint Impact of asymmetric dimethylarginine on mortality after acute myocardial infarction
    Marianne Zeller
    Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, Faculty of Medicine, University of Burgundy, Dijon Cedex, France
    Arterioscler Thromb Vasc Biol 28:954-60. 2008
    ..From a prospective cohort of patients with acute myocardial infarction (MI), we aimed to analyze the predictive value of circulating ADMA concentrations on prognosis...
  31. pmc High levels of asymmetric dimethylarginine are strongly associated with low HDL in patients with acute myocardial infarction
    Julie Lorin
    INSERM UMR866 Laboratory of Cardiometabolic Physiopathology and Pharmacology, University of Burgundy, Dijon, France
    PLoS ONE 8:e64796. 2013
    ..Asymmetric dimethylarginine (ADMA) mediates endothelial function by inhibiting nitric oxide synthase activity. In patients with acute myocardial infarction, we investigated the relationship between serum levels of HDL and ADMA...
  32. doi request reprint Regional heterogeneity of decreased myocardial norepinephrine and increased lipid peroxidation levels in patients with end-stage failing heart secondary to dilated or ischemic cardiomyopathy
    Luc Rochette
    Facultes de Medecine et de Pharmacie, Laboratoire de Physiologie et Pharmacologie Cardiovasculaires Expérimentales, Centre Hospitalier Universitaire, Dijon, France
    J Heart Lung Transplant 27:767-74. 2008
    ....
  33. ncbi request reprint Identification and quantification of free radicals during myocardial ischemia and reperfusion using electron paramagnetic resonance spectroscopy
    Catherine Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, IFR no 100 Facultés de Médecine et de Pharmacie, 7 Bd Jeanne d Arc 87900, 21079 Dijon Cedex, France
    Arch Biochem Biophys 420:209-16. 2003
    ..Spin trapping can also characterize nitric oxide. EPR spectroscopy can provide important data regarding redox state and free radical metabolism but ideally, the spin traps must not interfere with cell or organism function...
  34. doi request reprint Telomere length and cardiovascular disease
    Sébastien Saliques
    IFR Santé STIC, UFR de Medecine et Pharmacie, Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales LPPCE, Universite de Bourgogne, 7, boulevard Jeanne d Arc, 21000 Dijon, France
    Arch Cardiovasc Dis 103:454-9. 2010
    ....
  35. ncbi request reprint Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction
    Claudia Korandji
    Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, IFR100, Faculties of Medecine and Pharmacy, University of Burgundy, Dijon, France
    Clin Biochem 40:66-72. 2007
    ....
  36. doi request reprint Carbon monoxide: mechanisms of action and potential clinical implications
    Luc Rochette
    Laboratoire de Physiopathologie et Pharmacologies Cardio Métaboliques LPPCM, Inserm UMR866, Universite de Bourgogne, Facultes de Medecine et de Pharmacie, 7 Boulevard Jeanne d Arc, 21033 Dijon Cedex, France
    Pharmacol Ther 137:133-52. 2013
    ....
  37. doi request reprint Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood
    Ahmed Habbout
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales EA2979, Facultés de Médecine et Pharmacie, IFR Santé STIC, Universite de Bourgogne, 7 Boulevard Jeanne d Arc, 21000 Dijon, France
    Biochimie 94:117-24. 2012
    ....
  38. ncbi request reprint The activation pattern of the antioxidant enzymes in the right ventricle of rat in response to pressure overload is of heart failure type
    Aline Ecarnot-Laubriet
    Laboratory of Experimental Cardiovascular Physiopathology and Pharmacology I F R No 100, Faculties of Medicine and Pharmacy, University of Burgundy, 21079 Dijon, France
    Heart Dis 5:308-12. 2003
    ..This inability to activate antioxidant enzymes may contribute to the deleterious consequences of pressure overload on right ventricle systolic function...
  39. ncbi request reprint A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model
    Benjamin Lauzier
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expérimental, IFR n degrees 100, Faculte de Medecine et Pharmacie, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Fundam Clin Pharmacol 21:173-80. 2007
    ..The use of the peroxynitrite decomposition catalyst (FeTPPS) may help to improve myocardial preservation during a prolonged ischemia sequence...
  40. ncbi request reprint Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass
    Gaelle Clermont
    LPPCE Faculty of Medicine, Dijon, France
    Anesthesiology 96:80-7. 2002
    ..The aim of this study was to evaluate the time course and origin of radical oxygen species release, myocardial or not, in patients undergoing coronary artery surgery involving CPB...
  41. ncbi request reprint Alteration in plasma antioxidant capacities in chronic renal failure and hemodialysis patients: a possible explanation for the increased cardiovascular risk in these patients
    G Clermont
    L P P C E, Faculties of Medicine and Pharmacy, BP 87900, 21079 cedex, Dijon, France
    Cardiovasc Res 47:618-23. 2000
    ....
  42. ncbi request reprint In high-risk patients, combination of antiinflammatory procedures during cardiopulmonary bypass can reduce incidences of inflammation and oxidative stress
    Jean Jacques Goudeau
    Anaesthesia and Intensive Care Unit, Bocage Hospital, Dijon, France
    J Cardiovasc Pharmacol 49:39-45. 2007
    ..Therefore, pre-CPB therapeutic optimization can reduce the inflammatory response, lower the level of oxidative stress, and help to ameliorate clinical outcome in high-risk patients...
  43. pmc Increase in Levels of BDNF is Associated with Inflammation and Oxidative Stress during Cardiopulmonary Bypass
    Sebastien Amoureux
    LPPCE, IFR Santé STIC 100, Facultes de Medecine et de Pharmacie, Dijon, France Département d anesthésie réanimation, CHRU Le Bocage, Dijon, France
    Int J Biomed Sci 4:204-11. 2008
    ..The role played by this neurotrophin in this complex situation still needs to be elucidated, in particular its cellular origin. It is also necessary to understand whether BDNF has a beneficial or deleterious effect during CPB...
  44. doi request reprint Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects
    Julie Lorin
    Laboratoire de Physiopathologie et Pharmacologies Cardio Métaboliques LPPCM, Inserm UMR866, Facultes de Medecine et de Pharmacie, Universite de Bourgogne, Dijon, France
    Mol Nutr Food Res 58:101-16. 2014
    ....
  45. ncbi request reprint The influence of extracorporeal circulation on the susceptibility of erythrocytes to oxidative stress
    Jean Jacques Lahet
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultes de Medecine et de Pharmacie, IFR No 100, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Free Radic Res 38:683-9. 2004
    ..Such protection is of particular importance in a cell engaged in the transport of oxygen and suggests that RBC are equipped with mechanisms affording a protection against free radicals...
  46. doi request reprint Postnatal overfeeding in rodents by litter size reduction induces major short- and long-term pathophysiological consequences
    Ahmed Habbout
    Inserm UMR866, LPPCM, Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France
    J Nutr 143:553-62. 2013
    ..Together, these results suggest that the nutritional state in the immediate postnatal period should be taken into account, because it may have an impact on cardiometabolic risk in adulthood...
  47. ncbi request reprint In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1
    Caroline Perrin
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharmacie, Dijon, France
    Cell Mol Biol (Noisy-le-grand) 48:OL267-70. 2002
    ..In contrast, calpain inhibitor-1 showed no protection. In conclusion, our findings indicate that leupeptin and calpain inhibitor-1 are equipotent inhibitors on calpain activity but exhibit diffrent antioxidant efficacy...
  48. doi request reprint [Hydrogen sulfide (H2S), an endogenous gas with odor of rotten eggs might be a cardiovascular function regulator]
    L Rochette
    LPPCE, Facultés de Médecine et Pharmacie, 7, boulevard Jeanne d Arc, 21033 Dijon, France
    Ann Cardiol Angeiol (Paris) 57:136-8. 2008
    ..Being a reducing agent, H2S may alter cellular redox status. It is able to produce thiyls free radicals: SH degrees and S degrees . The advances in H2S researchs may revolutionize many conventional doctrines in the cardiovascular area...
  49. ncbi request reprint Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery
    C Perrin
    Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Faculties of Medicine and Pharmacy, IFR Santé N o 100, 21079 Dijon, France
    Cell Mol Biol (Noisy-le-grand) 49:OL497-505. 2003
    ..However, in our experimental conditions, these inhibitors did not afford improvement of post-ischemic myocardial function...
  50. ncbi request reprint [Calpains and cardiac diseases]
    C Perrin
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales LPPCE, IFR N 100, Faculte de Medecine, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Ann Cardiol Angeiol (Paris) 53:259-66. 2004
    ..Moreover, recent works have demonstrated that calpains are involved in the development of myocardial cell death by necrosis or apoptosis...
  51. ncbi request reprint [Role of AT1 receptors in functional adaptation to ischemia-reperfusion in solated rat hearts in relationship to oxidative stress]
    A Oudot
    , , bd Jeanne-d'Arc, BP 87900, 21079 Dijon
    Arch Mal Coeur Vaiss 94:799-804. 2001
    ....
  52. ncbi request reprint [Nitric oxide synthases and peripheral cardiovascular system]
    C Vergely
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultes de Medecine et de Pharmacie, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Ann Cardiol Angeiol (Paris) 51:109-16. 2002
    ..The formation of peroxynitrite has been implicated in the pathology of a large number of conditions involving oxidative stress such as atherosclerosis and heart failure...
  53. ncbi request reprint [Cellular injury associated with extracorporeal circulation]
    G Clermont
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultes de Medecine et de Pharmacie, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Ann Cardiol Angeiol (Paris) 51:38-43. 2002
    ..Now it is well recognized that the whole body inflammatory response induced by CPB is mainly responsible for postoperative organ dysfunctions...
  54. ncbi request reprint [A treatment with rosuvastatin induced a reduction of arterial pressure and a decrease of oxidative stress in spontaneously hypertensive rats]
    P Sicard
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, facultés de médecine and pharmacie, Dijon
    Arch Mal Coeur Vaiss 98:804-8. 2005
    ..In conclusion, these results are in accordance with the hypothesis that oxidative stress plays a crucial role in the pathogenesis of cardiovascular diseases including hypertension, and demonstrate the beneficial effects of rosuvastatin...
  55. doi request reprint [Oxidative stress is exacerbated in diabetic patients during cardiopulmonary bypass]
    J C Marty
    Service d Anesthesie Reanimation, CHU Bocage, Dijon, France
    Ann Cardiol Angeiol (Paris) 57:155-60. 2008
    ..The purpose of this study was to determine the influence of hyperglycemia on inflammation and oxidative stress in patients under CPB during cardiac surgery...
  56. pmc Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats
    P Sicard
    Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, Faculties of Medicine and Pharmacy, 7 Boulevard Jeanne d Arc, 21000 Dijon, France
    Br J Pharmacol 151:979-86. 2007
    ..Statins may reduce the risk of developing hypertension and ocular diseases. We evaluate the effects of rosuvastatin (ROSU) on retinal functionality and oxidative stress levels in normotensive and spontaneously hypertensive rats (SHR)...
  57. ncbi request reprint [Preventing the cardiotoxic effects of anthracyclins. From basic concepts to clinical data]
    S Delemasure
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultes de Medecine et de Pharmacie, Universite de Bourgogne, IFR Santé 100, Dijon, France
    Ann Cardiol Angeiol (Paris) 55:104-12. 2006
    ..The myocardial protection, with cardioprotective agents targeting oxidative stress during chemotherapy would be of great interest for an optimal use of the anthracyclines...
  58. pmc Pharmacokinetics of 1-nitrosomelatonin and detection by EPR using iron dithiocarbamate complex in mice
    Fabienne Peyrot
    Institut de Chimie des Substances Naturelles, CNRS, F 91198 Gif sur Yvette, France
    Biochem J 387:473-8. 2005
    ..MGD)2-Fe2+-NO was observed in the brain of NOM-treated mice in the first 10 min following injection, revealing that NOM was able to cross the blood-brain barrier, while GSNO was not...
  59. ncbi request reprint Direct demonstration of nitric oxide formation in organs of rabbits treated by transdermal glyceryl trinitrate using an in vivo spin trapping technique
    Gaelle Clermont
    LPPCE, Faculty of Medicine, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex IFR Santé no 100, France
    Fundam Clin Pharmacol 17:709-15. 2003
    ..These data suggest that GTN patch treatment induced NO release, and that tissue-specific differences in transdermal GTN-derived NO exist. The GTN-NO pathway appears to be largely involved in organs such as the liver, kidney and heart...
  60. ncbi request reprint Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius
    Caroline Martin
    Unite de Nutrition Lipidique, National Institute of Agronomical Research Dijon, France
    Aging Cell 6:165-77. 2007
    ..These changes appear to be related to modifications of the fatty acid profile of mitochondrial lipids...