Bruno Vellas

..We aimed to assess efficacy of long-term use of standardised ginkgo biloba extract for the reduction of incidence of Alzheimer's disease in elderly adults with memory complaints...

..The MAPT Study...

..The group also stressed the importance of clinical research to improve knowledge of disease course and assess management strategies and recommended specific area for research...

..Leon Thal suggested that this could have a much bigger impact than all the drugs we might ever hope to develop. The main objective of this article is to present the rationale for multi-domain preventive approaches...

..The aims of the Gispen study were to evaluate the validity of biomarkers that are currently being proposed as potential surrogate endpoints. We really think that this journal's special issue can contribute in this field...

..In the past, several studies suggest that Ginkgo biloba could have a potential benefit effect on cognitive function. The aim of the GuidAge Study is to evaluate the efficacy of 240 mg/d of EGb 761 in the prevention of AD...

..However, information on the evolution of nutritional status and its impact on the prognosis of AD is still scarce...

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..Resource allocation and proximity care have to be targeted. Research areas necessary to improve the care of patients with severe dementia has been selected...

..A short screening version (MNA-SF) has been developed, which, if positive, indicates the need to complete the full MNA. It takes less than 4 minutes to administer the MNA-SF and between 10 and 15 minutes for the full MNA...

..One year follow-up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery (NTB) and a decrease in brain volume compared with placebo...

..The aim of this study was to explore the predictive value of an abnormal one-leg balance (OLB) test for functional decline, nursing home admission, and mortality in community-dwelling patients affected with Alzheimer's disease (AD)...

..This study aims to investigate the effect of CEIs on three clinically relevant domains (rapid cognitive decline, institutionalization, and weight loss) in patients with Alzheimer's disease...

..Weight loss in Alzheimer's disease (AD) may be either progressive or rapid, with different consequences. The aim of this study was to characterize massive weight loss (>or= 5 kg over 6 months) during a 6.5-year follow-up...

..50, 95% CI = 1.04-2.17). In conclusion, weight loss predicted RCD in this cohort. Whether the prevention of weight loss (by improving nutritional status) impacts cognitive decline remains an open question...

..Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients...

..Data regarding the long-term disease progression outside of therapeutic trials are lacking. We examined the effects of standard of care for AD patients on the prognosis of the disease in a real-life study over a 4-year period...

..To describe the cognitive, functional, and nutritional features of patients admitted to a Special Acute Care Unit (SACU) for elderly patients with Alzheimer's disease (AD)...

..Risk for undernutrition and death are not increased in wanderers. Their higher risk of ADL disabilities and institutionalization are partly explained by their baseline characteristics...

..The primary objective of our study was to examine the evolution of AD in individuals with very mild AD (CDR 0.5) across a 2-year follow up...

..The aim of the present study was to describe the long-term evolution of Alzheimer's disease (AD) in a prospective cohort of patients under treatment with a close follow-up...

..5% presented a CDR score of 0.5. This study will enable us to evaluate the efficacy of EGb761 in the prevention of AD, and to assess the usefulness of various baseline characteristics as predictors of conversion to AD in this population...

..8 (0.3) points at two years (p < 0.001). An abnormal one-leg balance test is a marker of more advanced dementia and predicts a higher rate of cognitive decline...

..The quality of amino acids in the diet is an important factor for stimulating protein synthesis. Vitamin D deficiency should be treated, and new pharmacologic approaches for sarcopenia are currently assessed...

..To determine whether calf circumference (CC), related to appendicular skeletal muscle mass, can be used as a measure of sarcopenia and is related to physical function...

..In elders, decreased muscle mass (sarcopenia) and increased fat mass (obesity) may contribute to difficulties with physical function...

..006) were risk factors for institutional placement. Nutritional problems are reversible and patients with a low MNA score could benefit from a thorough geriatric assessment, in order to slow or prevent institutional placement...

..To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer's disease compared with usual care in memory clinics...

..To describe hospitalizations in a Special Acute Care inpatient Unit for older adults with Alzheimer's disease (AD) and other related disorders...

..The aim of the study was to evaluate whether GS, TLM, and TFM were associated factors with an increased risk for subsequent dementia in community-dwelling older women...

..To study the effects of oral nutritional supplements (OS) on body weight, body composition, nutritional status, and cognition in elderly patients with Alzheimer's disease (AD)...

..The potential association between use of C4A treatments, in particular EGb 761 (standardized Ginkgo biloba extracts), and dementia of the Alzheimer type was investigated...

..There is a lack of data concerning the optimal drug treatment duration and the reasons for discontinuation, particularly outside the clinical trial setting...

..An impairment of more than 7 points at the ADAS-cog was found in 21% of the subjects at 18 months and was associated with loss...

..The challenges to conduct phase 3 trials in the elderly should not offset the opportunities for the development of new strategies to counteract sarcopenia and prevent late-life disability...

..To test the hypothesis that low fat-free soft tissue mass and cognitive impairment are independently associated...

..The aim of this survey was to assess the prevalence of antidepressant use in AD and to identify the clinical factors associated with antidepressant prescription...

..To describe the characteristics and associated factors of Alzheimer disease (AD) patients with balance and gait impairments...

..There are presently no published data on age-related changes in body composition in French individuals older than 65 or 80 years. This paper presents a cross-sectional study of 7518 community-residing French women older than 75 years...

..Attrition, i.e. patient dropout, can threaten the validity of results in longitudinal studies. The aim of this study was to identify patient and caregiver factors predictive of attrition in a cohort of Alzheimer disease (AD) patients...

..To assess if cardiovascular disease risk factors (CVDRF) are predictive factors for poorer evolution of Alzheimer's disease (AD) patients in terms of cognitive decline...

..However, due to the bone mineral inter-machine differences, comparisons of DXA measurements from different machines should be interpreted with caution...

..Muscle strength (MS) may be impaired in obese persons, and this impairment may be a consequence of both obesity and low physical fitness...

..common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment...

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..To quantify transitions of residents into or out of nursing homes (NHs) and to describe psychotropic drug prescription at admission and discharge and with regard to dementia diagnosis...

..To report the associated factors with the nonuse of cholinesterase-inhibitors and memantine in residents from assisted living (AL) facilities suffering from dementia...

..A clear and consensual definition of endpoints is crucial for the success of further clinical trials in the field and will allow comparison of data across studies...

..Nutritional assessment should therefore form part of clinical evaluation of patients with AD at an early stage of the disease...

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..Increased risk of death was partly explained by baseline health status and was absent in the healthiest elderly...

..The aim of this study was to examine whether wandering during AD was associated with cerebral perfusion patterns measured by (99 m)Tc-labeled bicisate (ECD) brain SPECT...

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..The evaluation of gait speed over a short distance emerges from the literature as a tool with the capacity to identify frail older adults, and slow gait speed has been proven to be a strong predictor for frailty-adverse outcomes...

..We evaluated the psychometric properties of the Clinical Dementia Rating-Sum of Boxes (CDR-SB) to assess its suitability as a single primary endpoint as an alternative to the traditional co-primary approach...

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..Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence...

..Future prevention of Alzheimer disease may depend on lifestyle habits such as physical activity...

..There is currently insufficient evidence for recommending combination therapy in Alzheimer's disease...

..The critical analysis of international literature, conducted by Professor Bruno Vellas for the scientific committee, has served to support study of the latest knowledge in 2008...

..Weight loss is a common problem in patients with Alzheimer's Disease (AD). It is a predictive factor of mortality and it decreases patients' and caregivers' quality of life...

..Therefore, new pharmacologic agents may substantially reduce the functional decline in older people. This article reviews the new pharmacologic agents currently being assessed for treating sarcopenia...

..This article highlights some of the challenges faced by investigators when conducting clinical trials in AD, and it also offers some recommendations aimed at overcoming these challenges...

..We observed significant decrease of regional cerebral blood flow over the nondominant thalamus in sAHS+ compared to sAHS- patients. This result suggests the involvement of the nondominant thalamus in sAHS...

..The concentration of aluminum or silica in drinking water may be a potential environmental risk factor for Alzheimer disease (AD)...

..Because of the multifactorial origin of dementia, it appears that multidomain interventions could be a suitable candidate for preventive interventions, but designing such trials remains very challenging for researchers...

..These behaviours lead to weight loss and frequently to physicians using tube feeding. Little is known about factors correlated with feeding difficulties during AD...

..We investigated the associations between IADL incapacities and the various known correlates of frailty in a cohort of community-dwelling elderly women...

..Recreational physical activity, which increases energy expenditure, may help to maintain proper food intake. To compare the nutritional intake of inactive, active and very active healthy elderly women...

..Currently, several Aβ peptide immunotherapy approaches are under investigation but also against tau pathology...

..Increased attentiveness by clinicians to treatment response across this multidisciplinary spectrum in more advanced Alzheimer's disease is warranted...

..However, at present no biomarker is validated as surrogate endpoint. It seems today indispensable to use them in the therapeutic tries so as to validate and standardize their methods of acquisition, measure and analysis...

..Clinical trials in Alzheimer's disease (AD) include patients benefiting from recent improvements in AD management...

..To study appendicular muscle mass in women with Alzheimer's disease (AD) to investigate the association between sarcopenia and AD. To examine the AD associated changes in body fat distribution...

..Considering ageing of the population, the number of Alzheimer's disease cases should raise to 1.3 million in 2020 (20 patients for 1000 inhabitants) ant 2.1 million in 2040 (30 patients for 1000 inhabitants)...

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..To evaluate the frequency of and determine predictive factors for acute hospitalization in a prospective study of patients with Alzheimer's disease (AD)...

..These effects may be a consequence of galantamine's potentiating action at nicotinic receptors...

..To assess the association between cognitive status and functional gain during a rehabilitation programme for elderly patients with hip fracture...

..The aim of this study is to describe the progression of Alzheimer's disease (AD) in the oldest old (>or=85 years) and to compare it with the younger elderly...

..They also have a major negative impact on the caregiver's burden. We present an intervention study on the carers of demented patients in a long-term care unit...

..The review summarizes and discusses the proposed new definitions for sarcopenia and cachexia. It also highlights the overlapping of both conditions and the fact that these conditions frequently occur in elderly patients...

..caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or treat neurodegenerative disorders such as Alzheimer's disease? Is there a future for caloric restriction interventions in adults?..

..Future research should be focussed on redefining the criteria of the mild cognitive impairment entity. This could enable the better development of appropriate therapeutic interventions...

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..The aims of the present study were to evaluate the frequency and the causes of hospitalization in a large prospective cohort of mild to moderate patients with AD...

..In this review, we summarize preclinical and clinical research suggesting that DHA exerts beneficial effects on cognitive function with ageing...

..It is a matter of patients' right to benefit from access to innovation and clinical research whatever his age or diseases, while of course fully respecting the rules and protective measures that are in force...

..The study also collects imaging and biological data that could be used in future AD prevention and treatment trials...

..The endpoint prevention of mobility disability should be added to the well-established outcomes of treatment of the loss of muscular mass, muscle strength or muscle quality...

..The objective of the present study was to determine predictive factors for hospitalisation in AD patients...

..The aim of this article is to discuss available care strategies once the AD diagnosis has been made and to propose a follow-up plan as standard of care at a European level...

..To determine the predictive factors of hospitalisation in patients with Alzheimer's disease followed in the REAL.FR cohort...

..The importance of memory complaints should not be underestimated in clinical practice...

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..The major objective of this study is to analyse the impact of vascular risk factors on natural history of Alzheimer's disease...