Bruno Vellas

Summary

Country: France

Publications

  1. ncbi request reprint Impact of nutritional status on the evolution of Alzheimer's disease and on response to acetylcholinesterase inhibitor treatment
    B Vellas
    Department of Internal Medicine and Clinical Gerongology, Centre Hospitalier Universitaire Purpan Casselardit, F 31300 Toulouse, France
    J Nutr Health Aging 9:75-80. 2005
  2. ncbi request reprint Editorial: recruitment, retention and other methodological issues related to clinical trials for Alzheimer's disease
    B Vellas
    B Vellas, Gerontopole, Inserm U 1027, Alzheimer s Disease Research and Clinical Center, Toulouse, University Hospital, France
    J Nutr Health Aging 16:330. 2012
  3. pmc Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
    Ines Greco
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Transl Med 10:217. 2012
  4. pmc Methodological considerations in cost of illness studies on Alzheimer disease
    Nagede Costa
    Department of Medical Information, University Hospital of Toulouse, Toulouse, F 31059, France
    Health Econ Rev 2:18. 2012
  5. doi request reprint Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
    Bruno Vellas
    INSERM U1027, Toulouse, France
    Lancet Neurol 11:851-9. 2012
  6. ncbi request reprint Commentary: a brief history of geriatrics
    Bruno Vellas
    Centre de Geriatrie Toulouse, 170 Ave de Casselardit, 31300 Toulouse, France
    J Gerontol A Biol Sci Med Sci 59:1171-2; discussion 1132-52. 2004
  7. pmc Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders
    Bruno Vellas
    Department of Geriatrics INSERM U 558, Toulouse University Hospital Center, Toulouse, France
    Curr Alzheimer Res 6:144-51. 2009
  8. ncbi request reprint [Consensus statement on severe dementia]
    B Vellas
    CHU Casselardit, Toulouse
    Rev Neurol (Paris) 161:868-77. 2005
  9. ncbi request reprint Overview of the MNA--Its history and challenges
    B Vellas
    INSERM U 558, Department of Geriatrics, Toulouse University Hospital, Toulouse, France
    J Nutr Health Aging 10:456-63; discussion 463-5. 2006
  10. ncbi request reprint The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint
    B Vellas
    INSERM French National Institute of Health and Medical Research, U558, F 31073 Toulouse, France
    Neurology 67:S6-11. 2006

Detail Information

Publications165 found, 100 shown here

  1. ncbi request reprint Impact of nutritional status on the evolution of Alzheimer's disease and on response to acetylcholinesterase inhibitor treatment
    B Vellas
    Department of Internal Medicine and Clinical Gerongology, Centre Hospitalier Universitaire Purpan Casselardit, F 31300 Toulouse, France
    J Nutr Health Aging 9:75-80. 2005
    ..However, information on the evolution of nutritional status and its impact on the prognosis of AD is still scarce...
  2. ncbi request reprint Editorial: recruitment, retention and other methodological issues related to clinical trials for Alzheimer's disease
    B Vellas
    B Vellas, Gerontopole, Inserm U 1027, Alzheimer s Disease Research and Clinical Center, Toulouse, University Hospital, France
    J Nutr Health Aging 16:330. 2012
    ..The MAPT Study...
  3. pmc Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
    Ines Greco
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Transl Med 10:217. 2012
    ..The aim of this study was to use a novel in silico approach to discover a set of candidate biomarkers for AD...
  4. pmc Methodological considerations in cost of illness studies on Alzheimer disease
    Nagede Costa
    Department of Medical Information, University Hospital of Toulouse, Toulouse, F 31059, France
    Health Econ Rev 2:18. 2012
    ..To increase its credibility, closer agreement among researchers on the methodological principles of cost studies would be desirable...
  5. doi request reprint Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
    Bruno Vellas
    INSERM U1027, Toulouse, France
    Lancet Neurol 11:851-9. 2012
    ..We aimed to assess efficacy of long-term use of standardised ginkgo biloba extract for the reduction of incidence of Alzheimer's disease in elderly adults with memory complaints...
  6. ncbi request reprint Commentary: a brief history of geriatrics
    Bruno Vellas
    Centre de Geriatrie Toulouse, 170 Ave de Casselardit, 31300 Toulouse, France
    J Gerontol A Biol Sci Med Sci 59:1171-2; discussion 1132-52. 2004
  7. pmc Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders
    Bruno Vellas
    Department of Geriatrics INSERM U 558, Toulouse University Hospital Center, Toulouse, France
    Curr Alzheimer Res 6:144-51. 2009
    ..One year follow-up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery (NTB) and a decrease in brain volume compared with placebo...
  8. ncbi request reprint [Consensus statement on severe dementia]
    B Vellas
    CHU Casselardit, Toulouse
    Rev Neurol (Paris) 161:868-77. 2005
    ..Resource allocation and proximity care have to be targeted. Research areas necessary to improve the care of patients with severe dementia has been selected...
  9. ncbi request reprint Overview of the MNA--Its history and challenges
    B Vellas
    INSERM U 558, Department of Geriatrics, Toulouse University Hospital, Toulouse, France
    J Nutr Health Aging 10:456-63; discussion 463-5. 2006
    ..A short screening version (MNA-SF) has been developed, which, if positive, indicates the need to complete the full MNA. It takes less than 4 minutes to administer the MNA-SF and between 10 and 15 minutes for the full MNA...
  10. ncbi request reprint The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint
    B Vellas
    INSERM French National Institute of Health and Medical Research, U558, F 31073 Toulouse, France
    Neurology 67:S6-11. 2006
    ..In the past, several studies suggest that Ginkgo biloba could have a potential benefit effect on cognitive function. The aim of the GuidAge Study is to evaluate the efficacy of 240 mg/d of EGb 761 in the prevention of AD...
  11. ncbi request reprint Editorial: use of biomarkers in Alzheimer's trials
    B Vellas
    B Vellas, , U 558, Alzheimer s Disease Clinical Research Center, CHU Toulouse, France, E mail
    J Nutr Health Aging 13:331. 2009
    ..The aims of the Gispen study were to evaluate the validity of biomarkers that are currently being proposed as potential surrogate endpoints. We really think that this journal's special issue can contribute in this field...
  12. ncbi request reprint Disease modifying trials in Alzheimer's disease: perspectives for the future
    Bruno Vellas
    Gerontopole, CHU Toulouse, Department of Geriatric Medicine, Toulouse, France
    J Alzheimers Dis 15:289-301. 2008
    ....
  13. ncbi request reprint [Alzheimer's disease: 160,000 new cases each year in France]
    Bruno Vellas
    Hopitaux de Toulouse, CHU Casselardit, 31300 Toulouse
    Rev Prat 55:1867-8. 2005
  14. ncbi request reprint [Consensus statement on severe dementia]
    B Vellas
    CHU Casselardit, secteur A gériatrie, Toulouse
    Presse Med 34:1545-55. 2005
    ..The group also stressed the importance of clinical research to improve knowledge of disease course and assess management strategies and recommended specific area for research...
  15. doi request reprint Memory health clinics-a first step to prevention
    Bruno Vellas
    Department of Internal Medicine and Clinical Gerontology, Gerontopole, Toulouse Université Hospital, CHU La Grave Casselardit, Toulouse, France Inserm U 558, Toulouse, France
    Alzheimers Dement 4:S144-9. 2008
    ..Leon Thal suggested that this could have a much bigger impact than all the drugs we might ever hope to develop. The main objective of this article is to present the rationale for multi-domain preventive approaches...
  16. ncbi request reprint Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, 170, avenue de Casselardit, Toulouse 31059, France
    Age Ageing 42:196-202. 2013
    ..common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment...
  17. doi request reprint Prognosis of an abnormal one-leg balance in community-dwelling patients with Alzheimer's disease: a 2-year prospective study in 686 patients of the REAL.FR study
    Sandrine Sourdet
    Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
    J Am Med Dir Assoc 13:407.e1-6. 2012
    ..The aim of this study was to explore the predictive value of an abnormal one-leg balance (OLB) test for functional decline, nursing home admission, and mortality in community-dwelling patients affected with Alzheimer's disease (AD)...
  18. ncbi request reprint Outcome of Alzheimer's disease: potential impact of cholinesterase inhibitors
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire La Grave Casselardit, 170 avenue de Casselardit, TSA40031, 31059 Toulouse Cedex 9, France
    J Gerontol A Biol Sci Med Sci 61:516-20. 2006
    ..This study aims to investigate the effect of CEIs on three clinically relevant domains (rapid cognitive decline, institutionalization, and weight loss) in patients with Alzheimer's disease...
  19. doi request reprint Characteristics of Alzheimer's disease patients with a rapid weight loss during a six-year follow-up
    Olivier Guerin
    INSERM U558, Department of Internal Medicine and Clinical Gerontology, CHU de Toulouse, Universite Paul Sabatier, France
    Clin Nutr 28:141-6. 2009
    ..Weight loss in Alzheimer's disease (AD) may be either progressive or rapid, with different consequences. The aim of this study was to characterize massive weight loss (>or= 5 kg over 6 months) during a 6.5-year follow-up...
  20. doi request reprint Weight loss and rapid cognitive decline in community-dwelling patients with Alzheimer's disease
    Maria E Soto
    Alzheimer s Disease Research and Clinical Centre, Department of Geriatric Medicine, Gerontopole, Toulouse University Hospital, Toulouse, France
    J Alzheimers Dis 28:647-54. 2012
    ..50, 95% CI = 1.04-2.17). In conclusion, weight loss predicted RCD in this cohort. Whether the prevention of weight loss (by improving nutritional status) impacts cognitive decline remains an open question...
  21. doi request reprint Predictive value of rapid decline in mini mental state examination in clinical practice for prognosis in Alzheimer's disease
    Maria E Soto
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    Dement Geriatr Cogn Disord 26:109-16. 2008
    ..Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients...
  22. doi request reprint Prognosis of Alzheimer's disease today: a two-year prospective study in 686 patients from the REAL-FR Study
    Frederic Cortes
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, Toulouse, France
    Alzheimers Dement 4:22-9. 2008
    ..The aim of the present study was to describe the long-term evolution of Alzheimer's disease (AD) in a prospective cohort of patients under treatment with a close follow-up...
  23. ncbi request reprint GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer's disease in elderly subjects with memory complaints. i. rationale, design and baseline data
    Sandrine Andrieu
    INSERM, U558, F 31073, Toulouse, France
    Curr Alzheimer Res 5:406-15. 2008
    ..5% presented a CDR score of 0.5. This study will enable us to evaluate the efficacy of EGb761 in the prevention of AD, and to assess the usefulness of various baseline characteristics as predictors of conversion to AD in this population...
  24. doi request reprint Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional study
    Philipe de Souto Barreto
    Gérontopôle de Toulouse, Institut du vieillissement, Centre Hospitalo Universitaire de Toulouse CHU Toulouse, Toulouse, France
    J Am Med Dir Assoc 14:265-9. 2013
    ..Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents...
  25. doi request reprint Angiotensin-converting enzyme inhibitors and Alzheimer's disease progression in older adults: results from the Réseau sur la Maladie d'Alzheimer Français cohort
    Maria E Soto
    Department of Geriatric Medicine, Gerontopole, CHU Toulouse University Hospital, Toulouse, France INSERM, UMR1027, Toulouse, France
    J Am Geriatr Soc 61:1482-8. 2013
    ..To assess whether angiotensin-converting enzyme inhibitor (ACE-I) treatment is associated with less cognitive decline in older adults with Alzheimer's disease (AD) than in those using other hypertensive or no drugs...
  26. doi request reprint Long-term progression of Alzheimer's disease in patients under antidementia drugs
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Geriatrics, Purpan University Hospital, Gerontopole Toulouse University Hospital, France
    Alzheimers Dement 7:579-92. 2011
    ..Data regarding the long-term disease progression outside of therapeutic trials are lacking. We examined the effects of standard of care for AD patients on the prognosis of the disease in a real-life study over a 4-year period...
  27. ncbi request reprint Special acute care unit for older adults with Alzheimer's disease
    Maria E Soto
    CHU Toulouse, Department of Geriatric Medicine, Toulouse, France
    Int J Geriatr Psychiatry 23:215-9. 2008
    ..To describe the cognitive, functional, and nutritional features of patients admitted to a Special Acute Care Unit (SACU) for elderly patients with Alzheimer's disease (AD)...
  28. ncbi request reprint Wandering behavior and Alzheimer disease. The REAL.FR prospective study
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Pavillon Junot, Hopital La Grave Casselardit, 170 avenue de Casselardit, Toulouse, France
    Alzheimer Dis Assoc Disord 21:31-8. 2007
    ..Risk for undernutrition and death are not increased in wanderers. Their higher risk of ADL disabilities and institutionalization are partly explained by their baseline characteristics...
  29. ncbi request reprint A 2-year follow-up of 233 very mild (CDR 0.5) Alzheimer's disease patients (REAL.FR cohort)
    Fati Nourhashemi
    CHU Toulouse, Hôpital Casselardit, Service de médecine interne et gérontologie clinique, Toulouse, France
    Int J Geriatr Psychiatry 23:460-5. 2008
    ..The primary objective of our study was to examine the evolution of AD in individuals with very mild AD (CDR 0.5) across a 2-year follow up...
  30. doi request reprint An abnormal "one-leg balance" test predicts cognitive decline during Alzheimer's disease
    Yves Rolland
    INSERM, U558, Toulouse, France
    J Alzheimers Dis 16:525-31. 2009
    ..8 (0.3) points at two years (p < 0.001). An abnormal one-leg balance test is a marker of more advanced dementia and predicts a higher rate of cognitive decline...
  31. doi request reprint Treatment strategies for sarcopenia and frailty
    Yves Rolland
    INSERM U1027, F 31073, Avenue Jules Guesdes, University of Toulouse III, F 31073, France
    Med Clin North Am 95:427-38, ix. 2011
    ..The quality of amino acids in the diet is an important factor for stimulating protein synthesis. Vitamin D deficiency should be treated, and new pharmacologic approaches for sarcopenia are currently assessed...
  32. doi request reprint Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) Study
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
    Am J Clin Nutr 89:1895-900. 2009
    ..In elders, decreased muscle mass (sarcopenia) and increased fat mass (obesity) may contribute to difficulties with physical function...
  33. ncbi request reprint Risk factors for functional decline and institutionalisation among community-dwelling older adults with mild to severe Alzheimer's disease: one year of follow-up
    Maria E Soto
    Médicine Interne et Gériatrie, CHU Purpan Casselardit, Toulouse, Midi Pirinées, France
    Age Ageing 35:308-10. 2006
  34. ncbi request reprint Sarcopenia, calf circumference, and physical function of elderly women: a cross-sectional study
    Yves Rolland
    Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
    J Am Geriatr Soc 51:1120-4. 2003
    ..To determine whether calf circumference (CC), related to appendicular skeletal muscle mass, can be used as a measure of sarcopenia and is related to physical function...
  35. ncbi request reprint Nutritional risk factors for institutional placement in Alzheimer's disease after one year follow-up
    S Andrieu
    Department of Internal Medicine and Clinical Gerontology, Alzheimer Center, 170 chemin de Casselardit, 31300 Toulouse, France
    J Nutr Health Aging 5:113-7. 2001
    ..006) were risk factors for institutional placement. Nutritional problems are reversible and patients with a low MNA score could benefit from a thorough geriatric assessment, in order to slow or prevent institutional placement...
  36. doi request reprint Weight changes in Alzheimer's disease patients with increased aberrant motor behavior
    Marion Secher
    University of Toulouse III, F 31073, Toulouse, France Gerontopole, CMRR, F 31059, Toulouse, France
    Int J Geriatr Psychiatry 28:998-1004. 2013
    ..We investigated the impact of aberrant motor behavior (AMB) on weight changes in older adults with AD. The hypothesis that patients with AMB are more likely to lose weight than patients without AMB was assessed...
  37. doi request reprint Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force
    Bruno Vellas
    UMR1027 Inserm, Toulouse, France
    Alzheimers Dement 9:438-44. 2013
    ....
  38. doi request reprint Antidepressant use in Alzheimer's disease patients: results of the REAL.FR cohort
    Christophe Arbus
    Paul Sabatier University, Department of Psychiatry and Medical Psychology, Purpan Casselardit Hospital, Toulouse, France
    Int Psychogeriatr 22:120-8. 2010
    ..The aim of this survey was to assess the prevalence of antidepressant use in AD and to identify the clinical factors associated with antidepressant prescription...
  39. pmc Effectiveness of a specific care plan in patients with Alzheimer's disease: cluster randomised trial (PLASA study)
    Fati Nourhashemi
    Gerontopole, CMRR, Toulouse, France
    BMJ 340:c2466. 2010
    ..To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer's disease compared with usual care in memory clinics...
  40. doi request reprint Improving care of older adults with dementia: description of 6299 hospitalizations over 11 years in a special acute care unit
    Maria E Soto
    Department of Geriatric Medicine, Gérontopôle de Toulouse, Toulouse University Hospital, Toulouse, France
    J Am Med Dir Assoc 13:486.e1-6. 2012
    ..To describe hospitalizations in a Special Acute Care inpatient Unit for older adults with Alzheimer's disease (AD) and other related disorders...
  41. doi request reprint Gait speed, body composition, and dementia. The EPIDOS-Toulouse cohort
    Gabor Abellan van Kan
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Gerontol A Biol Sci Med Sci 67:425-32. 2012
    ..The aim of the study was to evaluate whether GS, TLM, and TFM were associated factors with an increased risk for subsequent dementia in community-dwelling older women...
  42. doi request reprint Predictive factors of discontinuation and switch of cholinesterase inhibitors in community-dwelling patients with Alzheimer's disease: a 2-year prospective, multicentre, cohort study
    Virginie Gardette
    Department of Epidemiology and Public Health, Toulouse University Hospital, Université de Toulouse UPS, INSERM U558, Gerontopole, Toulouse, France
    CNS Drugs 24:431-42. 2010
    ..There is a lack of data concerning the optimal drug treatment duration and the reasons for discontinuation, particularly outside the clinical trial setting...
  43. ncbi request reprint Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: a prospective randomized study
    Sylvie Lauque
    Alzheimer Research and Clinical Center, Toulouse University Hospital, Toulouse, France
    J Am Geriatr Soc 52:1702-7. 2004
    ..To study the effects of oral nutritional supplements (OS) on body weight, body composition, nutritional status, and cognition in elderly patients with Alzheimer's disease (AD)...
  44. ncbi request reprint Association of Alzheimer's disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study
    Sandrine Andrieu
    Department of Internal Medicine and Clinical Gerontology, Acute Unit for Alzheimer s Patients, Toulouse, France
    J Gerontol A Biol Sci Med Sci 58:372-7. 2003
    ..The potential association between use of C4A treatments, in particular EGb 761 (standardized Ginkgo biloba extracts), and dementia of the Alzheimer type was investigated...
  45. ncbi request reprint Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer?
    B Vellas
    B Vellas, INSERM U 558, Gerontopole, Pole Geriatrie, Centre Hospitalier Universitaire, Toulouse, France
    J Nutr Health Aging 11:338-41. 2007
    ..An impairment of more than 7 points at the ADAS-cog was found in 21% of the subjects at 18 months and was associated with loss...
  46. doi request reprint A follow-up intervention in severely demented patients after discharge from a special Alzheimer acute care unit: impact on early emergency room re-hospitalization rate
    Hélène Villars
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    Int J Geriatr Psychiatry 28:1131-40. 2013
    ..Emergency room (ER) re-hospitalizations are prevalent in severe Alzheimer's disease affected older patients...
  47. ncbi request reprint Is there a relationship between fat-free soft tissue mass and low cognitive function? Results from a study of 7,105 women
    Fati Nourhashemi
    Department of Internal Medicine and Gerontology Clinic, CHU Purpan Casselardit, Toulouse, France
    J Am Geriatr Soc 50:1796-801. 2002
    ..To test the hypothesis that low fat-free soft tissue mass and cognitive impairment are independently associated...
  48. pmc Clinical trials on sarcopenia: methodological issues regarding phase 3 trials
    Gabor Abellan van Kan
    Gerontopole, Department of Geriatric Medicine, Toulouse University Hospital, France
    Clin Geriatr Med 27:471-82. 2011
    ..The challenges to conduct phase 3 trials in the elderly should not offset the opportunities for the development of new strategies to counteract sarcopenia and prevent late-life disability...
  49. ncbi request reprint Body composition in French women 75+ years of age: the EPIDOS study
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, 170 avenue de Casselardit, F 31300 Toulouse, France
    Mech Ageing Dev 124:311-6. 2003
    ..There are presently no published data on age-related changes in body composition in French individuals older than 65 or 80 years. This paper presents a cross-sectional study of 7518 community-residing French women older than 75 years...
  50. ncbi request reprint Comparison of bone mineral density and body composition measurements in women obtained from two DXA instruments
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology Pr JL Albarède, Centre Hospitalier Universitaire Purpan Casselardit, 170 avenue de Casselardit, F 31300 Toulouse, France
    Mech Ageing Dev 124:317-21. 2003
    ..However, due to the bone mineral inter-machine differences, comparisons of DXA measurements from different machines should be interpreted with caution...
  51. doi request reprint Cardiovascular disease risk factors and progression of Alzheimer's disease
    Gabor Abellan van Kan
    INSERM U558, Department of Geriatric Medicine, CHU Toulouse, Toulouse, France
    Dement Geriatr Cogn Disord 27:240-6. 2009
    ..To assess if cardiovascular disease risk factors (CVDRF) are predictive factors for poorer evolution of Alzheimer's disease (AD) patients in terms of cognitive decline...
  52. doi request reprint Predictive factors of attrition in a cohort of Alzheimer disease patients. The REAL.FR study
    Nicola Coley
    INSERM, U558, University of Toulouse III, Toulouse, France
    Neuroepidemiology 31:69-79. 2008
    ..Attrition, i.e. patient dropout, can threaten the validity of results in longitudinal studies. The aim of this study was to identify patient and caregiver factors predictive of attrition in a cohort of Alzheimer disease (AD) patients...
  53. doi request reprint Gait and balance impairments in Alzheimer disease patients
    Virginia Mazoteras Muñoz
    Department of Geriatric Medicine, Univ Toulouse III, Toulouse, France
    Alzheimer Dis Assoc Disord 24:79-84. 2010
    ..To describe the characteristics and associated factors of Alzheimer disease (AD) patients with balance and gait impairments...
  54. pmc Persistent use of analgesic medications in mild-to-moderate Alzheimer's disease
    Adeline Gallini
    INSERM, UMR1027, 31062, Toulouse, France
    Drugs Aging 30:439-45. 2013
    ..Previous studies have reported a lower use of analgesics in patients with Alzheimer's disease (AD) than in non-AD elderly. To date, no study has focused on persistent analgesic use in patients with mild-to-moderate AD...
  55. doi request reprint Functional status and mortality in older women with gynecological cancer
    Matteo Cesari
    Gerontopole, Centre Hospitalier Universitaire de Toulouse, France
    J Gerontol A Biol Sci Med Sci 68:1129-33. 2013
    ..Screening tools for the identification of vulnerable older patients with cancer are needed. Aim of this study is to measure the prognostic value of multiple screening tools for the assessment of mortality risk in oncogeriatrics...
  56. ncbi request reprint Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional study
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
    Am J Clin Nutr 79:552-7. 2004
    ..Muscle strength (MS) may be impaired in obese persons, and this impairment may be a consequence of both obesity and low physical fitness...
  57. doi request reprint Prevention trials in Alzheimer's disease: an EU-US task force report
    Bruno Vellas
    INSERM, U1027, F 31073, Toulouse, France
    Prog Neurobiol 95:594-600. 2011
    ....
  58. doi request reprint Psychotropic drug consumption at admission and discharge of nursing home residents
    Yves Rolland
    INSERM, Toulouse, France
    J Am Med Dir Assoc 13:407.e7-12. 2012
    ..To quantify transitions of residents into or out of nursing homes (NHs) and to describe psychotropic drug prescription at admission and discharge and with regard to dementia diagnosis...
  59. doi request reprint Patterns of dementia treatment use in assisted living facilities: a cross-sectional study of 1975 demented residents
    Nadège Barro-Belaygues
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Am Med Dir Assoc 12:648-54. 2011
    ..To report the associated factors with the nonuse of cholinesterase-inhibitors and memantine in residents from assisted living (AL) facilities suffering from dementia...
  60. ncbi request reprint Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial
    Yves Rolland
    Internal Medicine Service and Gerontology Clinic, Hopital La Grave Casselardit, Toulouse, France
    J Am Geriatr Soc 55:158-65. 2007
    ....
  61. ncbi request reprint The assessment of frailty in older adults
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Pavillon JP Junod, University Hospital Toulouse, CHU Toulouse, 170 avenue de Casselardit, TSA 40031, 31059 Toulouse Cedex 9, France
    Clin Geriatr Med 26:275-86. 2010
    ..The evaluation of gait speed over a short distance emerges from the literature as a tool with the capacity to identify frail older adults, and slow gait speed has been proven to be a strong predictor for frailty-adverse outcomes...
  62. ncbi request reprint Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, 31300, Toulouse, France
    Eur J Epidemiol 21:113-22. 2006
    ..Increased risk of death was partly explained by baseline health status and was absent in the healthiest elderly...
  63. doi request reprint Endpoints for trials in Alzheimer's disease: a European task force consensus
    Bruno Vellas
    INSERM U558, Toulouse, France
    Lancet Neurol 7:436-50. 2008
    ..A clear and consensual definition of endpoints is crucial for the success of further clinical trials in the field and will allow comparison of data across studies...
  64. ncbi request reprint Family history of dementia does not influence the progression of Alzheimer's disease at two years: results from the REAL.FR Study
    Frederic Cortes
    Service de médecine interne et gérontologie clinique, Toulouse, France
    Am J Alzheimers Dis Other Demen 21:131-6. 2006
    ....
  65. ncbi request reprint A SPECT study of wandering behavior in Alzheimer's disease
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, 170 avenue de Casselardit, 31300 Toulouse, France
    Int J Geriatr Psychiatry 20:816-20. 2005
    ..The aim of this study was to examine whether wandering during AD was associated with cerebral perfusion patterns measured by (99 m)Tc-labeled bicisate (ECD) brain SPECT...
  66. ncbi request reprint Cognitive function and caregiver burden: predictive factors for eating behaviour disorders in Alzheimer's disease
    Stéphanie Rivière
    Department of Internal Medicine and Clinical Gerontology, Hopital La Grave Casselardit, Toulouse, France
    Int J Geriatr Psychiatry 17:950-5. 2002
    ..These behaviours lead to weight loss and frequently to physicians using tube feeding. Little is known about factors correlated with feeding difficulties during AD...
  67. doi request reprint Nutritional status is associated with disease progression in very mild Alzheimer disease
    Pierre Jean Ousset
    Department of Internal Medicine and Gerontology, Alzheimer Disease Center, CHU Purpan Casselardit, Toulouse, France
    Alzheimer Dis Assoc Disord 22:66-71. 2008
    ..Nutritional assessment should therefore form part of clinical evaluation of patients with AD at an early stage of the disease...
  68. pmc Nutrition and neurodegeneration: epidemiological evidence and challenges for future research
    Sophie Gillette-Guyonnet
    Gerontopole, Toulouse University Hospital, Department of Internal Medicine and Geriatrics, Purpan University Hospital, Toulouse F 31059, France
    Br J Clin Pharmacol 75:738-55. 2013
    ..Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed...
  69. doi request reprint Suitability of the Clinical Dementia Rating-Sum of Boxes as a single primary endpoint for Alzheimer's disease trials
    Nicola Coley
    University of Toulouse III, France
    Alzheimers Dement 7:602-610.e2. 2011
    ..We evaluated the psychometric properties of the Clinical Dementia Rating-Sum of Boxes (CDR-SB) to assess its suitability as a single primary endpoint as an alternative to the traditional co-primary approach...
  70. doi request reprint Associated factors with antipsychotic use in assisted living facilities: a cross-sectional study of 4367 residents
    Agnes Larrayadieu
    Department of Geriatric Medicine, Toulouse University Hospital Gérontopôle, 170, avenue de Casselardit, Toulouse 31059, France
    Age Ageing 40:368-75. 2011
    ..Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence...
  71. doi request reprint Managing cognitive dysfunction through the continuum of Alzheimer's disease: role of pharmacotherapy
    Julien Delrieu
    Alzheimers Disease Clinical Research Centre, Gerontopole, Toulouse University Hospital, Toulouse, France
    CNS Drugs 25:213-26. 2011
    ..There is currently insufficient evidence for recommending combination therapy in Alzheimer's disease...
  72. doi request reprint Healthy brain aging: role of exercise and physical activity
    Yves Rolland
    INSERM U558, Avenue J Guesdes, F 31073 Toulouse, France
    Clin Geriatr Med 26:75-87. 2010
    ..Future prevention of Alzheimer disease may depend on lifestyle habits such as physical activity...
  73. ncbi request reprint Disease-modifying trials in Alzheimer's disease: a European task force consensus
    Bruno Vellas
    Alzheimer Disease Research and Clinical Center, University of Toulouse, Toulouse, France
    Lancet Neurol 6:56-62. 2007
    ....
  74. ncbi request reprint Mild Alzheimer's disease: a "position paper"
    J Delrieu
    Service de medecine interne geriatrique et gerontologie clinique, Gerontopole, CHU Toulouse, Hopital Purpan Casselardit, Toulouse, France
    J Nutr Health Aging 13:503-19. 2009
    ..The critical analysis of international literature, conducted by Professor Bruno Vellas for the scientific committee, has served to support study of the latest knowledge in 2008...
  75. ncbi request reprint A nutritional education program could prevent weight loss and slow cognitive decline in Alzheimer's disease
    S Riviere
    Department of Internal Medicine and Clinical Gerontology, Hopital La Grave Casselardit, Toulouse, France
    J Nutr Health Aging 5:295-9. 2001
    ..Weight loss is a common problem in patients with Alzheimer's Disease (AD). It is a predictive factor of mortality and it decreases patients' and caregivers' quality of life...
  76. ncbi request reprint Current and future pharmacologic treatment of sarcopenia
    Yves Rolland
    INSERM U1027, University of Toulouse III, Avenue Jules Guesdes, France
    Clin Geriatr Med 27:423-47. 2011
    ..Therefore, new pharmacologic agents may substantially reduce the functional decline in older people. This article reviews the new pharmacologic agents currently being assessed for treating sarcopenia...
  77. doi request reprint AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials
    Bruno Vellas
    Department of Geriatrics, INSERM U558, Toulouse University Hospital Center, Toulouse, France
    Alzheimers Dement 7:e109-17. 2011
    ..This article highlights some of the challenges faced by investigators when conducting clinical trials in AD, and it also offers some recommendations aimed at overcoming these challenges...
  78. ncbi request reprint Sensory alien hand syndrome in corticobasal degeneration: a cerebral blood flow study
    Julien Delrieu
    Alzheimer s Disease Clinical Research Centre, Gerontopole, Toulouse University Hospital, Toulouse, France
    Mov Disord 25:1288-91. 2010
    ..We observed significant decrease of regional cerebral blood flow over the nondominant thalamus in sAHS+ compared to sAHS- patients. This result suggests the involvement of the nondominant thalamus in sAHS...
  79. doi request reprint Dementia prevention: methodological explanations for inconsistent results
    Nicola Coley
    INSERM unit 558, Toulouse, France
    Epidemiol Rev 30:35-66. 2008
    ..Because of the multifactorial origin of dementia, it appears that multidomain interventions could be a suitable candidate for preventive interventions, but designing such trials remains very challenging for researchers...
  80. ncbi request reprint Cognitive impairment and composition of drinking water in women: findings of the EPIDOS Study
    Sophie Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Hôpital Casselardit, Toulouse, France
    Am J Clin Nutr 81:897-902. 2005
    ..The concentration of aluminum or silica in drinking water may be a potential environmental risk factor for Alzheimer disease (AD)...
  81. ncbi request reprint Nutritional intake and recreational physical activity in healthy elderly women living in the community
    Y Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hôpital Casselardit, Pavillon Junod, 31300 Toulouse, France
    J Nutr Health Aging 9:397-402. 2005
    ..Recreational physical activity, which increases energy expenditure, may help to maintain proper food intake. To compare the nutritional intake of inactive, active and very active healthy elderly women...
  82. ncbi request reprint Instrumental activities of daily living as a potential marker of frailty: a study of 7364 community-dwelling elderly women (the EPIDOS study)
    F Nourhashemi
    Service de Médecine Interne et de, Toulouse, France
    J Gerontol A Biol Sci Med Sci 56:M448-53. 2001
    ..We investigated the associations between IADL incapacities and the various known correlates of frailty in a cohort of community-dwelling elderly women...
  83. doi request reprint 'Clinical trials in Alzheimer's disease': immunotherapy approaches
    Julien Delrieu
    Alzheimer s Disease Clinical Research Centre, Gerontopole, Toulouse University Hospital, France INSERM 1027, France
    J Neurochem 120:186-93. 2012
    ..Currently, several Aβ peptide immunotherapy approaches are under investigation but also against tau pathology...
  84. ncbi request reprint What are the treatment options for patients with severe Alzheimer's disease?
    Thierry Voisin
    Alzheimer s Disease Research Centre, Toulouse University Hospital, 170 avenue de Casselardit, 31300 Toulouse, France
    CNS Drugs 18:575-83. 2004
    ..Increased attentiveness by clinicians to treatment response across this multidisciplinary spectrum in more advanced Alzheimer's disease is warranted...
  85. doi request reprint [The Alzheimer's disease: how to estimate the impact of the pathology and the treatment?]
    Julien Delrieu
    Centre de Recherche Clinique sur la Maladie d Alzheimer, Gerontopole, Hôpital Universitaire de Toulouse, Toulouse, France INSERM U558, Toulouse, France
    Therapie 65:423-8. 2010
    ..However, at present no biomarker is validated as surrogate endpoint. It seems today indispensable to use them in the therapeutic tries so as to validate and standardize their methods of acquisition, measure and analysis...
  86. ncbi request reprint Determination of appendicular muscle mass by dual energy X-ray absorptiometry method in women with sarcopenia and Alzheimer's disease
    S Gillette-Guyonnet
    Department of Gerontology and Internal Medicine, Purpan University Hospital, Toulouse, France
    J Nutr Health Aging 4:165-9. 2000
    ..To study appendicular muscle mass in women with Alzheimer's disease (AD) to investigate the association between sarcopenia and AD. To examine the AD associated changes in body fat distribution...
  87. ncbi request reprint No additional benefit of HRT on response to rivastigmine in menopausal women with AD
    A S Rigaud
    Department of Geriatrics, Broca Hospital, Paris, France
    Neurology 60:148-9. 2003
  88. ncbi request reprint Balneotherapy, prevention of cognitive decline and care the Alzheimer patient and his family: outcome of a multidisciplinary workgroup
    M Secher
    Service de medecine interne geriatrique et gerontologie clinique, Gerontopole, CHU Toulouse, Hopital Purpan Casselardit, Toulouse, France
    J Nutr Health Aging 13:797-806. 2009
    ..Considering ageing of the population, the number of Alzheimer's disease cases should raise to 1.3 million in 2020 (20 patients for 1000 inhabitants) ant 2.1 million in 2040 (30 patients for 1000 inhabitants)...
  89. ncbi request reprint Six and 18-month changes in mild to moderate Alzheimer's patients treated with acetylcholinesterase inhibitors: what can we learn for clinical outcomes of therapeutic trials?
    F Cortes
    F Cortes, Alzheimer s Disease Research Centre, U 558, Toulouse, France
    J Nutr Health Aging 11:330-7. 2007
    ..Clinical trials in Alzheimer's disease (AD) include patients benefiting from recent improvements in AD management...
  90. ncbi request reprint Prevention of progression to dementia in the elderly: rationale and proposal for a health-promoting memory consultation (an IANA Task Force)
    S Gillette Guyonnet
    Gerontopole, Pole Geriatrie Gerontologie, Hopital La Grave Casselardit, Toulouse
    J Nutr Health Aging 12:520-9. 2008
    ....
  91. ncbi request reprint Predictive factors of acute hospitalization in 134 patients with Alzheimer's disease: a one year prospective study
    Sandrine Andrieu
    Department of Internal Medicine and Clinical Gerontology, Acute Unit for Alzheimer s Patients, Toulouse, France
    Int J Geriatr Psychiatry 17:422-6. 2002
    ..To evaluate the frequency of and determine predictive factors for acute hospitalization in a prospective study of patients with Alzheimer's disease (AD)...
  92. ncbi request reprint Early onset effects of galantamine treatment on attention in patients with Alzheimer's disease
    Bruno Vellas
    Memory Research Resource Center for Alzheimer s Disease, Service de Geriatrie, CHU Hôpital Lagrave Casselardit, Toulouse, France
    Curr Med Res Opin 21:1423-9. 2005
    ..This study was designed to test the effects of galantamine on attention in patients with mild-to-moderate Alzheimer's disease (AD) and to see how changes in attention affected their caregivers...
  93. ncbi request reprint Rehabilitation outcome of elderly patients with hip fracture and cognitive impairment
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
    Disabil Rehabil 26:425-31. 2004
    ..To assess the association between cognitive status and functional gain during a rehabilitation programme for elderly patients with hip fracture...
  94. doi request reprint Caloric restriction and brain function
    Sophie Gillette-Guyonnet
    Gérontopôle Toulouse, France
    Curr Opin Clin Nutr Metab Care 11:686-92. 2008
    ..caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or treat neurodegenerative disorders such as Alzheimer's disease? Is there a future for caloric restriction interventions in adults?..
  95. ncbi request reprint [Behavioral disorders in dementia: intervention study in a long-term care unit]
    Pierre Jean Ousset
    Service de médecine interne et gérontologie clinique, CHU Purpan Casselardit, Toulouse
    Psychol Neuropsychiatr Vieil 1:207-12. 2003
    ..They also have a major negative impact on the caregiver's burden. We present an intervention study on the carers of demented patients in a long-term care unit...
  96. ncbi request reprint Mild cognitive impairment: a nosological entity?
    Thierry Voisin
    Department of Internal Medicine and Clinical Gerontology, Acute Unit for Alzheimer s Patients, Toulouse University, Toulouse, France
    Curr Opin Neurol 16:S43-5. 2003
    ..Future research should be focussed on redefining the criteria of the mild cognitive impairment entity. This could enable the better development of appropriate therapeutic interventions...
  97. doi request reprint Cachexia versus sarcopenia
    Yves Rolland
    INSERM U558, University of Toulouse III, France
    Curr Opin Clin Nutr Metab Care 14:15-21. 2011
    ..The review summarizes and discusses the proposed new definitions for sarcopenia and cachexia. It also highlights the overlapping of both conditions and the fact that these conditions frequently occur in elderly patients...
  98. doi request reprint Alzheimer's disease progression in the oldest old compared to younger elderly patient: data from the REAL.FR study
    Fati Nourhashemi
    Gérontopôle Toulouse, France
    Int J Geriatr Psychiatry 24:149-55. 2009
    ..The aim of this study is to describe the progression of Alzheimer's disease (AD) in the oldest old (>or=85 years) and to compare it with the younger elderly...
  99. ncbi request reprint Progress in the development of new drugs in Alzheimer's disease
    Antoine Piau
    Gerontopole, Hopitaux de Toulouse, France
    J Nutr Health Aging 15:45-57. 2011
    ..This article exposes general classes of disease-modifying therapies under investigation...
  100. ncbi request reprint Descriptive analysis of hospitalizations of patients with Alzheimer's disease: a two-year prospective study of 686 patients from the REAL.FR study
    T Voisin
    Alzheimer s Disease Research Centre CMRR, F CMRR SF, Toulouse University Hospital, France
    J Nutr Health Aging 13:890-2. 2009
    ..The aims of the present study were to evaluate the frequency and the causes of hospitalization in a large prospective cohort of mild to moderate patients with AD...
  101. doi request reprint Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease
    Sophie Gillette-Guyonnet
    Gérontopôle de Toulouse, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France
    Alzheimers Dement 5:114-21. 2009
    ..The study also collects imaging and biological data that could be used in future AD prevention and treatment trials...