Reiner A Veitia

Summary

Country: France

Publications

  1. pmc Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses
    Giovanna Vinci
    Département de Génétique et Développement Inserm, Faculté de Médecine Paris Descartes, Institut Cochin, U567, CNRS, UMR 8104, Universite Paris 5, UM 3, Paris, France
    PLoS ONE 3:e2883. 2008
  2. ncbi Commonalities in fly embryogenesis and mammalian pituitary patterning
    Reiner A Veitia
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Trends Endocrinol Metab 18:261-5. 2007
  3. ncbi The robustness of the transcriptional response to alterations in morphogenetic gradients
    Reiner A Veitia
    Université Denis Diderot Paris VII and INSERM U709 Université Paris V, France
    Bioessays 28:282-9. 2006
  4. pmc Exploring the molecular etiology of dominant-negative mutations
    Reiner A Veitia
    Université Denis Diderot Paris VII Unité de Formation et de Recherche Department of Biology, 75005 Paris, France
    Plant Cell 19:3843-51. 2007
  5. doi Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects
    Reiner A Veitia
    INSERM U567, Team21 Genomics and Epigenetics of Placental Diseases, Genetics and Development Department, Institut Cochin, 75014 Paris, France
    Trends Genet 24:390-7. 2008
  6. ncbi Stochasticity or the fatal 'imperfection' of cloning
    Reiner A Veitia
    Université Denis Diderot Paris VII, INSERM U361 Reproduction et Physiopathologie Obstetricale, Hospital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014 Paris, France
    J Biosci 30:21-30. 2005
  7. pmc Paralogs in polyploids: one for all and all for one?
    Reiner A Veitia
    Universite Paris 7 Denis Diderot, Institut National de la Santé et de la, Recherche Médicale, E0021 Génomique, Fonctionelle du Développement, Paris, France
    Plant Cell 17:4-11. 2005
  8. doi One thousand and one ways of making functionally similar transcriptional enhancers
    Reiner A Veitia
    Institut Cochin, Département de Génétique et Développement, INSERM, Universite Paris, France
    Bioessays 30:1052-7. 2008
  9. ncbi Amino acids runs and genomic compositional biases in vertebrates
    Reiner A Veitia
    Université Denis Diderot Paris VII, INSERM E0021 and U361, Reproduction et Physiopathologie Obstetricale, Hopital Cochin, Pavillon Baudelocque, 123 Boulevarde de Port Royal, 75014 Paris, France
    Genomics 83:502-7. 2004
  10. pmc SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies
    Adrien Georges
    Programme de Pathologie Moléculaire et Cellulaire, Institut Jacques Monod, UMR 7592 CNRS Université Paris Diderot, Paris, France
    PLoS ONE 6:e25463. 2011

Collaborators

Detail Information

Publications53

  1. pmc Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses
    Giovanna Vinci
    Département de Génétique et Développement Inserm, Faculté de Médecine Paris Descartes, Institut Cochin, U567, CNRS, UMR 8104, Universite Paris 5, UM 3, Paris, France
    PLoS ONE 3:e2883. 2008
    ..However, we provide evidence for a preservation of the corresponding genes in two animals unable to synthesize cholesterol (auxotrophs): Drosophila melanogaster and Caenorhabditis elegans...
  2. ncbi Commonalities in fly embryogenesis and mammalian pituitary patterning
    Reiner A Veitia
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Trends Endocrinol Metab 18:261-5. 2007
    ..Variability in gene expression at territory boundaries might give rise to a poorly differentiated pool of cells, which could harbor stem-like properties. The ideas outlined here deserve further theoretical and experimental exploration...
  3. ncbi The robustness of the transcriptional response to alterations in morphogenetic gradients
    Reiner A Veitia
    Université Denis Diderot Paris VII and INSERM U709 Université Paris V, France
    Bioessays 28:282-9. 2006
    ..Our results highlight how non-linearities can be a source of robustness and the crucial role of the inhibitor in the generation of a sharp and robust response...
  4. pmc Exploring the molecular etiology of dominant-negative mutations
    Reiner A Veitia
    Université Denis Diderot Paris VII Unité de Formation et de Recherche Department of Biology, 75005 Paris, France
    Plant Cell 19:3843-51. 2007
  5. doi Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects
    Reiner A Veitia
    INSERM U567, Team21 Genomics and Epigenetics of Placental Diseases, Genetics and Development Department, Institut Cochin, 75014 Paris, France
    Trends Genet 24:390-7. 2008
    ....
  6. ncbi Stochasticity or the fatal 'imperfection' of cloning
    Reiner A Veitia
    Université Denis Diderot Paris VII, INSERM U361 Reproduction et Physiopathologie Obstetricale, Hospital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014 Paris, France
    J Biosci 30:21-30. 2005
    ..Finally, to what extent fluctuations in biological processes, usually thought of as noise, are in fact signal is also discussed...
  7. pmc Paralogs in polyploids: one for all and all for one?
    Reiner A Veitia
    Universite Paris 7 Denis Diderot, Institut National de la Santé et de la, Recherche Médicale, E0021 Génomique, Fonctionelle du Développement, Paris, France
    Plant Cell 17:4-11. 2005
  8. doi One thousand and one ways of making functionally similar transcriptional enhancers
    Reiner A Veitia
    Institut Cochin, Département de Génétique et Développement, INSERM, Universite Paris, France
    Bioessays 30:1052-7. 2008
    ..This can be explained by the existence of intra-enhancer compensatory mutations and the presence of overlapping/near binding sites for activators and repressors...
  9. ncbi Amino acids runs and genomic compositional biases in vertebrates
    Reiner A Veitia
    Université Denis Diderot Paris VII, INSERM E0021 and U361, Reproduction et Physiopathologie Obstetricale, Hopital Cochin, Pavillon Baudelocque, 123 Boulevarde de Port Royal, 75014 Paris, France
    Genomics 83:502-7. 2004
    ..A comparison with human is undertaken...
  10. pmc SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies
    Adrien Georges
    Programme de Pathologie Moléculaire et Cellulaire, Institut Jacques Monod, UMR 7592 CNRS Université Paris Diderot, Paris, France
    PLoS ONE 6:e25463. 2011
    ..We and others have previously shown that FOXL2 undergoes several post-translational modifications...
  11. doi Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations
    Bérénice A Benayoun
    INSERM U567, Team 21, Department of Genetics and Development, Paris, France
    Hum Mol Genet 18:632-44. 2009
    ..Taken together, our results establish that FOXL2 is an actor of the stress response and provide new insights into the pathogenic consequences of FOXL2 mutations...
  12. doi The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles
    Bérénice A Benayoun
    INSERM U567, Team 21, Département de Génétique et Développement, Institut Cochin 75014, Paris, France
    Hum Mol Genet 17:3118-27. 2008
    ..Taken together, our results give mechanistic insights on the molecular pathogenesis of FOXL2 polyAlanine expansions...
  13. pmc Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses
    Reiner A Veitia
    CNRS UMR 7592, Institut Jacques Monod, Paris, France
    PLoS ONE 4:e8201. 2009
    ..However, it might have important functions. Generation of junk DNA depends on proliferation of selfish DNA elements and on local or global DNA duplication followed by genic non-functionalization...
  14. pmc Gene expression regulation in the context of mouse interspecific mosaic genomes
    David L'Hôte
    U567 Department of Genetics and Development, Institut Cochin, INSERM, 24 rue du Faubourg St Jacques, Paris, 75014, France
    Genome Biol 9:R133. 2008
    ..To address this question, we have screened the testis transcriptome of interspecific recombinant congenic mouse strains (IRCSs) containing segments of Mus spretus origin at a homozygous state in a Mus musculus background...
  15. doi Interspecific resources: a major tool for quantitative trait locus cloning and speciation research
    David L'Hôte
    INSERM, U567, Institut Cochin, Paris, France
    Bioessays 32:132-42. 2010
    ..Therefore, we argue that interspecific resources may constitute a major genetic tool for positional cloning and for understanding some bases of speciation mechanisms...
  16. pmc Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G)
    Bérénice A Benayoun
    Programme de Pathologie Moléculaire et Cellulaire, Institut Jacques Monod, Paris, France
    PLoS ONE 5:e8789. 2010
    ..In addition, this mutation seems to be specific to adult OGCTs and is likely to be a driver of malignant transformation. However, its pathogenic mechanisms remain elusive...
  17. doi Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency
    Kamal Bouhali
    Evolution des Regulations Endocriniennes, CNRS UMR 7221, Museum national d histoire naturelle, Paris, France
    Hum Mol Genet 20:2642-50. 2011
    ..Our results bring new elements to our conceptual model of follicle maturation and maintenance and provide new potential genetic targets for cases of familial POI...
  18. ncbi Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development
    Lara Moumné
    Department of Genetics and Development, INSERM U567, Team21 Genomics and Epigenetics of Placental Diseases, Paris, France
    Hum Mol Genet 17:1010-9. 2008
    ....
  19. doi Recent advances in the study of genes involved in non-syndromic premature ovarian failure
    Paul Laissue
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France INSERM, U567 Paris, France
    Mol Cell Endocrinol 282:101-11. 2008
    ..Here, we review recent advances in the study of candidate genes...
  20. doi Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation
    Reiner A Veitia
    Centre National de la Recherche Scientifique, UMR7592, Institut Jacques Monod, Paris, France
    Trends Genet 29:385-93. 2013
    ..Understanding these issues is critical to understanding why an individual bearing a few damaging mutations can be severely diseased, whereas others harboring tens of potentially deleterious mutations can appear quite healthy. ..
  21. doi Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from?
    Adrien B Georges
    Unité Mixte de Recherche 7592 Centre National de la Recherche Scientifique, Institut Jacques Monod, Paris, France
    FASEB J 24:346-56. 2010
    ....
  22. doi Dynamics of the subcellular localization of RalBP1/RLIP through the cell cycle: the role of targeting signals and of protein-protein interactions
    Jonathan Fillatre
    Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, UMR 7592, Universite Paris Diderot, Sorbonne Paris Cité 15, rue Hélène Brion 75205 Paris, France
    FASEB J 26:2164-74. 2012
    ..Finally, we demonstrate the presence of post-transcriptional and post-translational isoforms of RalBP1 lacking the Ral-binding domain, which opens new possibilities for the existence of Ral-independent functions...
  23. pmc Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics
    Frank Batista
    Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, and Faculté de Médecine René Descartes, Université Paris V UM 3, 75014 Paris, France
    Proc Natl Acad Sci U S A 104:3330-5. 2007
    ..Altogether, these results provide insight into the activity of FOXL2 and may help in understanding the mechanisms of pathogenesis of FOXL2 mutations if the targets prove to be the same in the ovary...
  24. pmc Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure
    Sandrine Caburet
    Institut Jacques Monod, Universite Denis Diderot, CNRS UMR7592, Paris, France
    PLoS ONE 7:e33412. 2012
    ..A majority of POF cases are sporadic, but 10-15% are familial, suggesting a genetic origin of the disease. Although several causal mutations have been identified, the etiology of POF is still unknown for about 90% of the patients...
  25. ncbi Partial defects in transcriptional activity of two novel DAX-1 mutations in childhood-onset adrenal hypoplasia congenita
    Paul Laissue
    U567 INSERM and Université Denis Diderot Paris VII, Paris, France
    Clin Endocrinol (Oxf) 65:681-6. 2006
    ..We aimed at analysing their effects on protein localization, transcriptional activity and propose a structural-function relationship...
  26. doi The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways
    Bérénice A Benayoun
    INSERM U567, Team21, Genetics and Development Department, Institut Cochin, Paris, France
    Proteomics 8:3118-23. 2008
    ..The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post-translational "modification factory."..
  27. doi FOXL2 versus SOX9: a lifelong "battle of the sexes"
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex, France
    Bioessays 32:375-80. 2010
    ..These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions...
  28. doi Dominance and gene dosage balance in health and disease: why levels matter!
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex 13, France
    J Pathol 220:174-85. 2010
    ....
  29. doi Dominant negative factors in health and disease
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, 15 Rue Hélène Brion, Paris Cedex 13, France
    J Pathol 218:409-18. 2009
    ..Finally, the existence and potential relevance of an increasing number of physiological DN protein isoforms is briefly discussed...
  30. ncbi A sigmoidal transcriptional response: cooperativity, synergy and dosage effects
    Reiner A Veitia
    UFR de Biologie et Sciences de la Nature, Université Denis Diderot Paris VII, France
    Biol Rev Camb Philos Soc 78:149-70. 2003
    ..Although a formal proof linking HI and a sigmoidal response is lacking, it is tempting to explore the model from the perspective of dosage effects...
  31. doi A generalized model of gene dosage and dominant negative effects in macromolecular complexes
    Reiner A Veitia
    Institut Jacques Monod, Unite Mixte de Recherche 7592, Centre National de la Recherche Scientifique, and Université Paris Diderot Paris 7, Paris, France
    FASEB J 24:994-1002. 2010
    ..This situation has important evolutionary consequences and may eventually lead to reproductive isolation and speciation.-Veitia, R. A. A generalized model of gene dosage and dominant negative effects in macromolecular complexes...
  32. ncbi Reverse transcriptase template switching and false alternative transcripts
    Julie Cocquet
    INSERM U709, Hopital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014 Paris, France
    Genomics 88:127-31. 2006
    ..However, care should be taken in the annotation of alternative transcripts, especially when the RT used is poorly thermostable and when the putative intron is flanked by direct repeats, which are the substrate for template switching...
  33. pmc A genomic basis for the evolution of vertebrate transcription factors containing amino Acid runs
    Sandrine Caburet
    INSERM E0021 Génomique et Développement, IFR Alfred Jost, Hopital Cochin, 75014 Paris, France
    Genetics 167:1813-20. 2004
    ....
  34. pmc Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
    Reiner A Veitia
    Institut Jacques Monod, UMR 8104, CNRS, Paris, France
    Biol Direct 4:22. 2009
    ..Reviewers:This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin...
  35. ncbi Transcription factors: specific DNA binding and specific gene regulation
    Anne Laure Todeschini
    Institut Jacques Monod, Paris, France Université Paris Diderot, Paris, France
    Trends Genet 30:211-9. 2014
    ..Here, we explore the various ways in which TFs recognizing similar consensus sites distinguish their own targets from a large number of other sequences to ensure specific cellular responses. ..
  36. ncbi Nonlinear effects in macromolecular assembly and dosage sensitivity
    Reiner A Veitia
    UFR de Biologie et Sciences de la Nature, Université Denis Diderot Paris VII, Paris, France
    J Theor Biol 220:19-25. 2003
    ..Other effects involving cooperativity or sequential assembly may also play a role in palliating the effect of changes in input amounts of monomers...
  37. doi Why preeclampsia still exists?
    Sonia T Chelbi
    Inserm U1016, Institut Cochin, Paris, France CNRS, UMR8104, Paris, France
    Med Hypotheses 81:259-63. 2013
    ....
  38. doi FOXL2: a central transcription factor of the ovary
    Adrien Georges
    CNRS UMR 7592, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France Université Paris Diderot, Paris VII, Paris, France
    J Mol Endocrinol 52:R17-33. 2014
    ..Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes. ..
  39. pmc A regulatory domain is required for Foxn4 activity during retinogenesis
    Elise C Lelièvre
    Centre de Recherche des Cordeliers, INSERM UMR S872, 15, rue de l Ecole de Medecine, 75006, Paris, France
    J Mol Neurosci 46:315-23. 2012
    ..Thus, our study demonstrates that the domain between amino acids 402 and 455 is necessary for Foxn4 transcriptional activity both in vitro and in the retina...
  40. ncbi Sense and antisense Foxl2 transcripts in mouse
    Julie Cocquet
    INSERM E0021 and U361, Hopital Cochin, Pavillon Baudelocque, 123 Boulevard de Port Royal, 75014 Paris, France
    Genomics 85:531-41. 2005
    ..All in all our results provide new insights about the organization of the murine Foxl2 locus. This might help us understand its regulation and function...
  41. pmc Compositional biases and polyalanine runs in humans
    Julie Cocquet
    INSERM E0021 and U361, Reproduction et Physiopathologie Obstetricale, Hopital Cochin, 75014 Paris, France
    Genetics 165:1613-7. 2003
    ....
  42. ncbi Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure
    Paul Laissue
    INSERM 709, Genomics and Epigenetics of Placentary Pathology, Hopital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014, Paris, France
    Eur J Endocrinol 154:739-44. 2006
    ..In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF)...
  43. doi The forkhead factor FOXL2: a novel tumor suppressor?
    Bérénice A Benayoun
    Institut Jacques Monod, UMR 7592 CNRS, 15 Rue Hélène Brion, Paris, France
    Biochim Biophys Acta 1805:1-5. 2010
    ..Indeed, an in-depth review of existing data on FOXL2 reveals that its target genes and molecular partners can often be linked to cancer progression...
  44. ncbi Exploring the etiology of haploinsufficiency
    Reiner A Veitia
    UFR de Biologie et Sciences de la Nature, Universite Denis Diderot, Paris VII Immunogeénétique Humaine, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Bioessays 24:175-84. 2002
    ..This article is certainly another preliminary exploration of the complex matters of HI, which remain an intellectual challenge from many points of view...
  45. ncbi Dosage balance in gene regulation: biological implications
    James A Birchler
    Division of Biological Sciences, 117 Tucker Hall, University of Missouri, Columbia, MO 65211 7400, USA
    Trends Genet 21:219-26. 2005
    ..In this article, we discuss the potential contribution of regulatory balance to the control of quantitative traits, hybrid vigor, genome evolution and post-zygotic speciation mechanisms...
  46. pmc Gene dosage balance in cellular pathways: implications for dominance and gene duplicability
    Reiner A Veitia
    Genetics 168:569-74. 2004
  47. pmc The gene balance hypothesis: from classical genetics to modern genomics
    James A Birchler
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Plant Cell 19:395-402. 2007
  48. ncbi Gene dosage balance: deletions, duplications and dominance
    Reiner A Veitia
    Trends Genet 21:33-5. 2005
  49. pmc Rosetta Stone proteins: "chance and necessity"?
    Reiner A Veitia
    Genome Biol 3:INTERACTIONS1001. 2002
  50. ncbi Coding repeats and evolutionary "agility"
    Sandrine Caburet
    Inserm U709 Paris, France
    Bioessays 27:581-7. 2005
    ..In particular, they found that the repeat variations in two genes were significantly associated with changes in limb and skull morphology. These results open the possibility that such a mechanism contributes to the diversity of life...
  51. ncbi Deletions in the polyAlanine-containing transcription factor FOXL2 lead to intranuclear aggregation
    Lara Moumné
    INSERM U709 Génomique et Epigénétique des Pathologies Placentaires and Universités Paris V and VII, Paris 75014, France
    Hum Mol Genet 14:3557-64. 2005
    ..We also show that a complete deletion of the polyAla tract of FOXL2 induces a significant intranuclear aggregation. Our results enlarge the spectrum of mutations inducing FOXL2 aggregation...
  52. ncbi A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome (BPES) associated with ovarian dysfunction
    Jeyabalan Nallathambi
    Department of Genetics, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, India
    Hum Genet 121:107-12. 2007
    ..This is the first study providing genetic evidence for a recessive inheritance of BPES associated with ovarian dysfunction...