Reiner A Veitia

Summary

Country: France

Publications

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  2. pmc Meta-analysis of muscle transcriptome data using the MADMuscle database reveals biologically relevant gene patterns
    Daniel Baron
    INSERM, U915, Nantes, F 44000 France
    BMC Genomics 12:113. 2011
  3. ncbi A generalized model of gene dosage and dominant negative effects in macromolecular complexes
    Reiner A Veitia
    Institut Jacques Monod, Unite Mixte de Recherche 7592, Centre National de la Recherche Scientifique, and Université Paris Diderot Paris 7, Paris, France
    FASEB J 24:994-1002. 2010
  4. doi Dominant negative factors in health and disease
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, 15 Rue Hélène Brion, Paris Cedex 13, France
    J Pathol 218:409-18. 2009
  5. pmc Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
    Reiner A Veitia
    Institut Jacques Monod, UMR 8104, CNRS, Paris, France
    Biol Direct 4:22. 2009
  6. pmc Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses
    Reiner A Veitia
    CNRS UMR 7592, Institut Jacques Monod, Paris, France
    PLoS ONE 4:e8201. 2009
  7. doi FOXL2 versus SOX9: a lifelong "battle of the sexes"
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex, France
    Bioessays 32:375-80. 2010
  8. doi Dominance and gene dosage balance in health and disease: why levels matter!
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex 13, France
    J Pathol 220:174-85. 2010
  9. doi Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles
    David L'Hôte
    Institut Jacques Monod, UMR 7592 CNRS Université Paris Diderot, Paris 75205, France
    Hum Mol Genet 21:3264-74. 2012
  10. ncbi Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the pathogenicity of naturally occurring mutations
    Anne Laure Todeschini
    CNRS UMR 7592, Institut Jacques Monod, Equipe Génétique et Génomique du Développement Gonadique, 75205 Paris Cedex 13, France
    Hum Mol Genet 20:3376-85. 2011

Collaborators

  • Daniel Vaiman
  • Giovanni Levi
  • Samuel Bottani
  • Marc Bailly-Bechet
  • Vered Chalifa-Caspi
  • Jose Alain Sahel
  • Ignacio Bergada
  • Celine Charon
  • Sankaran Krishnaswamy
  • Laura Crisponi
  • charles sultan
  • Xuhua Xia
  • Elfride De Baere
  • Didier Dewailly
  • Enzo Lalli
  • Eric Pailhoux
  • Mikko Anttonen
  • Ayhan Kocer
  • Bérénice A Benayoun
  • David L'Hôte
  • Anne Laure Todeschini
  • Aurélie Dipietromaria
  • Sandrine Caburet
  • Adrien Georges
  • Marc Fellous
  • Paul Laissue
  • Adrien B Georges
  • Claude Bazin
  • Kamal Bouhali
  • Jana Auer
  • Frank Batista
  • Giovanna Vinci
  • Sonia T Chelbi
  • Elise C Lelièvre
  • Dimas Yusuf
  • Jonathan Fillatre
  • Daniel Baron
  • P J Eswari Pandaranayaka
  • Isabelle Rivals
  • Catherine Serres
  • Sophie Christin-Maitre
  • Xavier Montagutelli
  • Lara Moumné
  • Laurianne Bessière
  • Anne Vanet
  • Aurelie Auguste
  • Kelly L Prince
  • Roland H Wenger
  • Gieri Camenisch
  • Bruce E Torbett
  • Miranda S C Wilson
  • Satrajit Sinha
  • Mark W Woodcroft
  • Capucine Van Rechem
  • Raquel Marco-Ferreres
  • Oliver Hankinson
  • Christopher J Harvey
  • Chunyan Zhao
  • Florian Sennlaub
  • Xin M Luo
  • Rachel D Mullen
  • Dominique Leprince
  • Sekhar P Reddy
  • David Laperriere
  • Juan Hou
  • Daniel J Peet
  • Alison H Banham
  • Padma Sheela Jayaraman
  • Jerome E Roger
  • Margaret R Hough
  • Michael Wegner
  • Ralf Kist
  • Leonardo L Beccari
  • Carol F Webb
  • Seth Frietze
  • Amy Ticoll
  • Stephanie C Colvin
  • Delphine Delacour
  • Tiziana De Cristofaro
  • Angie Rizzino
  • Jason Park
  • Sylvie Mader
  • Harini Chakravarthy
  • Simon J Rhodes
  • Helma D C Schwenen
  • Warren A Cheung
  • Eugene Bolotin
  • Lara J Monteiro
  • Juliet M Daniel
  • Shyam Biswal

Detail Information

Publications42

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  2. pmc Meta-analysis of muscle transcriptome data using the MADMuscle database reveals biologically relevant gene patterns
    Daniel Baron
    INSERM, U915, Nantes, F 44000 France
    BMC Genomics 12:113. 2011
    ..However, using it is made difficult by the diversity of the available data: different microarray platforms, different gene nomenclature, different species studied, etc...
  3. ncbi A generalized model of gene dosage and dominant negative effects in macromolecular complexes
    Reiner A Veitia
    Institut Jacques Monod, Unite Mixte de Recherche 7592, Centre National de la Recherche Scientifique, and Université Paris Diderot Paris 7, Paris, France
    FASEB J 24:994-1002. 2010
    ..This situation has important evolutionary consequences and may eventually lead to reproductive isolation and speciation.-Veitia, R. A. A generalized model of gene dosage and dominant negative effects in macromolecular complexes...
  4. doi Dominant negative factors in health and disease
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, 15 Rue Hélène Brion, Paris Cedex 13, France
    J Pathol 218:409-18. 2009
    ..Finally, the existence and potential relevance of an increasing number of physiological DN protein isoforms is briefly discussed...
  5. pmc Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
    Reiner A Veitia
    Institut Jacques Monod, UMR 8104, CNRS, Paris, France
    Biol Direct 4:22. 2009
    ..Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence...
  6. pmc Whole genome duplications and a 'function' for junk DNA? Facts and hypotheses
    Reiner A Veitia
    CNRS UMR 7592, Institut Jacques Monod, Paris, France
    PLoS ONE 4:e8201. 2009
    ..However, it might have important functions. Generation of junk DNA depends on proliferation of selfish DNA elements and on local or global DNA duplication followed by genic non-functionalization...
  7. doi FOXL2 versus SOX9: a lifelong "battle of the sexes"
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex, France
    Bioessays 32:375-80. 2010
    ..These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions...
  8. doi Dominance and gene dosage balance in health and disease: why levels matter!
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, Paris Cedex 13, France
    J Pathol 220:174-85. 2010
    ....
  9. doi Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles
    David L'Hôte
    Institut Jacques Monod, UMR 7592 CNRS Université Paris Diderot, Paris 75205, France
    Hum Mol Genet 21:3264-74. 2012
    ..Altogether, these results suggest that the p.C134W mutated form fails to integrate signals through protein-protein interactions to regulate target promoter subsets and in particular to induce cell death...
  10. ncbi Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the pathogenicity of naturally occurring mutations
    Anne Laure Todeschini
    CNRS UMR 7592, Institut Jacques Monod, Equipe Génétique et Génomique du Développement Gonadique, 75205 Paris Cedex 13, France
    Hum Mol Genet 20:3376-85. 2011
    ..Our findings reveal new insights into the molecular effects of FOXL2 mutations affecting the FHD, which represent two-thirds of intragenic mutations, and provide the first  predictive tool of their effects...
  11. pmc SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies
    Adrien Georges
    Programme de Pathologie Moléculaire et Cellulaire, Institut Jacques Monod, UMR 7592 CNRS Université Paris Diderot, Paris, France
    PLoS ONE 6:e25463. 2011
    ..We and others have previously shown that FOXL2 undergoes several post-translational modifications...
  12. doi Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
    Bérénice A Benayoun
    CNRS UMR 7592, Institut Jacques Monod, Equipe Génétique et Génomique du Développement Gonadique 75205 Paris Cedex 13, France
    Hum Mol Genet 20:1673-86. 2011
    ..As granulosa cell tumors respond poorly to conventional chemotherapy, our findings on the deacetylase inhibitor nicotinamide provide an interesting option for targeted therapy...
  13. doi The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles
    Bérénice A Benayoun
    INSERM U567, Team 21, Département de Génétique et Développement, Institut Cochin 75014, Paris, France
    Hum Mol Genet 17:3118-27. 2008
    ..Taken together, our results give mechanistic insights on the molecular pathogenesis of FOXL2 polyAlanine expansions...
  14. ncbi The transcription factor FOXL2: at the crossroads of ovarian physiology and pathology
    Sandrine Caburet
    CNRS UMR 7592, Institut Jacques Monod, Equipe Génétique et Génomique du Développement Gonadique, 75205 Paris Cedex 13, France
    Mol Cell Endocrinol 356:55-64. 2012
    ..The elucidation of the impact of FOXL2 germinal and somatic mutations will allow a better understanding of the pathogenesis of BPES and of OGCTs...
  15. pmc Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G)
    Bérénice A Benayoun
    Programme de Pathologie Moléculaire et Cellulaire, Institut Jacques Monod, Paris, France
    PLoS ONE 5:e8789. 2010
    ..In addition, this mutation seems to be specific to adult OGCTs and is likely to be a driver of malignant transformation. However, its pathogenic mechanisms remain elusive...
  16. ncbi Interspecific resources: a major tool for quantitative trait locus cloning and speciation research
    David L'Hôte
    INSERM, U567, Institut Cochin, Paris, France
    Bioessays 32:132-42. 2010
    ..Therefore, we argue that interspecific resources may constitute a major genetic tool for positional cloning and for understanding some bases of speciation mechanisms...
  17. ncbi FOXL2: a central transcription factor of the ovary
    Adrien Georges
    CNRS UMR 7592, Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France Université Paris Diderot, Paris VII, Paris, France
    J Mol Endocrinol 52:R17-33. 2014
    ..Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes. ..
  18. doi Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency
    Kamal Bouhali
    Evolution des Regulations Endocriniennes, CNRS UMR 7221, Museum national d histoire naturelle, Paris, France
    Hum Mol Genet 20:2642-50. 2011
    ..Our results bring new elements to our conceptual model of follicle maturation and maintenance and provide new potential genetic targets for cases of familial POI...
  19. doi Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations
    Bérénice A Benayoun
    INSERM U567, Team 21, Department of Genetics and Development, Paris, France
    Hum Mol Genet 18:632-44. 2009
    ..Taken together, our results establish that FOXL2 is an actor of the stress response and provide new insights into the pathogenic consequences of FOXL2 mutations...
  20. doi Towards a functional classification of pathogenic FOXL2 mutations using transactivation reporter systems
    Aurélie Dipietromaria
    UMR7592 CNRS, Institut Jacques Monod, 75013 Paris, France
    Hum Mol Genet 18:3324-33. 2009
    ..The functional classification tool described here is a first step towards circumventing the lack of a clear-cut genotype-phenotype correlation in BPES...
  21. pmc Gene expression regulation in the context of mouse interspecific mosaic genomes
    David L'Hôte
    U567 Department of Genetics and Development, Institut Cochin, INSERM, 24 rue du Faubourg St Jacques, Paris, 75014, France
    Genome Biol 9:R133. 2008
    ..To address this question, we have screened the testis transcriptome of interspecific recombinant congenic mouse strains (IRCSs) containing segments of Mus spretus origin at a homozygous state in a Mus musculus background...
  22. ncbi The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways
    Bérénice A Benayoun
    INSERM U567, Team21, Genetics and Development Department, Institut Cochin, Paris, France
    Proteomics 8:3118-23. 2008
    ..The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post-translational "modification factory."..
  23. doi Exploring the mechanistic bases of heterosis from the perspective of macromolecular complexes
    Reiner A Veitia
    Institut Jacques Monod, CNRS UMR 7592, Batiment Buffon, 15 Rue Hélène Brion, Paris Cedex 13, France
    FASEB J 25:476-82. 2011
    ..Despite its simplicity, the dosage model accounts for the puzzling phenomenon of "progressive heterosis" in which polyploids with increasing genetic diversity exhibit progressively greater heterosis...
  24. doi Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation
    Reiner A Veitia
    Centre National de la Recherche Scientifique, UMR7592, Institut Jacques Monod, Paris, France
    Trends Genet 29:385-93. 2013
    ..Understanding these issues is critical to understanding why an individual bearing a few damaging mutations can be severely diseased, whereas others harboring tens of potentially deleterious mutations can appear quite healthy. ..
  25. pmc Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure
    Sandrine Caburet
    Institut Jacques Monod, Universite Denis Diderot, CNRS UMR7592, Paris, France
    PLoS ONE 7:e33412. 2012
    ..A majority of POF cases are sporadic, but 10-15% are familial, suggesting a genetic origin of the disease. Although several causal mutations have been identified, the etiology of POF is still unknown for about 90% of the patients...
  26. ncbi Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development
    Lara Moumné
    Department of Genetics and Development, INSERM U567, Team21 Genomics and Epigenetics of Placental Diseases, Paris, France
    Hum Mol Genet 17:1010-9. 2008
    ....
  27. ncbi FOXL2: at the crossroads of female sex determination and ovarian function
    Bérénice A Benayoun
    Institut Jacques Monod, Batiment Buffon, 15 rue Hélèna Brion, 75205 Paris Cx 13, France
    Adv Exp Med Biol 665:207-26. 2009
    ..The elucidation of the impact of the FOXL2 function in the ovary will allow a better understanding of normal ovarian development and function as well as the pathogenic mechanisms underlying BPES...
  28. doi Recent advances in the study of genes involved in non-syndromic premature ovarian failure
    Paul Laissue
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France INSERM, U567 Paris, France
    Mol Cell Endocrinol 282:101-11. 2008
    ..Here, we review recent advances in the study of candidate genes...
  29. doi Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from?
    Adrien B Georges
    Unité Mixte de Recherche 7592 Centre National de la Recherche Scientifique, Institut Jacques Monod, Paris, France
    FASEB J 24:346-56. 2010
    ....
  30. doi Dynamics of the subcellular localization of RalBP1/RLIP through the cell cycle: the role of targeting signals and of protein-protein interactions
    Jonathan Fillatre
    Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS, UMR 7592, Universite Paris Diderot, Sorbonne Paris Cité 15, rue Hélène Brion 75205 Paris, France
    FASEB J 26:2164-74. 2012
    ..Finally, we demonstrate the presence of post-transcriptional and post-translational isoforms of RalBP1 lacking the Ral-binding domain, which opens new possibilities for the existence of Ral-independent functions...
  31. doi Forkhead transcription factors: key players in health and disease
    Bérénice A Benayoun
    CNRS UMR 7592, Institut Jacques Monod, Equipe Génétique et Génomique du Développement Gonadique, 75205 Paris Cedex 13, France
    Trends Genet 27:224-32. 2011
    ..Uncovering such variants would be a big step towards understanding the functional interdependencies of different FOX members and their implications in complex pathologies...
  32. pmc Paralogs in polyploids: one for all and all for one?
    Reiner A Veitia
    Universite Paris 7 Denis Diderot, Institut National de la Santé et de la, Recherche Médicale, E0021 Génomique, Fonctionelle du Développement, Paris, France
    Plant Cell 17:4-11. 2005
  33. doi A post-translational modification code for transcription factors: sorting through a sea of signals
    Bérénice A Benayoun
    Institut Jacques Monod, Batiment Buffon, 15 Rue Hélène Brion, Paris Cedex 13, France
    Trends Cell Biol 19:189-97. 2009
    ..Thus, the coding potential of PTM combinations should both provide a further layer of information integration from several transduction pathways and warrant highly specific cellular outputs...
  34. ncbi Transcription factors: specific DNA binding and specific gene regulation
    Anne Laure Todeschini
    Institut Jacques Monod, Paris, France Université Paris Diderot, Paris, France
    Trends Genet 30:211-9. 2014
    ..Here, we explore the various ways in which TFs recognizing similar consensus sites distinguish their own targets from a large number of other sequences to ensure specific cellular responses. ..
  35. doi Why preeclampsia still exists?
    Sonia T Chelbi
    Inserm U1016, Institut Cochin, Paris, France CNRS, UMR8104, Paris, France
    Med Hypotheses 81:259-63. 2013
    ....
  36. pmc A regulatory domain is required for Foxn4 activity during retinogenesis
    Elise C Lelièvre
    Centre de Recherche des Cordeliers, INSERM UMR S872, 15, rue de l Ecole de Medecine, 75006, Paris, France
    J Mol Neurosci 46:315-23. 2012
    ..Thus, our study demonstrates that the domain between amino acids 402 and 455 is necessary for Foxn4 transcriptional activity both in vitro and in the retina...
  37. ncbi Partial defects in transcriptional activity of two novel DAX-1 mutations in childhood-onset adrenal hypoplasia congenita
    Paul Laissue
    U567 INSERM and Université Denis Diderot Paris VII, Paris, France
    Clin Endocrinol (Oxf) 65:681-6. 2006
    ..We aimed at analysing their effects on protein localization, transcriptional activity and propose a structural-function relationship...
  38. pmc Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses
    Giovanna Vinci
    Département de Génétique et Développement Inserm, Faculté de Médecine Paris Descartes, Institut Cochin, U567, CNRS, UMR 8104, Universite Paris 5, UM 3, Paris, France
    PLoS ONE 3:e2883. 2008
    ..However, we provide evidence for a preservation of the corresponding genes in two animals unable to synthesize cholesterol (auxotrophs): Drosophila melanogaster and Caenorhabditis elegans...
  39. ncbi Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure
    Paul Laissue
    INSERM 709, Genomics and Epigenetics of Placentary Pathology, Hopital Cochin, Pavillon Baudelocque, 123 Bd de Port Royal, 75014, Paris, France
    Eur J Endocrinol 154:739-44. 2006
    ..In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF)...
  40. doi The forkhead factor FOXL2: a novel tumor suppressor?
    Bérénice A Benayoun
    Institut Jacques Monod, UMR 7592 CNRS, 15 Rue Hélène Brion, Paris, France
    Biochim Biophys Acta 1805:1-5. 2010
    ..Indeed, an in-depth review of existing data on FOXL2 reveals that its target genes and molecular partners can often be linked to cancer progression...
  41. ncbi Nonlinear effects in macromolecular assembly and dosage sensitivity
    Reiner A Veitia
    UFR de Biologie et Sciences de la Nature, Université Denis Diderot Paris VII, Paris, France
    J Theor Biol 220:19-25. 2003
    ..Other effects involving cooperativity or sequential assembly may also play a role in palliating the effect of changes in input amounts of monomers...