M H Van Regenmortel

Summary

Country: France

Publications

  1. pmc Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism
    Marc H V Van Regenmortel
    Ecole Supérieure de Biotechnologie de Strasbourg at the Centre National de la Recherche Scientifique CNRS in Strasbourg, France
    EMBO Rep 5:1016-20. 2004
  2. ncbi request reprint Reductionism and the search for structure-function relationships in antibody molecules
    Marc H V Van Regenmortel
    Biotechnology School, CNRS, University of Strasbourg, France
    J Mol Recognit 15:240-7. 2002
  3. ncbi request reprint Improving the quality of BIACORE-based affinity measurements
    M H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, CNRS, Illkirch, France
    Dev Biol (Basel) 112:141-51. 2003
  4. pmc Emerging issues in virus taxonomy
    Marc H V Van Regenmortel
    Centre National de la Recherche Scientifique, Biotechnology School, University of Strasbourg, Illkirch, France
    Emerg Infect Dis 10:8-13. 2004
  5. doi request reprint What is a B-cell epitope?
    Marc H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, Illkirch Cedex, France
    Methods Mol Biol 524:3-20. 2009
  6. ncbi request reprint Biological complexity emerges from the ashes of genetic reductionism
    M H V Van Regenmortel
    School of Biotechnology, University of Strasbourg, Boulevard Sebastien Brand, 67400 Illkirch, France
    J Mol Recognit 17:145-8. 2004
  7. ncbi request reprint 15th meeting on Methods in Protein Structure Analysis. 29th August-2nd September, 2004, University of Washington, WA, USA
    Marc H V Van Regenmortel
    University of Strasbourg, School of Biotechnology, CNRS, Illkirch, 67400, France
    Expert Rev Proteomics 1:397-9. 2004
  8. ncbi request reprint Antigenicity and immunogenicity of synthetic peptides
    M H Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brandt, 67400 Illkirch, France
    Biologicals 29:209-13. 2001
  9. ncbi request reprint Recognition of peptides by antibodies and investigations of affinity using biosensor technology
    M H Van Regenmortel
    ESBS, CNRS, Boulv Sebastien Brant, Illkirch, 67400, France
    Comb Chem High Throughput Screen 4:385-95. 2001
  10. ncbi request reprint Virus species and virus identification: past and current controversies
    M H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, CNRS, Boulevard Sebastien Brandt, 67400 ILLKIRCH Cedex 2, France
    Infect Genet Evol 7:133-44. 2007

Collaborators

Detail Information

Publications19

  1. pmc Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism
    Marc H V Van Regenmortel
    Ecole Supérieure de Biotechnologie de Strasbourg at the Centre National de la Recherche Scientifique CNRS in Strasbourg, France
    EMBO Rep 5:1016-20. 2004
  2. ncbi request reprint Reductionism and the search for structure-function relationships in antibody molecules
    Marc H V Van Regenmortel
    Biotechnology School, CNRS, University of Strasbourg, France
    J Mol Recognit 15:240-7. 2002
    ..Although knowledge of antibody structure is of little use in vaccine design, it may help to develop therapeutic inhibitors and antibodies effective in the passive immunotherapy of viral infection...
  3. ncbi request reprint Improving the quality of BIACORE-based affinity measurements
    M H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, CNRS, Illkirch, France
    Dev Biol (Basel) 112:141-51. 2003
    ..There is little justification for the belief that ELISA methods provide in principle more reliable affinity parameters than biosensor technology...
  4. pmc Emerging issues in virus taxonomy
    Marc H V Van Regenmortel
    Centre National de la Recherche Scientifique, Biotechnology School, University of Strasbourg, Illkirch, France
    Emerg Infect Dis 10:8-13. 2004
    ..We briefly describe the changes in virus classification that were introduced in that report. We also discuss recent proposals to introduce a nonlatinized binomial nomenclature for virus species...
  5. doi request reprint What is a B-cell epitope?
    Marc H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, Illkirch Cedex, France
    Methods Mol Biol 524:3-20. 2009
    ..Methods for predicting the epitopes of proteins are discussed and the reasons for the low success rate of epitope prediction are analyzed...
  6. ncbi request reprint Biological complexity emerges from the ashes of genetic reductionism
    M H V Van Regenmortel
    School of Biotechnology, University of Strasbourg, Boulevard Sebastien Brand, 67400 Illkirch, France
    J Mol Recognit 17:145-8. 2004
  7. ncbi request reprint 15th meeting on Methods in Protein Structure Analysis. 29th August-2nd September, 2004, University of Washington, WA, USA
    Marc H V Van Regenmortel
    University of Strasbourg, School of Biotechnology, CNRS, Illkirch, 67400, France
    Expert Rev Proteomics 1:397-9. 2004
  8. ncbi request reprint Antigenicity and immunogenicity of synthetic peptides
    M H Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brandt, 67400 Illkirch, France
    Biologicals 29:209-13. 2001
    ..For this reason, it is not possible to develop a synthetic peptide vaccine using molecular design principles...
  9. ncbi request reprint Recognition of peptides by antibodies and investigations of affinity using biosensor technology
    M H Van Regenmortel
    ESBS, CNRS, Boulv Sebastien Brant, Illkirch, 67400, France
    Comb Chem High Throughput Screen 4:385-95. 2001
    ..The importance of peptide conformation in antibody recognition is discussed, and the antigenic reactivity of epitopes in synthetic peptides and in cognate, intact proteins is compared...
  10. ncbi request reprint Virus species and virus identification: past and current controversies
    M H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, CNRS, Boulevard Sebastien Brandt, 67400 ILLKIRCH Cedex 2, France
    Infect Genet Evol 7:133-44. 2007
    ..The names of virus species in current use are discussed as well as a binomial system that may be introduced in the future...
  11. ncbi request reprint The rational design of biological complexity: a deceptive metaphor
    Marc H V Van Regenmortel
    Ecole Superieure de Biotechnologie de Strasbourg, Centre de la Recherche Scientifique, Illkirch, France
    Proteomics 7:965-75. 2007
    ..Current developments in systems biology may give us eventually a better understanding of the immune system and this may enable us in the future to develop improved vaccines...
  12. pmc Antigenic mimicry of natural L-peptides with retro-inverso-peptidomimetics
    G Guichard
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9021, Centre National de la Recherche Scientifique, Strasbourg, France
    Proc Natl Acad Sci U S A 91:9765-9. 1994
    ..The use of retro-inverso-peptides to replace natural L-peptides is likely to find many applications in immunodiagnosis and as potential synthetic vaccines...
  13. ncbi request reprint Structure of viral B-cell epitopes
    M H Van Regenmortel
    Laboratoire d Immunochimie, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Res Microbiol 141:747-56. 1990
    ..The epitopes of four well-characterized viruses, namely poliovirus, foot-and-mouth disease virus, influenza virus and tobacco mosaic virus are briefly described...
  14. ncbi request reprint Analysing structure-function relationships with biosensors
    M H Van Regenmortel
    Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Cell Mol Life Sci 58:794-800. 2001
    ..However, biosensors can be used to determine and predict the influence of the chemical environment and of the structure of a ligand on binding kinetics...
  15. ncbi request reprint Mimicry of viral epitopes with retro-inverso peptides of increased stability
    N Benkirane
    Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Dev Biol Stand 87:283-91. 1996
    ..In view of their increased stability compared to natural L-peptides, retro-inverso peptidomimetics have considerable potential as synthetic viral vaccines...
  16. ncbi request reprint Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccines
    Shu Wen W Chen
    Ecole Superieure de Biotechnologie de Strasbourg, CNRS, F 67412 Illkirch, France
    Curr Med Chem 16:953-64. 2009
    ....
  17. doi request reprint Logical puzzles and scientific controversies: the nature of species, viruses and living organisms
    Marc H V Van Regenmortel
    FRE 3211 Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, CNRS Universite de Strasbourg, Boulevard Sebastien Brant, 67400 Illkirch, France
    Syst Appl Microbiol 33:1-6. 2010
    ..It is argued that viruses are genetic parasites rather than living organisms and that they have no place in the tree of life. This interpretation is based on an analysis of the properties of living agents and living organisms...
  18. ncbi request reprint A paradigm shift is needed in proteomics: 'structure determines function' should be replaced by 'binding determines function'
    Marc H V Van Regenmortel
    J Mol Recognit 15:349-51. 2002
  19. ncbi request reprint QSAR studies applied to the prediction of antigen-antibody interaction kinetics as measured by BIACORE
    Laurence Choulier
    UMR7100 CNRS, ESBS, Bld Sébastien Brandt, 67400 Illkirch Cedex, France and Biacore AB, Rapsgatan 7, SE754 50 Uppsala, Sweden
    Protein Eng 15:373-82. 2002
    ..Our results open new perspectives for the predictive optimization of interaction kinetics, with important implications in pharmacology and biotechnology...