Jean Paul Richalet

Summary

Affiliation: UFR SMBH
Country: France

Publications

  1. ncbi request reprint Chilean miners commuting from sea level to 4500 m: a prospective study
    Jean Paul Richalet
    A R P E Laboratoire Réponses cellulaires et fonctionnelles à l hypoxie, EA2363, Faculte de Medecine, Bobigny, Universite Paris 13, 74 rue Marcel Cachin, Bobigny, France
    High Alt Med Biol 3:159-66. 2002
  2. doi request reprint High altitude pulmonary edema, down syndrome, and obstructive sleep apneas
    Jean Paul Richalet
    AP HP, Hopital Avicenne, Service de Physiologie, explorations fonctionnelles et médecine du sport and Département d anesthésie et réanimation, Bobigny, France
    High Alt Med Biol 9:179-81. 2008
  3. doi request reprint Physiological risk factors for severe high-altitude illness: a prospective cohort study
    Jean Paul Richalet
    Universite Paris, Association pour la Recherche en Physiologie de l Environnement, Unité de Formation et de Recherche Santé Médecine Biologie Humaine, Bobigny, France
    Am J Respir Crit Care Med 185:192-8. 2012
  4. ncbi request reprint The scientific observatories on Mont Blanc
    J P Richalet
    ARPE, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, Bobigny, France
    High Alt Med Biol 2:57-68. 2001
  5. ncbi request reprint Acetazolamide: a treatment for chronic mountain sickness
    Jean Paul Richalet
    Laboratoire EA 2363, UFR SMBH, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Am J Respir Crit Care Med 172:1427-33. 2005
  6. doi request reprint Effects of high-altitude hypoxia on the hormonal response to hypothalamic factors
    Jean Paul Richalet
    Universite Paris 13, Unité de Formation et de Recherche Santé Médecine Biologie Humaine, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 299:R1685-92. 2010
  7. doi request reprint A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia?
    Jean Paul Richalet
    Universite Paris, UFR SMBH EA, Bobigny, France
    Clin Auton Res 19:335-42. 2009
  8. ncbi request reprint Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension
    Jean Paul Richalet
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris, Bobigny, France
    Am J Respir Crit Care Med 171:275-81. 2005
  9. doi request reprint Operation Everest III: COMEX '97
    Jean Paul Richalet
    Universite Paris, Bobigny, France
    High Alt Med Biol 11:121-32. 2010
  10. doi request reprint Acetazolamide for Monge's disease: efficiency and tolerance of 6-month treatment
    Jean Paul Richalet
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA 2363, ARPE, UFR SMBH, Bobigny, France
    Am J Respir Crit Care Med 177:1370-6. 2008

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Chilean miners commuting from sea level to 4500 m: a prospective study
    Jean Paul Richalet
    A R P E Laboratoire Réponses cellulaires et fonctionnelles à l hypoxie, EA2363, Faculte de Medecine, Bobigny, Universite Paris 13, 74 rue Marcel Cachin, Bobigny, France
    High Alt Med Biol 3:159-66. 2002
    ..In conclusion, CIH induced a clear acclimatization process. Subjects did not reach a health status comparable to that seen in permanent residents at HA and remained at risk of acute altitude-induced illnesses...
  2. doi request reprint High altitude pulmonary edema, down syndrome, and obstructive sleep apneas
    Jean Paul Richalet
    AP HP, Hopital Avicenne, Service de Physiologie, explorations fonctionnelles et médecine du sport and Département d anesthésie et réanimation, Bobigny, France
    High Alt Med Biol 9:179-81. 2008
    ..This observation might be of importance since an increasing number of young adults with Down syndrome participate in recreational or sport activities, including skiing and mountaineering...
  3. doi request reprint Physiological risk factors for severe high-altitude illness: a prospective cohort study
    Jean Paul Richalet
    Universite Paris, Association pour la Recherche en Physiologie de l Environnement, Unité de Formation et de Recherche Santé Médecine Biologie Humaine, Bobigny, France
    Am J Respir Crit Care Med 185:192-8. 2012
    ..An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness...
  4. ncbi request reprint The scientific observatories on Mont Blanc
    J P Richalet
    ARPE, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, Bobigny, France
    High Alt Med Biol 2:57-68. 2001
    ..After that pioneering era, few studies were done until 1984, when a team of the Association pour la Recherche en Physiologie de l'Environnement (ARPE) renovated the observatory and started to organize annual scientific expeditions...
  5. ncbi request reprint Acetazolamide: a treatment for chronic mountain sickness
    Jean Paul Richalet
    Laboratoire EA 2363, UFR SMBH, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Am J Respir Crit Care Med 172:1427-33. 2005
    ..Chronic mountain sickness or Monge's disease is characterized by an excessive polycythemia in high-altitude dwellers, with a prevalence of 5 to 18% above 3,200 m. To date, no pharmacologic treatment is available...
  6. doi request reprint Effects of high-altitude hypoxia on the hormonal response to hypothalamic factors
    Jean Paul Richalet
    Universite Paris 13, Unité de Formation et de Recherche Santé Médecine Biologie Humaine, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 299:R1685-92. 2010
    ..We conclude that prolonged exposure to high-altitude hypoxia induces contrasted changes in hormonal levels, but the hypophyseal response to hypothalamic factors does not appear to be blunted...
  7. doi request reprint A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia?
    Jean Paul Richalet
    Universite Paris, UFR SMBH EA, Bobigny, France
    Clin Auton Res 19:335-42. 2009
    ..In conclusion, no clear association was found between gene variants involved in oxygen sensing and chemoresponsiveness, although some mutations in the SDHB and SDHD genes deserve further investigations in a larger population...
  8. ncbi request reprint Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension
    Jean Paul Richalet
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris, Bobigny, France
    Am J Respir Crit Care Med 171:275-81. 2005
    ..05). Sildenafil protects against the development of altitude-induced pulmonary hypertension and improves gas exchange, limiting the altitude-induced hypoxemia and decrease in exercise performance...
  9. doi request reprint Operation Everest III: COMEX '97
    Jean Paul Richalet
    Universite Paris, Bobigny, France
    High Alt Med Biol 11:121-32. 2010
    ..The subjects reached the "summit" in better physiological conditions than would have been possible in the mountains, probably because acclimatization and other environmental factors such as cold and nutrition were controlled...
  10. doi request reprint Acetazolamide for Monge's disease: efficiency and tolerance of 6-month treatment
    Jean Paul Richalet
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA 2363, ARPE, UFR SMBH, Bobigny, France
    Am J Respir Crit Care Med 177:1370-6. 2008
    ..It has a considerable impact on public health in high-altitude regions. A preliminary study demonstrated the efficiency of acetazolamide (Acz) (250 mg/d for 3 wk) in reducing serum erythropoietin and hematocrit...
  11. doi request reprint Live and/or sleep high:train low, using normobaric hypoxia
    J P Richalet
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA2363, ARPE, Bobigny, France
    Scand J Med Sci Sports 18:29-37. 2008
    ..Virtually no data are available about the effect of this procedure upon anaerobic performance. The wide spread of these techniques deserves further investigations...
  12. doi request reprint Holmes-Adie syndrome associated with high altitude pulmonary edema and low chemo-responsiveness to hypoxia
    Jean Paul Richalet
    Service de Physiologie, Explorations Fonctionnelles et Médecine du Sport, AP HP, Hopital Avicenne, Bobigny, France
    Clin Auton Res 21:55-6. 2011
    ..Chemo-responsiveness to hypoxia should be explored before any exposure to moderate altitude in Holmes-Adie patients...
  13. ncbi request reprint Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes
    Pascal Mollard
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 74 rue Marcel Cachin, EA2363, ARPE, 93017 Bobigny Cedex, France
    Eur J Appl Physiol 100:663-73. 2007
    ..VEmax at 4,500 m (2) the greater.QaO2max decrement in TS due to a lower Sa'O2max and unchanged .Qmax 3) the smaller increase in O2ERmax in TS, insufficient to compensate the decrease in .QaO2max...
  14. ncbi request reprint Leukocyte's Hif-1 expression and training-induced erythropoietic response in swimmers
    Remi Mounier
    Laboratoire Inter Universitaire de Biologie des Activités Physiques et Sportives, Faculte de Medecine, Clermont Ferrand, France
    Med Sci Sports Exerc 38:1410-7. 2006
    ....
  15. doi request reprint Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia
    Xavier Woorons
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA 2363 UFR SMBH, Bobigny, France
    Eur J Appl Physiol 110:367-77. 2010
    ..157). This study demonstrated that exercise with VH induced a lower tissue oxygenation and a higher [La] than exercise with NB. This was caused by a severe arterial O(2) desaturation induced by both hypoxic and hypercapnic effects...
  16. ncbi request reprint Determinant factors of the decrease in aerobic performance in moderate acute hypoxia in women endurance athletes
    Pascal Mollard
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA2363, ARPE, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Respir Physiol Neurobiol 159:178-86. 2007
    ..The primary determinant factor of VO2 max decrement in moderate acute hypoxia in trained and untrained women is a reduced maximal O2 transport that cannot be compensate by tissue O2 extraction...
  17. ncbi request reprint Effects of intermittent hypoxia on heart rate variability during rest and exercise
    Camilo Povea
    Universite Paris 13, Faculte de Medecine, Bobigny, France
    High Alt Med Biol 6:215-25. 2005
    ..65, p < 0.001). The increase in total power, LF component, and LF/HF ratio suggests that intermittent hypoxic training increased the response of the autonomic nervous system mainly through increased sympathetic activity...
  18. ncbi request reprint Autonomic adaptations in andean trained participants to a 4220-m altitude marathon
    Jérémy Cornolo
    University Paris 13, ARPE, Laboratory of Functional and Cellular Responses to Hypoxia, Bobigny, France
    Med Sci Sports Exerc 37:2148-53. 2005
    ....
  19. doi request reprint Pulmonary pressure and cardiac function in chronic mountain sickness patients
    Maxime Maignan
    Universite Paris 13, EA 2363 Réponses Cellulaires et Fonctionnelles à l Hypoxie, Bobigny, France
    Chest 135:499-504. 2009
    ..We sought to assess the determinants of cardiac function in CMS patients with hypoxia-induced PH...
  20. ncbi request reprint Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafil
    Jérémy Cornolo
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 93017 Bobigny, France
    J Appl Physiol 97:935-40. 2004
    ..Sil had no deleterious effects on the cardiovascular response to high-altitude exposure and its control by the autonomic nervous system...
  21. ncbi request reprint Living high-training low: tolerance and acclimatization in elite endurance athletes
    Julien V Brugniaux
    Laboratoire Réponses cellulaires et fonctionnelles à l hypoxie EA2363, ARPE, UFR SMBH, Universite Paris 13, 74 rue Marcel Cachin, 93017, Bobigny Cedex, France
    Eur J Appl Physiol 96:66-77. 2006
    ..Comparison of the three patterns of training suggests that a LHTL session should not exceed 3,000 m, for at least 18 days, with a minimum of 12 h day(-1) of exposure...
  22. ncbi request reprint Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners
    Julien V Brugniaux
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Bobigny, France
    J Appl Physiol (1985) 100:203-11. 2006
    ..Therefore, both maximal and submaximal aerobic performance in elite runners were increased by LHTL mainly linked to an improvement in oxygen transport in early return to normoxia and probably to other process at Post2...
  23. doi request reprint Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia
    Pascal Mollard
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA2363, ARPE, Bobigny Cedex, France
    Respir Physiol Neurobiol 172:179-83. 2010
    ..In conclusion, except for P(O2) in normoxia, pre-warmed earlobe capillary blood is a good substitute to arterial blood to allow measurement of blood gas values in normoxia and hypoxia at rest and exercise...
  24. pmc Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia
    Luciana Hagström
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, EA 2363, 97017 Bobigny, France
    J Biomed Biotechnol 2010:137817. 2010
    ..EpoR mRNA is not up-regulated in both Epo-deficient and hypoxic gastrocnemius. These results suggest that muscle deconditioning observed in patients suffering from renal failure is not due to Epo deficiency...
  25. doi request reprint Acetazolamide and chronic hypoxia: effects on haemorheology and pulmonary haemodynamics
    Aurelien Pichon
    Sorbonne Paris Cité, Gr Ex, Laboratoire Réponses cellulaires et fonctionnelles à l hypoxie EA 2363, Bobigny, France
    Eur Respir J 40:1401-9. 2012
    ..The effect of acetazolamide is multifactorial by acting on erythropoiesis, pulmonary circulation, haemorheological properties and cardiac output, and could represent a pertinent treatment of chronic mountain sickness...
  26. doi request reprint Effects of acute hypoxia tests on blood markers in high-level endurance athletes
    Remi Mounier
    Laboratoire de Biologie des Activités Physiques et Sportives, Faculte de Medecine, 63000 Clermont Ferrand, France
    Eur J Appl Physiol 106:713-20. 2009
    ..This study shows a large inter-variability of blood markers in elite athletes in response to acute hypoxic exposure corroborating previous observations made in other populations...
  27. doi request reprint Epo deficiency alters cardiac adaptation to chronic hypoxia
    Raja El Hasnaoui-Saadani
    Universite Paris 13, Sorbonne Paris Cité, EA2363 Réponses cellulaires et fonctionnelles à l hypoxie, 93017 Bobigny, France
    Respir Physiol Neurobiol 186:146-54. 2013
    ..HIF/Epo pathway is activated in the heart of WT mice in hypoxia. Chronic hypoxia induced cardiac adaptive responses that were altered with Epo deficiency, failing to maintain oxygen delivery to tissues...
  28. ncbi request reprint Influence of "living high-training low" on aerobic performance and economy of work in elite athletes
    Laurent Schmitt
    Universite Paris 13, EA2363, ARPE, 74 rue Marcel Cachin, 93017 Bobigny, France
    Eur J Appl Physiol 97:627-36. 2006
    ..The efficiency of Hi-Lo is also evidenced 15 days later by higher V(O2) and power at RCP. This study emphasizes that during the post-altitude period, economy of work greatly increases in both groups...
  29. doi request reprint Thirteen days of "live high-train low" does not affect prooxidant/antioxidant balance in elite swimmers
    Vincent Pialoux
    Laboratoire de Biologie des Activités Physiques et Sportives, Faculte de Medecine, 63000 Clermont Ferrand, France
    Eur J Appl Physiol 106:517-24. 2009
    ..The LHTL did not affect the antioxidant status in elite swimmers; however, the normoxic endurance training induced preconditioning mechanisms in response to the 4,800 m test...
  30. doi request reprint Interaction between hypoxia and training on NIRS signal during exercise: contribution of a mathematical model
    Nicolas Bourdillon
    Universite Paris 13, Laboratoire Réponses cellulaires et fonctionnelles à l hypoxie EA 2363, Bobigny, France
    Respir Physiol Neurobiol 169:50-61. 2009
    ..At 4000m, athletes loose their advantages of adaptation to training due to a reduced arterial content, and both from NIRS variables and model output, characteristics of O(2) transfer of TA converge toward those of US...
  31. ncbi request reprint Prolonged expiration down to residual volume leads to severe arterial hypoxemia in athletes during submaximal exercise
    Xavier Woorons
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA2363, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Respir Physiol Neurobiol 158:75-82. 2007
    ..56; p<0.05), a widened PA(O2) - Pa(O2) (r=-0.85; p<0.001) and a right shift of the oxygen dissociation curve (r=-0.73; p<0.001)...
  32. ncbi request reprint Effect of acute hypoxia on maximal exercise in trained and sedentary women
    Xavier Woorons
    Laboratory of Functional and Cellular Responses to Hypoxia, UFR SMBH Universite Paris, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Med Sci Sports Exerc 37:147-54. 2005
    ..The purpose of this study was to determine the physiological responses of sedentary and endurance-trained female subjects during maximal exercise at different levels of acute hypoxia...
  33. ncbi request reprint Effects of a 4-week training with voluntary hypoventilation carried out at low pulmonary volumes
    Xavier Woorons
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA2363, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Respir Physiol Neurobiol 160:123-30. 2008
    ..The reduced exercise-induced blood acidosis in HYPO could be due to an improvement in muscle buffer capacity. This phenomenon may have a significant positive impact on anaerobic performance...
  34. ncbi request reprint Interactions between exposure to hypoxia and the training-induced autonomic adaptations in a "live high-train low" session
    Jérémy Cornolo
    Laboratoire, Réponses cellulaires et fonctionnelles à l hypoxie, Universite Paris 13, EA2363, ARPE, 93017, Bobigny, France
    Eur J Appl Physiol 96:389-96. 2006
    ..During an LHTL session, adaptations to hypoxia interacted with the autonomic and cardiovascular adaptations to training. However, these interactions did not limit the adaptations to the following sea-level training...
  35. ncbi request reprint Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat
    Olivier Eric Morel
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA 2363, Association pour la Recherche en Physiologie de l Environnement, UFR SMBH Université Paris 13, 74 rue Marcel Cachin, 93017 Bobigny, France
    Pflugers Arch 446:356-64. 2003
    ..However, the development and regression of pulmonary hypertension and RVH were related to the expression of some PKC isoforms suggesting that pathways other than alpha(1)-AR might be involved in hypoxia-induced ventricular hypertrophy...
  36. ncbi request reprint Exercise training improves lung gas exchange and attenuates acute hypoxic pulmonary hypertension but does not prevent pulmonary hypertension of prolonged hypoxia
    Fabrice Favret
    EA 2363 Laboratoire Réponses Cellulaires et Fonctionelles à l Hypoxie, Universite Paris 13, 930173 Bobigny, France
    J Appl Physiol (1985) 100:20-5. 2006
    ..ET effects may improve the response to acute hypoxia by increasing efficacy of gas exchange and lowering right ventricular work...
  37. doi request reprint [Altitude and the cardiovascular system]
    Jean Paul Richalet
    AP HP, Hopital Avicenne, Service de Physiologie, Explorations Fonctionnelles et Médecine du Sport, Bobigny Cedex, 93009 France
    Presse Med 41:638-43. 2012
    ..The only test allowing predicting the tolerance to high altitude is the hypoxia exercise test realized at 30% of maxVO(2)and at an equivalent altitude of 4,800m...
  38. doi request reprint 'Oxygen uptake efficiency slope' in trained and untrained subjects exposed to hypoxia
    Pascal Mollard
    Universite Paris 13, UFR SMBH, STAPS, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, UPRES EA 2363, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Respir Physiol Neurobiol 161:167-73. 2008
    ..The OUES(80) could be considered as an interesting sub-maximal index of cardiorespiratory fitness in normal or hypoxemic subjects unable to reach V(O2 peak)...
  39. doi request reprint Skeletal muscle intrinsic functional properties are preserved in a model of erythropoietin deficient mice exposed to hypoxia
    Luciana Hagström
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, 74 Rue Marcel Cachin 97017, EA2363, Bobigny, France
    Pflugers Arch 459:713-23. 2010
    ..These results suggest that skeletal muscles possess a great capacity of adaptation to Epo deficiency. Then Epo deficiency is not a sufficient factor to modify intrinsic functional properties of skeletal muscles...
  40. ncbi request reprint Exercise and hypoxia: the role of the autonomic nervous system
    Fabrice Favret
    Universite Paris 13, Laboratoire EA2363 Réponses Cellulaires et Fonctionnelles à l hypoxie, 74 rue Marcel Cachin, Bobigny, France
    Respir Physiol Neurobiol 158:280-6. 2007
    ....
  41. doi request reprint Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia
    Raja El Hasnaoui-Saadani
    Universite Paris, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 296:R801-11. 2009
    ..In Epo-TAg(h), the decrease in HIF-1alpha, VEGF proteins, and phospho-STAT-5 ratio in chronic hypoxia suggest that neuroprotective and angiogenesis pathways are altered...
  42. doi request reprint Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes
    Vincent Pialoux
    Universite d Auvergne, Laboratoire de Biologie des Activités Physiques et Sportives, Faculte de Medecine, 63000 Clermont Ferrand, France
    Respir Physiol Neurobiol 167:217-20. 2009
    ..69, P=0.01). The ventilatory acclimatization to hypoxia occurring in athletes after LHTL seems to be modulated by oxidative stress. Furthermore, LHTL induced a higher sensitivity of HIF-1 alpha mRNA to acute hypoxia in elite athletes...
  43. ncbi request reprint Simulated high altitude selectively decreases protein intake and lean mass gain in rats
    Olivier E Morel
    Universite Paris 13, Physiologie du Comportement Alimentaire, UFR Santé Médecine et Biologie Humaine, Bobigny, France
    Physiol Behav 86:145-53. 2005
    ..52, P < .05), more specifically with protein intake (r = -.57, P < .05). These results suggest that HA leads to a reduced preference for protein impairing fat-free mass gain and that leptin may contribute to this hypophagia...
  44. pmc Ageing and cardiorespiratory response to hypoxia
    François J Lhuissier
    University of Paris 13, Sorbonne Paris Cit e, EA2363 Réponses cellulaires et fonctionnelles àl hypoxie, Bobigny, France
    J Physiol 590:5461-74. 2012
    ..Training limits the negative effects of menopause in cardiorespiratory adaptations to hypoxia...
  45. doi request reprint Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine
    Aurelien Pichon
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 297:R978-87. 2009
    ..The sensitivity to severe acute hypoxia in pikas seems to be regulated by a peripheral nNOS mechanism...
  46. doi request reprint Non-invasive evaluation of the capillary recruitment in the human muscle during exercise in hypoxia
    Nicolas Bourdillon
    Universite Paris 13, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, EA 2363, and AP HP Hôpital AVicenne, Service de Physiologie, Explorations Fonctionnelles et Médecine du Sport, Bobigny, France
    Respir Physiol Neurobiol 165:237-44. 2009
    ....
  47. doi request reprint Effects of a high-carbohydrate versus high-protein meal on acute responses to hypoxia at rest and exercise
    Keyne Charlot
    EA2363, Laboratoire des Réponses Cellulaires et Fonctionnelles à l Hypoxie, UFR SMBH, Universite Paris 13, Sorbonne Paris Cité, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
    Eur J Appl Physiol 113:691-702. 2013
    ..001). HRV indices were not different between conditions. In conclusion, a high-CHO meal consumed prior to moderate exercise in hypoxia condition reduced oxygen desaturation compared to a high-protein meal...
  48. doi request reprint Ventilatory and cardiac responses to hypoxia at submaximal exercise are independent of altitude and exercise intensity
    François J Lhuissier
    Universite Paris 13, EA 2363 Réponses Cellulaires et Fonctionnelles à l Hypoxie, France
    J Appl Physiol (1985) 112:566-70. 2012
    ..05 to P < 0.001). Therefore, we suggest that HVR(e) and HCR(e) are invariant parameters that can be considered as intrinsic physiological characteristics of chemosensitivity to hypoxia...
  49. doi request reprint Improvement of energy expenditure prediction from heart rate during running
    Keyne Charlot
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, Sorbonne Paris Cité UFR SMBH EA2363, 74 rue Marcel Cachin, F 93017 Bobigny Cedex, France
    Physiol Meas 35:253-66. 2014
    ..In conclusion, EE estimation during running might be significantly improved by including running speed in the predictive models, a parameter readily available with treadmill or GPS. ..
  50. doi request reprint Swimmers can train in hypoxia at sea level through voluntary hypoventilation
    Xavier Woorons
    Université Paris 13 Nord, Sorbonne Paris Cité, EA2363, Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, UFR SMBH, Bobigny, France Electronic address
    Respir Physiol Neurobiol 190:33-9. 2014
    ..This study demonstrated that swimmers can train under hypoxic conditions at sea level and can accentuate the glycolytic stimulus of their training if they perform VH at low but not high pulmonary volume. ..
  51. ncbi request reprint Comparative response of EPO and soluble transferrin receptor at high altitude
    Paul Robach
    ARPE, Laboratory Cellular and Functional Responses to Hypoxia, Faculty of Medicine, Bobigny, France
    Med Sci Sports Exerc 36:1493-8; discussion 1492. 2004
    ..This study investigated the response of sTfR during high-altitude exposure in human and verified that sTfR was related to EPO response in this case...
  52. pmc Bosentan effects in hypoxic pulmonary vasoconstriction: Preliminary study in subjects with or without high altitude pulmonary edema-history
    Isabelle Pham
    Paris 13, University, Laboratory Cellular and Functional Responses to Hypoxia, Bobigny, France
    Pulm Circ 2:28-33. 2012
    ..8 times higher than during for both CS and HS. A single oral dose of bosentan similarly blunted the hypoxia-induced increase in PASP both in healthy and HAPE-susceptible subjects, without altering CO or SBP...
  53. ncbi request reprint Carlos Monge Cassinelli: a portrait
    Fabiola Leon-Velarde
    Cayetano Heredia University, Peru
    Adv Exp Med Biol 618:291-7. 2007
    ..This tribute and picture gallery pay tribute to Choclo, written by Fabiola Leon Velarde and Jean Paul Richalet.
  54. ncbi request reprint Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise
    Fabrice Favret
    Dept of Molecular and Integrative Physiology, Univ of Kansas Medical Center, Kansas City, KS 66160, USA
    J Appl Physiol 95:1531-41. 2003
    ....
  55. ncbi request reprint Respiratory control in residents at high altitude: physiology and pathophysiology
    Fabiola Leon-Velarde
    Universidad Peruana Cayetano Heredia, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencius Filosafia, Laboratorio de Transporte de Oxígeno, Lima, Peru
    High Alt Med Biol 7:125-37. 2006
    ....
  56. ncbi request reprint Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers
    Paul Robach
    Ecole Nationale de Ski et d Alpinisme, 35, route du Bouchet, 74401, Chamonix, France
    Eur J Appl Physiol 97:695-705. 2006
    ..0% (controls) and 3.7% (Hi-Lo). The present results suggest that increasing the altitude up to 3,500 m during Hi-Lo stimulates erythropoiesis but does not confer any advantage for maximal O2 transport...
  57. ncbi request reprint Recovery of plasma volume after 1 week of exposure at 4,350 m
    Paul Robach
    Ecole Nationale de Ski et d Alpinisme, BP 24, 74401 Chamonix, France
    Pflugers Arch 444:821-8. 2002
    ..However, neither PV recovery, nor hormonal responses were altered with PVX-induced normovolemia upon RSL...
  58. ncbi request reprint Consensus statement on chronic and subacute high altitude diseases
    Fabiola Leon-Velarde
    Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
    High Alt Med Biol 6:147-57. 2005
    ..Most of the cases of high altitude diseases are preventable if on-site personnel identify the condition and implement appropriate care...
  59. ncbi request reprint Living high-training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers
    Paul Robach
    Ecole Nationale de Ski et d Alpinisme, 35 route du Bouchet, 74401 Chamonix, France
    Eur J Appl Physiol 96:423-33. 2006
    ..The absence of any prolonged benefit after LHTL suggests that this LHTL model cannot be recommended for long-term purposes...
  60. ncbi request reprint Comments on Point:Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume"
    Norberto C Gonzalez
    J Appl Physiol 99:2456. 2005
  61. ncbi request reprint Transient neurological disorders during a simulated ascent of Mount Everest
    Emmanuel Cauchy
    Département de Médecine de Montagne de l Hôpital de Chamonix, Chamonix, France
    Aviat Space Environ Med 73:1224-9. 2002
    ..We report here on the clinical observations and testing to detect mechanisms in addition to hypocapnic vasoconstriction...