Genomes and Genes
Affiliation: UFR SMBH
- Impact of orlistat initiation on cardiovascular treatment use: a 6-year population-based cohort studySebastien Czernichow
Unite de Recherche en Epidemiologie Nutritionnelle, Faculté de Médecine SMBH, 74 rue Marcel Cachin, Bobigny, France
Eur J Prev Cardiol 19:484-9. 2012..Since obesity is associated with increased cardiovascular (CV) medication use and pharmaceutical costs, weight-loss drug use could beneficially impact CV medication use...
- Genome wide association study identifies KCNMA1 contributing to human obesityHong Jiao
Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
BMC Med Genomics 4:51. 2011..Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity...
- [N-6 fatty acids and cardiovascular health: dietary intake recommendations]Sebastien Czernichow
Unité de recherche d épidémiologie nutritionnelle, UMR INSERM U557, INRA, CNAM, UP13, CRNH IdF, Faculté SMBH, 74, rue Marcel Cachin, 93017 Bobigny, France
Med Sci (Paris) 27:614-8. 2011..In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5%, and ideally about 10% of total energy appears justified for the prevention of ischemic heart disease...
- Efficacy of weight loss drugs on obesity and cardiovascular risk factors in obese adolescents: a meta-analysis of randomized controlled trialsS Czernichow
The George Institute for International Health, The University of Sydney, Sydney, NSW, Australia
Obes Rev 11:150-8. 2010..32 kg; I(2) = 38%). There was little evidence that treatment was associated with adverse effects on cardiovascular risk factors but this requires verification from future large trials with longer study follow-up...
- Microvascular dysfunction in healthy insulin-sensitive overweight individualsSebastien Czernichow
Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, CRNH IdF, France
J Hypertens 28:325-32. 2010..In the present study, we measured skin capillary density and endothelial function in a group of normotensive overweight/obese nondiabetic individuals and healthy lean controls...
- Trends in the prevalence of obesity in employed adults in central-western France: a population-based study, 1995-2005Sebastien Czernichow
Unite de Recherche en Epidemiologie Nutritionnelle, Faculté de medicine SMBH, INSERM U557, INRA U1125, CNAM, UP13, CRNH IdF, 93017 Bobigny, France
Prev Med 48:262-6. 2009..The aim of this study was to assess, according to socioeconomic status (SES), whether a shift in the obesity prevalence trends could be observed since the French National Nutrition and Public Health Program was implemented in 2001...
- Impact of blood pressure lowering on cardiovascular outcomes in normal weight, overweight, and obese individuals: the Perindopril Protection Against Recurrent Stroke Study trialSebastien Czernichow
George Institute for International Health, University of Sydney, Sydney, Australia
Hypertension 55:1193-8. 2010..However, the greater baseline level of cardiovascular risk in those with higher body mass index meant that these patients obtained the greatest benefit...
- Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adultsSebastien Czernichow
Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, Paris 13 University, 93017 Bobigny, France
Am J Clin Nutr 90:329-35. 2009..Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS...
- Macrovascular and microvascular dysfunction in the metabolic syndromeSebastien Czernichow
Nutritional Epidemiology Research Unit, UMR U557 INSERM, U1125 Inra, CNAM, Paris 13, CRNH IdF, Bobigny, France
Hypertens Res 33:293-7. 2010..The common mechanism linking MetS components to CVD risk through small- and large-artery dysfunctions may be mediated through metabolic factors related to insulin resistance, not to increased BP...
- Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCESebastien Czernichow
The George Institute for International Health, The University of Sydney, New South Wales, Australia
Eur J Cardiovasc Prev Rehabil 18:312-9. 2011....
- The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trialsSebastien Czernichow
The George Institute, Sydney, Australia
J Hypertens 29:4-16. 2011..The objective was to compare the risk reductions achieved by different blood pressure-lowering regimens among individuals with different baseline blood pressures...
- Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: evidence from an individual-participant meta-analysis of 82 864 participants from nine cohort studiesS Czernichow
Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
Obes Rev 12:680-7. 2011..In conclusion, measures of abdominal adiposity, but not BMI, were related to an increased risk of CVD mortality. No difference was observed in discrimination capacities between adiposity markers...
- Dairy consumption and 6-y changes in body weight and waist circumference in middle-aged French adultsAnne Claire Vergnaud
INSERM U557, INRA U1125, CNAM EA3200, Paris 13 University, and the Research Unit on Nutritional Epidemiology, CRNH IdF, Bobigny, France
Am J Clin Nutr 88:1248-55. 2008..Some studies have shown an inverse relation between calcium intake and body weight or fat mass...
- Associations between dietary patterns and arterial stiffness, carotid artery intima-media thickness and atherosclerosisEmmanuelle Kesse-Guyot
UMR, INSERM U557 INRA U1125 CNAM Université Paris 13, CRNH IdF, Bobigny, France
Eur J Cardiovasc Prev Rehabil 17:718-24. 2010..The aim of this study was to investigate the relationship between carotid-femoral pulse-wave velocity (PWV), common carotid-arteries intima-media thickness (CCA-IMT) and plaques with dietary patterns measured 7.5 years earlier...
- Relationships between different types of fruit and vegetable consumption and serum concentrations of antioxidant vitaminsLuc Dauchet
INSERM, U557, Bobigny, France
Br J Nutr 100:633-41. 2008..These results describe antioxidant serum concentrations according to fruit and vegetable consumption in a large sample and support the findings of previous studies involving a more limited number of subjects...
- Blood pressure variables and cardiovascular risk: new findings from ADVANCEAndre Pascal Kengne
ADVANCE Collaborative Group, The George Institute for International Health, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
Hypertension 54:399-404. 2009..However, SBP may be the simplest and most useful predictor across a wider range of age groups and populations...
- Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrationsSebastien Czernichow
Nutritional Epidemiology Unit, French Institute of Health and Medical Research, CRNH Ile de France, Bobigny, France
Am J Clin Nutr 84:395-9. 2006..Observational data suggest a protective effect of several antioxidants on fasting plasma glucose (FPG) and type 2 diabetes. However, randomized trials have yielded inconsistent results...
- Influence of dairy product consumption on children's blood pressure: results from the QUALITY cohortWen Lun Yuan
INSERM, Centre for research in Epidemiology and Population Health, Villejuif, France
J Acad Nutr Diet 113:936-41. 2013..Our results indicate that high intake of dairy (≥2 servings per day) has antihypertensive effects on blood pressure among youth. ..
- Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer riskMathilde Touvier
INSERM U557 National Institute of Health and Medical Research, INRA, CNAM, University of Paris 13 UREN, SMBH, 74 rue Marcel Cachin, F 93017 Bobigny, France
World J Gastroenterol 18:2805-12. 2012..To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models...
- Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control studyMathilde Touvier
Nutritional Epidemiology Unit, INSERM U557, Paris 13 University, 74 rue Marcel Cachin, F 93017 Bobigny, France
Am J Epidemiol 177:3-13. 2013..quartile 1, multivariate OR = 3.04, 95% CI: 1.28, 7.23; P(trend) = 0.03). These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated with increased prostate and breast cancer risk, respectively...
- Association between the French nutritional guideline-based score and 6-year anthropometric changes in a French middle-aged adult cohortEmmanuelle Kesse-Guyot
INSERMU557, INRAU1125, CNAM, Paris 13 University, Human Nutrition Research Center, Bobigny, France
Am J Epidemiol 170:757-65. 2009..89, 95% confidence interval: 0.80, 0.99) after a 6-year follow-up period. These observations support the role of nutritional guidelines in prevention of age-related weight increase and development of obesity...
- Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteriesMahmoud Zureik
National Institute of Health and Medical Research Unit 258, Villejuif, France
Arterioscler Thromb Vasc Biol 24:1485-91. 2004..Limited data exist from randomized trials evaluating, noninvasively, the impact of antioxidant supplementation on vascular structure and function...
- Adherence to French nutritional guidelines is associated with lower risk of metabolic syndromeEmmanuelle Kesse-Guyot
Unite de Recherche en Epidemiologie Nutritionnelle, UMR U557 INSERM, U1125 Inra, CNAM, Paris 13, CRNH IdF, Bobigny, France
J Nutr 141:1134-9. 2011..Improvement in compliance with nutritional recommendations may help to reduce the burden of CVD disease in the general population...
- Energy density and 6-year anthropometric changes in a middle-aged adult cohortAnne Claire Vergnaud
Centre de Recherche en Nutrition Humaine Ile de France, UMR U557 INSERM, U1125 Inra, CNAM, SMBH Université Paris 13, 74 rue Marcel Cachin, F 93017 Bobigny Cedex, France
Br J Nutr 102:302-9. 2009..This relationship could be mediated by physical activity level. Further research needs to be performed in other populations to determine whether ED could be effective strategies to prevent weight gain...
- The Nutrinet-Santé Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional statusSerge Hercberg
Unite de Recherche en Epidemiologie Nutritionnelle, UMR U 557 Inserm U 1125 Inra CNAM Université Paris, France
BMC Public Health 10:242. 2010..using a web-based approach...
- Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohortPilar Galan
U557 INSERM UMR INSERM INRA CNAM, Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Public Health Nutr 9:70-4. 2006..We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population...
- Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohortLuc Dauchet
UMR U557 INSERM, France
Am J Clin Nutr 85:1650-6. 2007..Although short-term effects of the Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure have been shown in intervention studies, less is known about the long-term effects...
- Differential associations of dietary sodium and potassium intake with blood pressure: a focus on pulse pressureJean François Buyck
UMR INSERM U557 INRA U1125 CNAM Université Paris 13, CRNH IdF, Bobigny, France
J Hypertens 27:1158-64. 2009....
- Pulse pressure amplification, adiposity and metabolic syndrome in subjects under chronic antihypertensive therapy: the role of heart rateAnne Claire Vergnaud
INSERM U557, INRA U1125CNAM EA3200, Iniv Paris 13, CRNH IdF, Bobigny, F 93017 France
Atherosclerosis 199:222-9. 2008..However, the relationships of BMI, WC and metabolic syndrome (MS) with central wave reflections and pulse pressure (PP) amplification have never been investigated...
- Association between dietary patterns and depressive symptoms over time: a 10-year follow-up study of the GAZEL cohortAgnès Le Port
Inserm U1018, University of Versailles St Quentin Centre for research in Epidemiology and Population Health, Villejuif, France
PLoS ONE 7:e51593. 2012..The objective of this study was to examine the longitudinal association between dietary patterns and depressive symptoms assessed repeatedly over 10 years in the French occupational GAZEL cohort...
- Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)Beverley Balkau
INSERM U780 IFR69, Villejuif, France University Paris Sud, Orsay, France
Diabetes Care 31:2056-61. 2008..To provide a simple clinical diabetes risk score and to identify characteristics that predict later diabetes using variables available in the clinic setting as well as biological variables and polymorphisms...
- Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control studyMathilde Touvier
INSERM U557, National Institute of Health and Medical Research, INRA, CNAM, Paris 13 University, Bobigny, France
Am J Clin Nutr 95:944-50. 2012..Mechanistic data suggest that n-3 PUFAs and endothelial function may interact and play a role in carcinogenesis, but epidemiologic evidence is lacking...
- Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trialPilar Galan
UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, F 93017 Bobigny, France
BMJ 341:c6273. 2010..To investigate whether dietary supplementation with B vitamins or omega 3 fatty acids, or both, could prevent major cardiovascular events in patients with a history of ischaemic heart disease or stroke...
- Low total and nonheme iron intakes are associated with a greater risk of hypertensionPilar Galan
UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, F 93017 Bobigny, France
J Nutr 140:75-80. 2010..Our data support a possible role of low nonheme iron intake, independent of heme iron intake, in the development of hypertension...
- Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysisRachel Huxley
The George Institute for International Health, The University of Sydney, Australia
Arch Intern Med 169:2053-63. 2009..Similar associations have also been reported for decaffeinated coffee and tea. We report herein the findings of meta-analyses for the association between coffee, decaffeinated coffee, and tea consumption with risk of diabetes...
- The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidenceRachel R Huxley
The George Institute for International Health, University of Sydney, Sydney, Australia
Int J Cancer 125:171-80. 2009....
- n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendationsSebastien Czernichow
Nutritional Epidemiology Research Unit, UMR INSERM U557, INRA U1125, CNAM, UP13, CRNH IdF, Faculté SMBH, 74 rue Marcel Cachin, 93017 Bobigny, France
Br J Nutr 104:788-96. 2010..n-6 PUFA benefits are even increased when SFA intake is also reduced. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5 %, and ideally about 10 %, of total energy appears justified...
- Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndromeDominique Roulot
Unité d Hépatologie, Hopital Avicenne, Assistance Publique, Hopitaux de Paris, Bobigny, France
J Hepatol 48:606-13. 2008..The aim of the present study was to prospectively assess liver stiffness values in the general population and to determine potential factors, which may influence these values...
- Obesity phenotypes in midlife and cognition in early old age: the Whitehall II cohort studyArchana Singh-Manoux
INSERM, U1018, Center for Research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
Neurology 79:755-62. 2012..To examine the association of body mass index (BMI) and metabolic status with cognitive function and decline...
- International collaborative project to compare and monitor the nutritional composition of processed foodsElizabeth Dunford
The George Institute for Global Health, Missenden Rd, Camperdown, NSW, Australia
Eur J Prev Cardiol 19:1326-32. 2012..Our objective is to compare the nutritional composition of processed foods between countries, between food companies, and over time...
- [Obesity in the adult]Sebastien Czernichow
Centre de Recherche en Nutrition Humaine Ile de France, Hôpital Avicenne AP HP, 93017 Bobigny, Université Paris 13 SMBH
Rev Prat 56:2275-81. 2006
- The variability of reported salt levels in fast foods across six countries: opportunities for salt reductionElizabeth Dunford
The George Institute for Global Health, Sydney, Australia
CMAJ 184:1023-8. 2012..Our objective was to examine the reported salt levels for products offered by leading multinational fast food chains...
- Calcium and vitamin D intake by postmenopausal women with osteoporosis in FranceSebastien Czernichow
Department of Public Health, Avicenne Hospital, University of Paris 13, Bobigny, France
Curr Med Res Opin 26:1667-74. 2010..To assess dietary calcium and vitamin D intake and their relationship with prescription medication and nutritional supplement use among postmenopausal women with osteoporosis in France...
- Very low oral doses of vitamin B-12 increase serum concentrations in elderly subjects with food-bound vitamin B-12 malabsorptionJacques Blacher
INSERM U 258, Hopital Paul Brousse, Villejuif, France
J Nutr 137:373-8. 2007..Our results could be beneficial in the design of a public health program for safe flour cofortification with folic acid...
- Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgeryMarion Valette
Paris 13 University, Sorbone Paris Cité, Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, CRNH IdF, Bobigny, France
PLoS ONE 7:e48221. 2012..This is the first case-control study to show that MC4R mutations and polymorphisms do not affect weight loss and body composition over one year after bariatric surgery...
- Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph nodePierre Saintigny
Laboratoire d Oncologie Cellulaire et Moleculaire, EA 3410, Universite Paris 13, Bobigny, France
Lung Cancer 58:205-13. 2007..The present study was therefore designed to evaluate VEGF-C/VEGFR-3 coexpression in tumour cells from the primary tumour and corresponding LN metastases...