Antoine Triller

Summary

Country: France

Publications

  1. doi request reprint New concepts in synaptic biology derived from single-molecule imaging
    Antoine Triller
    INSERM UR497, Ecole Normale Superieure, Biologie Cellulaire de la Synapse N and P, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:359-74. 2008
  2. doi request reprint A common molecular basis for membrane docking and functional priming of synaptic vesicles
    Lea Siksou
    Ecole Normale Superieure, Biologie de la Synapse Normale et Pathologique, 46 rue d Ulm, 75005 Paris, France
    Eur J Neurosci 30:49-56. 2009
  3. ncbi request reprint Cytoskeleton regulation of glycine receptor number at synapses and diffusion in the plasma membrane
    Cécile Charrier
    Laboratoire de Biologie Cellulaire de la Synapse, Institut National de la Sante et de la Recherche Medicale, Unité 789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 26:8502-11. 2006
  4. doi request reprint Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics
    Hiroko Bannai
    Biologie Cellulaire de la Synapse N and P, Ecole Normale Superieure Paris, INSERM U789, 46 Rue d Ulm 75005 Paris, France
    Neuron 62:670-82. 2009
  5. doi request reprint Gephyrin oligomerization controls GlyR mobility and synaptic clustering
    Martino Calamai
    INSERM U789 Biologie Cellulaire de Synapse and Département de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:7639-48. 2009
  6. doi request reprint Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites
    Christian G Specht
    Biologie Cellulaire de la Synapse, Inserm U1024, Institute of Biology, Ecole Normale Supérieure ENS, 46 rue d Ulm, Paris 75005, France
    Neuron 79:308-21. 2013
  7. ncbi request reprint Three-dimensional architecture of presynaptic terminal cytomatrix
    Lea Siksou
    INSERM U789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 27:6868-77. 2007
  8. doi request reprint A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses
    Cécile Charrier
    Biologie Cellulaire de la Synapse, IBENS, Ecole Normale Superieure, Inserm U1024, CNRS UMR8197, Paris, France
    Nat Neurosci 13:1388-95. 2010
  9. doi request reprint Homeostatic regulation of synaptic GlyR numbers driven by lateral diffusion
    Sabine Levi
    Biologie Cellulaire de la Synapse, INSERM U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:261-73. 2008
  10. pmc Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe
    Ignacio Izeddin
    Laboratoire Kastler Brossel, CNRS UMR 8552, Department of Physics, Ecole Normale Superieure, Universite Pierre et Marie Curie Paris 6, Paris, France
    PLoS ONE 6:e15611. 2011

Collaborators

Detail Information

Publications46

  1. doi request reprint New concepts in synaptic biology derived from single-molecule imaging
    Antoine Triller
    INSERM UR497, Ecole Normale Superieure, Biologie Cellulaire de la Synapse N and P, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:359-74. 2008
    ..In this primer, we will review the different approaches used to track single molecules in live neurons, compare them to bulk measurements, and discuss the different concepts that have emerged from their application to synaptic biology...
  2. doi request reprint A common molecular basis for membrane docking and functional priming of synaptic vesicles
    Lea Siksou
    Ecole Normale Superieure, Biologie de la Synapse Normale et Pathologique, 46 rue d Ulm, 75005 Paris, France
    Eur J Neurosci 30:49-56. 2009
    ..These results indicate that SV docking at the plasma membrane and functional priming are respective morphological and physiological manifestations of the same molecular process mediated by SNARE complexes and Munc13s...
  3. ncbi request reprint Cytoskeleton regulation of glycine receptor number at synapses and diffusion in the plasma membrane
    Cécile Charrier
    Laboratoire de Biologie Cellulaire de la Synapse, Institut National de la Sante et de la Recherche Medicale, Unité 789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 26:8502-11. 2006
    ..Consequently, GlyR number at synapses may be rapidly modulated by the cytoskeleton through the regulation of lateral diffusion in the plasma membrane and of receptor stabilization at synapses...
  4. doi request reprint Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics
    Hiroko Bannai
    Biologie Cellulaire de la Synapse N and P, Ecole Normale Superieure Paris, INSERM U789, 46 Rue d Ulm 75005 Paris, France
    Neuron 62:670-82. 2009
    ..This transient activity-dependent reduction of inhibition would favor the onset of LTP during conditioning...
  5. doi request reprint Gephyrin oligomerization controls GlyR mobility and synaptic clustering
    Martino Calamai
    INSERM U789 Biologie Cellulaire de Synapse and Département de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:7639-48. 2009
    ..Since alterations in the oligomerization properties of gephyrin are related to the dynamics of GlyRs, the gephyrin splice variant ge(2,4,5) may be implicated in the modulation of synaptic strength...
  6. doi request reprint Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites
    Christian G Specht
    Biologie Cellulaire de la Synapse, Inserm U1024, Institute of Biology, Ecole Normale Supérieure ENS, 46 rue d Ulm, Paris 75005, France
    Neuron 79:308-21. 2013
    ..The competition of glycine and GABAA receptor complexes for synaptic binding sites highlights the potential of single-molecule imaging to quantify synaptic plasticity on the nanoscopic scale. ..
  7. ncbi request reprint Three-dimensional architecture of presynaptic terminal cytomatrix
    Lea Siksou
    INSERM U789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 27:6868-77. 2007
    ..This 3D analysis reveals the morphological constraints exerted by the presynaptic molecular scaffold. SVs are tightly interconnected in the axonal bouton, and this network is preferentially connected to the AZ...
  8. doi request reprint A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses
    Cécile Charrier
    Biologie Cellulaire de la Synapse, IBENS, Ecole Normale Superieure, Inserm U1024, CNRS UMR8197, Paris, France
    Nat Neurosci 13:1388-95. 2010
    ..This provides a mechanism for maintaining or adjusting the steady state of postsynaptic molecule exchanges and the level of glycinergic inhibition in response to neuron- and glia-derived signals or extracellular matrix remodeling...
  9. doi request reprint Homeostatic regulation of synaptic GlyR numbers driven by lateral diffusion
    Sabine Levi
    Biologie Cellulaire de la Synapse, INSERM U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:261-73. 2008
    ..This provides a mechanism for a rapid homeostatic regulation of the inhibitory glycinergic component at mixed glycine-GABA synapses in response to increased NMDA excitatory transmission...
  10. pmc Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe
    Ignacio Izeddin
    Laboratoire Kastler Brossel, CNRS UMR 8552, Department of Physics, Ecole Normale Superieure, Universite Pierre et Marie Curie Paris 6, Paris, France
    PLoS ONE 6:e15611. 2011
    ....
  11. ncbi request reprint Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses
    Cyril Hanus
    Laboratoire de Biologie Cellulaire de la Synapses, Institut National de la Sante et de la Recherche Medicale, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 26:4586-95. 2006
    ..Moreover, the action of the potassium channel blocker 4-aminopyridine and receptor antagonists indicate that the dynamics of postsynaptic gephyrin scaffolds are controlled by synaptic activity...
  12. pmc Multiple association states between glycine receptors and gephyrin identified by SPT analysis
    Marie Virginie Ehrensperger
    Laboratoire Kastler Brossel, Centre National de la Recherche Scientifique UMR8552, Ecole Normale Superieure, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France
    Biophys J 92:3706-18. 2007
    ..Within clusters, we identified two subpopulations of GlyR with distinct degrees of stabilization between receptors and scaffolding proteins...
  13. pmc The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin
    Jayanta Mukherjee
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, Ecole Normale Superieure, Inserm U1024, 75230 Paris Cedex 05, France
    J Neurosci 31:14677-87. 2011
    ....
  14. ncbi request reprint Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography
    Philippe Rostaing
    INSERM U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Eur J Neurosci 24:3463-74. 2006
    ..Particularly, filamentous projections were observed linking the PSD to the actin cytoskeleton. Thus, synaptic ultrastructure can be analysed under more realistic conditions following HPF...
  15. ncbi request reprint Regulation of gephyrin assembly and glycine receptor synaptic stability
    Cecile Bedet
    INSERM U789, the Laboratoire de Biologie Cellulaire de la Synapse, Ecole Normale Superieure, F 75005, Paris, France
    J Biol Chem 281:30046-56. 2006
    ..These data suggest that the relative expression level of cellular variants influence the overall oligomerization pattern of gephyrin and thus the turnover of synaptic GlyR...
  16. pmc Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analyzed by single quantum dot imaging
    Cedric Bouzigues
    Laboratoire Kastler Brossel, Centre National de la Recherche Scientifique, Physics Department, Ecole Normale Superieure, and Université Pierre et Marie Curie Paris 6, 24, rue Lhomond, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:11251-6. 2007
    ..Altogether, our results reveal a microtubule-dependent polarized reorganization of chemoreceptors at the cell surface and suggest that this polarization serves as an amplification step in GABA gradient sensing by nerve GCs...
  17. ncbi request reprint Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate
    Cyril Hanus
    Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Sante et de la Recherche Medicale, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 24:1119-28. 2004
    ..Therefore, our data strongly suggest that some GlyR clusters are associated with gephyrin on their way to the cell surface and that this association increases the accumulation of GlyR at the plasma membrane...
  18. ncbi request reprint Target-dependent use of co-released inhibitory transmitters at central synapses
    Guillaume P Dugué
    Laboratoire de Neurobiologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8544, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 25:6490-8. 2005
    ..Thus, postsynaptic selection of coreleased fast transmitters is used in the CNS to increase the diversity of individual neuronal outputs and achieve target-specific signaling in mixed inhibitory networks...
  19. ncbi request reprint Imaging the lateral diffusion of membrane molecules with quantum dots
    Hiroko Bannai
    INSERM U789, Biologie Cellulaire de la Synapse N and P, Ecole Normale Superieure Paris, 46, rue d Ulm 75005 Paris, France
    Nat Protoc 1:2628-34. 2006
    ..The experimental procedure described for neurons below takes about 45 min. This technique is applicable to various cultured cells...
  20. doi request reprint Control of the postsynaptic membrane viscosity
    Marianne Renner
    Institut National de la Sante et de la Recherche Medicale, Biologie Cellulaire de la Synapse, 75005 Paris, France
    J Neurosci 29:2926-37. 2009
    ..Therefore, lipid composition and actin-dependent protein compaction regulate viscosity of the PSM and, consequently, the molecular flow in and out of synapses...
  21. ncbi request reprint Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!
    Antoine Triller
    INSERM UR497, Ecole Normale Superieure, 46 rue d Ulm, Paris F75005, France
    Trends Neurosci 28:133-9. 2005
    ..This review is part of the TINS Synaptic Connectivity series...
  22. ncbi request reprint The development of hippocampal interneurons in rodents
    Lydia Danglot
    Laboratoire de Biologie de la Synapse Normale et Pathologique, Unité Inserm U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Hippocampus 16:1032-60. 2006
    ..We will finally review potential mechanisms underlying the development of GABAergic interneurons...
  23. doi request reprint Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons
    Laetitia Hennekinne
    Ecole Normale Superieure, Institut de Biologie de l ENS, IBENS, Paris, France
    J Neurosci 33:11432-9. 2013
    ..These results suggest a role of TSP-1 in controlling the balance between excitation and inhibition which could help the recovery of normal synaptic activity after injury responses. ..
  24. doi request reprint Ultrastructural organization of presynaptic terminals
    Lea Siksou
    Institute of Biology of the Ecole Normale Supérieure, 46 rue d Ulm, 75005 Paris, France
    Curr Opin Neurobiol 21:261-8. 2011
    ....
  25. ncbi request reprint Single quantum dot tracking of membrane receptors
    Cedric Bouzigues
    Laboratoire Kastler Brossel, Physics Department, Ecole Normale Superieure, Paris, France
    Methods Mol Biol 374:81-91. 2007
    ..Single QD tracking is nevertheless a general method, suitable to study many transmembrane proteins...
  26. ncbi request reprint Morphologically identified glycinergic synapses in the hippocampus
    Lydia Danglot
    Laboratoire de Biologie Cellulaire de la Synapse N and P, Institut National de la Santé et de la Recherche Médicale U497, Ecole Normale Superieure, 75005 Paris, France
    Mol Cell Neurosci 27:394-403. 2004
    ..Finally, GlyR clusters could be detected at synaptic sites with the GABAA receptor gamma2 subunit and gephyrin, suggesting that mixed GABA/glycine synapses might exist in the hippocampus...
  27. doi request reprint Single-particle tracking methods for the study of membrane receptors dynamics
    Damien Alcor
    Biologie Cellulaire de la Synapse, INSERM U789, Ecole Normale Superieure, Paris, France
    Eur J Neurosci 30:987-97. 2009
    ..Constraints, limitations and future developments are discussed...
  28. ncbi request reprint Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
    Anne Roumier
    Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Santé et de la Recherche Médicale INSERM U497, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    J Neurosci 24:11421-8. 2004
    ..KARAP/DAP12 may thus alter microglial physiology and subsequently synaptic function and plasticity through a novel microglia-neuron interaction...
  29. ncbi request reprint Synaptic structure and diffusion dynamics of synaptic receptors
    Antoine Triller
    Biologie Cellulaire de la Synapse N and P, INSERM U497, Ecole Normale Superieure, Paris, France
    Biol Cell 95:465-76. 2003
    ....
  30. doi request reprint Adaptive and non-adaptive changes in activity-deprived presynaptic terminals
    Süzel Horellou
    Institute of Biology of the Ecole Normale Supérieure, 46 rue d Ulm, 75005, Paris, France INSERM U1024, Paris, France CNRS UMR8197, Paris, France
    Eur J Neurosci 39:61-71. 2014
    ..The modification of the distribution, but not the amount, of RIM1/2 may explain the contradiction between the morphological and electrophysiological findings. ..
  31. ncbi request reprint Preservation of immunoreactivity and fine structure of adult C. elegans tissues using high-pressure freezing
    Philippe Rostaing
    Biologie Cellulaire de la Synapse, Ecole Normale Superieure, Paris, France
    J Histochem Cytochem 52:1-12. 2004
    ..elegans tissues by using postembedding immunogold labeling...
  32. doi request reprint Synaptic stability and plasticity in a floating world
    Kimberly Gerrow
    Biologie Cellulaire de la Synapse, Institute de Biologie de l Ecole Normale Supérieure, 46 rue d Ulm, 75005 Paris, France
    Curr Opin Neurobiol 20:631-9. 2010
    ..We will briefly review here recent data on this mechanism, which ultimately tunes the number of receptors at synapses and therefore synaptic strength...
  33. ncbi request reprint Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking
    Maxime Dahan
    Laboratoire Kastler Brossel, CNRS UMR 8552, Ecole Normale Supérieure and Université Pierre et Marie Curie, 24 rue Lhomond, 75005 Paris, France
    Science 302:442-5. 2003
    ..The entry of GlyRs into the synapse by diffusion was observed and further confirmed by electron microscopy imaging of QD-tagged receptors...
  34. ncbi request reprint Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells
    Sheela Vyas
    INSERM U497, Ecole Normale Superieure, 46, rue d Ulm, Paris 75005, France
    J Biol Chem 279:30983-93. 2004
    ....
  35. ncbi request reprint Herpes simplex virus type 1 glycoprotein B sorting in hippocampal neurons
    Corinne Potel
    Laboratoire de Virologie, UPRES EA 3622, Faculté de Médecine Cochin, Universite Paris V, bâtiment Gustave Roussy, porte 636, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Gen Virol 84:2613-24. 2003
    ..These results suggest that the cytoplasmic tail of gB plays a role in maturation and transport and subsequently in axonal sorting in differentiated hippocampal neurons...
  36. pmc Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Neuron 43:633-45. 2004
    ..Since n-3 PFAs are essential for p85-mediated CNS insulin signaling and selective protection of postsynaptic proteins, these findings have implications for neurodegenerative diseases where synaptic loss is critical, especially AD...
  37. ncbi request reprint Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
    Isabelle Roux
    Inserm UMRS587, Unité de Génétique des Déficits Sensoriels, College de France, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Cell 127:277-89. 2006
    ..Thus, otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the IHC ribbon synapse...
  38. ncbi request reprint Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes
    Jens C Fuhrmann
    Max Planck Institute for Brain Research, Department of Neurochemistry, D 60528 Frankfurt Main, Germany
    J Neurosci 22:5393-402. 2002
    ..Because Dlc-1 and Dlc-2 have been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, our results suggest that motor proteins are involved in the subcellular localization of gephyrin...
  39. pmc Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function
    Anne Roumier
    INSERM, U789, Laboratoire de Biologie Cellulaire de la Synapse, Paris, France
    PLoS ONE 3:e2595. 2008
    ..Synaptic dysfunctions may be at the origin of cognitive impairments, however the link between prenatal inflammation and synaptic defects remains to be established...
  40. ncbi request reprint Tumor necrosis factor-alpha and neuronal development
    Alain Bessis
    Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, INSERM U497 Ecole Normale Supérieure, Paris, France
    Neuroscientist 11:277-81. 2005
    ..TNFalpha is also likely to induce immediate and delayed prodeath effects in adult and pathological tissues. Data obtained in embryonic systems will thus help to develop new therapeutic approaches to pathological neuronal death in adults...
  41. pmc Modeling synaptic dynamics driven by receptor lateral diffusion
    David Holcman
    Department of Mathematics, Weizmann Institute of Science, Rehovot, Israel
    Biophys J 91:2405-15. 2006
    ....
  42. ncbi request reprint Activation of presynaptic GABA(A) receptors induces glutamate release from parallel fiber synapses
    Brandon M Stell
    Laboratoire de Physiologie Cérébrale, Unité de Formation et de Recherche Biomédicale, Universite Paris Descartes, 75006 Paris, France
    J Neurosci 27:9022-31. 2007
    ..From these data, we conclude that GABA(A)Rs located on parallel fibers depolarize parallel fiber terminals beyond the threshold for Na+ channel activation and thereby induce glutamate release onto MLIs and Purkinje cells...
  43. pmc Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids
    Roger Cachope
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 56:1034-47. 2007
    ..Similar interactions between endocannabinoid and dopaminergic systems may be widespread and potentially relevant for the motor and rewarding effects of cannabis derivatives...
  44. doi request reprint Despite GABAergic neurotransmission, GABAergic innervation does not compensate for the defect in glycine receptor postsynaptic aggregation in spastic mice
    Emilie Muller
    UMR 7102 Neurobiologie des Processus Adaptatifs, Universite Pierre et Marie Curie, Bat B, Case 1, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Eur J Neurosci 27:2529-41. 2008
    ..They also indicate that GABAergic neurotransmission does not compensate for defects in GlyR postsynaptic aggregation leading to spastic syndrome in C57BL/6J SPA mice...
  45. doi request reprint Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor
    Shirley Wakselman
    Laboratoire de Biologie Cellulaire de la Synapse, Institut National de Santé et de Recherche Médicale, Unité 789, 75230 Paris Cedex 05, France
    J Neurosci 28:8138-43. 2008
    ..Thus, our data show that the process of developmental neuronal death triggered by microglia is similar to the elimination of pathogenic cells by the innate immune cells...
  46. ncbi request reprint Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study
    Cendra Agulhon
    Institut National de la Santé et de la Recherche Médicale INSERM U513, CHU Henri Mondor, 94000 Creteil, France
    J Comp Neurol 462:71-89. 2003
    ..Furthermore, its cell expression pattern suggests that it may contribute to specialized cellular function in the rat CNS such as neuronal metabolism, neurotransmission, and control of brain amino acid homeostasis...