Research Topics
Species | Jean Marc TreluyerSummaryCountry: France Publications
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Publications
Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance doseJ M Treluyer
Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Paris, France
Pediatrics 108:E73. 2001..To compare the antipyretic efficacy of an initial 30-mg/kg acetaminophen loading dose versus a 15-mg/kg maintenance dose...- Minimum effective dose of midazolam for sedation of mechanically ventilated neonatesJ M Treluyer
Pharmacologie, Hopital Cochin Saint Vincent de Paul, AP HP, Universite Paris V, Paris, France
J Clin Pharm Ther 30:479-85. 2005..To determine the minimal effective dose (MED) of intravenous midazolam, required for appropriate sedation in 95% of patients, 1 h after drug administration... - Sedation in children undergoing CT scan or MRI: effect of time-course and tolerance of rectal chloral hydrateJean Marc Treluyer
Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris 14, France
Fundam Clin Pharmacol 18:347-50. 2004..3% of the procedures. This sedation procedure appeared efficient and safe during ambulatory CT scan and NMR imaging. The long-term effect of chloral hydrate, however, remains to be evaluated... 
High concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patientsJean Marc Treluyer
Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP, Universite Rene Descartes, 75674 Paris Cedex 14, France
Antimicrob Agents Chemother 46:4009-12. 2002..Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy..- Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and childrenJ M Treluyer
Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Saint Vincent de Paul, Paris, France
Antimicrob Agents Chemother 46:1381-7. 2002..5 mg/kg of body weight twice daily than with a regimen of 15 mg/kg once a day for MICs of 1 to 8 mg/liter... - Evidence of impaired cisapride metabolism in neonatesJ M Treluyer
Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP et Université Paris René Descartes, 82 avenue Denfert Rochereau 75674 Paris Cedex 14, France
Br J Clin Pharmacol 52:419-25. 2001..Owing to the difficulties associated with in vivo pharmacokinetic studies in a paediatric population, we explored the in vitro metabolism of cisapride by human cytochrome P450... - Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virusHelene Chappuy
Pharmacologie Clinique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
Am J Obstet Gynecol 191:558-62. 2004..The purpose of this study was to investigate placental transfer and amniotic fluid concentrations of protease inhibitors when they are given to pregnant women who are infected with human immunodeficiency virus... - Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 womenSihem Benaboud
Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 56:776-82. 2012..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment... - Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patientsDeborah Hirt
Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 65:548-57. 2008..However, for MDR1 and CYP2C19 polymorphism, there have been contradictory studies, showing either no impact on nelfinavir concentration or modified concentrations which could influence virological response... - Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 womenSihem Benaboud
Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
Antimicrob Agents Chemother 56:857-62. 2012.... - Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 womenDeborah Hirt
Pharmacologie Clinique, Hopital Saint Vincent de Paul, Paris, France
Antimicrob Agents Chemother 50:2079-86. 2006..The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery... - Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavirConstance Delaugerre
Service de Virologie EA 3620, Hopital Necker Enfants Malades, Paris, France
J Acquir Immune Defic Syndr 37:1269-75. 2004..In pretreated children, LPV plasma levels should be optimized in an attempt to achieve sufficient drug concentrations to overcome the resistance level... - Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapyVincent Jullien
Service de Pharmacologie Clinique, Hopital Cochin Saint Vincent de Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
Antimicrob Agents Chemother 49:3361-6. 2005..In patients without tubular dysfunction, AUC(0-24) values markedly decreased from 6.7 to 1.4 mg . h/liter for BW/S(CR) increasing from 0.44 to 1.73. The relevance of a dosage adjustment based on BW/S(CR) should be further evaluated... - Maternal-fetal transfer and amniotic fluid accumulation of nucleoside analogue reverse transcriptase inhibitors in human immunodeficiency virus-infected pregnant womenHelene Chappuy
Pharmacology, Hopital Cochin Saint Vincent de Paul, 82, avenue Denfert Rochereau, 75674 Paris Cedex 14, France
Antimicrob Agents Chemother 48:4332-6. 2004..The efficacy or toxicity of NRTIs may vary according to placental transfer... - Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescentsFrantz Foissac
EA 3620 Université Paris Descartes, Paris, France
Br J Clin Pharmacol 72:940-7. 2011..To investigate atazanavir (ATV) population pharmacokinetics in children and adolescents, establish factors that influence ATV pharmacokinetics and investigate the ATV exposure after recommended doses... - Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samplesDeborah Hirt
Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
Br J Clin Pharmacol 64:634-44. 2007..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid... 
Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patientsNaïm Bouazza
EA 3620, Universite Paris Descartes, Sorbonne Paris Cité France, Paris, France
J Acquir Immune Defic Syndr 58:283-8. 2011..The main goal was then to suggest for the first time the dose of tenofovir disoproxil fumarate (TDF) to give in children...- Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effectSaik Urien
CIC 0901 Inserm Necker Cochin and EA 3620, Paris, France
Cancer Chemother Pharmacol 67:597-603. 2011.... - Readability of the written study information in pediatric research in FranceVéronique Ménoni
Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
PLoS ONE 6:e18484. 2011..The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability... - Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 yearsVincent Jullien
Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
Antimicrob Agents Chemother 50:3548-55. 2006..The consequences of these pharmacokinetic discrepancies and the necessity to modify the currently recommended dosage regimen should be further investigated... - Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?Deborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:4407-13. 2009..These assumptions should be prospectively confirmed... - Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonatesSihem Benaboud
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:331-7. 2011..The neonate must receive sdNVP immediately after birth when the infant is born less than 30 min after maternal drug intake to keep NVP concentrations above the IC(50)... - A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-naive and -experienced patientsMarion Bouillon-Pichault
Universite Paris Descartes, Paris, France
Antivir Ther 14:923-9. 2009..However, the probability to achieve these target C(troughs) with the current 400 mg twice-daily or 800 mg once-daily doses of the new tablet form, and the influence of body weight on this probability are unknown... - Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAARTJulie Bertrand
UMR 738, INSERM, Universite Paris Diderot, UFR de Medecine, 16, rue Henri Huchard, 75018, Paris, France
Eur J Clin Pharmacol 65:667-78. 2009..To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety... - Pharmacokinetics and virological efficacy after switch to once-daily lopinavir-ritonavir in treatment-experienced HIV-1-infected childrenFrantz Foissac
EA 3620 Université Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:4320-5. 2011..The switch from the BID to the QD LPV/r regimen led to equivalent exposure and lower C(trough) values and resulted in lower levels of virological control in these antiretroviral-experienced children... - Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)D Hirt
Universite Paris Descartes, EA3620, Paris, France
Clin Pharmacol Ther 85:182-9. 2009..Tenofovir showed good placental transfer (60%). Administering 13 mg/kg of TDF as soon as possible after birth should produce neonatal concentrations comparable with those observed in adults... - Lopinavir/ritonavir population pharmacokinetics in neonates and infantsSaik Urien
EA 3620, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 71:956-60. 2011..Lopinavir/ritonavir pharmacokinetics have been fully investigated in adults and children... - Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell lineSandra Manceau
EA 3620, Universite Paris Descartes, Paris, France
J Chemother 24:48-55. 2012..5-fold, respectively (P<10(-6)). ABCB1 induction by DEX in CCRF-CEM cells suggests a potential risk of interaction in lymphocytes when associating DEX to ABCB1 substrates in antiretroviral multitherapies in vivo... - Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitisDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Ther Drug Monit 31:557-65. 2009..2 days. Serum Mn concentrations could be related to a decrease in PT; the effect was longer in patients with an early decrease in total bilirubin serum concentrations... - Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitisNaïm Bouazza
EA 3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Br J Clin Pharmacol 74:971-7. 2012.... - Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort studyOdile Launay
Universite Paris Descartes, Paris, France
PLoS ONE 7:e52303. 2012..The objectives of the COFLUPREG study, initially set up to assess the incidence of serious forms of A/H1N1 influenza, were to assess the consequences of maternal vaccination on pregnancy outcomes and maternal seroprotection at delivery... - Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescentsNaïm Bouazza
EA 3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:3498-504. 2011.... - Potential benefit of Bayesian forecasting for therapeutic drug monitoring in neonatesGerard Pons
Perinatal and Pediatric Pharmacology, Saint Vincent de Paul Hospital, Rene Descartes University, Paris, France
Ther Drug Monit 24:9-14. 2002.... - Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothersAlbane Simon
Unité d Endocrinologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
JAMA 306:70-8. 2011..A warning about its tolerance in premature newborns was recently released, and transient elevation of 17-hydroxyprogesterone (17OHP) was noted in 2 newborns treated with lopinavir-ritonavir in France... - Vitamin D3 supplementation scheme in HIV-infected patients based upon pharmacokinetic modelling of 25-hydroxycholecalciferolFrantz Foissac
EA 3620 Université Paris Descartes, Sorbonne Paris Cité, France Unité de Recherche Clinique Paris Centre, Assistance Publique Hopitaux de Paris, Paris, France
Br J Clin Pharmacol 75:1312-20. 2013.... - Comparative transplacental transfer of taxanes using the human perfused cotyledon placental modelPaul Berveiller
Department of Clinical Pharmacology and Clinical Research Unit, INSERM Cliniques P 0901, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Am J Obstet Gynecol 207:514.e1-7. 2012..The use of taxanes (paclitaxel and docetaxel) in pregnant cancer patients is increasing. We aimed to compare their transplacental transfer using the gold standard human placental perfusion model, to guide drug selection... - An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic studyDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 65:629-36. 2008..Few studies of ibuprofen pharmacokinetics have been performed and were limited to small groups of preterm infants, showing a large intersubject variability and an increase in clearance with either postnatal or gestational age... - Didanosine population pharmacokinetics in West African human immunodeficiency virus-infected children administered once-daily tablets in relation to efficacy after one year of treatmentDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:4399-406. 2009..03) than that with a lower AUC. A didanosine dose of 360 mg/m2 administered as tablets should be a more appropriate dose than 240 mg/m2 to improve efficacy for these children. However, data on adverse events with this dosage are missing... - ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapiesCarole Giraud
Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre de Recherche Clinique Paris Descartes, Site Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
Expert Opin Drug Metab Toxicol 6:571-89. 2010..This variability may affect the intracellular concentrations and efficacy of drugs acting within lymphocytes, such as antiretroviral drugs... - Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytesCarole Giraud
Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
J Clin Pharmacol 50:226-30. 2010..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns... - Interferon-ribavirin in association with stavudine has no impact on plasma human immunodeficiency virus (HIV) type 1 level in patients coinfected with HIV and hepatitis C virus: a CORIST-ANRS HC1 trialDominique Salmon-Ceron
Department of Internal Medicine, Cochin Saint Vincent de Paul Hospital, Assistance Publique, Hopitaux de Paris, 75014 Paris France
Clin Infect Dis 36:1295-304. 2003.... - Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter studyHelene Chappuy
Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
Acta Paediatr 101:1089-94. 2012..We evaluated the extent to which parents understood the medical information about hospitalization of their child in an emergency department and looked for characteristics likely to increase the risk of poor comprehension... - Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approachSihem Benaboud
EA3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Eur J Clin Pharmacol 69:499-506. 2013.... - Hospitalization for severe bacterial infections in children after exposure to NSAIDs: a prospective adverse drug reaction reporting studySandrine Leroy
Pediatric Emergency Medicine Unit Department of Pediatrics, Cochin Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, Paris, France
Clin Drug Investig 30:179-85. 2010..NSAIDs are widely used to treat fever and pain in children, but their possible role in the progression of some bacterial infections is controversial... - Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitusChristophe Bardin
Pharmacy Pharmacology Toxicology Department, Hotel Dieu, 1 Place du Parvis Notre Dame, Paris Cedex 04, France
Eur J Clin Pharmacol 68:961-8. 2012.... - An observational study of bevacizumab-induced hypertension as a clinical biomarker of antitumor activityOlivier Mir
Department of Medical Oncology, Teaching Hospital Cochin, AP HP, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, F75014 Paris, France
Oncologist 16:1325-32. 2011..This study aimed to describe the incidence of bevacizumab-induced hypertension and factors associated with its development, then to retrospectively assess its relation with activity... - Transplacental transfer of oseltamivir and its metabolite using the human perfused placental cotyledon modelPaul Berveiller
Clinical Research Unit, Institut National de la Sante et de la Recherche Medicale, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
Am J Obstet Gynecol 206:92.e1-6. 2012.... - Benefit of therapeutic drug monitoring of protease inhibitors in HIV-infected patients depends on PI used in HAART regimen--ANRS 111 trialXavier Duval
Inserm CIC 007, Hopital Bichat, Paris, France
Fundam Clin Pharmacol 23:491-500. 2009.... - Functional role of p-glycoprotein and binding protein effect on the placental transfer of lopinavir/ritonavir in the ex vivo human perfusion modelPierre Francois Ceccaldi
Department of Obstetrics and Gynecology, Louis Mourier Hospital, AP HP, Paris 7 University, 92701 Colombes, France
Obstet Gynecol Int 2009:726593. 2009..This mechanism may play a role in fetal exposure to maternal antiretroviral therapy... - The readability of information and consent forms in clinical research in FranceVéronique Ménoni
Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
PLoS ONE 5:e10576. 2010..These studies all showed that such documents had a low level of readability. Our objective is to evaluate the readability of Information and Consent Forms (ICFs) used in clinical research... - Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaximeJacques Lepercq
Universite Paris Descartes, and Service de Gynécologie Obstétrique, Groupe Hospitalier Cochin Saint Vincent De Paul, 82, avenue Denfert Rochereau, Paris 75014, FranceParis, France
Antimicrob Agents Chemother 53:2342-5. 2009..The effectiveness of this regimen for the prevention of neonatal sepsis needs to be evaluated with a larger population... - Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonatesDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:1067-73. 2009..FTC was shown to have good placental transfer (80%). Administering 1 mg FTC/kg as soon as possible after birth or 2 mg/kg 12 h after birth should produce neonatal concentrations comparable to the concentrations observed in adults... - A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)Pierre Quartier
Université Paris Descartes and Hôpital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
Ann Rheum Dis 70:747-54. 2011..To assess the efficacy of the interleukin 1 receptor antagonist anakinra in systemic-onset juvenile idiopathic arthritis (SJIA)... - Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleenInnocent Safeukui
Molecular Immunology of Parasites Unit, CNRS URA 2581, Institut Pasteur, Paris, France
Blood 112:2520-8. 2008..Cryptic ring retention uncovers a new role for the spleen in the control of parasite density, opening novel intervention opportunities... - Determinants of non-vaccination against pandemic 2009 H1N1 influenza in pregnant women: a prospective cohort studyRomain Freund
INSERM U953, recherche épidémiologique en santé périnatale et santé des femmes et des enfants, Universite Pierre et Marie Curie, Paris, France
PLoS ONE 6:e20900. 2011..The study objective was to evaluate pandemic flu vaccine uptake and factors associated with non-vaccination in a population of pregnant women...