Jean Marc Treluyer

Summary

Country: France

Publications

  1. ncbi request reprint Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Paris, France
    Pediatrics 108:E73. 2001
  2. pmc Evidence of impaired cisapride metabolism in neonates
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP et Université Paris René Descartes, 82 avenue Denfert Rochereau 75674 Paris Cedex 14, France
    Br J Clin Pharmacol 52:419-25. 2001
  3. ncbi request reprint Minimum effective dose of midazolam for sedation of mechanically ventilated neonates
    J M Treluyer
    Pharmacologie, Hopital Cochin Saint Vincent de Paul, AP HP, Universite Paris V, Paris, France
    J Clin Pharm Ther 30:479-85. 2005
  4. pmc Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and children
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Saint Vincent de Paul, Paris, France
    Antimicrob Agents Chemother 46:1381-7. 2002
  5. pmc High concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patients
    Jean Marc Treluyer
    Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP, Universite Rene Descartes, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 46:4009-12. 2002
  6. ncbi request reprint Sedation in children undergoing CT scan or MRI: effect of time-course and tolerance of rectal chloral hydrate
    Jean Marc Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris 14, France
    Fundam Clin Pharmacol 18:347-50. 2004
  7. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
  8. pmc Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012
  9. ncbi request reprint Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus
    Helene Chappuy
    Pharmacologie Clinique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Am J Obstet Gynecol 191:558-62. 2004
  10. pmc Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients
    Deborah Hirt
    Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:548-57. 2008

Detail Information

Publications69

  1. ncbi request reprint Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Paris, France
    Pediatrics 108:E73. 2001
    ..To compare the antipyretic efficacy of an initial 30-mg/kg acetaminophen loading dose versus a 15-mg/kg maintenance dose...
  2. pmc Evidence of impaired cisapride metabolism in neonates
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP et Université Paris René Descartes, 82 avenue Denfert Rochereau 75674 Paris Cedex 14, France
    Br J Clin Pharmacol 52:419-25. 2001
    ..Owing to the difficulties associated with in vivo pharmacokinetic studies in a paediatric population, we explored the in vitro metabolism of cisapride by human cytochrome P450...
  3. ncbi request reprint Minimum effective dose of midazolam for sedation of mechanically ventilated neonates
    J M Treluyer
    Pharmacologie, Hopital Cochin Saint Vincent de Paul, AP HP, Universite Paris V, Paris, France
    J Clin Pharm Ther 30:479-85. 2005
    ..To determine the minimal effective dose (MED) of intravenous midazolam, required for appropriate sedation in 95% of patients, 1 h after drug administration...
  4. pmc Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and children
    J M Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Saint Vincent de Paul, Paris, France
    Antimicrob Agents Chemother 46:1381-7. 2002
    ..5 mg/kg of body weight twice daily than with a regimen of 15 mg/kg once a day for MICs of 1 to 8 mg/liter...
  5. pmc High concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patients
    Jean Marc Treluyer
    Pharmacologie Perinatale et Pediatrique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP, Universite Rene Descartes, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 46:4009-12. 2002
    ..Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy..
  6. ncbi request reprint Sedation in children undergoing CT scan or MRI: effect of time-course and tolerance of rectal chloral hydrate
    Jean Marc Treluyer
    Pharmacologie Perinatale et Pediatrique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris 14, France
    Fundam Clin Pharmacol 18:347-50. 2004
    ..3% of the procedures. This sedation procedure appeared efficient and safe during ambulatory CT scan and NMR imaging. The long-term effect of chloral hydrate, however, remains to be evaluated...
  7. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
    ..Pediatric experience with atazanavir combined with antiretroviral drugs administered once daily is very limited...
  8. pmc Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012
    ..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment...
  9. ncbi request reprint Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus
    Helene Chappuy
    Pharmacologie Clinique, Universite Rene Descartes, Hopital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Am J Obstet Gynecol 191:558-62. 2004
    ..The purpose of this study was to investigate placental transfer and amniotic fluid concentrations of protease inhibitors when they are given to pregnant women who are infected with human immunodeficiency virus...
  10. pmc Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients
    Deborah Hirt
    Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:548-57. 2008
    ..However, for MDR1 and CYP2C19 polymorphism, there have been contradictory studies, showing either no impact on nelfinavir concentration or modified concentrations which could influence virological response...
  11. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
    ..5 +/- 2.5 mg x h/L, which is slightly greater than the mean AUC value reported in adults. This study confirms the relevance of the current weight-based abacavir dosage regimen in pediatric patients...
  12. pmc Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012
    ....
  13. pmc Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy
    Vincent Jullien
    Service de Pharmacologie Clinique, Hopital Cochin Saint Vincent de Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 49:3361-6. 2005
    ..In patients without tubular dysfunction, AUC(0-24) values markedly decreased from 6.7 to 1.4 mg . h/liter for BW/S(CR) increasing from 0.44 to 1.73. The relevance of a dosage adjustment based on BW/S(CR) should be further evaluated...
  14. pmc Maternal-fetal transfer and amniotic fluid accumulation of nucleoside analogue reverse transcriptase inhibitors in human immunodeficiency virus-infected pregnant women
    Helene Chappuy
    Pharmacology, Hopital Cochin Saint Vincent de Paul, 82, avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 48:4332-6. 2004
    ..The efficacy or toxicity of NRTIs may vary according to placental transfer...
  15. ncbi request reprint In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism
    Carole Giraud
    Department of Pharmacology, Universite Paris Descartes, Faculte de Medecine, Groupe Hospitalier Cochin St Vincent de Paul, Paris, France
    Drug Metab Dispos 34:608-11. 2006
    ..11-4.24)]. The major in vitro inhibitory effect of STP on CLB metabolism and mostly on NCLB biotransformation is consistent with the changes in vivo in CLB and NCLB plasma concentrations in children treated by the association CLB/STP...
  16. pmc Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women
    Deborah Hirt
    Pharmacologie Clinique, Hopital Saint Vincent de Paul, Paris, France
    Antimicrob Agents Chemother 50:2079-86. 2006
    ..The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery...
  17. ncbi request reprint Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir
    Constance Delaugerre
    Service de Virologie EA 3620, Hopital Necker Enfants Malades, Paris, France
    J Acquir Immune Defic Syndr 37:1269-75. 2004
    ..In pretreated children, LPV plasma levels should be optimized in an attempt to achieve sufficient drug concentrations to overcome the resistance level...
  18. pmc Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescents
    Frantz Foissac
    EA 3620 Université Paris Descartes, Paris, France
    Br J Clin Pharmacol 72:940-7. 2011
    ..To investigate atazanavir (ATV) population pharmacokinetics in children and adolescents, establish factors that influence ATV pharmacokinetics and investigate the ATV exposure after recommended doses...
  19. doi request reprint Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patients
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Sorbonne Paris Cité France, Paris, France
    J Acquir Immune Defic Syndr 58:283-8. 2011
    ..The main goal was then to suggest for the first time the dose of tenofovir disoproxil fumarate (TDF) to give in children...
  20. doi request reprint High exposure to zidovudine during the first 2 weeks of life and concentration-toxicity relationships
    Deborah Hirt
    AP HP, Unite de recherche clinique, Hôpital Tarnier, Paris, France CIC 0901 Inserm, Cochin Necker, Paris, France AP HP, Service de Pharmacologie Clinique, Hopital Cochin, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France INSERM CESP U1018 Equipe VIH et IST, Le Kremlin Bicetre, France University of Paris Sud, Le Kremlin Bicetre, France AP HP, Service d Epidémiologie et Santé Publique, Hopital Bicetre, Le Kremlin Bicetre, France AP HP, Service de Neonatologie, hôpital Cochin Port Royal, Paris, France Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris, France Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France and AP HP, Unite d immunologie, Hématologie et Rhumatologie pédiatriques
    J Acquir Immune Defic Syndr 63:555-62. 2013
    ....
  21. pmc Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007
    ..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid...
  22. doi request reprint A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-naive and -experienced patients
    Marion Bouillon-Pichault
    Universite Paris Descartes, Paris, France
    Antivir Ther 14:923-9. 2009
    ..However, the probability to achieve these target C(troughs) with the current 400 mg twice-daily or 800 mg once-daily doses of the new tablet form, and the influence of body weight on this probability are unknown...
  23. pmc Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates
    Sihem Benaboud
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:331-7. 2011
    ..The neonate must receive sdNVP immediately after birth when the infant is born less than 30 min after maternal drug intake to keep NVP concentrations above the IC(50)...
  24. pmc Readability of the written study information in pediatric research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e18484. 2011
    ..The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability...
  25. doi request reprint Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
    Saik Urien
    CIC 0901 Inserm Necker Cochin and EA 3620, Paris, France
    Cancer Chemother Pharmacol 67:597-603. 2011
    ....
  26. pmc Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4407-13. 2009
    ..These assumptions should be prospectively confirmed...
  27. pmc Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years
    Vincent Jullien
    Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 50:3548-55. 2006
    ..The consequences of these pharmacokinetic discrepancies and the necessity to modify the currently recommended dosage regimen should be further investigated...
  28. ncbi request reprint Fluoroquinolone safety in pediatric patients: a prospective, multicenter, comparative cohort study in France
    Martin Chalumeau
    Perinatal and Pediatric Pharmacology Unit, Universite Rene Descartes, Hôpital Saint Vincent de Paul AP HP, Paris, France
    Pediatrics 111:e714-9. 2003
    ..To evaluate the safety of fluoroquinolones (FQ) in comparison with other antibiotics in pediatric patients...
  29. pmc Pharmacokinetics and virological efficacy after switch to once-daily lopinavir-ritonavir in treatment-experienced HIV-1-infected children
    Frantz Foissac
    EA 3620 Université Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:4320-5. 2011
    ..The switch from the BID to the QD LPV/r regimen led to equivalent exposure and lower C(trough) values and resulted in lower levels of virological control in these antiretroviral-experienced children...
  30. pmc Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART
    Julie Bertrand
    UMR 738, INSERM, Universite Paris Diderot, UFR de Medecine, 16, rue Henri Huchard, 75018, Paris, France
    Eur J Clin Pharmacol 65:667-78. 2009
    ..To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety...
  31. ncbi request reprint HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy
    Nicolas Dupin
    Service de Dermatologie CRPI, Universite Rene Descartes, Paris V, Hopital Tarnier Cochin, 89 rue d Assas, 75006 Paris, France
    AIDS 16:2419-24. 2002
    ..To determine HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy...
  32. pmc Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study
    Odile Launay
    Universite Paris Descartes, Paris, France
    PLoS ONE 7:e52303. 2012
    ..The objectives of the COFLUPREG study, initially set up to assess the incidence of serious forms of A/H1N1 influenza, were to assess the consequences of maternal vaccination on pregnancy outcomes and maternal seroprotection at delivery...
  33. pmc Evaluation of nevirapine dosing recommendations in HIV-infected children
    Frantz Foissac
    EA 3620 Université Paris Descartes Sorbonne Paris Cité, Unité de RechercheClinique, Hôpital Tarnier, 89 rue d Assas, Paris, France
    Br J Clin Pharmacol 76:137-44. 2013
    ..The aims of this study were to investigate the population pharmacokinetics of NVP in children, establish factors that influence NVP pharmacokinetics and evaluate the current dosing recommendations...
  34. doi request reprint Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)
    D Hirt
    Universite Paris Descartes, EA3620, Paris, France
    Clin Pharmacol Ther 85:182-9. 2009
    ..Tenofovir showed good placental transfer (60%). Administering 13 mg/kg of TDF as soon as possible after birth should produce neonatal concentrations comparable with those observed in adults...
  35. pmc Lopinavir/ritonavir population pharmacokinetics in neonates and infants
    Saik Urien
    EA 3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 71:956-60. 2011
    ..Lopinavir/ritonavir pharmacokinetics have been fully investigated in adults and children...
  36. ncbi request reprint Quantification of tipranavir in human plasma by high-performance liquid chromatography with UV detection
    Emmanuelle Giraud
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pharmacologie Clinique, France
    J Chromatogr B Analyt Technol Biomed Life Sci 830:86-90. 2006
    ..The method was linear and has been validated over a concentration range of 2-80 mg/l. The mean precision and accuracy of the method were respectively, 10.5 and -9.1%. The mean recovery was 70.8%...
  37. ncbi request reprint In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19
    Carole Giraud
    Pharmacologie, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Universite Rene Descartes, Paris, France
    Drug Metab Dispos 32:1279-86. 2004
    ....
  38. ncbi request reprint Determination of tenofovir in human plasma by high-performance liquid chromatography with spectrofluorimetric detection
    Vincent Jullien
    Service de Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Chromatogr B Analyt Technol Biomed Life Sci 785:377-81. 2003
    ..The average coefficient of the limit of quantification (5 microg/l) was 5.38% and at this concentration, a signal-to-noise ratio of 500 was measured..
  39. pmc Population pharmacokinetics study of recommended zidovudine doses in HIV-1-infected children
    Floris Fauchet
    EA 3620 Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Antimicrob Agents Chemother 57:4801-8. 2013
    ..9 kg and from 300 to 250 mg BID for the WB from 30 to 39.9 kg. The highest dose, 300 mg BID, should be started from body weights of 40 kg. ..
  40. doi request reprint Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line
    Sandra Manceau
    EA 3620, Universite Paris Descartes, Paris, France
    J Chemother 24:48-55. 2012
    ..5-fold, respectively (P<10(-6)). ABCB1 induction by DEX in CCRF-CEM cells suggests a potential risk of interaction in lymphocytes when associating DEX to ABCB1 substrates in antiretroviral multitherapies in vivo...
  41. doi request reprint Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Ther Drug Monit 31:557-65. 2009
    ..2 days. Serum Mn concentrations could be related to a decrease in PT; the effect was longer in patients with an early decrease in total bilirubin serum concentrations...
  42. doi request reprint Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach
    Sihem Benaboud
    EA3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Eur J Clin Pharmacol 69:499-506. 2013
    ....
  43. pmc Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Br J Clin Pharmacol 74:971-7. 2012
    ....
  44. ncbi request reprint Pharmacogenomics of fluorouracil, irinotecan, and oxaliplatin in hepatic metastases of colorectal cancer: clinical implications
    Frederike Lentz
    Service de Pharmacologie, Hopital Saint Vincent de Paul, avenue Denfert Rochereau, Paris, 75014, France
    Am J Pharmacogenomics 5:21-33. 2005
    ..However, the existing data are very promising in respect to the potential to guide dose and drug selection for more efficient and less toxic chemotherapy of hepatic metastases...
  45. ncbi request reprint Tocolytic effects of intravenous nitroglycerin
    Marina De Spirlet
    Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent de Paul AP HP, Universite Paris V, Paris, France
    Fundam Clin Pharmacol 18:207-13. 2004
    ..The present study suggests that nitroglycerin is not as effective as expected in controlling uterine contractions during severe preterm labor in patients where beta2 agonists cannot be used...
  46. doi request reprint Lopinavir/ritonavir monotherapy as a nucleoside analogue-sparing strategy to prevent HIV-1 mother-to-child transmission: the ANRS 135 PRIMEVA phase 2/3 randomized trial
    Roland Tubiana
    Service de Maladies Infectieuses, AP HP, Hopital Pitie Salpetriere, Paris, France
    Clin Infect Dis 57:891-902. 2013
    ..This multicenter trial evaluated whether lopinavir/ritonavir (LPV/r) monotherapy in HIV type 1-infected women not requiring antiretrovirals for themselves could control maternal viral load (VL)...
  47. pmc Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescents
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:3498-504. 2011
    ....
  48. doi request reprint Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothers
    Albane Simon
    Unité d Endocrinologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    JAMA 306:70-8. 2011
    ..A warning about its tolerance in premature newborns was recently released, and transient elevation of 17-hydroxyprogesterone (17OHP) was noted in 2 newborns treated with lopinavir-ritonavir in France...
  49. ncbi request reprint Potential benefit of Bayesian forecasting for therapeutic drug monitoring in neonates
    Gerard Pons
    Perinatal and Pediatric Pharmacology, Saint Vincent de Paul Hospital, Rene Descartes University, Paris, France
    Ther Drug Monit 24:9-14. 2002
    ....
  50. pmc Vitamin D3 supplementation scheme in HIV-infected patients based upon pharmacokinetic modelling of 25-hydroxycholecalciferol
    Frantz Foissac
    EA 3620 Université Paris Descartes, Sorbonne Paris Cité, France
    Br J Clin Pharmacol 75:1312-20. 2013
    ....
  51. doi request reprint Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model
    Paul Berveiller
    Department of Clinical Pharmacology and Clinical Research Unit, INSERM Cliniques P 0901, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Am J Obstet Gynecol 207:514.e1-7. 2012
    ..The use of taxanes (paclitaxel and docetaxel) in pregnant cancer patients is increasing. We aimed to compare their transplacental transfer using the gold standard human placental perfusion model, to guide drug selection...
  52. pmc Didanosine population pharmacokinetics in West African human immunodeficiency virus-infected children administered once-daily tablets in relation to efficacy after one year of treatment
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4399-406. 2009
    ..03) than that with a lower AUC. A didanosine dose of 360 mg/m2 administered as tablets should be a more appropriate dose than 240 mg/m2 to improve efficacy for these children. However, data on adverse events with this dosage are missing...
  53. doi request reprint ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies
    Carole Giraud
    Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre de Recherche Clinique Paris Descartes, Site Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Expert Opin Drug Metab Toxicol 6:571-89. 2010
    ..This variability may affect the intracellular concentrations and efficacy of drugs acting within lymphocytes, such as antiretroviral drugs...
  54. doi request reprint Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  55. ncbi request reprint Interferon-ribavirin in association with stavudine has no impact on plasma human immunodeficiency virus (HIV) type 1 level in patients coinfected with HIV and hepatitis C virus: a CORIST-ANRS HC1 trial
    Dominique Salmon-Ceron
    Department of Internal Medicine, Cochin Saint Vincent de Paul Hospital, Assistance Publique, Hopitaux de Paris, 75014 Paris France
    Clin Infect Dis 36:1295-304. 2003
    ....
  56. pmc An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:629-36. 2008
    ..Few studies of ibuprofen pharmacokinetics have been performed and were limited to small groups of preterm infants, showing a large intersubject variability and an increase in clearance with either postnatal or gestational age...
  57. pmc Functional role of p-glycoprotein and binding protein effect on the placental transfer of lopinavir/ritonavir in the ex vivo human perfusion model
    Pierre Francois Ceccaldi
    Department of Obstetrics and Gynecology, Louis Mourier Hospital, AP HP, Paris 7 University, 92701 Colombes, France
    Obstet Gynecol Int 2009:726593. 2009
    ..This mechanism may play a role in fetal exposure to maternal antiretroviral therapy...
  58. doi request reprint Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study
    Helene Chappuy
    Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 101:1089-94. 2012
    ..We evaluated the extent to which parents understood the medical information about hospitalization of their child in an emergency department and looked for characteristics likely to increase the risk of poor comprehension...
  59. doi request reprint Hospitalization for severe bacterial infections in children after exposure to NSAIDs: a prospective adverse drug reaction reporting study
    Sandrine Leroy
    Pediatric Emergency Medicine Unit Department of Pediatrics, Cochin Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, Paris, France
    Clin Drug Investig 30:179-85. 2010
    ..NSAIDs are widely used to treat fever and pain in children, but their possible role in the progression of some bacterial infections is controversial...
  60. doi request reprint Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus
    Christophe Bardin
    Pharmacy Pharmacology Toxicology Department, Hotel Dieu, 1 Place du Parvis Notre Dame, Paris Cedex 04, France
    Eur J Clin Pharmacol 68:961-8. 2012
    ....
  61. pmc An observational study of bevacizumab-induced hypertension as a clinical biomarker of antitumor activity
    Olivier Mir
    Department of Medical Oncology, Teaching Hospital Cochin, AP HP, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, F75014 Paris, France
    Oncologist 16:1325-32. 2011
    ..This study aimed to describe the incidence of bevacizumab-induced hypertension and factors associated with its development, then to retrospectively assess its relation with activity...
  62. pmc The readability of information and consent forms in clinical research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    PLoS ONE 5:e10576. 2010
    ..These studies all showed that such documents had a low level of readability. Our objective is to evaluate the readability of Information and Consent Forms (ICFs) used in clinical research...
  63. pmc Benefit of therapeutic drug monitoring of protease inhibitors in HIV-infected patients depends on PI used in HAART regimen--ANRS 111 trial
    Xavier Duval
    Inserm CIC 007, Hopital Bichat, Paris, France
    Fundam Clin Pharmacol 23:491-500. 2009
    ....
  64. pmc Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime
    Jacques Lepercq
    Universite Paris Descartes, and Service de Gynécologie Obstétrique, Groupe Hospitalier Cochin Saint Vincent De Paul, 82, avenue Denfert Rochereau, Paris 75014, FranceParis, France
    Antimicrob Agents Chemother 53:2342-5. 2009
    ..The effectiveness of this regimen for the prevention of neonatal sepsis needs to be evaluated with a larger population...
  65. pmc Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:1067-73. 2009
    ..FTC was shown to have good placental transfer (80%). Administering 1 mg FTC/kg as soon as possible after birth or 2 mg/kg 12 h after birth should produce neonatal concentrations comparable to the concentrations observed in adults...
  66. doi request reprint Transplacental transfer of oseltamivir and its metabolite using the human perfused placental cotyledon model
    Paul Berveiller
    Clinical Research Unit, Institut National de la Sante et de la Recherche Medicale, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Am J Obstet Gynecol 206:92.e1-6. 2012
    ....
  67. pmc A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
    Pierre Quartier
    Université Paris Descartes and Hôpital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Ann Rheum Dis 70:747-54. 2011
    ..To assess the efficacy of the interleukin 1 receptor antagonist anakinra in systemic-onset juvenile idiopathic arthritis (SJIA)...
  68. pmc Determinants of non-vaccination against pandemic 2009 H1N1 influenza in pregnant women: a prospective cohort study
    Romain Freund
    INSERM U953, recherche épidémiologique en santé périnatale et santé des femmes et des enfants, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 6:e20900. 2011
    ..The study objective was to evaluate pandemic flu vaccine uptake and factors associated with non-vaccination in a population of pregnant women...
  69. doi request reprint Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen
    Innocent Safeukui
    Molecular Immunology of Parasites Unit, CNRS URA 2581, Institut Pasteur, Paris, France
    Blood 112:2520-8. 2008
    ..Cryptic ring retention uncovers a new role for the spleen in the control of parasite density, opening novel intervention opportunities...