- DNA vaccines: a reviewM A Liu
Transgene, Strasbourg, France
J Intern Med 253:402-10. 2003..The breadth of applications for DNA vaccines thus ranges from prophylactic vaccines to immunotherapy for infectious diseases, cancer, and autoimmune and allergic diseases...
- Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse modelMaria G Isaguliants
Department of Virology, Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
Vaccine 22:1810-9. 2004..Immunization of HLA-A(*)0201-transgenic mice with RT minigenes induced RT-specific cellular responses detected by interferon-gamma secretion. This documents first steps in creating therapeutic vaccine against drug-resistant HIV strains...
- Gene-based vaccines and immunotherapeuticsMargaret Liu
Transgene, 11 rue de Molsheim, 67082 Strasbourg, France
Proc Natl Acad Sci U S A 101:14567-71. 2004..Both are encoded by a highly attenuated vaccinia virus vector [modified vaccinia Ankara (MVA)] and both are coexpressed with IL-2. Encouraging results seen in both of these programs are described...
- Can successful vaccines teach us how to induce efficient protective immune responses?Paul Henri Lambert
Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
Nat Med 11:S54-62. 2005....
- Intracellular targeting of CEA results in Th1-type antibody responses following intradermal genetic vaccination by a needle-free jet injection deviceSusanne Johansson
Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
ScientificWorldJournal 7:987-99. 2007..In contrast, utilizing the DNA construct that resulted in intracellular targeting of CEA led to a reduced capacity to induce CEA-specific antibodies, but instead induced a Th1-biased immune response...